ライフサイエンスコーパス: helicase

1 first report of a full-length octameric MCM helicase.

2 ement of Cdc45 and GINS to form the CMG holo-helicase.

3 ample is the genome maintenance protein RecQ helicase.

4 catalytic core of the eukaryotic replicative helicase.

5 ors, including Mpp6, Rrp47, and the Mtr4 RNA helicase.

6 f replication, oriC, to load the replicative helicase.

7 ely 80%, permits recoupling of polymerase to helicase.

8 along ssDNA; however, the monomer is a poor helicase.

9 ementary targets, and Cas3 executor nuclease/helicase.

10 zation domain extends toward the side of the helicase.

11 regions and supports the binding of Pif1 DNA helicase.

12 ogaster mutants that lack the Bloom syndrome helicase.

13 the DSB-responsive kinase Tel1, but not Sgs1 helicase.

14 trigger the assembly of the replication fork helicase.

15 ated that it is an ATP-dependent RNA and DNA helicase.

16 n many proteins but has not been reported in helicases.

17 t regulates DHX9 and, potentially, other RNA helicases.

18 and negatively by multiple host DEAD-box RNA helicases.

19 RecQ4 are DNA-stimulated ATPases and robust helicases.

20 n of multiple nucleases, topoisomerases, and helicases.

21 etic lethal interaction among the human RecQ helicases.

22 cycle of the common catalytic core of these helicases.

23 A replication, including the Mcm replicative helicases.

24 m is clearly different to those of other RNA helicases.

25 ntiviral RNAi pathway, such as Dicer-related helicase 1 (DRH-1), to display hypersusceptibility to VS

26 etic framework for G4 disruption by DEAH-box helicase 36 (DHX36), the dominant G4 resolvase in human

27 Human RecQ-like helicase 4 (RECQL4) plays crucial roles in replication i

28 on by phosphorylating the Mcm2-7 replicative helicase [5-7].

29 In Saccharomyces cerevisiae, the Pif1 helicase, a telomerase inhibitor, lies at the interface

30 s, we propose a mechanism through which RecQ helicases achieve recombination precision and efficiency

31 gh Mcm2-7 activation requires binding of the helicase-activating proteins Cdc45 and GINS (forming the

32 Helicase activation occurs efficiently in the context of

33 helicase, and both ATPase and ATP-dependent helicase activities are inhibited by Rev in a dose-depen

34 that RPS3 inhibits ATPase, DNA binding, and helicase activities of RECQL4 through their direct inter

35 Our results indicate that WRN helicase activity alone is not rate-limiting for the dev

36 since Srs2 is a multifunctional protein with helicase activity and the ability to displace Rad51 reco

37 Understanding regulation of RECQL4 helicase activity by interaction partners will allow dec

38 rmational state of its 2B subdomain, and its helicase activity has been correlated with a closed 2B c

39 The Dna2 helicase activity has been implicated in Okazaki fragmen

40 ryotes, binds CMG and greatly stimulates its helicase activity in vitro.

41 e-dependent manner, although ATP-independent helicase activity is not.

42 This indicates that the helicase activity of a UvrD dimer is promoted via direct

43 Notably, helicase activity of FANCJ was essential for controlling

44 Mutations abolishing the helicase activity of Mss116 do not prevent the interacti

45 ed by the co-opted PK is used to promote the helicase activity of recruited cellular DEAD-box helicas

46 onding residues in bacterial uS3 promote the helicase activity of the elongating ribosome, suggesting

47 tion fork-like structures and stimulates its helicase activity on DNA fork duplexes.

48 e that Srs2 interaction with PCNA allows the helicase activity to unwind fork-blocking CAG/CTG hairpi

49 cellular partners in order to coordinate its helicase activity to various processes including replica

50 Helicase activity, as well as the conserved winged-helix

51 This result suggests that in addition to its helicase activity, eIF4A uses the free energy of ATP bin

52 Dna2, a flap endonuclease with 5'-3' helicase activity, is involved in the resection process.

53 Phosphorylation of RECQL4 stimulates its helicase activity, promotes DNA end resection, increases

54 Contrary to expectations, Mer3 helicase activity, proposed to extend the displacement l

55 sequence and position dependent and required helicase activity.

