ライフサイエンスコーパス: helicity

1 lix and that water is not necessary for PPII helicity.

2 intrinsic potential in this protein to gain helicity.

3 ins is essential for maintaining H. pylori's helicity.

4 rate classification and to correctly display helicity.

5 opulation distribution and thereby the stack helicity.

6 electronic properties and, most importantly, helicity.

7 econd vortex, we found conservation of total helicity.

8 nd eventual refolding to apparently opposite helicity.

9 ified peptide (NYAD-1) showed enhanced alpha-helicity.

10 a conformational change with increased alpha-helicity.

11 minal deletions are accompanied by a loss of helicity.

12 l (Gly-Pro-Pro)5 "host" modules which ensure helicity.

13 ydrophobicity, high amphipathicity, and high helicity.

14 of peptides, TM2 and TM6, display low alpha helicity.

15 erior to the KTA scaffold in inducing triple helicity.

16 ith its sign determined by sign of the light helicity.

17 istry that show a propensity to induce alpha-helicity.

18 serving transformations is equivalent to the helicity.

19 chiral sulfoxides in inducing backbone alpha-helicity.

20 hisms if and only if it is a function of the helicity.

21 ntly through the duplex depends upon the DNA helicity.

22 permeability, liquid crystallinity and chain helicity.

23 and henceforth recover the key properties of helicity.

24 ind monomeric sCT at acidic pH, inducing sCT helicity.

25 o DBMs are the primary modulators of bZIP-bR helicities.

26 o have either increased or decreased overall helicities.

27 ling the structure of two tubes of different helicities.

28 am patterns operating with opposite incident helicities.

29 ical content compared with 37pA (5A, 12+/-1% helicity; 37pA, 28+/-2% helicity) and showed less self-a

30 Helicity, a topological measure of the intertwining of v

31 nd 2) predict how modulation of residual p53 helicity affects binding, in good agreement with experim

32 ernal twist to illustrate why the centreline helicity alone will lead to ambiguous results if a twist

33 While con-G exhibits no helicity alone, it undergoes a structural transition to

34 onformation, as mutations that disrupt alpha-helicity also abrogate inhibition.

35 of peptides does not correlate exactly with helicity, amphipathicity, charge, the number of charges,

36 They display high apo and/or Ca(2+)-induced helicity and act as potent and selective inhibitors of t

37 ough we observe no correlation between alpha-helicity and affinity, we observe a limited correlation

38 lles around the receptor; (ii) loss of alpha-helicity and decreased interhelical packing interactions

39 4R, A168D, and A171P--show a decreased alpha-helicity and do not show a cooperative sigmoidal melt wi

40 This result has important implications for helicity and energy considerations in various physical c

41 We show that finger loop helicity and flexibility may underlie coupling to hundre

42 to a saddle-shaped particle involves loss of helicity and formation of loops in opposing antiparallel

43 carbon nanotube structures that have defined helicity and handedness and cover the entire chiral angl

44 r a staple) can covalently stabilize peptide helicity and improve its pharmacological properties.

45 hile 40% trifluoroethanol (TFE) induces >90% helicity and is unperturbed by the spin label.

46 ered flexible C-terminus displaying residual helicity and large-amplitude backbone motions on the pic

47 no direct correlation between the fractional helicity and potency in signaling via the cAMP pathway.

48 of the BNIP3 transmembrane domain alters its helicity and protection of its backbone amides.

49 ntitative agreement with NMR-derived residue helicity and recapitulate the experimental observation t

50 inds to a nanotube of defined handedness and helicity and resembles a well-folded biomacromolecule wi

51 CP-1 alone had low alpha-helicity and self-associated to form a trimer in phospha

52 observe a limited correlation between alpha-helicity and sequence specificity that emphasizes the ro

53 The helicity and structures of the chimeric peptides were co

54 equence--of structural deviations from alpha-helicity and the annotation of amino acid sequences for

55 ractively calculates and visualizes the mean helicity and the dissociation probability at each sequen

56 n of molecular chirality into supramolecular helicity and the molecules' inherent propensity for well

57 een shown to exhibit concentration-dependent helicity and to exist as an ill-defined equilibrium popu

58 le and applied to the peptide to enhance its helicity and, as a consequence, its potency and serum ha

59 th 37pA (5A, 12+/-1% helicity; 37pA, 28+/-2% helicity) and showed less self-association but, similar

60 hange in the myosin VI tail (31% increase in helicity) and when associated with lipid vesicles, it ca

61 that integrate molecular chirality, absolute helicity, and 3-D intrinsically chiral topological nets

62 ry of the solution structure, well-preserved helicity, and a significant number of native contacts.

