ライフサイエンスコーパス: helical

1 el, separating trajectories into straight or helical.

2 Helical 1D electronic systems are a promising route towa

3 ractions of JMJD6 with residues in the inter-helical alpha1-alpha2 loop of the ET domain.

4 mp_lipid_acc is applicable to both alpha-helical and beta-barrel membrane proteins of diverse arc

5 undergo high-fidelity association with both helical and coil-forming synthetic polymers.

6 ined helix-turn-helix architectures in which helical and sheet subcomponents conserve their respectiv

7 Paired helical and straight filaments differ in their inter-pro

8 Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filament

9 cally different alpha-synuclein fibrils, one helical and the other ribbon-like, are shown to form tog

10 KRK)) both form SAHs, of which EK2R1 is more helical and thermo-stable suggesting Arg increases stabi

11 altered the VKK38 secondary structure from a helical apo-peptide with a flexible center to an end-to-

12 The analysis revealed the exact helical arrangement and the super-helical twist of the f

13 tiple functions contributing to the filament helical arrangement, the polymer remodeling into tubulin

14 Some studies point to a beta-helical arrangement, whereas others suggest a parallel i

15 ClpC forms large two-helical assemblies that associate via head-to-head conta

16 In this study, we present a fuel-dependent helical assembly of a supramolecular polymer.

17 The interplay among the helical assembly, molecular pockets, and solvent molecul

18 angle of approximately 50 degrees along the helical axis due to A-minor interactions.

19 ersible in-plane orthogonal switching of its helical axis in response to the combined effect of tempe

20 A kinked helical beam and anchor domain link the Piezo repeats to

21 r entrapment of the non-protonated, circular helical (blue) structure of phycocyanin and the anionic

22 conformational changes in a C-terminal four-helical bundle region of ExoU as it interacts with lipid

23 o acid residues on the exterior of the alpha-helical bundle yields monodisperse macromolecules with p

24 leotide MRS2500 (orthosteric, contacting the helical bundle) and urea BPTU (allosteric, on the extern

25 inds to a remote allosteric site outside the helical bundle.

26 overed by alpha-helical lids, to multi-alpha-helical bundles and layers.

27 ll with the size found in solution for alpha-helical bundles of peptides with a similar amino acid se

28 nd consist of a series of four-transmembrane helical bundles that we term Piezo repeats.

29 with four helical domains organized into two helical bundles.

30 te that the [1,2-a]-isomer adopts a twisted, helical C2-symmetric structure and that its protonated f

31 mescale accompanying transitions between non-helical (C2-endo) to helical (C3-endo) conformations dur

32 transitions between non-helical (C2-endo) to helical (C3-endo) conformations during formation of two

33 Pb10 consists of an alpha-helical capsid-binding domain and an Ig-like domain expo

34 ibutes to the extreme thermostability of the helical capsid.

35 N-terminal domain homologs, the helical carotenoid proteins (HCPs), have been found amon

36 mily of soluble carotenoid-binding proteins (Helical Carotenoid Proteins [HCPs]), paralogs of the N-t

37 tural, functional and mechanistic analogs of helical, cationic AMPs, which offer broad-spectrum antib

38 self-aggregation of I2 molecules into triple-helical chains within the confined nanovoids has been ob

39 eously assembles luminescent one-dimensional helical chains, characterized as {Au(I)(mu-6-TG)} n , ex

40 (IMPDH) forms octamers that polymerize into helical chains.

41 e method to assess the dynamics of the inter-helical channel motion of both full-length M2 and the tr

42 They can be compared to previously described helical closed-shell receptors in which a window has bee

43 es at 10 +/- 0.5 MeV obtained by irradiating helical coil targets with a few joules, sub-ps laser pul

44 optimised by employing a recently developed helical coil technique, which exploits the transient sel

45 structural basis for stabilization of triple helical collagen peptides containing aza-glycine and we

46 cial for the folding and stability of triple-helical collagen, the most abundant protein in nature.

47 Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and cataly

48 These helical conductors exhibit strong non-local transport si

49 osite chiralities, paving the way towards 1D helical conductors with fractional quantum statistics.

