ライフサイエンスコーパス: heighten

1 meostatic and hedonic responses appear to be heightened.

2 We found that GP-A82V had heightened ability to infect primate cells, including hu

3 (compared with slow) metabolizers exhibited heightened abstinence-induced neural responses to smokin

4 This heightened activation has been hypothesized to underlie

5 (BLA) is critical for fear learning, and its heightened activation is widely thought to underpin a va

6 ropsychiatric disorders are characterized by heightened activation of the amygdala.

7 Heightened activity of ET-1 in neonatal endothelium prob

8 Heightened activity of ET-1 in the neonatal endothelium

9 VD than in control subjects, consistent with heightened activity of this mechanical force-sensitive s

10 in Samburu, northern Kenya that experienced heightened adult mortality driven by drought and intense

11 Bdnf-e1 and -e2 mutant males displayed heightened aggression accompanied by convergent expressi

12 D-containing NMDARs in the PLmPFC in alcohol-heightened aggression.

13 as alcohol-heightened (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder co

14 ere, male mice were characterized as alcohol-heightened (AHAs) or alcohol non-heightened aggressors (

15 se cell types was mutually correlated during heightened alertness.

16 el of fungal asthma wherein infection during heightened allergic inflammation was protective against

17 ed distracters is statistically explained by heightened amygdala reactivity.

18 Heightened and extended inflammation underlies the patho

19 We hypothesize that the heightened antibacterial monocyte responses after vaccin

20 iabetes mellitus (T1D) is characterized by a heightened antibody (Ab) response to pancreatic islet se

21 s with enhanced pharmacological profiles and heightened antiviral activity.

22 Interestingly, the heightened anxiety in TTC9A(-/-) mice under EB influence

23 tress-induced reinstatement is paralleled by heightened anxiety measures, suggesting that countering

24 In the current study, the heightened anxiety was also observed in adult MAM animal

25 that peripubertal diazepam treatment reduced heightened anxiety, decreased BLA neuron firing rates an

26 tion, and c-Fos activation, in parallel with heightened anxiety-like behavior and nociceptive hyperse

27 uation to a novel environment, together with heightened anxiety-related behavior in a stressful envir

28 ous NPY release, potentially contributing to heightened anxiety.

29 ause of implantation failure associated with heightened apicobasal polarity of luminal epithelial cel

30 stress administered following a delay led to heightened arousal and increased generalization of SCRs

31 olved in a variety of behaviors that rely on heightened arousal, but whether they directly and causal

32 Heightened attention to threat following violence exposu

33 means that, during a state of locomotion and heightened attention, the population activity in primary

34 ocomotion and a dilated pupil, indicative of heightened attention.

35 onstrated that control states, for instance, heightened attentional selectivity, can become directly

36 lescence is a developmental period marked by heightened attunement to social evaluation.

37 l during infection or cancer, at the cost of heightened autoimmunity.

38 nt inhibitory mechanisms in the amygdala and heightened autonomic drive, as seen in chronic anxiety d

39 is that suicidal behavior is associated with heightened aversion to risk and loss, which might produc

40 lescence is a unique developmental period of heightened awareness about other people.

41 s in HCM has recently emerged because of the heightened awareness and understanding of the disease, d

42 Practice-based teaching heightened awareness of individuals' own practice and ma

43 In older patients, heightened awareness of nosocomial RV infections is warr

44 Since then, a heightened awareness of the damaging practice of using J

45 ncurrently enhanced CD4 help for B cells and heightened B cell activation.

46 ococcal challenge in Cmah(-/-) mice leads to heightened bacterial loads, virulence, and NanA expressi

47 ssing the risk variant IFIH1(T946) exhibited heightened basal and ligand-triggered production of type

48 ng the United States coast during periods of heightened basin-wide hurricane activity.

49 nd exogenous virus resulted in significantly heightened Black Queen Cell Virus (BQCV) titers and lowe

50 diagnostic confidence of experts in cHP was heightened by the presence of these diagnostic items.