63 o produce nanotubes with defined handedness, helicity, and endohedral filling.

64 he subunit dimensions, interaction energies, helicity, and geometrical constraints coming from the do

65 igned to emulate the amphipathic patterning, helicity, and hydrophobicity of SP-C, and to include no,

66 electric polarization with no change of spin-helicity, and present a phenomenological theory that suc

67 membranes followed complex kinetics, induced helicity, and shifted the histidine pK(a) from 6.8 to ap

68 the properties of proteins including charge, helicity, and their tendency to aggregate.

69 based on this conversion is shown to be spin-helicity- and magnetization-dependent.

70 ional space as stem base-pairs form and gain helicity; and (iii) attainment of proper loop geometry a

71 We find that the alpha-helicity (approximately 70%), median melting temperature

72 r results suggest that deviations from alpha-helicity are encoded locally in sequence patterns only a

73 Some basic properties of helicity are reviewed, with particular reference to (i)

74 to chiral rosette nanotubes with predefined helicities as indicated by the resulting induced circula

75 Predicted curves display the mean helicity as a function of temperature or as derivative p

76 self-assembly into nanoribbons with specific helicity as a result of chirality-sensitive interactions

77 stereomeric complex will favor either P or M helicity as a result of minimizing steric interactions o

78 emaining residues do not exhibit significant helicity as determined by NMR.

79 sociated they show a significant increase in helicity, as well as a cooperative unfolding transition.

80 ine guest data; and comparisons of errors in helicity assignments from shifts and ellipticity data sh

81 The loss of helicity associated with increasing temperature may be v

82 a-helical configurations with 80% fractional helicity at 300 K.

83 enic in nature, with increased peptide alpha-helicity at a lower pH.

84 form of alpha-synuclein exhibits stabilized helicity at its N terminus and increased affinity for li

85 was alpha-helical and achieved maximal alpha-helicity at pH 5.0 in the presence of SUVs.

86 This interaction enables an enhanced valley helicity at room temperature (0.33 +/- 0.05) observed in

87 celles, there appears to be a break in alpha-helicity at sites 59-61, near the middle of the transmem

88 An increase in alpha-helicity at the N-terminus of aS is supported by CD data

89 omains does not correlate with the predicted helicity based on amino acid sequence, pointing out that

90 shift indices reveal a region of significant helicity between residues 9 and 29.

91 ection process can be viewed as transferring helicity between scales, rather than dissipating it.

92 n solution, but that in longer oligomers the helicity breaks down and transmission of chirality in th

93 s maximize its "antimicrobialness") and its -helicity, but minimize mutational distance to known AMPs

94 the Kar3/Cik1 nonmotor region shows greater helicity by CD analysis and rotary-shadow EM reveals a s

95 It was possible to manipulate the degree of helicity by the alteration of only two amino acid residu

96 elicity state after the dissipation of twist helicity by viscosity.

97 licity of the protein, and adoption of alpha-helicity can be induced by sodium dodecyl sulfate.

98 Here we show how spontaneous helicity can be induced in a synthetic polymeric nanobri

99 Our results show that helicity can remain constant even in a viscous fluid and

100 linked peptides with substantially increased helicity, cell permeability, proteolytic stability, and

101 cules with a reduced degree of time-averaged helicity compared to those packed in undamaged fibrils-w

102 led analogs exhibited significantly enhanced helicity compared with the native peptide in a metal-fre

103 Thus, any deviation from helicity conservation is entirely due to the intrinsic t

104 Our results suggest that helicity conservation plays an important role in fluids

105 asi-classical limit of helicity emerges from helicity considerations for individual superfluid vortex

106 ution to achieve simultaneous handedness and helicity control for all three electronic types of carbo

107 d DNA to achieve simultaneous handedness and helicity control for all three types of nanotubes.

