ライフサイエンスコーパス: helices

1 oligomers also resemble those of PPI peptide helices.

2 connects the fourth and fifth transmembrane helices.

3 25 repeats capped by N- and C-terminal alpha-helices.

4 bone H-bonds between six polyproline 2 (PP2) helices.

5 ther in part by the Anbu specific C-terminal helices.

6 ns with curved beta sheets topped with alpha helices.

7 panding the natural repertoire of RNA triple helices.

8 ic interactions with neighboring amphipathic helices.

9 or only the surface-exposed algal SSU alpha-helices.

10 al imidazole amino acids fold into canonical helices.

11 pping the C-termini of alpha-helices and 310-helices.

12 s of macrodipoles between neighbouring alpha-helices.

13 ulting in a total of six transmembrane alpha-helices.

14 higher numbers of inter-residue contacts in helices.

15 alize flexible hinge points within the stalk helices.

16 helix impair Brr2 translocation through RNA helices.

17 IV gp41 and represents a bundle of six alpha-helices.

18 tes, with GDP-bound-like orientations of the helices.

19 sertion (also called wedging) of amphipathic helices.

20 ide chains in the first turn of the M2 alpha-helices.

21 accommodate two strands from collagen triple helices.

22 de smaller than the Young's moduli of triple helices.

23 hat connect neighboring layers of DNA double helices.

24 idual complexes, including 132 transmembrane helices.

25 hibit three highly conserved predicted alpha-helices.

26 ong functional regions and between companion helices.

27 oline receptor formed by transmembrane alpha-helices.

28 atest deprotection occurring at the edges of helices.

29 nd a right-handed crossing angle between the helices.

30 ion and thereby stability of collagen triple helices.

31 membrane domain of the enzyme via two alpha-helices.

32 re dominant in the middle portions of the TM helices.

33 omodimers formed by transmembrane (TM) alpha-helices.

34 rane-exposed polar residues in transmembrane helices 1 and 2 of BR may provide the molecular basis fo

35 xtracellular loops 4 and 6 and transmembrane helices 1, 6, 10 and 11.

36 ealed that S15 binds a three-way junction of helices 20, 21, and 22, including nucleotides 652-654 an

37 s, the N-terminal domain contains four alpha-helices, 20 to 30 amino acids long.

38 e motif positioned between membrane-spanning helices 4 and 5.

39 ffinity sites located near the transmembrane helices 5-7 of the receptor.

40 oring the spatial positions of transmembrane helices 6 and 7 at the cytoplasmic surface using site-di

41 t of the extracellular ends of transmembrane helices 6 and 7.

42 ow that the large loop between transmembrane helices 7 and 8 of FtsW is important for the interaction

43 asmic site in the loop between transmembrane helices 8 and 9, which influences the electrostatic pote

44 stallographic study showed that CaM embraces helices A and B with the apo C lobe and calcified N lobe

45 3 pharmacodynamic effect by binding to IL-13 helices A and D, thus preventing IL-13 from interacting

46 -forming domain comprising six transmembrane helices, a pore helix, and a selectivity filter.

47 We found that these alpha-helices act as a transient intermediate to beta-sheet an

48 rupt folding of this region into amphipathic helices (AHs) significantly decreased lipid droplet targ

49 scopy, that COR15A starts to fold into alpha-helices already under mild dehydration conditions (97% r

50 lay a role in capping the C-termini of alpha-helices and 310-helices.

51 translational insertion of the transmembrane helices and a fluidic surface for proper assembly and di

52 Here we show that alpha helices and beta strands differ significantly in their a

53 All models revealed 12 transmembrane helices and connecting loops and represented the partial

54 rive termination by folding into the trigger helices and contacting the terminator hairpin after inva

55 ne ligand-binding sites in the transmembrane helices and effector docking sites at the intracellular

56 he conceptual advance in Swellix is to count helices and generate all possible combinations of helice

57 O)-modified RNA duplexes form regular A-form helices and in UV-melting experiments the stability of t

58 Swellix bundles similar helices and includes improvements in memory use and effi

59 tertiary contacts from different connecting helices and junctions (DeltaGHJH) or from changes in the

60 motions and slower collective motions of TM helices and of structured loops, and used the simple mod