56 D monomer to a more open state that shows no helicase activity.

57 is an RNA-induced ATPase with a 3'-->5' RNA helicase activity.

58 e 834 (R834C) and up to 90% reduction of WRN helicase activity.

59 more closed state resulting in activation of helicase activity.

60 hat the analogous Escherichia coli (Ec) DnaB helicase also interacts specifically with the excluded D

61 We have measured the ATPase, helicase and DNA binding properties of various RECQL5 co

62 his new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1-XPF endonuclease in cooperation with

63 k repair, including the Bloom syndrome (BLM) helicase and exonuclease 1 (EXO1), play a major role in

64 ions and revealed an interaction between HCV helicase and LGP2.

65 ging clarity to the respective roles of UvrD helicase and Mfd translocase in repair of UV-induced dam

66 Previous studies demonstrated helicase and NTPase activities for DDX3X, but important

67 que fusion of Cas2, with the type I effector helicase and nuclease for invader destruction, Cas3.

68 UL8 has been reported to stimulate the helicase and primase activities of the complex in the pr

69 teractions among the hepatitis C virus (HCV) helicase and RLR helicases in live cells with quantitati

70 he conserved winged-helix (WH) motif and the helicase and RNase D C-terminal (HRDC) domain play impor

71 l hairpin substrates in the presence of RecQ helicase and saturating adenine triphosphate let us dedu

72 sion process in which both strands enter the helicase and the duplex unwinding point is internal, fol

73 mediated TCR") that is dependent on the UvrD helicase and the guanosine pentaphosphate (ppGpp) alarmo

74 Our results demonstrate that DDX43 is a dual helicase and the KH domain is required for its full unwi

75 In eukaryotes, the Cdc45-MCM-GINS (CMG) helicase and the leading-strand polymerase, Pol epsilon,

76 ce [MCM] subunits 2-7, and the GINS complex) helicase and triggers disassembly of the replication mac

77 f yeast CMG shows that duplex DNA enters the helicase and unwinding occurs in the central channel.

78 known to modulate TE expression, such as RNA helicases and autophagy genes.

79 nation for the ATP-gated behavior of SF2 RNA helicases and receptor proteins.

80 is both an ATP-dependent and ATP-independent helicase, and both ATPase and ATP-dependent helicase act

81 s, oligomerizes to function as efficient RNA helicase, and does not unwind DNA duplexes.

82 major components: RNase E, PNPase, RhlB RNA helicase, and enolase.

83 strategy to explore selective inhibitors for helicases, and 9 could be a promising starting point for

84 DDX43, also known as HAGE (helicase antigen gene), is a member of the DEAD-box prot

85 Here, we identify the conserved RNA helicase Aquarius/EMB-4 as a direct and essential link b

86 e duplication and demonstrate that accessory helicases are a major determinant of this balance.

87 RecQ helicases are essential in the maintenance of genome sta

88 RecQ helicases are important maintainers of genome integrity

89 Replicative helicases are loaded onto DNA by dedicated initiator, lo

90 Replicative helicases are ring-shaped hexamers that encircle DNA for

91 Replicative hexameric helicases are thought to unwind duplex DNA by steric exc

92 This processing requires Zuc and the helicase Armitage (Armi).

93 ring-shaped minichromosome maintenance (MCM) helicases around DNA in opposite orientations.

94 origin licensing requires loading two Mcm2-7 helicases around origin DNA in a head-to-head orientatio

95 Genetic analysis identified the Srs2 helicase as a prime candidate to promote SDSA.

96 ork identified a number of cellular DEAD-box helicases as in vivo binding partners of Rev, and siRNA

97 ion surface is important for origin melting, helicase assembly, and the recruitment of pol alpha to M

98 ipt and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, s

99 In contrast, the DnaB helicase associates stably with the replication fork, pr

100 tic factors, telomeric proteins, and the RNA helicase, ATRX.

101 Brr2 is an RNA helicase belonging to the Ski2-like subfamily and an ess

102 t mechanisms whereby Cdc45-Mcm2-7-GINS (CMG) helicase binds Pol epsilon and tethers it to the leading

103 s1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA

104 hat whereas either WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta progressi

105 domain, which also transiently contacts the helicase Brr2.

106 itution strongly and selectively reduces WRN helicase, but not exonuclease activity.