108 Helicity-controllable focal line and focal point in the

109 Helicity-controllable real and virtual focal planes, as

110 bled asymmetric harmonic response to achieve helicity-controlled multiple structured wavefronts such

111 To ascertain whether this helicity could first be manifested inside the ribosomal

112 a methionine substitution indicated altered helicity coupled with reduced thermal stability.

113 intact but expanded by 40%, and total apoA-I helicity decreased from 95% to 72%.

114 larly polarized light, so-called all-optical helicity dependent switching, has renewed interest in th

115 mpower advanced research and applications in helicity-dependent focusing and imaging devices, angular

116 r-intuitive dual-polarity flat lens based on helicity-dependent phase discontinuities for circularly

117 Here we show a comprehensive study of the helicity-dependent photocurrent in (Bi1-x Sb x )2Te3 thi

118 photons are known to generate a directional helicity-dependent photocurrent in three-dimensional top

119 ac cone and the underlying mechanism for the helicity-dependent photocurrent is still not understood.

120 nic effect as the dominant mechanism for the helicity-dependent photocurrent.

121 We demonstrate that all-optical helicity-dependent switching (AO-HDS) can be observed no

122 magneto-optic waveguide media engenders spin-helicity-dependent unidirectional propagation.

123 porphyrins in the complex adopt a preferred helicity dictated by the substituents at the chiral cent

124 Sequence analyses (helicity, disorder, and polarity) and solvent accessibil

125 The possibility of a helicity-driven inverse cascade in 3D fluids had been re

126 Other mutants had only slight changes in helicity due to insertions in genes encoding MviN/MurJ,

127 us to explain how a quasi-classical limit of helicity emerges from helicity considerations for indivi

128 tep of the dominant kinetic pathway, whereas helicity exerts its influence only at a later step.

129 canning rates (0.025 degrees C min(-1)), the helicity, F, approached a quasistatic state in which it

130 cores, protection factor-derived fractional helicities FH are assigned in the range 10-30 degrees C

131 s PF(i) that define uniquely high fractional helicities FH for the peptide Ala(n) regions.

132 del underlies all calculations of fractional helicities FH from CD spectra of helical polypeptides.

133 three-dimensional topological insulator with helicity, fixing the orientation of their spin relative

134 d helical character, with a complete loss of helicity for M144 and M145.

135 acetylation results in a slightly increased helicity for the N-terminal ~10 residues of the protein,

136 tra of membrane-associated Fgp41 showed high helicity for the residues C-terminal of the FP.

137 dness in a process involving the transfer of helicity from 1a to 2c and the transfer of chirality fro

138 nding lanthanides, with an increase in alpha-helicity from 20% in the absence of metal to 38% and 35%

139 rough a reconnection enables the transfer of helicity from links and knots to helical coils.

140 residue 4 (L) to residue 9 (K) has a strong helicity from our simulations, which is supported by exp

141 efficient valley and spin control by optical helicity have recently been demonstrated in this materia

142 beta residues to promote alpha/beta-peptide helicity; here we show that an engineered ion pair array

143 NDI-PMDI pi-pi stacked dimers with opposite helicities in the solid state.

144 hat dimerization is facilitated by increased helicity in a thicker bilayer.

145 using NMR and CD confirm induction of alpha-helicity in Abeta mediated by ADH-41.

146 Most peptides exhibit higher alpha helicity in anionic sodium dodecyl sulfate than in neutr

147 e case (MAP-1) where stapling enhanced alpha-helicity in aqueous and lipid environments, leakage was

148 Kd of 80 nM, reflecting the large degree of helicity in C52L as measured by circular dichroism spect

149 fibers with helical tunnels of complementary helicity in CH2Cl2.