61 hanges in the NMR spectra of residues in the helices and on the surface of beta-strands S3, S9, and S

62 The monomeric molecule consists of 10 alpha-helices and one short beta-hairpin, and, although the st

63 lso interacts with most of the transmembrane helices and periplasmic regions of SecY, with a clusteri

64 cle the receptor ion channel, stabilizing M2 helices and pore loops, illustrating how TARPs alter rec

65 SR trimer revealed a more compact packing of helices and side chains at the intermonomer interface, c

66 studies suggested that NS4B contained eleven helices and six of them form five potential transmembran

67 Additionally, both helices and strands are significantly more robust than c

68 with the distancing of the N- and C-terminal helices and subsequent solvent exposure of the hydrophob

69 s were consistently observed for three alpha-helices and the adenosine binding regions for AK complex

70 s a smaller and less complex DBD lacking the helices and the big loops outside the core.

71 pes are three-fold degenerate states akin to helices and the multiple state of canting spin stripes i

72 uption of the interaction between C-terminal helices and the NBD1 core upon VX-809 binding is observe

73 evolution from disordered monomers to alpha-helices and then to beta-sheets when the proteins encoun

74 All four proteins include transmembrane helices and together form the membrane anchor of complex

75 of the transporter contains 12 transmembrane helices and two periplasmic loops that suggest a plausib

76 SL (bifunctional spin-label) onto the F or G helices and using DEER (double electron-electron resonan

77 of Fpn, (3) hepcidin interacted with up to 4 helices, and (4) hepcidin binding should occlude Fpn and

78 cts two DNA-binding domains, two amphipathic helices, and an in-plane membrane anchor in IL-26, which

79 ein contained three beta-sheets, seven alpha-helices, and coils.

80 nalization of Aop-containing collagen triple helices, and molecular dynamics simulations.

81 such as tubes, jagged ribbons, nested tubes, helices, and nested rings.

82 ith conformational changes involving several helices, and we localize flexible hinge points within th

83 ctures featuring hybrid topologies of coils, helices, and/or pi-stacked sheets that, on a basic level

84 of native Rubisco, suggesting that the alpha-helices are catalytically neutral.

85 es at the C-termini of the alpha1 and alpha2 helices are consistent with a helix scissors motion or a

86 Whereas almost stable helices are formed C terminally to the oligomerization d

87 ers of the ErbB family, the backbones of the helices are in contact, and they invariably display netw

88 the apo-PhuS C-terminal alpha6/alpha7/alpha8-helices are largely unstructured, whereas the apo-PhuS H

89 C bilayers, with increased water access, the helices are less responsive to changes in pH.

90 ta-Caa(l) residues, where right-handed 12/10-helices are predominating.

91 oligomerization domain, extremely transient helices are present in the N-terminal region.

92 alpha-helices; when ATP is scarce, the alpha-helices are proposed to inhibit ATP hydrolysis by assumi

93 nding pattern and the handedness of foldamer helices are rare so far.

94 es, giving new insight into how single alpha-helices are stabilized.

95 Multi-stranded helices are widespread in nature.

96 acing state, and we show that the C-terminal helices, arranged in a zipper-like fashion, play a cruci

97 e spatial arrangement of pigments, employing helices as scaffolds.

98 elopment of all-cis polyproline type I (PPI) helices, as tools for modulating biological functions.

99 ormational changes occur in loops connecting helices, as well as the short 310 helix initiating the C

100 Post-TS, hinge helices assemble and the DBD-hinge helix-O-DNA module do

101 d 5'-AUAGC-3' bulge preorganize the adjacent helices at nearly orthogonal orientations.

102 Finally, we find helices at the interfaces of HIV and RSV CA assemblies h

103 e identified by vibrational couplings across helices at their interface.

104 While several approaches to responsive helices based on hydrogels and liquid crystalline polyme

105 As a result of this transition, the S6 helices bend and rotate, exposing different residues to

106 consisting of 42 aa arranged in three alpha-helices, build an elongated superhelical structure.

107 ignificantly more extended than linear alpha-helices but less extended than straight chains.

108 scales, are smaller in the central parts of helices, but increase toward their cytoplasmic sides as

109 on donors and carbonyl acceptors on opposing helices (Calpha-H...O horizontal lineC hydrogen bonds).