107 of human DDX3X are typical for DEAD-box RNA helicases, but diverge quantitatively from its highly si

108 an cells detect RNA viruses through a set of helicases called RIG-I-like receptors (RLRs) that initia

109 te between the C-terminal and the N-terminal helicase cassettes, while 12 binds an RNA-binding site i

110 We previously showed that the cellular DNA helicase ChlR1 is required for loading of the bovine pap

111 16 (HPV16), associate with the cellular DNA helicase ChlR1.

112 le is known about whether and how these RecQ helicases co-operate and/or complement each other in res

113 ary, these results reveal a new role for the helicase complex in 3' cap-independent translation eleme

114 Here we show that loss of the BLM helicase complex suppresses FANCC phenotypes and we conf

115 2 gene (UL52; a component of the DNA primase/helicase complex), bICP4, IEtu2, and the unique short re

116 The helicase complex, consisting of eIF4A, eIF4B, and ATP, s

117 res loading minichromosome maintenance (MCM) helicase complexes at many DNA replication origins, an e

118 step towards the assembly of two replicative helicase complexes at origins, moving in opposite direct

119 ilarities, physical interaction with the CMG helicase component SLD5, and an expression pattern confi

120 The eukaryotic CMG (Cdc45, Mcm2-7, GINS) helicase consists of the Mcm2-7 hexameric ring along wit

121 It contains a helicase core domain in its C terminus and a potential K

122 DEAD-box RNA helicases (DBRHs) modulate RNA secondary structure, allo

123 genes ribosomal protein RPL35A, putative RNA helicase DDX24, and coatomer complex I (COPI) subunit AR

124 Here, we identified the RNA helicase DDX39B as a potent activator of this exon and c

125 Five host RNA helicases (DDX3X, DDX5, DHX9, DHX37, DDX52) were inhibit

126 cinoma cells, we identified the DEAD-box RNA helicase DDX41 as a novel regulator of p21 expression.

127 Cellular DEAD-box helicase DEAD-box protein 1 (DDX1) plays a role in HIV r

128 In addition, in a helicase-deficient mutant, Rad51-dependent JMs are detec

129 he absence of Srs2 recruitment to PCNA or in helicase-deficient mutants, breakage at a CAG/CTG repeat

130 We report a novel molecular assay, based on helicase-dependent amplification (HDA), for the detectio

131 fense and set the stage for the discovery of helicase-dependent functions in other Dicers.

132 Here, we identified the RNA helicase DHX15 as a novel AR co-activator using a yeast

133 s anti-viral, while three other cellular RNA helicases (DHX29, DHX35, RIG-I) were identified as pro-v

134 increases the stability of the DEAH-box RNA helicase DHX33, which is critically involved in ribosoma

135 lasm, where it co-localizes with the RNA/DNA helicase Dhx9 and paraspeckles; as well as GW/P-bodies i

136 port on the identification of the DExH/D-box helicase DHX9 as an intranuclear Nup98 binding partner.

137 Our data show that, via RNA helicase Dhx9, Nlrp9b recognizes short double-stranded R

138 Chd1 (Chromodomain Helicase DNA Binding Protein 1) is a conserved ATP-depen

139 tions, this approach uncovered the chromatin helicase DNA-binding factor CHD1 as a putative synthetic

140 The chromodomain helicase DNA-binding family of ATP-dependent chromatin r

141 For the chromodomain helicase DNA-binding protein 1 (Chd1) remodeler, nucleos

142 TCF19 interacted with CHD4 (chromodomain helicase DNA-binding protein 4), which is a part of the

143 m loss of function mutations in chromodomain helicase DNA-binding protein 7 (CHD7(LOF)) and lysine (K

144 We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associ

145 modelers, we found that ATPases chromodomain helicase DNA-binding protein 9 (CHD9) and Brahma homolog

146 Recently, it was shown that chromodomain helicase DNA-binding protein-7 (CHD7) interacts with RUN

147 ngly, the stoichiometries of the replicative helicase, DNA polymerase, and clamp loader complexes are

148 The Chromodomain-Helicase-DNA binding (CHD) Type III proteins are a subfa

149 The group III chromodomain-helicase-DNA-binding (CHD) family of ATP-dependent chrom

150 he structurally similar Escherichia coli Rep helicase does not elicit this effect.