50 The peptide agonist retains an alpha-helical conformation as it sits deep within the receptor

51 ha-helical region and induces a unique alpha-helical conformation in Abeta.

52 nt stapled peptide, DD5-o, revealed an alpha-helical conformation in methanol, stabilized by an unusu

53 when kafirin was dissolved in GAA its alpha-helical conformation increased substantially.

54 The right-handed helical conformation is engineered into the polymers by

55 We show that the gating brake assumes a helical conformation upon binding CaM, with associated c

56 that both compounds adopt a right-handed 310-helical conformation with both nitronyl nitroxide pendan

57 had similar FTIR spectra, with greater alpha-helical conformation, than the kafirin preparations whic

58 ophases in which the peptides adopt an alpha-helical conformation.

59 cceptors at neutral pH and disrupt the alpha-helical conformation.

60 of molecular spur gears due to the linear-to-helical conformational switching triggered by complexati

61 that W41F M2 retains the pH-dependent alpha-helical conformations and tetrameric structure of the wi

62 onal structural and dynamical aspects of the helical conformations are explored, with a focus on cont

63 s predominantly disordered but samples alpha-helical conformations covering residues 15-24 and 29-35

64 l-suited and straightforward for PASs as the helical conformations formed result from constraints imp

65 Double-stranded DNA and RNA adopt different helical conformations, including the unusual Z-conformat

66 g of Ca(2+) induced an increase in the alpha-helical content and a conformational change that lead to

67 lly calibrated with the experimental data on helical content and affinity, and shown to be consistent

68 dducted human Hb that revealed loss of alpha-helical content and deoxygenation.

69 y is outlined for the design of hand-twisted helical crystals.

70 Helical CT images of the patients were acquired separate

71 L-12 whereby cognate receptor binding to the helical cytokine subunits primes recruitment of the shar

72 We previously characterized alpha-helical cytotoxic islet amyloid polypeptide oligomers wh

73 t-dimerization region, termed here the split helical dimerization (SHED) region.

74 2 complex, revealing that both proteins form helical dimers that assemble into an unusual tetramer.

75 ange charge transport can occur along double helical DNA, but active control (switching) of single-DN

76 common lysine under-hydroxylation effect at helical domain cross-linking sites in skin, bone, tendon

77 uman MFN1 containing the GTPase domain and a helical domain during different stages of GTP hydrolysis

78 ur study provides evidence for a role of the helical domain in establishing a catalytically competent

79 -105) that mimics the polar face of the apoE helical domain involved in receptor interactions.

80 The helical domain is composed of elements from widely dispe

81 Mutations in the helical domain of Cya mimic the disease-related mutation

82 nk, which reduces the tilt of the C-terminal helical domain relative to the bilayer normal, includes

83 uman nucleotidyl cyclases disrupt the normal helical domain structure.

84 igns the two membrane-binding regions in the helical domain toward the lipid bilayer, allowing membra

85 tor-GS complex, including a flexible alphaT* helical domain.

86 lacked part of the CC1 coiled-coil and HLX2 helical domain.

87 Compared with the EHD2 structure, the helical domains are 50 degrees rotated relative to the G

88 mammalian cells, C-terminally located alpha-helical domains are sufficient to promote translocation.

89 In bacteria, we found that the alpha-helical domains have to precede the IDD or beta-strands,

90 er, translocation could be restored by alpha-helical domains in a position- and organism-dependent ma

91 T=13 shell protein P8 consists of two alpha-helical domains joined by a linker, which allows the tri

92 The helical domains of each Cya monomer form a tight hairpin

93 d to adopt a tetrameric structure with alpha-helical domains on one side and beta-strands and loops o

94 The topology of BTA121 is unique with four helical domains organized into two helical bundles.

95 DDs and beta-strands in the absence of alpha-helical domains.

96 at the loop ends, and a quencher at an alpha-helical element involved in the node forming the loop.

97 ouble-click macrocyclization approach to non-helical, extended, or irregularly structured peptides, w

98 d, and it was found to be located in the 310-helical family.