110 ntly in their ability to tolerate mutations: helices can accumulate more mutations than strands witho

111 ng that local movements of the transmembrane helices can control ion access to the pore even in the N

112 CD81 pack as two largely separated pairs of helices, capped by the large extracellular loop (EC2) at

113 t the C-terminus form a bundle of five alpha-helices co-linear with the five-fold axis of symmetry.

114 inner and outer ends of adjacent pore-lining helices come closer during opening, likely through a hin

115 ossing and the splaying apart of pore-lining helices commanding ion passage.

116 as a mixture in equilibrium of two different helices (compressed and stretched), both less dynamic th

117 olic nucleotide binding domains and coupling helices conferred by intracellular loops extending from

118 ue motif is pre-populated with two transient helices connected by a hydrophobic linker.

119 The nascent chain forms two alpha-helices connected by an alpha-turn and a loop, enabling

120 ce analysis revealed that SDH3 and SDH4 lack helices conserved in other organisms.

121 There, the conformation of transmembrane helices constituting a membrane-spanning furrow that pro

122 a periplasmic loop between two transmembrane helices contain conserved charged residues and are impli

123 catalytic mechanism, rotation of equivalent helices controls protease activity by movement of the eq

124 of motions on the cytoplasmic side of the TM helices correlates with the ability of ASR to undergo la

125 tability, and synthetic accessibility of eta-helices could facilitate their utilization in a wide ran

126 at being more than just membrane anchors, TM helices could play an important role in the clustering a

127 Nucleation of hinge helices creates TS, burying sidechain amide nitrogens.

128 ab epitope is mainly composed of residues in helices D and A of IL-13.

129 s by assuming an "up" state, where the alpha-helices, devoid of ATP, enter the alpha3beta3-catalytic

130 stable beta-sheet core, the peripheral alpha-helices display significant local fluctuations leading t

131 thway lies between the core and gate ring of helices, distinct from the transporter pathway.

132 hree distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD) and an intact

133 olding of polypeptide side chains into alpha-helices dramatically enhances the polymerization rate du

134 ces that generated globally amphiphilic (GA) helices, each with a nonpolar domain formed by six cyclo

135 ucturing and repositioning of two C-terminal helices enable MapZ to disrupt the CheR1 active site by

136 pseudoknot interaction between the P2 and P4 helices, even at high metabolite concentrations.

137 r124, and Arg125 in the stromal loop linking helices F and G of cyt b6f subunit IV are crucial for st

138 implying that certain conformations of these helices facilitate clustering, whereas others do not.

139 dues on the carboxy-terminal half of the TM1 helices form a bottleneck along the ion conduction pathw

140 Two antiparallel alpha-helices form a coiled-coil domain linked by a large exte

141 B, the alpha1 helices unfold and the alpha2 helices form a tight two-helix coiled-coil.

142 ic Arabidopsis SSUs containing the SSU alpha-helices from Chlamydomonas reinhardtii can form hybrid R

143 es such as the minimum number and lengths of helices from crystallography, cryoelectron microscopy, o

144 ed conserved amino acid residues in membrane helices H and I.

145 ular loop, the H-I loop, connecting membrane helices H and I.

146 Ala2.47 mediates the interaction between helices H1 and H2, while Ser4.53 mediates the interactio

147 ile Ser4.53 mediates the interaction between helices H3 and H4.

148 tween its beta-ionone ring and transmembrane helices H5 and H6, while deprotonation of its protonated

149 tructural feature that facilitates motion of helices H5, H6, and H7, which is required for receptor a

150 e (helix H5), at the dimerization interface (helices H6 and H7 and loop L7) of the globin domain and

151 nate the A-tRNA-namely, ribosomal RNA (rRNA) helices H89, H91, and ribosomal proteins (rProtein) uL16

152 e globin domain and in the ATP-binding site (helices H9 and H11) of the kinase domain.

153 y (cryo-ET) results indicate that the single helices have a periodic pitch of approximately 100 nm an

154 ackbone hydrogen bonds in transmembrane (TM) helices have the potential to be very strong due to the

155 our-helix bundles with a core of three alpha-helices held together by a [4Fe-4S] cluster.