51 ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasi

52 erapeutic interventions in disease states of heightened cardiac sympathetic activity are targeted to

53 y and reduced cardiac baroreflex sensitivity heighten cardiovascular risk, althogh whether such auton

54 tic stress disorder (PTSD) may contribute to heightened cardiovascular disease risk by promoting a pr

55 s and 16,485 patients with moderate COPD and heightened cardiovascular risk were included in the stud

56 In patients with moderate COPD and heightened cardiovascular risk, treatment with fluticaso

57 h placebo in patients with moderate COPD and heightened cardiovascular risk.

58 erine growth restriction (IUGR) and leads to heightened cardiovascular risks later in life.

59 ovide the first mechanistic insight into the heightened caries susceptibility associated with CLP and

60 p apnoea (OSA), have been shown to exhibit a heightened carotid body (CB) chemosensory reflex and hyp

61 p apnoea (OSA), have been shown to exhibit a heightened carotid body (CB) chemosensory reflex and hyp

62 on of AOE genes and ROS levels, reversed the heightened CB chemosensory reflex and hypertension, and

63 DC) must undergo maturation characterized by heightened cell surface expression of MHC and costimulat

64 Heightened cellular activation promotes the capacity of

65 hat a similar modification is observed under heightened cholinergic modulation.

66 Active management of heater-coolers and heightened clinical awareness are imperative given the c

67 with TMD may at least in part contribute to heightened clinical pain, perhaps via central sensitizat

68 cacy in preventing acute GVHD in settings of heightened clinical risk that use myeloablative conditio

69 ted myeloid-driven experimental colitis with heightened clinical, histopathological, and cytokine rea

70 Protective measures and heightened clinician awareness are essential to guarante

71 in previously healthy individuals, requiring heightened clinician awareness.

72 en restricted to dopamine neurons, developed heightened cocaine-induced locomotor responses.

73 y or exclusively in dopamine neurons exhibit heightened cocaine-induced locomotor responses.

74 Indeed, heightened concentrations of inflammatory signals, inclu

75 Nonetheless, our findings heighten concern regarding the pandemic potential of rec

76 Heightened conditioned fear expression may be a prospect

77 Patients with COPD had heightened cough responses to capsaicin but reduced resp

78 RATIONALE: Heightened cough responses to inhaled capsaicin, a trans

79 evealed here provides a neural substrate for heightened craniofacial affective pain.

80 ifferences disappeared-because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to th

81 llustrate a physiological phenomenon whereby heightened D1R-SPN activity can regulate corticostriatal

82 Mothers experience heightened depression and anxiety following very preterm

83 e profiling of NTT substitution R13P reveals heightened discrimination against unfavorable AUG contex

84 e substantially to poor asthma control and a heightened disease burden.

85 s (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism.

86 mimicry, and were retained across periods of heightened drought.

87 ular Ag, which can be used as an adjuvant to heighten effective immune responses for protein-based va

88 We also show that such inhibitors heighten efficacy of our nanobiologics on naive tumors b

89 s of great concern for clinical therapy, and heightened efforts are needed to control its disseminati

90 For clinical trials conducted in an era of heightened efforts to avoid HF hospitalizations, inclusi

91 n of expanded MEFs in this case also reveals heightened emission increases associated with load shift

92 Our recent studies demonstrated that heightened emotionality, as measured both physiologicall

93 increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as th

94 We found that heightened ERK signaling activity in aRG is tightly link

95 Recent studies have demonstrated that heightened excitability and plasticity may be critical f

96 Early heightened expression levels of AKAP7, a gene encoding a

97 ubsequent in vitro experiments revealed that heightened expression of AKAP7 and ITGA3 in primary huma

98 lls (TCM) from HIV-infected individuals have heightened expression of BCL-2 relative to procaspase 8,

99 not breach central tolerance, but it led to heightened expression of endogenous Ig H and L chains in

100 ole blood collected before vaccination, that heightened expression of genes that augment B-cell respo

101 hput RNA sequencing analyses that identified heightened expression of the chromatin architectural fac

102 fore a stressor, in order to protect against heightened fear responses to aversive stimuli.

