ライフサイエンスコーパス: heavily

1 may thus appear to discount the future more heavily.

2 We show that most modern wild rice is heavily admixed with domesticated rice through both poll

3 r, an intense stress may halt germination or heavily affect various developmental stages and select f

4 The seventh cholera pandemic has heavily affected Africa, although the origin and contine

5 nder-approximate the effect seen in the most heavily affected areas.

6 y ASD-penetrant FMR1 and CHD8 genes are also heavily affected by MIA.

7 It is shown that 2DEG characteristics are heavily affected by the employed buffer layers between A

8 samplers were deployed in a rural community heavily affected by the natural gas boom.

9 ing and memory, is one of the first and most heavily affected regions.

10 Guinea, Liberia, and Sierra Leone were most heavily affected, but Ebola cases were exported to sever

11 show that hole-doped samples of PbTe can be heavily alloyed with SrTe well beyond its thermodynamic

12 The chemistry of the elements is heavily altered by high pressure, with stabilization of

13 The valence band is also heavily altered due to oxidation and amorphization.

14 e onset of endocycle S (endo-S) phase, H1 is heavily and specifically loaded into late replicating ge

15 We show that heavily annotated ('multifunctional') genes are likely t

16 this problem, rock phosphate fertilisers are heavily applied, often with negative environmental and s

17 We found that the orexin neurons are heavily apposed by axon terminals of glutamatergic and G

18 eagle expedition were examples of the large, heavily armored herbivores later known as glyptodonts.

19 y atherosclerosis, critical limb ischemia is heavily associated with smoking and diabetes.

20 This evidence is heavily based on the use of zeta inhibitory peptide (ZIP

21 properties of marketed CNS drugs, which are heavily biased toward "traditional" aminergic targets an

22 Here we show that in all donors a heavily biased use of two immunoglobulin heavy chain ger

23 Its heavily-built body bears flattened and overlapping gastr

24 functional category as being influenced most heavily by methylation.

25 me spectroscopic methods are influenced more heavily by specific membrane folding intermediates, and

26 h lesions, whereas others allow treatment of heavily calcified and tortuous segments.

27 The initial loss of calcium was less in heavily calcified aortas and was associated with an incr

28 (RA) is an important interventional tool for heavily calcified coronary lesions.

29 centromere core replicates in mid S, before heavily compacted classical heterochromatin, including p

30 Many areas have been heavily contaminated by heavy metals from industry and a

31 We report on two farms in Switzerland heavily contaminated by polychlorinated biphenyls (PCBs)

32 n operator26PFASs per year and hectare from (heavily) contaminated sites.

33 s physical and chemical properties, which is heavily controlled by its molecular structure.

34 vations by the Dawn spacecraft that reveal a heavily cratered surface, a heterogeneous crater distrib

35 Parts of Ceres' surface are heavily cratered, but the largest expected craters are a

36 ding associated predictions, and it has been heavily criticized and deemed obsolete.

37 s have superior cognitive abilities has been heavily criticized, primarily because of the lack of exp

38 Therapeutic options are heavily curtailed by a dearth of knowledge about the con

39 which is likely to cause phonon modes to be heavily damped and localized.

40 ations in the magnetically ordered phase and heavily damped electromagnons in the paramagnetic phase

41 in low-income and middle-income countries is heavily debated and one prominent strategy is social fra

42 Interestingly, this model remains heavily debated in roots, because of both the complex ro

43 the principal transport mechanism, has been heavily debated.

44 Paramagnetic particles heavily decorated with anti-ERalpha antibody and horsera

45 During memory encoding, CA3 stores heavily decorrelated engrams to prevent interference bet

46 m ilicifolium on seven reefs in Singapore; a heavily degraded urbanized reef system.

47 A single, heavily deleted copy of this retrovirus has been found i

48 dissipative non-equilibrium) structures that heavily depend on the method of preparation (i.e., pathw

49 based insights into molecular evolution may heavily depend on the software used.

50 properties of layered metal dichalcogenides heavily depend on their phase and layer stacking.

51 Malaria control is heavily dependent on chemotherapeutic agents for disease

52 m tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty acids.