156 features such as flexible junctions between helices help guide RNA tertiary folding, the mechanisms

157 acceptor at the ends of a long loop between helices I and II, and a Cys residue as a quencher for th

158 chimera (C1C2), an engineered combination of helices I-V from ChR1, without its C-terminus, and helic

159 f aromatic residues located in transmembrane helices II, IV, and V of subunit B, near glycine residue

160 ere the Ax peptides are accommodated between helices III/IV and III'/IV'.

161 depends on the sequence or length of the TM helices, implying that certain conformations of these he

162 signal transmitted to the transmembrane (TM) helices in a CitA construct in liposomes.

163 onstrate the ability of M2-seq to detect RNA helices in a complex biological environment.

164 d lipid surfaces via their amphipathic alpha-helices in a manner typical of apolipoproteins.

165 que binding domain consisting of three alpha helices in addition to a typical GT-A-type glycosyltrans

166 itro M2-seq experimentally resolves 33 of 68 helices in diverse structured RNAs including ribozyme do

167 tions at transmembrane segment (TM) 6 and 12 helices in HEK293 cells.

168 ociation of various combinations of the four helices in Im9 (referred to as H1, H2, H3, and H4) by ex

169 e association of de novo designed (AALALAA)3 helices in liposomes.

170 ociation and dissociation events between the helices in membrane, thus leading to a free energy lands

171 67 form a coiled-coil of two monomeric alpha-helices in parallel orientation.

172 solated protein folds into amphipathic alpha-helices in response to increased crowding conditions, su

173 tuations of retinal ligand and transmembrane helices in rhodopsin.

174 erance, GTPase associated region and key RNA helices in the A, P and E functional sites of the 50S su

175 operating even in the absence of amphipathic helices in the BAR domain, and could in principle apply

176 guided by correspondences between the alpha-helices in the density map and model, and does not requi

177 P and a magnesium ion are bound to the alpha-helices in the down state.

178 attributed to the specific packing of triple helices in the fibril core.

179 olecular arrangement of the N-terminal alpha-helices in the filament core, including a melted central

180 observed solely with probes that contain the helices in the linker.

181 ton channel involves association of the plug helices in the periplasmic region of the MotB dimer into

182 ng N terminus, and semi-rigid polyproline II helices in the proline-rich flanking domain (PRD).

183 The high content of alpha-helices in Tra1 enabled tracing of the majority of its m

184 string of water molecules centred at kinked helices in two inverted-repeat triple-helix bundles (THB

185 residues provided by a bundle of four alpha-helices inclined at approximately 30 degrees to the plan

186 ramers consisting of two concentric rings of helices, including previously not seen triangular, squar

187 ere, a robust method for microfabrication of helices inspired by Bauhinia seedpods, based on trilayer

188 This brings the extended helices into close proximity, including a repulsive stre

189 TPP1 consists of several loops and helices involved in extensive interactions with POT1C.

190 rsion angle defined by each segment of three helices is prescribed by the net twist of the middle seg

191 Two helices located in a periplasmic loop between two transm

192 e metabolite mostly stabilizes the P1 and P3 helices, magnesium serves an important role in stabilizi

193 de novo prediction of single trans-membrane helices, making mutations and refining the structure wit

194 cause of the hydrophobicity of transmembrane helices, making them difficult to study using common aqu

195 equence of APP and possibly other cleaved TM helices may be designed, in part, to make their backbone

196 l by which conformational changes in H and R helices mediate CLH-3b regulation by activation domain p

197 between CBS domains and the H and R membrane helices mediated by the H-I loop.

198 d the membrane arm contains 78 transmembrane helices, mostly contributed by antiporter-like subunits

199 D) and the loop region between the M1 and M2 helices move during activation and the CTD is detached f

200 rolled frameworks from concatenated multiple helices (multihelices) with controlled chirality is demo

201 ight-handed twist of the DNA, with the alpha helices occupying the major groove.

202 omain, while binding of collagen-like triple-helices occurs within blades I and II of this domain.