150 onal circularly polarized wave with the same helicity in forward and backward is generated based on n

151 ar dichroism and NMR indicated the degree of helicity in H2O, aqueous trifluoroethanol, or micelles.

152 The generation of a chiral helicity in helicenes was observed because of a severe i

153 pha-synuclein, the significant gain of alpha-helicity in K2 at low concentrations of sodium dodecyl s

154 ts were evaluated as possible sources of the helicity in linear perfluorinated alkanes through analys

155 tructure in aqueous buffers, and significant helicity in membrane-like environments, including SDS mi

156 not be directly correlated to the degree of helicity in micelles.

157 -is a surprisingly weak director of absolute helicity in nickel-salen foldamers.

158 fluorophenyl)ethyl)glycine monomers enforced helicity in peptoids that typically exhibit threaded loo

159 driving force for the origin of the observed helicity in perfluoroalkanes.

160 ved basis for understanding and manipulating helicity in real flows.

161 spite its relevance across a range of flows, helicity in real fluids remains poorly understood becaus

162 helix content in membranes rather than their helicity in solution.

163 The increased helicity in the cytosol is similar to that seen in previ

164 constraining role of the analogous magnetic helicity in the determination of stable knotted minimum-

165 ely helical) that corresponds to a region of helicity in the mature structure is already manifest in

166 valley selection rules, which have opposite helicity in the monolayer.

167 r dichroism (UV CD) spectra revealed greater helicity in the secondary structures of R56A and DeltaR5

168 domain 4 suggested that it may deviate from helicity in the vicinity of residue 155.

169 ide or nonylglucoside showed decreased alpha-helicity in transmembrane regions, decreased alpha-helic

170 We found that peptide helicity in water and interface increased linearly with

171 yclically constrained gamma residues promote helicity in water.

172 d leads to prediction of preferred porphyrin helicity independent of conformational A values.

173 e-polymerized diacetylene vesicles, with 12% helicity induced in 50% v/v of trifluoroethanol.

174 hobicity/hydrophilicity, amphipathicity, and helicity (induced by single amino acid substitutions in

175 chieved using a crafted combination of light helicity, intensity and wavelength, and is further tuned

176 Only ClCH2CH2Cl induces single-handed helicity into the nanotubes.

177 hing the feasibility of covalently triggered helicity inversion as a new mode of operation for chirop

178 nds, perturbation may involve either dynamic helicity inversion or a reversible change in the lanthan

179 Helicity is a molecular necessity in the higher series o

180 mpared to other methods, indicating that DNA helicity is best approximated by the quantum method.

181 rocess is cooperative and the supramolecular helicity is biased toward the helical preference of the

182 iginal twists of the interacting tubes, then helicity is conserved during reconnection.

183 is is consistent with the finding that alpha-helicity is estimated to be 36% by CD analysis of synthe

184 Although helicity is largely abolished in the unfolded states of

185 The induced preferred helicity is maintained by the OPV stacks even after the

186 sence of Na(+) and K(+) ions, no increase in helicity is observed with respect to the conformation in

187 Kinetic helicity is one of the invariants of the Euler equations

188 alpha-helix spectrum, suggesting that alpha-helicity is reversibly lost upon light irradiation.

189 esigned peptide analogs in which the average helicity is significantly increased compared with DP178

190 The exploitation of helicity is thus demonstrated to develop a novel set of

191 Helicity is, like energy, a quadratic invariant of the E

192 molecule, capable of freely adopting P or M helicity, is described for molecular recognition and chi

193 n end products altered protein structure and helicity, little structural data and information current

194 In the second step an inversion of the helicity (M-->P) of the cis azobenzene unit takes place.

195 ased peptide is in accord with the change in helicity measured by circular dichroism.

196 ons to quantitatively reproduce experimental helicity measurements obtained by circular dichroism.

197 The patterns in substrate helicity mirror those found in the unfolded state in the

198 sufficiency of currently accepted literature helicity modeling parameters.