103 The likelihood for such defects is heightened for biopharmaceuticals due to their complexit

104 power and bottom-up causality correlate with heightened frontal gamma power, they also correlated wit

105 h post-traumatic stress disorder also showed heightened frontal processing (augmented frontal gamma p

106 Heightened generalization of fear from an aversively rei

107 sustained, especially when accompanied by a heightened genetic predisposition for response to physic

108 Trigger sounds elicited heightened heart rate (HR) and galvanic skin response (G

109 ggest the existence of a sensitive period of heightened hippocampal plasticity in CA1 of pre-adolesce

110 ext 15 years predicted to be attributable to heightened HIV transmission risk among currently or prev

111 , impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis.

112 e data (n = 234 GEO, n = 384 TCGA) confirmed heightened humoral responses (CD20, CD22, AID) in melano

113 m Vesta suggesting that smooth terrains with heightened hydrogen concentrations indicate that ground-

114 In particular, the occurrence of heightened hydrogen concentrations within large smoother

115 hroughout repeated restraint abolished their heightened hypothalamic-pituitary-adrenal responsivity a

116 systemic bacterial infection was worsened by heightened IL-4 activity, with IL-4 restricting G-CSF-in

117 ction and increased viral load; however, the heightened immunopathology and susceptibility to subsequ

118 ts that inhibiting complement activation may heighten immunotherapeutic responses in lung cancer, off

119 and malaria infection in endemic areas; the heightened impact of combined etiologies on anemia sever

120 This finding has heightened importance in the context of the current refu

121 n and Syme noted many years ago is likely to heighten in the future, as demographic characteristics s

122 ic circumstances on medication adherence was heightened in black patients (odds ratio: 8.01; 95% conf

123 this child rearing style was associated with heightened indications of mental burden, depressiveness,

124 isk is due in part to immune dysfunction and heightened inflammation and immune activation associated

125 Heightened inflammation and immune activation in HIV-1+

126 crobe, Thevaranjan et al. (2017) reveal that heightened inflammation is associated with deregulation

127 ll expansion, low CD4/CD8 T-cell ratios, and heightened inflammation persist in antiretroviral therap

128 Importantly, the heightened inflammatory profile of microglia in aging is

129 The prolonged and heightened inflammatory response in CF is, in part, medi

130 ent of renal microvascular perfusion and the heightened inflammatory response that exacerbate ischemi

131 suggesting that a preinflammatory state and heightened inflammatory response to surgery are potentia

132 ed inflammation, Retnla(-/-) mice suffered a heightened inflammatory response, including increased mo

133 ial products in the systemic circulation and heightened inflammatory state.

134 te an emerging pathogenic exposure through a heightened inflammatory state.

135 ogenous interferon-gamma, which prolongs and heightens inflammatory responses.

136 Loss of dysbindin-1A resulted in heightened initial exploration and disruption in subsequ

137 iven photochemistry has continued to attract heightened interest due to its capacity to efficiently h

138 ntrols intestinal homeostasis and, given the heightened interest in miRNA-based therapies, may offer

139 the translational relevance of LAG3 and the heightened interest in the impact of dual LAG3/PD1 targe

140 Th1/Th17 phenotypic profile, as reflected by heightened interferon gamma and interleukin 17 (IL-17) p

141 lso identified young childhood as a stage of heightened interindividual variability.

142 In addition, the FEP group showed heightened internetwork connectivity between the default

143 ity, consistent with the hypothesis that the heightened intrinsic infectivity of GP-A82V contributed

144 th prior MI, those with concomitant PAD have heightened ischemic risk.

145 nsitivity to erythropoietin stimulation, and heightened JAK-STAT activation.

146 ynorphin (DYN) A-like peptide expression and heightened kappa-opioid receptor (KOR) signaling in the

147 There remains a need for heightened levels of concern regarding risks arising fro

148 ceased to grow, and concomitantly exhibited heightened levels of cytosolic ribonuclease activity tha

149 17A-secreting Vgamma4 gammadelta T cells and heightened levels of IL-17 and IL-36 family of cytokines

150 nd bacterial load in the pleural cavity, and heightened levels of pleural and serum proinflammatory c

151 h significantly decreased survival rates and heightened levels of proinflammatory cytokines in both p

152 , an inability to fight bacterial infection, heightened levels of proinflammatory cytokines, overt gr

153 nflammatory cytokine profile associated with heightened LPS levels.