203 esults imply that disorder in the N-terminal helices of 14-3-3zeta is a consequence of the dimer-mono

204 Asp(21) promoted disorder in the N-terminal helices of 14-3-3zeta, suggesting that this residue play

205 rmation of an HCA2-23 complex in which three helices of 2 are stacked, two of them being linked to an

206 mental dimeric structures formed by TM alpha-helices of 21 single-pass membrane proteins (including 4

207 , and mutations on the surfaces of predicted helices of ASXH abolished BAP1 association and stimulati

208 All six transmembrane helices of CmTMEM175 are tightly packed within each subu

209 een the lipid bilayer and transmembrane (TM) helices of Escherichia coli chemoreceptors alone are suf

210 folding/folding events within the C-terminal helices of holo-PhuS and the N-terminal alpha1/alpha2-he

211 ) binding the C and N termini of the B and C helices of IFN-beta, respectively.

212 cture of the complex between the distal (2B) helices of K1 and K10 to better understand how human ker

213 ipid regions near certain transmembrane (TM) helices of MOR induce an effective long-range attractive

214 of assembling chiral left- and right-handed helices of plasmonic nanoparticles (NPs), we introduce t

215 sed of only a fluorescent protein and the TM helices of Tar to demonstrate that interactions between

216 ird (M3) and fourth transmembrane (M4) alpha-helices of the alpha4 subunit.

217 interacts with the loop connecting two alpha-helices of the F-box-combining site.

218 ther by sequentially replacing the loops and helices of the six-helix bundle from enzyme with those f

219 xclusively adenosine triphosphates to unwind helices, oligomerizes to function as efficient RNA helic

220 ed, antiparallel beta-sheet flanked by alpha-helices on each side, representing a unique oligomerizat

221 Here, we present cryo-EM structures of Drp1 helices on nanotubes with distinct lipid compositions to

222 of distortions caused by chiral springs and helices on the colloidal self-organization in a nematic

223 nomeric and coacervated ELP3 and form stable helices only after chemical cross-linking.

224 ithout a hydrophobic core, and without alpha-helices or beta-sheets.

225 condary structure, where it folds into alpha helices or unstructured loops.

226 built-in support even for base pairs, double helices, or hairpin loops.

227 ergy required to open the transmembrane pore helices, our results strongly support a hypothesis that

228 te pseudoknots include two subdomains: P2ab (helices P2a and P2b with a 5/6-nt internal loop) and the

229 region containing at least 26 transmembrane helices per protomer.

230 nerated three-dimensional models of TM alpha-helices positioned in membranes; (iv) amino acid sequenc

231 sing mutations in either of the two coupling helices predicted to interact with nucleotide binding do

232 es and generate all possible combinations of helices rather than counting and combining base pairs.

233 ich transmits to the adjacent D, E, H, and I helices, resulting in a collapse of the active site cavi

234 The arrangement of the transmembrane helices reveals hallmarks of an active conformation simi

235 ic and hydrophobic residues in pore helix 1, helices S5 and S6, and helix S6 of a neighbouring subuni

236 Naturally-occurring single alpha-helices (SAHs), are rich in Arg (R), Glu (E) and Lys (K)

237 In these trajectories, the helices separated from one another to create a more acce

238 that bifurcates toward the membrane with its helices separating to embrace subunit a from two sides.

239 e: primary (amino acid sequence), secondary (helices, sheets and turns), tertiary (three-dimensional

240 protein-inspired secondary structures (e.g., helices, sheets) have been produced from unnatural backb

241 aracterize the large-scale motions of the TM helices, simulating multiple association and dissociatio

242 are allosterically coupled to transmembrane helices so as to expose ion binding sites to alternate s

243 ike architecture, in which amphipathic alpha helices stacked perpendicular to the fibril axis into ti

244 Upon axially stretching the helices, such bandgaps are suppressed, enabling the desi

245 d loop and an alpha-helical hairpin [trigger helices (TH)] required for rapid nucleotide addition.

246 ts in a loss of stability of the amphipathic helices TH1-3 and the hydrophobic core helix TH8 at pH 6

247 into antimicrobial pores and form contiguous helices that are biologically promiscuous and hemolytic.

248 Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS fa

249 f holo-PhuS and the N-terminal alpha1/alpha2-helices that are dampened or eliminated in the holo-PhuS

250 the fabrication of synthetic collagen triple helices that are nearly a micrometre in length.

251 revisiae allowed identification of the alpha-helices that belong to the a subunit and revealed the ex

252 macromolecule with spatially organized alpha-helices that can catalyse its own formation.