53 Immune control of viral infections is heavily dependent on helper CD4(+) T cell function.

54 ays in that the overall Simoa performance is heavily dependent on the choice of antibodies; however,

55 l for the tasks, in which the performance is heavily dependent on the feature selection techniques, l

56 The quality of results from such screens is heavily dependent on the selection of optimal screen des

57 uantitative genetic trait prediction problem heavily depends on the encoding of genotypes, for both s

58 of internal noncompressible hemorrhage still heavily depends on transfusion of whole blood or blood's

59 A heavily diluted sample of subgingival plaque was inocula

60 e resonator system-intrinsic InSb wires on a heavily doped (epsilon-near-zero) InSb substrate-we demo

61 tribute it to intrinsic superconductivity of heavily doped individual phosphorene layers, while the i

62 e the critical concentration nc for films of heavily doped nanocrystals devoid of ligands at their su

63 insights into the photophysical processes in heavily doped nanocrystals will give rise to enhanced pr

64 room temperature based on bilayer n-MoS2 and heavily doped p-germanium, etc.

65 bed at the surface of the solar cell, in the heavily doped region, and the photo-generated electron-h

66 ransition (MIT) induced by magnetic field in heavily-doped Nb:STO (SrNb0.2Ti0.8O3) epitaxial thin fil

67 more adverse events in childhood, smoke more heavily, eat poorer diets, etc., than generations born e

68 Heavily electron-doped iron-selenide high-transition-tem

69 ttering to study the spin excitations of the heavily electron-doped iron-selenide material Li0.8Fe0.2

70 underlying the enhanced superconductivity in heavily electron-doped iron-selenide remains unclear.

71 e in mouse models of infection, even against heavily encapsulated strains.

72 ae, and Aspergillus fumigatus when mice were heavily engrafted with leukemia cells, had severe chemot

73 DMRs located within intergenic regions were heavily enriched for AP-1 transcription factor binding s

74 force behind broad, coherent variability of heavily exploited fish species.

75 antic and are both economically valuable and heavily exploited.

76 logy to Huntington disease (HD) has not been heavily explored.

77 ocioeconomic conditions, as in Zanzibar, are heavily exposed to enteric pathogens, but capable of rap

78 and nuclear factor I/A (Nfia), that are each heavily expressed in AII amacrine cells in the mature mo

79 MET is heavily expressed in neuronal growth cones at early deve

80 App is heavily expressed in neurons, the focus of the vast majo

81 Current drug design has been heavily focused on initial efficacy, and we do not fully

82 a protein's outer membrane regions are more heavily footprinted by OH radicals whereas the regions s

83 ls also accumulated nitric oxide and stained heavily for ethylene biosynthetic transcripts.

84 ectrometry (MS), but neutral sulfur clusters heavily fragment under MS conditions, preventing their e

85 terrestrial carbon sink but is also the most heavily fragmented forest biome in the world.

86 bunit of the HIV-1 envelope (Env) protein is heavily glycosylated at approximately 25 glycosylation s

87 n regulates the levels and activation of the heavily glycosylated Notch receptor involved in normal a

88 late in the HCMV replication cycle and is a heavily glycosylated protein that first localizes to the

89 Human IgM is heavily glycosylated, featuring five N-linked glycan sit

90 oil collected days after the accident from a heavily impacted area, soil sampled two years later from

91 Gulf of Mexico saltmarsh sediments were heavily impacted by Macondo well oil (MWO) released from

92 nd tomato but also for other vegetable crops heavily impacted by tospoviruses.

93 rites, and Dichocoenia stokesi were the most heavily impacted coral species, and were reduced to <3%

94 or oiled laid over vegetation to represent a heavily impacted marsh habitat, with unoiled vertical st

95 complex patterns of trophic control for the heavily impacted North Sea ecosystem.

96 tructure across the Colorado Front Range and heavily impacted the Cache La Poudre River watershed.

97 Stromal content heavily impacts the transcriptional classification of co

98 t of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and ma

99 ponses to a wide range of visual properties, heavily implicating future research on anxiety-preventio

100 economic development, China began investing heavily in protecting and restoring natural capital star

101 On the one hand, organizations invest heavily in systematic strategies to accelerate innovatio

102 each species, where individuals invest more heavily in weapon length at the expense of testes mass.

