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1 ctivation of their endogenous immunoglobulin heavy chain variable regions.
2 the mutational status of the immunoglobulin heavy-chain variable region are important in clinical ma
3 the antibodies, particularly in CDR3 of the heavy chain variable region, are proposed to account for
4 non-immune llama single-domain VHH (camelid heavy-chain variable region derived from heavy-chain-onl
6 c leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic hypermutation i
8 cytic leukemia (CLL) express a restricted Ig heavy chain variable region gene (VH gene) repertoire.
10 view, we examined the role of immunoglobulin heavy-chain variable region gene (IGHV) mutation status
13 , 71% were nonmutated for the immunoglobulin heavy-chain variable region gene, 34% were CD38+, and 34
14 treatment irrespective of the immunoglobulin heavy-chain variable-region gene (IGHV) mutational statu
15 usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H)) and the 70-kD
16 clusively with rearrangements of a single Ig heavy-chain variable-region gene (V(H)3-30), despite an
19 pendix of young rabbits is a site of primary heavy chain variable region-gene diversification and B c
21 We applied deep repertoire sequencing of IgG heavy chain variable region genes (IgG-VH) in paired cer
22 utations also present mutated immunoglobulin heavy chain variable region genes (IGHVs), being the mos
23 of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV) each is assoc
25 cells that express unmutated immunoglobulin heavy-chain variable region genes (IgV(H)) generally exp
27 CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain.
28 xpression was more evident in immunoglobulin heavy chain variable region (IGHV)-mutated, CD38(-) or e
29 Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status,
30 -CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different st
31 argely derive from a specific antibody gene, heavy-chain variable region IGHV1-69, after limited affi
32 he absence of mutation in the immunoglobulin heavy chain variable region (IgV(H)) (P < .001), and wer
33 onal status of the rearranged immunoglobulin heavy-chain variable-region (IgV(H) ) gene, and the time
34 predicted antibody sequences for the entire heavy chain variable region, including framework, CDR1,
35 CL1/CL2 combination score and immunoglobulin heavy chain variable region mutation status were indepen
36 CL1/CL3 combination score and immunoglobulin heavy chain variable region mutation status were indepen
37 tablished prognostic markers (immunoglobulin heavy chain variable-region mutation status, CD38 or ZAP
38 els of PFS and OS showed that immunoglobulin heavy chain variable region mutational status was signif
39 xa and Puma, independently of immunoglobulin heavy chain variable region mutational status, CD38, and
40 lity complex class I-binding epitopes in the heavy chain variable region of anti-DNA antibodies from
42 sensitive methods, immunoglobulin light and heavy chain variable region patient-specific limiting-di
43 lobulin heavy-chain (IgH) intronic enhancer, heavy-chain variable region promoters, the Ig kappa intr
44 t-generation sequencing of an immunoglobulin heavy chain variable region repertoire before vaccinatio
45 neDB, a system for analyzing vast amounts of heavy chain variable region sequences and exploring the
50 y mutated antibody is domain exchange of the heavy-chain variable region (V(H)) with the V(H) of the
51 Specific B-cell clone expansion involved the heavy chain variable region (Vh) 5 and Vh7 B-cell recept
52 Ib (amino acids 365-394) is replaced by the heavy chain variable region (VH) domain of monoclonal an
53 bsequent LCL, for clonal immunoglobulin (lg) heavy chain variable region (VH) gene rearrangements.
55 sporadic B-CLL the same immunoglobulin (Ig) heavy chain variable region (VH) gene usage and occurren
57 ozen tissue sections and their rearranged Ig heavy chain variable region (VH) genes of the V186.2/V3
58 argeted B-cell response, we analyzed the IgG heavy chain variable region (VH) repertoire expressed in
59 cation of a single rearranged immunoglobulin heavy chain variable region (VH) sequence for each clone
60 repertoire sequencing of immunoglobulin (Ig) heavy chain variable regions (VH) from CSF and subsorted
61 proline at position 41, a non-CDR residue in heavy chain variable regions (VH), is important for huma
62 positive B cells expressing 6 immunoglobulin heavy-chain variable region (VH) subgroups before and 7
65 mplementary determining region (CDR2) of the heavy chain variable region were elucidated by LC/MS ana
66 clones used V(H)HAR genes for the coding of heavy chain variable region with limited numbers of nucl
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