99 They are helical fibres of pilin proteins assembled by a multi-co

100 Herein, we constructed helical fibrils through chiral self-assembly of nucleoba

101 51 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brai

102 analyses in cortical regions in which paired helical filament tau accumulation is expected in AD.

103 types, as well as amyloid beta 42 and paired helical filament tau.

104 distinct from that of actin subunits in the helical filament.

105 The formation of paired helical filaments (PHF), which are composed of hyperphos

106 DNA recombinase Rad51, which forms extended helical filaments on the ssDNA.

107 uggests a possible evolutionary pathway from helical filaments to highly symmetric or pseudosymmetric

108 terial species swim by rotating single polar helical flagella.

109 Bacterial mobility is powered by rotation of helical flagellar filaments driven by rotary motors.

110 Recombinant mIFN (rmIFN) exhibited an alpha-helical fold characteristic of type I IFNs and bound to

111 ly that phosphorylation at Y102 disrupts the helical fold of the N-terminal region of E2 and its inte

112 nd solved its crystal structure, a novel all-helical fold organized into highly ordered fibrils.

113 Helical foldamer 2 was synthesized and bound to human ca

114 by CD and NMR confirm left-handedness of the helical foldamers as well as HCA dimerization.

115 can readily bind to the nanofibers by triple helical folding, allowing facile display of bioactive mo

116 Bacterial flagella change their helical form in response to environmental stimuli, leadi

117 irimat and DFH-055 causes stabilization of a helical form of SP1.

118 r molecules that are flanked with the triple helical forming GlyProHyp repeats can readily bind to th

119 lasmic domains to favor opening of the inner helical gate.

120 egant and nearly ubiquitous two-layer, alpha-helical glycolipid transfer protein (GLTP)-fold now furt

121 Unlike other mutants that exhibit helical growth of fixed handedness, the orientation of c

122 cycles between an unfolded loop and an alpha-helical hairpin [trigger helices (TH)] required for rapi

123 NTD of DnaB altered the conformation of the helical hairpin and/or compromised its pairwise arrangem

124 (I142T) in a subdomain previously named the helical hairpin in the NTD of DnaB altered the conformat

125 CuxR consists of a Cupin domain, a helical hairpin, and bipartite helix-turn-helix motif.

126 gned to fold and self-assemble into a double helical host having a cylindrical cavity complementary t

127 B hypervariable regions (HVRs) and not alpha-helical HVRs.

128 this interaction partially restructured the helical IL-23p19 subunit of IL-23 and restrained its IL-

129 single-layered hexamer tubes facilitated 3D helical image reconstruction from cryo-electron microsco

130 results show that penetratin is mostly alpha-helical in the cytosol and acquires a more beta-sheet an

131 omega (omega6), which is predominantly alpha-helical, in contrast to largely unstructured native omeg

132 The block angle at each helical junction is controlled by the change in stripe d

133 ad-hoc treatment of multi-loops, also called helical-junctions, that persists today.

134 ward the N-terminus and (B) to the lack of a helical kink upon ligand binding.

135 The frequent occurrence of Ser or Thr based helical kinks in membrane proteins suggests that a simil

136 n how alpha-helical proteins use amphipathic helical layering and bundling to form modular lipid-bind

137 structure to a system that links four double-helical layers; we use a central weaving oligonucleotide

138 1 interacts with several short motifs, named helical leucine-rich motifs (HLMs), spread in the long C

139 Additionally, we find that the helical lid of DnaK is a highly dynamic unit of the stru

140 beta-sheet cups and baskets covered by alpha-helical lids, to multi-alpha-helical bundles and layers.

141 of two triple helical repeats connected by a helical linker.

142 er a short flexible linker or a set of rigid helical linkers.

143 The topologies of alpha-helical membrane proteins are generally thought to be de

144 erhelical packings are ubiquitously found in helical membrane proteins, although their interaction dy

145 translational folding of two bacterial alpha-helical membrane proteins, DsbB and GlpG.

146 plated polymerization process that generates helical metallopolymer strands over 75 repeat units long

147 sed library of oligopyridylamide based alpha-helical mimetics was designed to target the central alph

148 and-twisting of the crystals to give grossly helical morphologies.