103 Ocular imaging has been heavily incorporated into glaucoma management and provid

104 and Cornu aspersum from around the U.K. are heavily infected with several nematode species including

105 dies in specific subtypes of cancer that are heavily infiltrated with adaptive immune cells.

106 These tumors were more heavily infiltrated with tumor-associated neutrophils (T

107 Links between individuals also heavily influence their levels of cooperation.

108 ng infections caused by MDR bacteria will be heavily influenced by a precision medicine approach, wit

109 ls: participants whose donation behavior was heavily influenced by affective empathy exhibited higher

110 ollectively, we conclude that cancer risk is heavily influenced by extrinsic factors.

111 Feeding behavior is heavily influenced by hippocampal-dependent mnemonic fun

112 t of high-quality trauma systems with access heavily influenced by insurance status.

113 long-range order at low temperature, but are heavily influenced by interactions and disorder due to t

114 le in carbon cycling and that this carbon is heavily influenced by land management practises.

115 However, this was heavily influenced by medical consultants.

116 endogenous cysteines, and whose activity is heavily influenced by neighboring lipids.

117 Reproduction is heavily influenced by nutrition and metabolic state.

118 m signaling, and tissue inflammation are all heavily influenced by the balance of rates of reaction a

119 of the Drosophila melanogaster adult wing is heavily influenced by the expression of proteins that di

120 The metastatic process is heavily influenced by the extracellular matrix (ECM) den

121 SOC was not associated with the MAT, but was heavily influenced by the intrinsic processes of SOC for

122 ptible to common reporting biases, or may be heavily influenced by the presence of other symptoms.

123 h a pristine site and at a site historically heavily influenced by wastewater treatment plants and an

124 The structure of the monomer heavily influences whether this material forms a highly

125 arized membrane surrounding the brain and is heavily innervated by sensory nerves.

126 critical micelle concentration, accumulates heavily inside cholesterol-rich late endosomes in Npc1(-

127 of possible colour-producing structures are heavily inspired by the elaborate architectures they fin

128 pitranscriptomics, which are predicted to be heavily involved in cognitive function.

129 tex (lPFC) of primates is hypothesized to be heavily involved in decision-making and selective visual

130 The most dense and heavily labeled population of cells was found in the org

131 We observed a heavily male-biased sex ratio in gametophyte plants (ram

132 At Spy cave, Belgium, Neanderthal diet was heavily meat based and included woolly rhinoceros and wi

133 more resistant to oxidative stress and more heavily melanized than VNBII isolates.

134 ndicated that the mir-124 gene loci are more heavily methylated in a Colombian population characteriz

135 odies) in the human genome are thought to be heavily methylated.

136 ich is based on robust statistics and allows heavily mixed clusters to be untangled.

137 tRNAs, rRNAs, and spliceosomal RNAs are also heavily modified and depend on the modifications for the

138 The protein is heavily modified by the accumulation of polyubiquitin ch

139 fications, PCR was used for the synthesis of heavily modified DNA, whereas terminal deoxynucleotidyl

140 nd that RRM domains are also one of the most heavily modified domains in the human proteome.

141 One salient feature of tRNA is its heavily modified status, which can critically impact its

142 roducts that are ribosomally synthesized and heavily modified.

143 Detection of AR amplification, heavily mutated AR (>/=2 mutations), and RB1 loss were a

144 ay regulates cell growth and movement and is heavily mutated in cancer.

145 The heavily mutated landscape of coding and non-coding mutat

146 The auditory system is heavily myelinated and operates at the upper limits of a

147 The large polymeric nets made up by the heavily O-glycosylated MUC2 mucin forms this physical ba

148 rimarily ligand centered, the dx2-y2 orbital heavily occupied, in what would normally be called a Cu(

149 sles and rubella elimination strategies rely heavily on achieving and maintaining high vaccination co

150 Frogs and toads rely heavily on acoustic communication for coordinating repro

151 Many rely heavily on administrative data as a surrogate to reflect

152 % of overall water consumption and it relies heavily on an aquifer (about 50% of agricultural consump

153 gram involve a stepwise approach that relies heavily on analytical methods to demonstrate through a "

154 and interfaces; but these calculations rely heavily on average atomic models extracted from crystall

155 Society currently relies heavily on centralized production and large scale distri

156 Both countries rely heavily on coal for energy, and sulfur dioxide (SO2) emi

157 for the Mid-Atlantic PJM system that relies heavily on coal-fired generation.