151 y of the full-length protein, the C-terminal helicase domain had no unwinding activity on RNA substra

152 is locally unwound and threaded through the helicase domain in an adenosine triphosphate-dependent m

153 upon recent findings on the function of the helicase domain in discriminating between different RNAs

154 NS5 MTase or POL domain or in the DENV2 NS3 helicase domain in the DENV2 chimera RNAs by repeated pa

155 RNA termini, unexpectedly, we found that the helicase domain is required for binding blunt, but not 3

156 ll positioned to recruit substrates into the helicase domain of Dicer-2.

157 ve determined crystal structures of the core helicase domain of RECQL5 both with and without the nucl

158 ethylase and four other genes annotated as a helicase domain, a phospholipase D (PLD) domain, a DUF19

159 erted in between the RecA modules of the RNA helicase domain.

160 nteract with the Hel2 subdomain of Dicer-2's helicase domain.

161 region, which connects the HIRAN and ATPase/helicase domains.

162 The assembly of the replication fork helicase during S phase is key to the initiation of DNA

163 th cellular E2-binding factors and the viral helicase E1; however, in contrast, the Y102E mutant asso

164 e function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other

165 unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes

166 Hepatitis C viruses (HCV) encode a helicase enzyme that is essential for viral replication

167 Unlike other replicative helicases, eukaryotic CMG helicase partially encircles d

168 trigger (RQT) subcomplex composed of the RNA helicase-family protein Slh1/Rqt2, the ubiquitin-binding

169 1, and is countered by the FANCM-related DNA helicase Fml1.

170 cation termination is the removal of the CMG helicase from chromatin.

171 we present the structure of the archaeal MCM helicase from Pyrococcus abyssi in its single octameric

172 s, including a detailed understanding of DNA helicase function and synaptonemal complex structure.

173 solution, elucidating the molecular basis of helicase function by relaxases and revealing insights in

174 The currently accepted view of hexameric helicase function is by steric exclusion, where the heli

175 Unexpectedly, we found a requirement for the helicase function of Dna2 in end resection in budding ye

176 loom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair.

177 The PcrA/UvrD helicase functions in multiple pathways that promote bac

178 Escherichia coli UvrD DNA helicase functions in several DNA repair processes.

179 ss, by crRNA-displaying Cascade and nuclease-helicase fusion enzyme Cas3, respectively.

180 Loss-of-function mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrom

181 a conserved complex of genes, including the helicase gene, showing consistently high levels of adapt

182 This helicase has become the focus of extensive basic researc

183 ataricus minichromosome maintenance (SsoMCM) helicase has been shown to unwind DNA via a SEW mode to

184 strand on the exterior surface of hexameric helicases have also been shown to be important for DNA u

185 he ATP hydrolysis cycle of the superfamily 2 helicase Hel308 during translocation on single-stranded

186 e DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phosphoryla

187 elicase-like transcription factor (HLTF) DNA helicase in a proteasome-dependent manner by redirecting

188 patterning in Drosophila and the role of Blm helicase in controlling this patterning.

189 1 and FAN-1 nucleases, and the DOG-1 (FANCJ) helicase in ICL resolution, influenced by the replicativ

190 ese data unravel the novel function of FANCJ helicase in regulating SCR and SCR associated gene ampli

191 Replicative helicases in all cell types are hexameric rings that unw

192 the hepatitis C virus (HCV) helicase and RLR helicases in live cells with quantitative microspectrosc

193 Our work implicates distinct RNA helicases in specific steps along the nuclear piRNA path

194 y screen targeting the 58 human DEAD-box RNA helicases in two permissive human cancer cells (HeLa and

195 e potent and selective Brr2 inhibitor 9 with helicase inhibitory activity.

196 MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replication origins.

197 DDX3X is a conserved DEAD-box RNA helicase involved in translation initiation and other pr

198 Unlike many helicases involved in genome stability no hUPF1 binding

199 Minichromosome Maintenance (MCM) replicative helicase is a crucial component of replisomes.

200 The replication fork helicase is composed of Cdc45, Mcm2-7 and GINS (CMG).

201 The FANCJ DNA helicase is linked to hereditary breast and ovarian canc

202 chinery, and that unloading of Rad51 by Srs2 helicase is required for efficient PCNA loading and rest

203 Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukaryotic DNA replica

204 3 and of all other spliceosomal DEAH-box RNA helicases is still elusive.