149 wild type pgp1 into 11168-GS did not restore helical morphology.

150 and purified from Escherichia coli The alpha-helical motif was not required for protein biosynthesis,

151 ce of eIF4E through a single canonical alpha-helical motif, while metazoan eIF4E-binding proteins (m4

152 et, wherein further orthogonal assembly with helical motifs is possible.

153 rded around beta-sheet structures than alpha-helical motifs.

154 the His37 tetrad, we believe that this inter-helical motion accompanies proton conduction.

155 the ultradense electron bunch under resonant helical motion in CP laser fields.

156 bined with a precise characterization of the helical motion of the cell body to lift the 2D data to 3

157 flagellum, is characterized by a generalized helical motion.

158 ultradense relativistic electron bunches in helical motions and hence emitting brilliant vortical ga

159 A fused pi-helical N-heterocyclic carbene (NHC) system was prepared

160 aced nanorobot is reported, made of magnetic helical nanomotors cloaked with the plasma membrane of h

161 rcular polarization that depends on both the helical NHC P/M stereochemistry and the iridium Delta/La

162 eoprotein and other viral proteins to form a helical nucleocapsid.

163 ies of the nucleoprotein (N), giving rise to helical nucleocapsids.

164 Furthermore, it demonstrates that alpha-helical oligomers conformers are valid epitope for the d

165 ional assays, that MlaA is a monomeric alpha-helical OM protein that functions as a phospholipid tran

166 of constrained peptide inhibitors having non-helical or extended conformations.

167 DGA, the developing heart has the classical helical organization observed in mature mammalian tissue

168 Control over the helical organization of synthetic supramolecular systems

169 olvent molecules, which in turn dictates the helical organization of the resulting supramolecular ass

170 te of the thick filament is characterized by helical packing of most of the myosin head or motor doma

171 hat vary in size and topology of their alpha-helical packing.

172 The helical parameters in the crystal structure of the new c

173 Helical paths are beneficial for some forms of chemotaxi

174 recedented solvent-directed "switch" both in helical pattern and handedness was observed when the seq

175 Peptide variants of p145, a conserved helical peptide epitope from the M protein of Streptococ

176 derivatives of ovispirin-3 (OV-3), an alpha-helical peptide from the cathelicidin family, demonstrat

177 Moreover, use of a triple-helical peptide that reconstitutes the collagen-binding

178 By combining an alpha-helical peptide that self-assembles into a hexameric coi

179 ifs, which increase retention of amphipathic helical peptides in RP, reduce peptide retention in HILI

180 e first for any conformationally homogeneous helical peptoids containing only alpha-chiral aliphatic

181 gold nanoparticle single helices, varying in helical pitch and nanoparticle dimensions, that is assem

182 used as a handle to systematically tune the helical pitch from 80 to 130 nm; and (ii) influences the

183 channels in which opening is regulated by a helical plug connected to an extended coil-coiled platfo

184 rtions of the re-entrant M2 loops, while the helical portions of M2 contribute to extensive hydrophob

185 process for the rapid discovery of new alpha-helical PPI modulators.

186 ibe a strategy that exploits selective alpha-helical PPIs, transferring these characteristics to smal

187 supramolecular helicity is biased toward the helical preference of the sergeant.

188 shaft (rod), a universal joint (hook) and a helical propeller (filament).

189 The stability effects of local helical propensity and peptide charge are well described

190 We observed that peptides with higher helical propensity tend to have higher than predicted el

191 g multiple Pro and Gly (residues with lowest helical propensity) retain stronger than predicted.

192 endoplasmic reticulum (rER), and the triple-helical protein collagen is the most abundant extracellu

193 Here, we focus on how alpha-helical proteins use amphipathic helical layering and bu

194 Formation of helical pseudorotaxane complexes, foldaxanes, between th

195 Here, we report a 3.6-A helical reconstruction electron cryomicroscopy structure

196 5 binds to the central discordant alpha-helical region and induces a unique alpha-helical confor

197 ure of Nop15 that reveals a C-terminal alpha-helical region obscures its canonical RNA-binding surfac

198 this effect to a specific, C-terminal alpha-helical region of BPIFA1.