158 with hearing impairment are thought to rely heavily on context to compensate for reduced audibility.

159 olves and dogs, with the former relying more heavily on cooperative activities, predicts that at leas

160 osis of biofilm-associated infections relies heavily on culturing methods, which fail to detect noncu

161 ical role in males whereas females rely more heavily on D1 receptors, an effect that could be explain

162 pread bioapplications, in many cases relying heavily on delivery vehicles to introduce them into cell

163 ated disease management approaches that rely heavily on diverse phytosanitary measures.

164 Since labelling currently relies heavily on due diligence involving a paper trail, there

165 Modern disease studies rely heavily on exome sequencing, yet an adequate method for

166 challenges the gut microbiota, which relies heavily on host diet for metabolic substrates and the ga

167 ce population, prevalence estimates depended heavily on how LTBI was defined and test agreement was o

168 most notorious ectoparasites, bed bugs rely heavily on human or animal blood sources for survival, m

169 treatments involving these prodrugs depends heavily on identifying the correct treatment schedule, a

170 elief Hypothesis, supernatural belief relies heavily on intuitive thinking-and decreases when analyti

171 the accuracy of downstream analyses depends heavily on it.

172 hange are limited and local populations rely heavily on lakes for nutrition.

173 of cloudiness, lower crop canopies rely more heavily on light in the form of sunflecks, the quantity

174 studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvi

175 l determination of inorganic clusters relies heavily on mass spectrometry because of, in most cases,

176 or events in the history of life, and relies heavily on memorizing near-meaningless taxonomic ranks.

177 It is argued that the latter relies heavily on modifications to foods, resulting in enhanced

178 Chromosomally unstable cancer cells rely heavily on MPS1 to cope with the stress arising from abn

179 imited by the abundance of MutSbeta and rely heavily on Msh3 ATPase function.

180 e clinical management of severe pain depends heavily on opioids acting through mu opioid receptors en

181 ent approaches to molecular diagnostics rely heavily on PCR amplification and optical detection metho

182 isease and epidemics that seems to draw more heavily on peers.

183 monitoring lacks clear protocols and relies heavily on physical methods.

184 ive computation, however, these methods rely heavily on prior knowledge and are limited in genome-wid

185 d sub-Basin Amazon NBE estimates have relied heavily on process-based biosphere models, despite lack

186 ng, and writing, that are considered to rely heavily on proprioception.

187 Previous studies have relied heavily on recordings from blebs formed after axon trans

188 rs, or cellular delivery, both of which rely heavily on robust and reproducible bioconjugation techni

189 sitioning, suggesting that they may not rely heavily on rostrocaudal positioning to guide their funct

190 ectional observational studies, which relied heavily on self-report data such as surveys and scales.

191 We also agree that human cognition relies heavily on structured relational representations.

192 aptic plasticity of subicular neurons relies heavily on T-channels.

193 interventions in many cases is known to rely heavily on the ability of Abs to interact with a set of

194 ch counteraction can occur is seen to depend heavily on the amino acid composition of the peptide.

195 the survival of MDA-MB-231 TNBC cells relied heavily on the BCL-2/BCL-XL signaling axes in cells.

196 that its ability to mediate packaging relies heavily on the context of the downstream sequences.

197 o-bedside translation of nanomedicine relies heavily on the development of nanocarriers with superior

198 he biosynthesis of enveloped viruses depends heavily on the host cell endoplasmic reticulum (ER) glyc

199 ynthesis of complex organic molecules relies heavily on the introduction and manipulation of function

200 n countries where FMD is endemic, which rely heavily on the maintenance of the cold chain, with poten

201 The accuracy of this technique relies heavily on the selection of adequate reference genes.

202 ocardiography, and serum biomarkers featured heavily on the top-20 lists as opposed to traditional ca

203 to improve neurodevelopmental outcomes rely heavily on touch [8].