154 dhood as a potential developmental period of heightened malleability for the amygdala-medial prefront

155 lar, slowed aging models are associated with heightened mechanisms of mitochondrial proteostatic main

156 nt changes in middle age suggest a period of heightened metabolic activity and cellular damage associ

157 ch contributes to poorer quality of life and heightened metastatic progression in patients.

158 reconstitution to residual inflammation and heightened morbidities in HIV-1-infected cART recipients

159 ectious inflammatory conditions that lead to heightened morbidity and mortality.

160 a challenge as the primary factor underlying heightened mortality.

161 ike behavior in DIO-prone rats, including 1) heightened motivation for palatable food; 2) excessive i

162 Decidual senescence with heightened mTORC1 signaling is also a signature of human

163 n the face of a global environment marked by heightened nationalism and xenophobia, member states mus

164 The findings thus implicate heightened negative valuation in decision-making under r

165 Heightened neural drive promoting a ventilatory response

166 Here, we provide evidence that heightened neural excitability instead reflects a state

167 The prevailing view is that heightened neural excitability, indexed by decreased alp

168 Critical periods are temporary windows of heightened neural plasticity early in development.

169 ral immune system that converge to promote a heightened neuroinflammatory environment.

170 Heightened NF-kappaB activation was not associated with

171 Previous studies have shown that heightened nicotine cravings and blunted response to str

172 These data also suggest that heightened noradrenergic activity in the BLA underlies s

173 pupil size in the ASD group, thus suggesting heightened noradrenergic responsivity in line with compr

174 Repeated exposure to noise could lead to a heightened or lessened response.

175 sociated with systemic chronic inflammation, heightened oxidative stress, and atherogenic lipid profi

176 ue injury can sensitize DRG neurons, causing heightened pain sensitivity, often leading to chronic pa

177 investigated at posthatching day 25 during a heightened period of sexual differentiation (following B

178 Studies suggest that heightened peripheral inflammation contributes to the pa

179 fe periods, during which the epigenome shows heightened plasticity to stress exposure, such as in ear

180 Heightened platelet reactivity, however, is associated w

181 Heightened platelet reactivity, shortened tail-bleeding

182 ions did not seem to be directly mediated by heightened platelet reactivity.

183 onary intervention and may additionally have heightened platelet reactivity.

184 evel checks and insulin use, suggesting that heightened postoperative vigilance and a lower threshold

185 including the arrested growth morphology and heightened PR (Pathogenesis Related) gene expression.

186 Heightened prediction error activity in brain reward reg

187 ngs of ASD probands did not show evidence of heightened preference for geometric images.

188 A LipA-deficient strain induces heightened pro-inflammatory cytokine production, which i

189 on functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibil

190 The heightened proliferation of NK cells from NKp46-Cre-Gata

191 ated to elevated CCR5 levels combined with a heightened proliferative state and suggests that TFR cel

192 Developmental BPA exposures heighten prostate cancer susceptibility in a complex dos

193 Previous studies have uncovered heightened prostatic susceptibility to hormone-induced n

194 y T cells that persist long-term and provide heightened protection.

195 ave identified several hundred residues with heightened reactivity that are enriched at protein funct

196 etained proliferative capacity and exhibited heightened reconstitution in competitive transfer assays

197 Our main outcome measure was heightened regret as measured by the Decisional Regret S

198 ment and to identify factors associated with heightened regret.

199 impulsivity is significantly associated with heightened relapse risk.

200 t an alternative reinforcer over aggression, heightened relapse vulnerability and progressive ratio r

201 spontaneous infiltration of eosinophils and heightened responses to papain in the lung and increased

202 Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and who

203 ings show that abstained smokers exhibited a heightened reward positivity to cigarette rewards relati

204 endocrine, and environmental changes to the heightened reward sensitivity and increased vulnerabilit

205 ore or early after transplantation may be at heightened risk for late-term transplant-related morbidi

206 developing new treatments for individuals at heightened risk for neuroimmune disorders are considered

207 osed to neglect or social deprivation are at heightened risk for psychiatric disorders and abnormal s

208 r, racial and ethnic minority parents are at heightened risk for regret.