199 Here we experimentally demonstrate a helicity multiplexed metasurface hologram with high effi

200 The demonstrated helicity multiplexed metasurface hologram with its high

201 emonstrate broadband, flexible, conformable, helicity multiplexed metasurface holograms operating in

202 electronic character, lengths, diameters and helicities, (n,m), as well as other amorphous, graphitic

203 results in topological fluid mechanics, the helicity of a flux tube can be calculated in terms of wr

204 ship between side chain structure and the 14-helicity of a well-studied class of foldamers, beta(3)-p

205 ide homolog of this segment, exhibited alpha-helicity of approximately 45% in the presence of dimyris

206 r Pro(1171) or Glu(1168) increased the alpha-helicity of BAR and reduced its inhibitory activity in v

207 he same relative positions regardless of the helicity of DOTA.

208 The measured alpha-helicity of each peptide was consistent with the expecte

209 ents of BBL, for example, find a decrease in helicity of helix 2 surrounding His166 on its protonatio

210 elity are interchangeable by controlling the helicity of incident light.

211 The binding and helicity of KL(4) is dependent on the level of monounsat

212 opportunities for valley control through the helicity of light.

213 interaction by determining its effect on the helicity of model peptides using a combination of CD and

214 ation of the chirality of NDI-Delta into the helicity of nanotubes.

215 dichroism analysis indicated that the alpha-helicity of psoriasin increases by more than 20% in the

216 The increases of bilayer thickness and helicity of rhodopsin are accompanied by higher metarhod

217 The effects of cross-linking on the alpha-helicity of selected peptides were examined by CD and NM

218 The role of the helicity of small molecules in enantioselective catalysi

219 index that is tunable through adjusting the helicity of structures, while the wavefront revolution p

220 Our results indicate that the nascent helicity of sub-domain LH plays a key role mediating the

221 Typically, switching the helicity of supramolecular assemblies involves external

222 o ligate and substantially enhance the alpha-helicity of the amphipathic C terminus of lacritin.

223 ic acid to the tweezer induces a predictable helicity of the bis(porphyrin), which is detected as a b

224 A processive change in the helicity of the body creates these waves and enables dir

225 n length but not cholesterol, suggesting the helicity of the bound state may be controlled by the bil

226 condary shifts at pH5.3 showed a decrease in helicity of the C-terminus of helix 2, where His166 is l

227 on are related to the handedness and the net helicity of the coassemblies, respectively.

228 s influence HAMP stability by modulating the helicity of the control cable segment.

229 forming a six-membered ring that favors one helicity of the electrocyclization transition state.

230 netic semiconductor and measured through the helicity of the electroluminescence due to the spin-vall

231 are consistent with an increase in the alpha-helicity of the first six residues of aS, although a hig

232 The predicted helicity of the folded peptide based on helix length and

233 he N-terminal tail or on how to modulate the helicity of the full-length peptides.

234 ble to control, for the first time, both the helicity of the helix and the form of the herringbone.

235 that are interchangeable by controlling the helicity of the incident light.

236 lens or a cylindrical lens, depending on the helicity of the incident light.

237 Specifically, by controlling the helicity of the input light, the positive and negative p

238 mages are interchangeable by controlling the helicity of the input light.

239 phospholipid vesicles, and adoption of alpha-helicity of the K-segment accounts for most of the confo

240 lical Dirac fermions, and that reversing the helicity of the light reverses the direction of the phot

241 Hall voltage whose sign is controlled by the helicity of the light.

242 in growth, we suggest that it originates the helicity of the nanotube.

243 he curvature of the cap and, presumably, the helicity of the nanotube.

244 f the free energy minimum and the structural helicity of the peptides are comparable in the implicit-

245 (-) of Ala25 is removed, consistent with the helicity of the peptides skewed toward the N-terminus.

246 role of the solvent, the metal ion, and the helicity of the polymer in the aggregation are discussed

247 The working model suggests that the observed helicity of the porphyrin tweezer is dictated via steric

248 nding is accompanied by an increase in alpha-helicity of the protein, and adoption of alpha-helicity

249 or and drive reversible changes in the alpha-helicity of the protein.

250 les results in an apparent increase of alpha-helicity of the protein.