204 multifaceted layers of protection and relies heavily on trophoblasts, the fetal-derived cells that co

205 Consequently, our understanding relies heavily on untested theories, especially regarding the s

206 ould not be frozen at 100 K and proved to be heavily one-sided (if not anancomeric).

207 In a heavily overdoped, metallic but non-superconducting LSCO

208 We report that heavily overdoping a Bi2Sr2CaCu2O8+delta superconductor

209 e molecular sequence datasets that are often heavily partitioned in order to accurately model the und

210 ed of a blend of polyaspartic acid (PAA) and heavily PEGylated polyaspartic acid (PAA-PEG), was highl

211 d that the tetrahedral structure of water is heavily perturbed, the effect being equivalent to pressu

212 The CTD is heavily phosphorylated and serves as a scaffold, interac

213 Caspase-9 is the most heavily phosphorylated of all caspases, with phosphoryla

214 even in good visibility conditions, in this heavily photopolluted environment, and to altitudes up t

215 Histologic examination showed heavily pigmented intradermal proliferation of large, ep

216 on was significantly enhanced in the already heavily polluted capital city of China.

217 Under heavily polluted conditions, the UHI intensity was reduc

218 China is one of the most heavily polluted nations and is also the largest agricul

219 , there are multifold differences in several heavily polluted regions, among the scenarios, in the ch

220 lding energy efficiency standards within the heavily populated and polluted South Coast Air Basin (So

221 onse along the Pacific margin, exposing many heavily populated regions to increased coastal flooding

222 g climate pattern and urbanization in a more heavily populated U.S.

223 The respiratory tract is heavily populated with innate immune cells, but the mech

224 obiology, polytheonamides represent the most heavily post-translationally modified biomolecules that

225 ing complete remissions in a large subset of heavily pretreated adult patients and the vast majority

226 without unexpected toxicity in our cohort of heavily pretreated AL patients.

227 se 3 trial, we randomly assigned adults with heavily pretreated B-cell precursor ALL, in a 2:1 ratio,

228 afety profile and is active in patients with heavily pretreated ccRCC, validating direct HIF-2alpha a

229 rongest signals of efficacy observed in less heavily pretreated individuals.

230 the dose-escalation phase, 25 patients with heavily pretreated MM (22) or Waldenstrom macroglobuline

231 combination with dexamethasone is active in heavily pretreated MM and propose a RP2D of 45 mg/m(2) (

232 l response or better in approximately 30% of heavily pretreated MM patients as monotherapy.

233 b treatment induced favorable responses in a heavily pretreated patient cohort, justifying further st

234 nts after venetoclax failure, we analyzed 67 heavily pretreated patients on 3 early phase clinical tr

235 regimen and improves survival in responding, heavily pretreated patients with AL amyloidosis.

236 summarize the first-in-human experience in 3 heavily pretreated patients with intramedullary and exte

237 e safety profile and therapeutic activity in heavily pretreated patients with metastatic colorectal c

238 l-tolerated and induced durable responses in heavily pretreated patients with metastatic NSCLC.

239 d and induced early and durable responses in heavily pretreated patients with metastatic TNBC.

240 ty profile, is an active salvage regimen for heavily pretreated patients with relapsed or refractory

241 of brentuximab vedotin plus bendamustine in heavily pretreated patients with relapsed or refractory

242 Between 2004 and 2011, 76 heavily pretreated patients with relapsed/refractory NHL

243 and dexamethasone is active and tolerated in heavily pretreated patients with RRMM.

244 disease control in the setting of high risk, heavily pretreated patients.

245 erated and has high single agent activity in heavily pretreated relapsed and refractory multiple myel

246 These results in heavily pretreated rrPMBCL patients demonstrate that PD-

247 In this small, heavily pretreated study population, trastuzumab deruxte

248 prednisone (REP) had remarkable activity in heavily pretreated, lenalidomide-refractory MM patients.