253 g to RNAP uses the residues in the beta' rim helices that contribute to the ppGpp binding site in the

254 n by altering the structure of transmembrane helices that line the cavity.

255 tly solved by cryo-EM, revealing a bundle of helices that may act as coiled springs to transmit the f

256 ocating KtrB dimer to organize into two long helices that penetrate deeply into the regulatory RCK do

257 eotide-binding domain and four transmembrane helices that protrude in the periplasm into a binding do

258 nacting this design yields individual triple helices that, in length, match or exceed those in natura

259 RNA polymerase surrounded by the beta' clamp helices, the beta protrusion, and the beta lobe domains

260 stress compared to their constituent triple helices-the Young's moduli of fibrils/fibril bundles are

261 ure, which is distinct from known RNA triple helices, thereby expanding the natural repertoire of RNA

262 ophobicity to the hydrophobic half of alphaS helices, thereby stabilizing alphaS-membrane interaction

263 ar signaling chain through the transmembrane helices; this chain connects chemokine binding residues

264 ands folded into hyperstable collagen triple helices (Tm approximately 80 degrees C).

265 activity, whereas mutations in transmembrane helices (TM), alphaTM2 and alphaTM4, abolish the stimula

266 , with each subunit having two transmembrane helices, TM1 and TM2.

267 h synthetic peptides mimicking transmembrane helices (TMH), we show that such superpotent behavior fo

268 ientations of residues within trans-membrane helices (TMHs) of the OWF conformation and to reconstruc

269 sport mechanism, in particular transmembrane helices (TMs) 1a and 7 as well as extracellular loops (E

270 s revealed the hydrophobic face of two alpha-helices to be critical for membranous localization.

271 of hydrophobic interactions of transmembrane helices to manipulate the assembly of ssMPs and create a

272 gger loop (TL), which folds into the trigger helices to promote nucleotide addition, also is proposed

273 undergo a dynamic transition from the alpha-helices to the beta-sheets, which marks the onset of pla

274 g the pilus structure core and that parts of helices two and three are primarily surface-exposed.

275 re dominated by four-sided right-handed beta-helices typically consisting of mixtures of type II and

276 astic kinase-off lesion of CCW B, the alpha1 helices unfold and the alpha2 helices form a tight two-h

277 to smoothly unwind, this conflict bends the helices until the helix of one protomer breaks to reliev

278 distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of

279 in both GLP-1R and GCGR and located outside helices V-VII near the intracellular half of the recepto

280 a family of chiral gold nanoparticle single helices, varying in helical pitch and nanoparticle dimen

281 TMD conformations, which involves bending of helices VI and VII around flexible glycine hinges.

282 s I-V from ChR1, without its C-terminus, and helices VI-VII from ChR2, is used as a template for ChR2

283 substituted cysteines in all the pore-lining helices, we show that the state-dependent accessibility

284 the NMR spectra of a series of designed eta-helices were altogether consistent with the primary adop

285 Solution-phase structures of eta-helices were obtained by simulated annealing using NOE-d

286 sion efficiency remained equally potent when helices were replaced by synthetic membrane-binding moti

287 P molecule bound to its two C-terminal alpha-helices; when ATP is scarce, the alpha-helices are propo

288 imolar proportions to form two single-handed helices which are complementary to each other, giving ri

289 The TM domain of Lnt contains eight TM helices which form a membrane-embedded cavity with a lat

290 sulated ferritin (EncFtn) has two main alpha helices, which assemble in a metal dependent manner to f

291 movements of individual transmembrane domain helices, which correlated with the opening and closing m

292 descriptor language, allowing insertions in helices, which enables better characterization of ribozy

293 n accommodate ligands, notably long parallel helices, which have a large hydrophobic central pocket.

294 he global folding and interactions of double helices with hundreds of basepairs.

295 s, and have not been applied to concatenated helices with more than two segments.

296 tendril, refers to a kink that connects two helices with opposite chiralities.

297 ly 90 degrees ) alignments of the allosteric helices, with respect to the membrane surface direction.

298 tructural alterations of the A-, B- and/or C-helices within each of the mutated spectrin repeats.

299 bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-

300 Two amphipathic helices within the Naa60 C terminus bind the membrane di