251 Remarkably, the preferred helicity of the stacks of achiral AOPV3 can be retained

252 efficiency of which depends on the magnetic helicity of the structure.

253 In contrast, the helicity of the transmembrane domain of monomeric C991-5

254 eristics one has to understand the origin of helicity of their structures.

255 We measured the total helicity of thin-core vortex tubes in water.

256 e demonstrated a substantial increase in the helicity of this region in the presence of detergent mic

257 The nascent helicity of this sub-domain is conserved and we hypothes

258 33 leads only to marginal changes in average helicities on the ensemble level, underlying conformatio

259 om substitution on the main chain, and chain helicity on the depolarization behavior of polymers have

260 or the polymer/metal ion ratio, and (b) the helicity on the surface and the interior of the particle

261 orientation solely by changing either photon helicity or energy.

262 The conjecture that helicity (or knottedness) is a fundamental conserved qua

263 on of the inherent microscopic chirality and helicity present in individual phage particles at the ma

264 ither as 50% helicity temperatures or as the helicity probability at specific temperatures.

265 rminations of particle size/shape and apoA-I helicity provide additional support for the saddle-shape

266 (4,5)P2-bearing vesicles has increased alpha-helicity, providing direct spectroscopic proof of a conf

267 The helicity reporting parameters t/c and [theta](222) have

268 pling between this polarization and magnetic helicity required for multiferroicity.

269 in opposite directions upon excitation-spin-helicity reversals.

270 ng the applicability of the enone sector and helicity rules in dichroic studies and potential restric

271 s of the observed deviations from sector and helicity rules to determine the absolute configuration o

272 symmetry in bilayers, the photoluminescence helicity should no longer be locked to the valleys.

273 ing a new method for quantifying the spatial helicity spectrum, we find that the reconnection process

274 of Asp(632) also severely impaired the alpha-helicity, stability, and conformation of six-helix bundl

275 olution toward and maintenance of a constant helicity state after the dissipation of twist helicity b

276 function of sequence position either as 50% helicity temperatures or as the helicity probability at

277 of freedom in handedness and a multitude of helicities that give rise to three distinct types of ele

278 for vortex filaments appears to result in a helicity that does not retain its key attribute as a qua

279 t/guest complexes with a preferred porphyrin helicity that exhibit intense exciton split CD spectra.

280 by altering their conformation, charge, and helicity, thereby enhancing their resistance toward prot

281 Inducing alpha-helicity through side-chain cross-linking is a strategy

282 s suggest that small effects of mutations on helicity translate into a reduced ability to incorporate

283 cular dichroism revealed a loss of 31% alpha-helicity upon dimer dissociation.

284 c analogues and demonstrated increased alpha helicity upon peptide stapling.

285 This helicity varies from one bZIP-bR to another despite a si

286 s good predictions for the heat capacity and helicity versus temperature and urea.

287 alpha-Helicity was confirmed by a crystal structure of the MDM

288 Chemical reinforcement of BID BH3 alpha helicity was required to reveal the direct BID BH3-BAX a

289 The level of helicity was unaffected over a 1- to 8-mM concentration

290 By controlling the light helicity, we could confine the Bloch-Siegert shift to oc

291 chromenes 3 and 4 with varying magnitudes of helicity were designed in pursuit of o-quinonoid interme

292 Similar levels of alpha-helicity were observed in trifluoroethanol and the pepti

293 duced chiral inversion, whereas those with M-helicity were obtained from the gel form with chiral hol

294 on, gold nanoparticle superstructures with P-helicity were prepared from the sol form of the template

295 They exhibit nascent helicity which has been localized to a segment referred

296 emblies occur without compromising intrinsic helicity, while both parallel and antiparallel beta-shee

297 However, there was also a prompt loss of helicity, whose amplitude increased with increasing Tf,

298 (con-G) manifests an increase in conantokin helicity with increasing vesicle concentration.

299 d best matched absorbance data and predicted helicity, with the exponential method displaying low-tem

300 In this setting, helicity would be expected to acquire its simplest form.