249 al new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenstrom's m

250 al new treatment choice for patients who had heavily pretreated, rituximab-refractory Waldenstrom's m

251 Patients were heavily pretreated, with a median of four (range, one to

252 c potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such

253 gement: switching under external constraints heavily recruited prefrontal control regions, whereas na

254 the endogenous opioid beta-endorphin and are heavily regulated by opioids.

255 ll-specific responses, TGF-beta pathways are heavily regulated by secondary factors, such as membrane

256 This process is heavily regulated by such master transcription factors a

257 rise of Big moralizing Gods in a complex and heavily regulated social environment.

258 The workforce of the NHS is heavily reliant on EU staff.

259 fT is essential for S. aureus when growth is heavily reliant upon lipoamide-utilizing enzymes, but di

260 ns indicate that the somatosensory system is heavily relied upon for food consumption and prehensile

261 gical interpretation of metabolomics studies heavily relies on knowledge-based tools that contain inf

262 However, doctors heavily rely on the visual feedback provided by the endo

263 ptual response.SIGNIFICANCE STATEMENT Humans heavily rely on visual information to interact with thei

264 se showed that the molecules of the rTCA are heavily represented in such compound databases.

265 that primary isolates of HIV and SIV are so heavily resistant to antibody-mediated neutralization.

266 d (2) although scientific psychology must be heavily revised, the autonomy and irreducibility of folk

267 eceived neuromuscular blockade (46%) or were heavily sedated with State Behavioral Scale scores -3/-2

268 Our results demonstrate that a heavily semantic approach to sortal anaphora resolution

269 mest temperatures were recorded in the sites heavily shaded in vegetation during the austral winter a

270 The high incidence of nuclear activity among heavily stripped jellyfish galaxies may be due to ram pr

271 enesis, progression and metastasis have been heavily studied, especially with respect to identifying

272 thin artificial switching paradigms has been heavily studied, the neurobiology of natural switching w

273 abling the rapid and modular construction of heavily substituted pyrrolidines.

274 When the base is heavily sulfonated, neutrals elute after the anions.

275 that lipid synthesis by oligodendrocytes is heavily supplemented by astrocytes in vivo and that hori

276 The MR imaging technique included 1-mm heavily T2-weighted [TR 2000 ms; TE-200 ms] fast spin ec

277 The heavily telescoped process includes seven steps, two cry

278 he carbonate liquid structure is found to be heavily temperature-dependent.

279 d P concentrations and lower N : P ratios in heavily than lightly human-impacted environments, furthe

280 ons (eg, pupillary light reflex) contributed heavily to a linear model predicting behavioral state, w

281 ergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing

282 neral intelligence (g) in nonhumans but lean heavily toward mammalian data.

283 antly improve OS compared with prednisone in heavily treated patients with mCRPC and progressive dise

284 Deep, durable responses were observed in heavily treated patients.

285 insights into the evolution of plasticity in heavily twinned face-centered cubic metals, with the pot

286 ION: Results of trials for stalled drugs are heavily under-reported.

287 fects of biodemographic processes, which are heavily underexplored in current GWAS and which are impo

288 ical care can be accelerated by drawing more heavily upon implementation science and that until this

289 "the oldest of all pesticides," is the most heavily used agricultural pesticide in California and Eu

290 ting that it may promote the housekeeping of heavily used and strong synapses in response to the incr

291 the three swine farms where florfenicol was heavily used compared with the other sites.

292 Steels are heavily used in infrastructure and the transportation in

293 ClusPro is a heavily used protein-protein docking server based on the

294 prolonged wake, clearing worn components of heavily used synapses.

295 in solution-phase organic chemistry that are heavily used to protect/deprotect different functionalit

296 Although the server is heavily used, runs are generally completed in <4 h.

297 bination and DNA mismatch repair and is also heavily utilized in DNA-based computation and locomotion

298 ular perforation induction of SAH in mice, a heavily-utilized model.

299 oduce a new chemometric approach to identify heavily weathered and contaminated microplastics without

300 lexible, so prior knowledge is weighted more heavily when sensory estimates are imprecise, requiring