209 with peripheral artery disease (PAD) are at heightened risk of acute limb ischemia (ALI), a morbid e

210 y, after a major amputation, patients are at heightened risk of amputation on the contralateral leg.

211 e potential for self-recognition, conferring heightened risk of autoimmune disease.

212 Patients with diabetes mellitus are at heightened risk of both adverse microvascular and cardio

213 Several factors have been associated with a heightened risk of conduction disturbances and permanent

214 African Americans have a heightened risk of developing chronic and end-stage kidn

215 n the glucocerebrosidase gene (GBA) confer a heightened risk of developing Parkinson's disease (PD) a

216 Longitudinal studies of ADHD show heightened risk of multiple mental health and social dif

217 ontaminants cross the placenta, presenting a heightened risk of perturbing fetal development.

218 experience an acute coronary syndrome are at heightened risk of recurrent ischemic events, including

219 Despite the heightened risk of serious influenza during infancy, vac

220 y account for unpleasant odor and a possible heightened risk of tetanus.

221 l data might help us identify populations at heightened risk of widespread vaccine refusal.

222 dilation, vascular inflammation, dissection, heightened ROS generation, and smooth muscle cell loss.

223 impaired lysosomal maturation, resulting in heightened ROS production and attenuated lysosomal acidi

224 roughput, enhanced signal-to-noise, and even heightened selectivity via functionalization with an emb

225 t naive CD8(+) T cells expressing markers of heightened self-recognition are selectively retained, bu

226 These results demonstrate a heightened sensitivity for crossmodal statistics in infa

227 Our results demonstrate that the heightened sensitivity of the brain to ischemic damage i

228 Moreover, CS-deficient mice showed heightened sensitivity to a self-antigen, whereas increa

229 een in Arabidopsis thaliana for mutants with heightened sensitivity to actin-disrupting drugs.

230 load reduction was observed, suggesting that heightened sensitivity to afterload is a significant con

231 lated by learning and experience, suggesting heightened sensitivity to change during critical periods

232 at impair the Hippo signaling pathway showed heightened sensitivity to gemcitabine.

233 and Akt activation, interpreted to reflect a heightened sensitivity to IGF-1 stimulation upon HFD fee

234 We determined whether the heightened sensitivity to influenza infection could be r

235 In this window of heightened sensitivity to sensory and social cues, Mecp2

236 kt/mTOR pathway, which was associated with a heightened sensitivity to the inhibitors of PI3K and mam

237 e potential for vertebral patterns to confer heightened sensitivity, with similar specificity, in dis

238 Secondary outcomes were changes in heightened-sensitivity and quality of life scores.

239 In 3 outbreaks with heightened severity attributed to enhanced pathogen viru

240 the southern populations will be followed by heightened sexual selection, which may exacerbate the pr

241 ren with an anxious temperament are prone to heightened shyness and behavioral inhibition (BI).

242 egional difference is well correlated with a heightened signal transmission for plantar paw circuits,

243 at efficacious responses to this drug can be heightened significantly by coadministration of an artif

244 th low salivary FGF2 exhibited significantly heightened skin conductance responses to the CS without

245 of scratching was greater around periods of heightened social stress, such as being in proximity to

246 The heightened state of vulnerability in these patients conf

247 These heightened states of arousal are often in the absence of

248 d pathway enrichment analysis indicated that heightened stress response and reduction in genes associ

249 howed elevated ventilation rates, indicating heightened stress, in response to impulsive additional n

250 We find that heightened stx activity leads to homeotic transformation

251 We conclude that heightened surface ozone levels will potentially lead to

252 ognized role of ILC2s might help explain the heightened susceptibility of human asthmatic airways to

253 xhibited reduced thermodynamic stability and heightened susceptibility to fibrillation.

