ライフサイエンスコーパス: hedgehog protein

1 and synergistically in the presence of Sonic Hedgehog protein.

2 oss membrane protein that binds the secreted Hedgehog protein.

3 ence documenting the in vivo source of Sonic hedgehog protein.

4 beta-turn from the autoprocessing domain of Hedgehog protein.

5 atched gene required for release of secreted Hedgehog protein.

6 nts treated directly with active recombinant hedgehog protein.

7 e signaling from posteriorly localized Sonic hedgehog protein.

8 direct application of the recombinant Sonic hedgehog protein.

9 rrow stripes of cells abutting the source of Hedgehog protein.

10 s for a functionally important domain of the hedgehog protein.

11 the signaling mechanisms of the Wnt and the Hedgehog proteins.

12 ting protein) because of its ability to bind Hedgehog proteins.

13 ome is associated with abnormal diffusion of Hedgehog proteins.

14 nthesis, embryonic cholesterol transport and Hedgehog proteins.

15 ment, including the covalent modification of Hedgehog proteins.

16 icroinjection of RNA encoding active Xenopus hedgehog proteins.

17 edgehog signalling as a result of binding to Hedgehog proteins: a negative regulatory feedback loop e

18 The secreted Wingless and Hedgehog proteins activate huckebein expression in disti

19 eloping rostral central nervous system Sonic hedgehog protein also participates in ventral regionaliz

20 in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholestero

21 The Drosophila Hedgehog protein and its vertebrate counterpart Sonic he

22 re consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital

23 PTCH1 binds Hedgehog proteins and inhibits signaling in the absence

24 r developmental signalling molecules such as hedgehog proteins and the bone morphogenetic proteins, W

25 bone morphogenetic proteins (BMPs) and Sonic hedgehog protein are secreted factors that regulate dors

26 To investigate whether hedgehog proteins are also involved in the development o

27 Hedgehog proteins are intercellular long-range signaling

28 Hedgehog proteins are secreted from cells and undergo au

29 Hedgehog proteins are secreted morphogens that play crit

30 that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibits GLI-

31 nvergent evolution, but in at least one case-hedgehog protein autoprocessing-there is definitely a cl

32 or endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of

33 These results show that Hedgehog proteins can regulate mitogenesis and photorece

34 Hedgehog proteins constitute one of the major classes of

35 Hedgehog proteins control morphogenesis by promoting GLI

36 ing in mouse and Drosophila; in both species Hedgehog proteins define a posterior domain of the limb

37 og interacting protein, and the interference hedgehog protein family, suggesting a unique mechanism o

38 role for oxysterols in the effects of Sonic hedgehog protein focuses on their role in normal fetal d

39 ne ureas is reported as potent modulators of Hedgehog protein function.

40 The N-terminal domain (ShhNp) of Sonic hedgehog protein, generated by cholesterol-dependent aut

41 rt a model in which GAS1 helps transform the Hedgehog protein gradient into the observed activity gra

42 To determine whether hedgehog proteins have activities on developing retinal

43 accompanying paper, we provide evidence that Hedgehog protein (Hh), being secreted from P compartment

44 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing acti

45 nscription factors that mediate responses to Hedgehog proteins (Hh) in flies and vertebrates, respect

46 edge, these are the earliest functions for a hedgehog protein in post-implantation development in the

47 Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt

48 ants, previously implicated in signalling by Hedgehog proteins in the zebrafish embryo.

49 Smoothened is controlled by three different hedgehog proteins, Indian, Desert, and Sonic hedgehog, t

50 acid, or fibroblast growth factor and sonic hedgehog proteins into antagonist-treated embryos.

51 that, in addition to cholesterol, the human hedgehog protein is palmitoylated.

52 the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small subfamily of m

53 n occurs during somite stages due to varying Hedgehog protein levels, while later expansion refines t

54 tion and indicate that delivery of exogenous hedgehog proteins may have therapeutic potential for the

55 Hedgehog proteins mediate many of the inductive interact

56 Hedgehog proteins modulate development and patterning of

57 nsforming growth factor beta1 (TGFbeta1) and hedgehog proteins or antagonists of the Wnt/beta-catenin

58 e were combinatorial effects of TGFbeta1 and hedgehog proteins or antagonists of the Wnt/beta-catenin

59 Evolutionarily conserved hedgehog proteins orchestrate the patterning of embryoni

60 probably exclusive role for Disp1 is within hedgehog protein-producing cells.

61 A gene encoding a receptor for the hedgehog protein, ptc-2, is expressed by retinal neuroep

62 ls with the amino-terminal fragment of Sonic hedgehog protein results in an increase in the proportio

63 Sonic Hedgehog protein (SHH), secreted by retinal ganglion cel

64 neuroepithelium under the influence of sonic hedgehog protein (SHH).

65 N-terminal recombinant Sonic Hedgehog protein (SHH-N) was added to rat retinal cultur

66 e, cholesterol- and palmitate-modified Sonic hedgehog protein signal (ShhNp) when added to cultured c

67 ced but dose-dependent response to the Sonic hedgehog protein signal in vitro, demonstrating that thi

68 limit the range of signaling by sequestering Hedgehog protein signal within imaginal disc epithelium.

69 isp1 activity is only required for paracrine hedgehog protein signaling by the cholesterol modified f

70 substantially reduced mitogenic response to Hedgehog protein signaling.

71 teins mediate the transcriptional effects of Hedgehog protein signals.

72 of SZP in the culture medium, in response to hedgehog proteins (sonic hedgehog [SHH] and Indian hedge

73 Hedgehog proteins stimulated SZP accumulation.

74 ytic biogenesis mechanism similar to that of hedgehog proteins, the inteins, and the N-terminal nucle

75 ose product is necessary for the movement of Hedgehog protein through tissues.

76 Signalling is activated by binding of Hedgehog protein to the multipass membrane protein Patch

77 in the HI+cyclopamine (an antagonist of the hedgehog protein)+UCBMC group compared with the HI+UCBMC

78 Hedgehog protein undergoes post-translational palmitoyla

79 Hedgehog proteins use an auto-processing strategy to gen

80 h PTCH molecules with respect to the various Hedgehog proteins, we have isolated the human PTCH2 gene

81 in the N-terminal domain of the murine Sonic hedgehog protein, which also exhibits an architecture fo

82 ress the selector gene engrailed and secrete Hedgehog protein whilst A compartment cells need the pat

83 ) in modulating signaling pathways involving hedgehog proteins, wingless-related proteins and fibrobl

84 ycoprotein that binds to all three mammalian Hedgehog proteins with an affinity comparable to that of