205 DNA damage at tDNAs in the absence of these helicases is suppressed by destabilizing R-loops while P

206 Unlike other superfamily 2 (SF2) helicases, JFH-1 NS3 does not require long 3' overhangs,

207 rated mice expressing a mutant mitochondrial helicase (K320E-TWINKLE) in the epidermis to accelerate

208 mponents of the HCV replication complex is a helicase known as nonstructural protein 3 (NS3).

209 : an endonuclease (R.CglI) and a DEAD-family helicase-like ATPase (H.CglI).

210 Chromatin remodelers use a helicase-like ATPase motor to reposition and reorganize

211 eomic approaches suggested that Vpr degrades helicase-like transcription factor (HLTF) DNA helicase i

212 anking nucleosomes or roadblocks resulted in helicase loading being dependent on an additional origin

213 blocks that inhibited ORC-DNA binding showed helicase loading defects.

214 We observed inhibition of helicase loading without inhibition of ORC-DNA binding o

215 ed, the remaining roadblock had no effect on helicase loading.

216 n specificity by preventing non-specific MCM helicase loading.

217 Consistent with a sliding helicase-loading intermediate, when either one of the fl

218 sides of the origin to restrict sliding of a helicase-loading intermediate.

219 ur findings support a model in which sliding helicase-loading intermediates increase the flexibility

220 DNA unwinding by the replicative helicase may continue during such pauses, but a self-gov

221 that DHX36 disrupts G4s with a conventional helicase mechanism that is tuned for great efficiency an

222 s of extensive basic research on the general helicase mechanism, and it is also of interest as a nove

223 rk stability by inhibiting DNA2 nuclease/WRN helicase-mediated degradation of stalled forks.

224 changes are located within highly conserved helicase motifs and were found to either impair ATPase a

225 ication are licensed upon loading of the MCM helicase motor onto DNA.

226 Ps, including the binding effects of the RNA helicase MOV10 on mRNA degradation, the potentially diff

227 ical proximity and coupled activities of RNA helicase Mtr4 (and senataxin) with the noncoding RNA pro

228 The HerA-NurA helicase-nuclease complex cooperates with Mre11 and Rad5

229 AdnAB, the helicase-nuclease implicated in mycobacterial HR, consis

230 double-strand break (DSB) by a multisubunit helicase-nuclease machine (e.g. RecBCD, AddAB or AdnAB)

231 o target dsDNA degradation by a trans-acting helicase-nuclease.

232 NA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands,

233 n the strategies used to deposit replicative helicases onto DNA and to melt the DNA helix in preparat

234 A replication, but not its activity as a DNA helicase or its ability to bind to ssDNA.

235 , whereas integration was independent of the helicase or nuclease activities of Cas3.

236 YFP fused to either biologically active HCV helicase or one RLR (i.e. RIG-I, MDA5, or LGP2), express

237 and FCD-2 (FANCD2), the WRN-1 or HIM-6 (BLM) helicases, or the GEN-1 or MRT-1 (SNM1) nucleases.

238 d that Dia2 functions with the Sgs1 and Mph1 helicases (orthologs of human BLM and FANCM, respectivel

239 other replicative helicases, eukaryotic CMG helicase partially encircles duplex DNA at a forked junc

240 ic interaction of Sub1 with the G4-resolving helicase Pif1, suggesting a possible mechanism by which

241 myces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3.

242 Specialized helicases play an important role in unwinding DNA struct

243 incorporation of Cdc45 into the replicative helicase, possesses a partner called MTBP (Mdm2-binding

244 tive to DNA sequence and structure, with the helicases preferentially unwinding D-loops.

245 's replication machinery includes a trimeric helicase-primase composed of helicase (UL5) and primase

246 ethyl-2-[4-(2-pyridinyl)phenyl ]acetamide, a helicase-primase inhibitor for the treatment of herpes s

247 , whereas deletion of the FANCM-related Mph1 helicase promotes BIR.

248 We identify a new role for the Pif1 helicase: promotion of replication and suppression of DN

249 n and potentially regulating activity of the helicase Prp22.

250 The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as w

251 Together, these data suggest that this helicase regulates p21 expression at the translational l

252 factors in assembly of the replication fork helicase remain unclear.