254 ng edge of the critical period can restore a heightened susceptibility to MD more typical of an earli

255 r by system stress, manifest as a strikingly heightened susceptibility to provoked colitis, and conve

256 We provide the first evidence for heightened sympathetic outflow and reduced cBRS in RA th

257 PVN) is increased and critically involved in heightened sympathetic vasomotor tone in hypertension.

258 tone in hypertension.SIGNIFICANCE STATEMENT Heightened sympathetic vasomotor tone is a major contrib

259 weight at ART initiation was associated with heightened systemic inflammation.

260 These include conditions associated with a heightened tendency for inappropriate laryngeal closure

261 l gestures or verbal questions and display a heightened tendency to encode and retain such sought-aft

262 Heightened Th1 responses in Gkn2 knockout mice were link

263 for stabilization and maintenance of IL-17, heightened Th17, and Tc17 responses in immunized mice sp

264 oit an expanded amino acid alphabet can thus heighten the ambitions of protein engineers wishing to d

265 ughput screen for small molecules that could heighten the cytotoxicity of mTORC1 inhibitors.

266 The potential to heighten the efficacy of antiangiogenic agents was explo

267 prevent biologic complications and hence to heighten the long-term success rate.

268 as type 2 diabetes and chronic hypertension) heighten the risk of adverse outcomes for mother and chi

269 In addition, GDM+MIA heightened the maternal inflammatory state and gave rise

270 ithromycin detected in research studies have heightened the need available commercial diagnostic assa

271 riately, in addition to weak health systems, heightens the challenge faced by prescribers.

272 agonist JTE907 (3 mg/kg) during immunization heightens the intensity and breadth of antigen-specific

273 onstrate that depletion of TC-PTP expression heightens the phosphorylation of STAT family members, ca

274 Little is known whether PH heightens the risk of heart failure (HF) admission or mo

275 nce of chronic kidney disease, which further heightens the risk of hyperkalemia, especially when reni

276 ses conventional antiferroelectric order and heightens the sensitivity towards collective intercolumn

277 gh EpSCs benefit from inflammatory tuning by heightening their responsiveness to subsequent stressors

278 oncurrently with NK cell-based therapies may heighten therapeutic benefits by augmenting NK cell-medi

279 identifies an epitranscriptomic mechanism in heightened transcriptional coordination during mammalian

280 iseases are immune disorders associated with heightened type 2 immune responses and IL-5 and IL-13 pr

281 ned surveillance of unfolded proteins, and a heightened unfolded protein response (UPR).

282 ephropathy exhibited diminished H3K27me3 and heightened UTX content.

283 Such heightened variability poses greater challenges to opera

284 an anti-angiogenic TSP1 fragment, suppresses heightened vascular endothelial growth factor signaling

285 following infection, a finding confirmed by heightened vascular permeability following virus challen

286 iated with greater pericardial restraint and heightened ventricular interdependence, reflected by inc

287 asing complexity and prolonged use warrant a heightened vigilance for early and late side effects, a

288 AN have slower gastric emptying and heightened visceral perception compared to HC and OB.

289 PNNs coincides with the end of the period of heightened visual cortex plasticity in juveniles, wherea

290 The onset and offset of heightened vulnerability are attributed to a tightly orc

291 By calling attention to this heightened vulnerability of black Americans, our finding

292 Our genetic studies highlight the heightened vulnerability of liver cells to subtle change

293 he neurobiological processes underlying this heightened vulnerability remain poorly understood.

294 mortality and disability among patients with heightened vulnerability should be developed and tested.

295 exposure and disease, identifying periods of heightened vulnerability to chemical exposures, and dete

296 respiratory neural control system exhibits a heightened vulnerability to sustained hypoxia (SH, 11% O

297 uction in growth, a response that is further heightened when therapeutic inhibition of VEGF receptor

298 cent evidence that fluid intelligence can be heightened with cognitive training.

299 increased analgesia, delayed tolerance, and heightened withdrawal in response to morphine administra

300 t cancers at earlier stages or indirectly by heightening women's awareness of breast health concerns.