ライフサイエンスコーパス: hedgehog

1 nsitization pathway presumably downstream of Hedgehog.

2 pon activation of signaling pathways such as Hedgehog.

3 ts that retain activation by cholesterol and Hedgehog.

4 rgrowth and the cooperation between Egfr and Hedgehog.

5 gehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions atypical

6 of Zwitch, we generated a conditional sonic hedgehog a (shha) allele.

7 Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian hedgehog

8 subgroup of HCA with beta-catenin and sonic hedgehog activation associated with malignant transforma

9 methyl-beta-cyclodextrin treatment enhances Hedgehog activation by a pathway agonist.

10 high levels of Gli1 expression, a marker of hedgehog activation, consistent with non-injured control

11 enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiat

12 in cytonemes, and that cholesterol-modified Hedgehog acts through Dispatched to increase cytoneme oc

13 Side-by-side comparison of PORCN and Hedgehog acyltransferase (HHAT), two enzymes that attach

14 cartilage growth plate structure, defective Hedgehog and altered ERK signalling.

15 We demonstrate that Hedgehog and Dispatched colocalize in cytonemes, and tha

16 ins conserved in mammals and discovered that Hedgehog and G-protein-coupled receptor pathways were li

17 than tissue from the other groups as well as hedgehog and mTOR pathway inhibition.

18 as an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that ma

19 These results suggest that crosstalk between Hedgehog and retinoid signaling modulates BTZ sensitivit

20 vascular smooth muscle contraction, and the hedgehog and Wnt signaling pathways) by hyper-methylatio

21 pathways interacting with Glide/Gcm: Notch, Hedgehog, and JAK/STAT, which all involve feedback loops

22 ive effect was associated with inhibition of hedgehog, and mTOR pathways and angiogenesis.

23 lls by targeting multiple pathways including hedgehog, and mTOR pathways and angiogenesis.

24 Signaling pathways (retinoic acid, sonic hedgehog, and Notch) that pattern the neural tube were s

25 critical importance, the mechanism by which Hedgehog antagonizes Patched has remained unknown.

26 multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast growth

27 Using this method, we examined Hedgehog-containing cytonemes and identified a role for

28 ling at cilia that maintains TZ function and Hedgehog-dependent embryonic development.

29 Together, these results demonstrate a Hedgehog-dependent mechanism underlying mammalian intrin

30 report Inpp5e(-/-) embryos exhibit aberrant Hedgehog-dependent patterning with reduced Hedgehog sign

31 n experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disruption of

32 ning cytonemes and identified a role for the Hedgehog deployment protein Dispatched in cytoneme stabi

33 der also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth muscle f

34 Proteins in the hedgehog family undergo self-catalyzed endoproteolysis i

35 sly undescribed two-step mechanism involving Hedgehog/Gli and unplugged/MuSK signaling pathways.

36 muscle genetic program as a direct target of Hedgehog/Gli signaling.

37 on factors strongly correlate with activated Hedgehog/GLI signalling but not with the Hh ligands.

38 ned angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling

39 educed at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased B cell

40 it is often related to the activation of the Hedgehog (Hh) and MET signaling cascades driving the epi

41 The Hedgehog (Hh) and PI3K/AKT pathways were upregulated in

42 Here we show that epidermal Hedgehog (Hh) and Transforming growth factor-beta (TGF-b

43 Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the

44 nt of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity f

45 Here, we find excess Hedgehog (HH) ligand secretion and loss of PTCH2 in myel

46 Previously we demonstrated that Hedgehog (Hh) morphogen is transported via vesicles alon

47 ulate development by mediating the action of Hedgehog (Hh) morphogens.

48 ex vivo and in vivo models, we identify the Hedgehog (HH) paracrine system as a candidate signaling

49 anism of BRAFi resistance driven by elevated Hedgehog (Hh) pathway activation that is observed in a c

50 es, we show that Mdr49 is a component of the Hedgehog (hh) pathway and it potentiates the signaling a

51 nic trioxide and itraconazole antagonize the hedgehog (HH) pathway at sites distinct from those treat

52 Recently, the Hedgehog (Hh) pathway has emerged as an essential regula

53 ation, is interrupted in mice treated with a hedgehog (Hh) pathway inhibitor (HPI), and that gustator

54 The Hedgehog (Hh) pathway is a highly conserved signaling ca

55 Hedgehog (Hh) pathway is involved in epithelial-mesenchy

56 Targeting the Hedgehog (Hh) pathway represents a potential leukaemia s

57 ting and transcriptional activity of GLI1, a Hedgehog (Hh) pathway transcriptional activator and self

58 mas are associated with misactivation of the Hedgehog (Hh) pathway.