199 nthetic peptide incorporating the core alpha-helical region of cNK-lysin, have antimicrobial activity

200 on stabilizes a soluble conformation where a helical region of N17 propagates into the polyQ region,

201 The alpha-helical region of separase (also known as Esp1) contains

202 ereby defining an important function for the helical region of separase.

203 In summary, we have identified a BECN1 helical region that transitions between packing as part

204 dissolved pEAbeta (3-42) contains two alpha-helical regions connected by a flexible linker, whereas

205 suggesting that the full length of the alpha-helical regions of Hic is required for an optimal intera

206 y profile based on the linkage of two triple helical repeats connected by a helical linker.

207 (binding site-I) and extracellular loop and helical residues (binding site-II) of the receptor.

208 Moreover, the active layers for the helical ribbon-based photodetectors are solution-cast bu

209 rphology at high ionic strengths and as long helical ribbons at lower salt content.

210 owing photodetectors based on four different helical ribbons that differ in the wavelength of their r

211 row bandwidth for detection results from the helical ribbons' high absorption coefficient, good elect

212 a coiled-coil domain for the 'pole' and four helical 'ribs' spanning the N-terminal TRPM homology reg

213 ity of unique residues align along the outer helical ridge.

214 A helical scaffold in the C-lobe constitutes the inositol

215 tural features including constricting rings, helical scaffolds, and hydrophobic membrane insertions a

216 ies of amino acid residues to participate in helical secondary structure at room temperature in the a

217 aS acquires an alpha-helical secondary structure in the presence of DHA and,

218 heir long terminal repeats and differed in a helical segment of envelope involved in entry and target

219 y dynamic polypeptide chain comprising three helical segments and lacking persistent long-range inter

220 ming 3D shapes by providing new insight into helical segments as building blocks, with potential appl

221 Sequences having helical segments flanking a central bent aromatic beta-s

222 and E4 isoforms is similar except that some helical segments in apoE4 spanning residues 12 to 20 and

223 ating ATP to inactivating ADP triggers short helical segments in the K(+)-translocating KtrB dimer to

224 lyroll-like periplasmic domain and six alpha-helical segments in the transmembrane domain.

225 positions, dynamics, and stabilities of the helical segments in these two proteins, in their normal

226 sing of the cytoplasmic ends of the S6 alpha-helical segments.

227 odel, we find that the channel prefers alpha-helical sequences over beta-sheet sequences.

228 ng in opposite directions, thus leading to a helical shape.

229 Peptides derived from helical sites in LF showed increasingly longer single-ch

230 ion, revealing an extensive network of alpha-helical solenoids organized into a diamond ring conforma

231 n spectroscopy, we report the observation of helical spin texture in monolayer, centrosymmetric and s

232 the ventral surface of LES are arranged in a helical/spiral fashion.

233 extensions create a highly unusual all alpha-helical split-dimerization region, termed here the split

234 e ankyrin repeat domain of NOMPC resembles a helical spring, suggesting its role of linking mechanica

235 tio is likely to be important in determining helical stability in de novo and naturally-occurring pol

236 smosensing core through osmolality-dependent helical stabilization.

237 y different propensities for single-stranded helical stacking.

238 lobular head and its junction with the alpha-helical stalk of the prefusion protein.

239 Unlike other approaches used for realizing helical states, the graphene electron-hole bilayer can b

240 A bioresorbable metallic helical stent was explored as a new device opportunity (

241 In this study, developed Mg-based helical stent was inserted and expanded in vessels with

242 ms coiled-coil dimers, which assemble into a helical strand that runs along the whole approximately 1

243 gs suggest that GTP caps retain the filament helical structure and hydrolysis triggers filament stiff

244 The unwinding of the helical structure at the grid walls drives the lens shap

245 a channel that is predicted to have an alpha-helical structure for protein import.

246 tion-arresting SP1 mutation T8I also induces helical structure in SP1 and further global dynamical an

247 ral angle bias in the unfolded state and PP2 helical structure in the native state.