253 UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regu

254 ion events in bacteria often require the RNA helicase Rho.

255 e terminators, or by a nascent RNA-dependent helicase, Rho.

256 and in solution, similar to the HJ migration helicase RuvB in Gram-negative bacteria.

257 The RNA/DNA helicase senataxin (SETX) is one of the best characteris

258 ort second-end homology, absence of the RecQ helicase Sgs1 promotes gene conversion, whereas deletion

259 (with the exception of TLR3) and RIG-I-like helicase signaling, whereas in vaccinated MyD88(-/-) mic

260 sponses needed concurrent TLR and RIG-I-like helicase signaling.

261 auses, but a self-governing mechanism, where helicase speed is reduced by approximately 80%, permits

262 re complex structure used in high-resolution helicase studies, a DNA hairpin adjacent to 33 nt of ssD

263 interacting peptide (CIP) of the replicative helicase subunit Sld5.

264 it interacts with the MOV10 RISC complex RNA helicase, suggesting a role for IRAV in the processing o

265 rner syndrome protein (WRN) is a RecQ family helicase that has been implicated in the efficient proce

266 LIMIT2 (ISE2) is a chloroplast-localized RNA helicase that is indispensable for proper plant developm

267 The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair

268 UPF1 is an RNA helicase that orchestrates nonsense-mediated decay and o

269 d that ISE2 is a non-canonical Ski2-like RNA helicase that represents a separate sub-clade unique to

270 ore enzyme of the eukaryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) comple

271 Mcm2-7 hexamer structure found in the active helicase, the N-tier ring of the Mcm2-7 hexamer in the D

272 lisome requires 24 proteins, forming the CMG helicase, the Pol epsilon DNA polymerase, the RFC clamp

273 cation initiation, the core component of the helicase-the Mcm2-7 hexamer-is loaded on origin DNA as a

274 D) of DnaB to impair the ability of this DNA helicase to interact with primase.

275 quires an active large T (LT) phosphoprotein helicase to replicate.

276 on factories depend on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping

277 This mode of translocation allows helicases to bypass blocks on the strand that is exclude

278 ouble HJs are primarily dissolved by the BLM helicase-TopoisomeraseIIIalpha-RMI1-RMI2 (BTR) complex,

279 f the host restriction factor SAMHD1 or host helicase transcription factor (HLTF), respectively.

280 Escherichia coli UvrD is an SF1A DNA helicase/translocase that functions in chromosomal DNA r

281 quence within Hel308 affects the kinetics of helicase translocation.

282 that sheds light on how superfamily 1 and 2 helicases turn ATP hydrolysis into motion along DNA.

283 teracted functionally with the mitochondrial helicase TWINKLE.

284 In addition to the RNA helicase UAP56 and the mRNA export factors ALY2-4 and MO

285 udes a trimeric helicase-primase composed of helicase (UL5) and primase (UL52) subunits and a third s

286 xpands on the existing SE model of hexameric helicase unwinding to include contributions from the exc

287 The Srs2 helicase unwinds DNA hairpins, facilitates replication,

288 we describe a new role for the ATP-dependent helicase UPF1 and its interaction with the RNA localizat

289 iRNAs does not require the ATP-dependent RNA helicase UPF1 in vitro, we report here that cellular Tum

290 ly, strand-specific blocks only affect these helicases when placed on the tracking strand, not the ex

291 talytic lobe is anchored to the motor of the helicase, whereas the polymerization domain extends towa

292 Humans have five RecQ helicases, whereas simpler organisms have only one.

293 ly interacts with the conserved meiotic Mer3 helicase, which recruits it to recombination hotspots, i

294 case activity of recruited cellular DEAD-box helicases, which are involved in the production of exces

295 Many RNA viruses also encode helicases, which are sometimes covalently linked to prot

296 DHX30 is a member of the family of DExH-box helicases, which use ATP hydrolysis to unwind RNA second

297 tes the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, delta, and epsilon

298 DDX3 is a DEAD box RNA helicase with oncogenic properties.

299 ed DNA is promoted by Rep and UvrD accessory helicases with Deltarep DeltauvrD cells being inviable u

300 he H/ACA snoRNP protein yNhp2/hNHP2, the RNA helicase yRok1/hROK1(DDX52), the ribosome biogenesis fac