59 e that TB4 influences HSC activation through hedgehog (Hh) pathway.

60 In the Drosophila wing disc, Hedgehog (Hh) produced by posterior compartment cells di

61 Hedgehog (HH) signaling critically regulates embryonic a

62 Hedgehog (Hh) signaling has been shown to inhibit adipos

63 rted, the association of WDR34 function with Hedgehog (Hh) signaling has not been established, and ac

64 Hedgehog (Hh) signaling in vertebrates depends on primar

65 Hedgehog (Hh) signaling induces the Hippo pathway effect

66 Hedgehog (Hh) signaling is fundamentally important for d

67 normalities found in OMOD1 patients and that Hedgehog (Hh) signaling is significantly reduced in the

68 The Hedgehog (Hh) signaling pathway governs complex developm

69 The Hedgehog (Hh) signaling pathway is activated in many can

70 The Hedgehog (HH) signaling pathway is essential for the mai

71 The hedgehog (Hh) signaling pathway plays a central role dur

72 Hedgehog (Hh) signaling plays a pivotal role in animal d

73 Hedgehog (Hh) signaling promotes B lymphopoiesis in a no

74 Hedgehog (Hh) signaling regulates cell fate and self-ren

75 c target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms a

76 In Hedgehog (Hh) signaling, the GPCR-family protein Smoothe

77 To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screen

78 programs induce primary cilia formation and Hedgehog (Hh) signaling, which has previously been impli

79 sin, Kif7, which is a conserved regulator of Hedgehog (Hh) signaling.

80 ) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling.

81 li3 for degradation and negatively regulates Hedgehog (Hh) signaling.

82 reased primary cilia formation and activated hedgehog (Hh) signaling.

83 activating PKCiota-dependent cell autonomous Hedgehog (Hh) signaling.

84 The Hedgehog (Hh) signalling pathway is one of the key regul

85 During murine villus development, epithelial Hedgehog (Hh) signals promote aggregation of subepitheli

86 es that transduce intercellular cues such as Hedgehog (Hh) signals.

87 are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonideg

88 ne morphogenetic proteins (BMPs), Notch, and Hedgehog (Hh).

89 ted protein required for the transduction of Hedgehog (HH).

90 Uncontrolled hedgehog (HH)/glioma-associated oncogene (GLI) and WNT/b

91 Indian Hedgehog (Ihh) regulates chondrocyte and osteoblast diff

92 gehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with upregulation of the transcripti

93 ermore, both the Hh co-receptor Interference hedgehog (Ihog) and the glypicans are critical for this

94 tter interchangeably encoded by interference hedgehog (ihog) or brother of ihog (boi).

95 beta-catenin or treatment with FGF18 rescued hedgehog-induced phenotypes.

96 tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell different

97 mutagenesis and inhibitory via production of hedgehog-inhibiting vitamin D3 (D3).

98 on experienced by cancer patients undergoing Hedgehog inhibitor treatment.

99 In vivo treatment of tumors with the Hedgehog inhibitor vismodegib reduce CAF and CSC expansi

100 apeutic target in T-ALL and demonstrate that hedgehog inhibitors approved by the US Food and Drug Adm

101 Targeting CAFs with Hedgehog inhibitors may offer a novel therapeutic strate

102 Thus, our results demonstrate that hedgehog inhibits selective beta-catenin target gene exp

103 Hedgehog/INTein (HINT) domains catalyzing protein splici

104 The 2 variants annotated to the genes hedgehog interacting protein (HHIP) and family with sequ

105 Genetic variants annotated to the hedgehog interacting protein (HHIP) are robustly associa

106 on the sonic hedgehog (Shh)-binding loop of hedgehog-interacting protein (HHIP) and subjected to mul

107 Overexpression of sonic hedgehog ligand (SHH) in infected WT mice accelerated th

108 Furthermore, overexpression of a transgenic hedgehog ligand in the epithelium also partially restore

109 In this setting, CSCs secrete the Hedgehog ligand SHH, which regulate CAFs via paracrine a

110 gehog signaling is triggered by the secreted Hedgehog ligand, which binds and inhibits Patched, thus

111 is associated with ectopic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog

112 Using sonic hedgehog lineage tracing, we show that the third and fou

113 Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and bio

114 loblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling.

115 iding the most potent inhibitor of the sonic hedgehog/patched interaction reported to date.

116 In contrast, potent inhibitors of the sonic hedgehog/patched interaction, the most upstream event in

117 f SHH or IHH in mouse T cells in vivo caused hedgehog pathway activation in both lymphoid and epithel

118 investigating and targeting ligand-dependent hedgehog pathway activation in cancer and other patholog

119 Hedgehog pathway activation is associated with ectopic e

120 a polar/stalk cell fate through suppressing Hedgehog pathway activity.