248 tyrosine into the cationic polypeptide, the helical structure of AMPs was distorted owing to the sid

249 The triple-helical structure of collagen, the most abundant protein

250 emonstrate that phosphorylation distorts the helical structure of TIRAP PBM, reducing PI interactions

251 sformations by either intensifying the alpha helical structure or changing from alpha helical to beta

252 Subunit b contributes a central alpha-helical structure to the peripheral stalk, extending fro

253 es coupled folding and binding to form alpha-helical structure upon interacting with KIX.

254 erized as type I and maintained their triple-helical structure, confirmed by SDS-PAGE and FTIR.

255 lian cells, which is usually associated with helical structure, hydrophobicity, and charge density.

256 ated by bacterial phosphatase to restore the helical structure, thus contributing to strong membrane

257 is an all-or-none process related to loss of helical structure, weak unfolding and ejection of the pr

258 r, this interaction leads to a change in the helical structure, which alters G-domain interactions to

259 acid at a time, without altering their alpha-helical structure, which is required for correct antigen

260 change from compact random coil to extended helical structure-the disappearance of a band at 495 nm

261 a disordered regime and only little residual helical structure.

262 e, consecutive nucleobase pairs might impact helical structure.

263 ors, and the polypeptides regain their alpha-helical structure.

264 fications to create a membrane-spanning beta-helical structure.

265 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in

266 ide groups in hydrogen-bond stabilization of helical structures is a major factor, which determines s

267 gurable zigzag pattern deformation of a soft helical superstructure is demonstrated in a photorespons

268 developed a thermally driven, self-organized helical superstructure, i.e., thermoresponsive cholester

269 Strikingly, whereas the chirality of helical swimming is the same as the microscopic chiralit

270 motilities, including oscillatory swimming, helical swimming, and run-and-tumble motion.

271 iochemical experiments, we identify an alpha-helical switch that shifts a carbonyl oxygen into the ac

272 While these two structures have the same helical symmetry and repeat distance and nearly identica

273 n dimerizations, which generates an expanded helical symmetry when compared to other dynamins.

274 Motion in plants often relies on dynamic helical systems as seen in coiling tendrils, spasmoneme

275 rface, contains a discrete amphipathic alpha-helical targeting sequence, and participates in both hom

276 were stimulated by collagen without the non-helical telopeptide region compared with intact collagen

277 We find that the helical TM5i conformation is associated with a higher pr

278 pha helical structure or changing from alpha helical to beta strand depending on the solvents and mol

279 ical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc the

280 iotherapy, volumetric modulated arc therapy, helical tomotherapy, and adaptive radiotherapy.

281 effect, chiral topological superconductors, helical topological superconductors and Weyl semimetals.

282 erized by most of the myosin motors lying on helical tracks on the filament surface, making them unav

283 nel opening is accompanied by an alpha-to-pi-helical transition in the pore-lining transmembrane heli

284 we defined a general approach that disfavors helical transitions leading to post-fusion conformations

285 to study conformational dynamics of a seven-helical transmembrane (TM) protein, Anabaena Sensory Rho

286 N582 is located in the middle of a short 310-helical turn (D580-S584), in which most amino acids have

287 omplex stability emerges from the C-terminal helical turn, consisting of residues 8-13 in S-peptide w

288 nce-specific site as a monomer over a single helical turn.

289 ATPase domain and the adjacent DNA gyre 1.5 helical turns from the dyad axis of symmetry.

290 emodeling reactions if within one and a half helical turns of superhelix location 2 (SHL2), where the

291 ve longitudinal and lateral displacements of helical turns related to constriction.

292 e distances vary, however, over time because helical turns were observed to transiently pair and diss

293 the exact helical arrangement and the super-helical twist of the flagellin subunits within the filam

294 the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DN

295 containing cell wall polymers is to suppress helical twisting of expanding plant cells.

296 tro and FKBP19 seems to interact with triple helical type I collagen.

297 uctured N-terminal region that becomes alpha-helical upon binding.

298 For an isolated helical vortex, we observed evolution toward and mainten

299 For helical vortices that are stretched or compressed by a s

300 g fivefold intramolecular coupling to form a helical ZrPAH with 16 fused rings (from a precursor with