121 ion of SHH ligand, SMO antagonists, or other Hedgehog pathway agonists did not affect GLI1 expression

122 We identify the hedgehog pathway as a novel therapeutic target in T-ALL

123 Activation of the hedgehog pathway by addition of a Smoothened agonist or

124 We evaluated the hypothesis that the Hedgehog pathway controls Yap1 activation during liver r

125 significantly lower mRNA abundance of sonic hedgehog pathway elements at P0 vs E12.5, while abundanc

126 e receptor target genes including the Indian Hedgehog pathway genes are significantly down-regulated

127 identification of chemical modulators of the hedgehog pathway have yielded several antagonists of the

128 and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS.

129 xpression data, we provide evidence that the hedgehog pathway is activated in 20% of T-ALL samples.

130 n-class macrocyclic peptide modulator of the hedgehog pathway is expected to provide a valuable probe

131 our results reveal that dysfunctions in the Hedgehog pathway play an important role in hepatic steat

132 a that form are of normal length and traffic Hedgehog pathway proteins within the cilium correctly.

133 are also lost upon pharmacologic blockade of Hedgehog pathway response, accounting for the loss of ta

134 naminones, proved to inhibit efficiently the Hedgehog pathway through direct antagonism of the wild-t

135 (BCCs) are characterized by upregulation of Hedgehog pathway through loss of PTCH1 or activation of

136 Here, we identify the Hedgehog pathway transcription factor GLI1 as a critical

137 We find that Gli2, the major Hedgehog pathway transcriptional effector, acts within m

138 In our model, the hedgehog pathway was downregulated by Mtb-stimulation, b

139 ediator of progesterone action in the Indian Hedgehog pathway, by ChIP analysis.

140 Our findings show how Nestin drives hedgehog pathway-driven cancers and uncover in Gli3 a th

141 and the relocalization of components of the Hedgehog pathway.

142 ating its ability to negatively regulate the hedgehog pathway.

143 iveness and OR transport is regulated by the Hedgehog pathway.

144 INHBE and GLI1 genes and activation of sonic hedgehog pathway.

145 Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved for use in adult

146 biology, with a focus on Notch, Hes/Hey, and hedgehog pathways.

147 tity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord.

148 Other hedgehog point mutants at D303, also unreactive with cho

149 or endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of

150 n occurs during somite stages due to varying Hedgehog protein levels, while later expansion refines t

151 limit the range of signaling by sequestering Hedgehog protein signal within imaginal disc epithelium.

152 Hedgehog proteins control morphogenesis by promoting GLI

153 , Patched, is transcriptionally activated by Hedgehog, providing essential negative feedback in all t

154 We saw increased Gli1 (hedgehog readout) in postnatal Six2creFrs2alphaKO inters

155 Hedgehog receptor function requires both Patched and Iho

156 The Drosophila Hedgehog receptor functions to regulate the essential do

157 The Hedgehog receptor, Patched, is transcriptionally activat

158 n Yap1 inhibited induction of both Yap1- and Hedgehog-regulated genes that enable HSC to become myofi

159 ted hepatocytes from up-regulating Yap1- and Hedgehog-regulated transcription factors that normally p

160 Hedgehog regulates differentiation and proliferation of

161 Such pharmacologic enhancement of Hedgehog response, however, results in additional TRC fo

162 ally enhanced by pharmacologic activation of Hedgehog response.

163 ensuring appropriate pathway activity in all Hedgehog-responsive cells, how the transporter-like rece

164 In vivo, mutating Indian Hedgehog results in a sex ratio bias against females, an

165 oosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SHH-guided neur

166 Sonic hedgehog (Shh) attracts spinal cord commissural axons to

167 e to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 and that

168 Sonic hedgehog (Shh) expression in the limb bud organizing cen

169 that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal.

170 strate a requirement for the Hh ligand Sonic Hedgehog (Shh) for the progression of SCLC.

171 n axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh) guides axons via a noncanonical signaling

172 Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demons

173 reFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets of non-dilated P7 mutant proxi

174 Sonic hedgehog (Shh) is a mitogen for spinal cord progenitors,

175 Sonic hedgehog (Shh) is a secreted protein that controls the p

176 Sonic hedgehog (SHH) is an essential morphogenetic signal that

177 In the early limb bud, for instance, Sonic hedgehog (Shh) is expressed in the distal posterior mese

178 eated with Smoothened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood brain b

179 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validated the

180 n, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

181 pic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with upregu

182 Treatment with the Sonic hedgehog (Shh) pathway agonist purmorphamine or cyclin-d

183 The Sonic Hedgehog (SHH) pathway is a key signaling pathway orches

184 IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway.

185 l buds and suppress epithelial-derived sonic hedgehog (SHH) production.

186 a transmembrane protein related to the Sonic hedgehog (Shh) receptor, Patched, and involved in intrac

187 Sonic Hedgehog (SHH) reduces ciliary cAMP levels, inhibits cil

188 Sonic hedgehog (Shh) signal transduction was downregulated in

189 has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation.

190 hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple aspect

191 scued mandibular morphogenesis through sonic hedgehog (SHH) signaling to the mesenchyme.

192 In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly expresse

193 ression profile consistent with active Sonic Hedgehog (SHH) signaling.

194 el of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud specifie

195 TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1.

196 ups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily treatm

197 Here, we show that Sonic hedgehog (Shh), which encodes a secreted protein signal,

198 clic peptide was designed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interacting prot

199 SLOS resemble those seen in congenital Sonic Hedgehog (SHH)-deficient conditions, leading to the prop

200 Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural c

201 We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2

202 d shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patients.

203 ong-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma.

204 xpression, controlled by the morphogen Sonic hedgehog (Shh).

205 conserved long-range limb enhancer of Sonic hedgehog (Shh).

206 development via the secreted morphogen Sonic hedgehog (Shh).

207 sites in the limb-specific enhancer of Sonic hedgehog (SHH).

208 tween molecular subgroups (WNT, n = 4; sonic hedgehog [SHH; n = 4]; group 4 [n = 41]; group 3 with [n

209 Tetrapod limbs are patterned by asonic hedgehog(Shh)-expressing signalling centre known as the

210 ited by conditional gene inactivation of the Hedgehog signal mediator Smoothened (Smo) as well as by

211 tion, even with downstream genetic rescue of Hedgehog signal response.

212 re speculated to act as key intermediates in Hedgehog signal transduction, but their precise identity

213 criptome profiling shows that Msi2 represses Hedgehog signaling activity and that Shh is its direct t

214 Notably, sonic hedgehog signaling activity influences clonal spatial di

215 is able to effectively suppress Shh-mediated hedgehog signaling and Gli-controlled gene transcription

216 n genetic disease that phenocopies deficient Hedgehog signaling and is caused by genetic loss of 7-DH

217 cts of LiCl on chondrocyte primary cilia and Hedgehog signaling and shows for the first time that pha

218 ed hepatic stellate cells (HSCs), disrupting Hedgehog signaling blocked activation of Yap1, and knock

219 quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follic

220 Here we report that LiCl (50 mM) inhibits Hedgehog signaling in bovine articular chondrocytes such

221 sults suggest that the presence of activated hedgehog signaling in enthesis cells early in the healin

222 r examine the involvement of Gli1+ cells and hedgehog signaling in enthesis healing, Gli1 expression

223 In mice, disrupting Hedgehog signaling in MFs inhibited liver regeneration a

224 We find that aberrant hedgehog signaling in microscopic BCCs activates p53 in

225 e, we demonstrate that constitutively active Hedgehog signaling in murine intermediate mesoderm-deriv

226 ings both define a physiological function of Hedgehog signaling in olfaction and provide an important

227 Moreover, Hedgehog signaling in two Nestin-expressing progenitor p

228 Hedgehog signaling induced expression of a dominant nega

229 he time of surgical correction, suggest that Hedgehog signaling is abnormally regulated during the ge

230 Hedgehog signaling is activated in osteoarthritis, where

231 Hedgehog signaling is critical for vertebrate central ne

232 Hedgehog signaling is triggered by the secreted Hedgehog

233 we showed that hepatocellular inhibition of Hedgehog signaling leads to steatosis by altering the ab

234 Importantly, inhibition of Hedgehog signaling offers an avenue to target the vulner

235 pathway that is distinct from the canonical Hedgehog signaling pathway that specifies cell fate and

236 f cell lines with aberrant activation of the Hedgehog signaling pathway.

237 ition of the CRD-BP-GLI1 RNA interaction and Hedgehog signaling pathway.

238 cer, results from aberrant activation of the Hedgehog signaling pathway.

239 dependent gene sets identified the Notch and Hedgehog signaling pathways as key determinants in coord

240 Planarian glia and their regulation by Hedgehog signaling present a novel tractable system for

241 We demonstrate that Hedgehog signaling requires sterol binding to Smoothened

242 Hedgehog signaling requires the primary cilium such that

243 e determined that constitutive activation of hedgehog signaling specifically within interzone cells i

244 Hedgehog signaling specifies tissue patterning and renew

245 opic population of cells expressing Ptch2, a Hedgehog signaling target.

246 of BCAR4, which subsequently coordinates the Hedgehog signaling to enhance the transcription of glyco

247 the functional interplays between Hippo and Hedgehog signaling underlying temporal and spatial contr

248 Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (S

249 Using mouse genetics, we show increasing Hedgehog signaling via Smoothened M2 expression rescues

250 In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis

251 icating alpha-cell exhibited activated Sonic hedgehog signaling, a pathway not previously known to co

252 Cilia are essential for Hedgehog signaling, and humans affected by skeletal cili

253 e epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not block

254 lular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis o

255 y through regulating cell cycle progression, Hedgehog signaling, and WNT signaling.

256 rs were characterized by activation of sonic hedgehog signaling, due to focal deletions that fuse the

257 non-dilated proximal tubules), and augmented hedgehog signaling, features also seen in other PKD mode

258 cells produced elongated cilia, had altered hedgehog signaling, had increased post-translation modif

259 urthermore, our results suggest that, during Hedgehog signaling, ligand binding inhibits Patched by t

260 c removal of GPR161, a negative regulator of Hedgehog signaling, permits the appropriate transduction

261 s for gp130, interleukin 6, cytokines, sonic hedgehog signaling, STAT3 phosphorylation (activation),

262 Consistent with the erroneous activation of hedgehog signaling, we demonstrate that GATA4 and GATA6

263 eceptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell c

264 against its oncogenic effects by inhibiting Hedgehog signaling, whereas dietary vitamin D3 does not.

265 CF7L2 isoforms in mouse chondrocytes rescued hedgehog signaling-induced Fgf18 downregulation, while o

266 d c-Myc phosphorylation and increased Wnt or Hedgehog signaling.

267 ls indicating a clear dependence of cells on Hedgehog signaling.

268 mooth muscle cell differentiation induced by Hedgehog signaling.

269 (-/-) ciliopathy phenotypes and "normalizes" Hedgehog signaling.

270 odulated by Merlin, leading to activation of Hedgehog signaling.

271 s in mice with disruptions in cilia-mediated Hedgehog signaling.

272 tivated mitogen-activated protein kinase and hedgehog signaling.

273 ent TGFbeta signaling, and increased WNT and Hedgehog signaling.

274 ium-associated trafficking of Smoothened and Hedgehog signaling.

275 dative stress causing aberrant activation of Hedgehog signaling.

276 nd contribute to tendon repair by activating Hedgehog signaling.

277 ch regulate CAFs via paracrine activation of Hedgehog signaling.

278 characteristic of decreased cilia-dependent Hedgehog signaling.

279 the requirement of a ciliary compartment for Hedgehog signaling.

280 t Hedgehog-dependent patterning with reduced Hedgehog signaling.

281 ssor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by ma

282 Cholesterol can regulate the Hedgehog signalling pathway by directly binding to a rec

283 rfamily, constituting a key component of the Hedgehog signalling pathway.

284 In turn, Egfr cooperates with Hedgehog signalling.

285 functions, including growth factor and Sonic hedgehog signalling.

286 ing, permits the appropriate transduction of Hedgehog signals in Bbs mutants.

287 ncogenic Ras elicits and integrates Egfr and Hedgehog signals to drive overgrowth remains unclear.

288 , through the action of Sertoli cell-derived Hedgehog signals, become positive for GLI1.

289 n ADM that is balanced by cross-talk between Hedgehog/SMO and AKT/GLI2 pathways in stromal fibroblast

290 Hedgehog/Smoothened (Hh/Smo) signaling has been variably

291 states of matter (such as dipolar skyrmions, hedgehog states) and associated phenomena in ferroic mat

292 3 accumulated at the transition zone (TZ) in Hedgehog-stimulated Inpp5e(-/-) cells, which was associa

293 gene Ptch1 and a recapitulation of the sonic hedgehog subgroup of human medulloblastomas.

294 The Hedgehog subgroup showed worst survival (hazard ratio 1.

295 r treatment; and the effect of vismodegib on hedgehog target gene expression.

296 (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role in root formation.

297 onserved aspartate residue (D303, or D46) of hedgehog was identified as the general base that activat

298 regulatory landscape of IHH (encoding Indian hedgehog), which cause multiple, highly localized phenot

299 ttranslational mechanism, regulated by Sonic hedgehog, which is important to suppress Pax6 activity a

300 cal processes: Notch pathway, down-regulated Hedgehog/Wnt pathway, and cell cycle.