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1 trimers, potentially via a coiled-coil alpha-helix.
2 in mechanism involving the amphipathic alpha-helix.
3 ed on the formation of a parallel DNA triple helix.
4 urbs the conformation of its DNA-recognition helix.
5 pendants positioned on the same side of the helix.
6 ellin monomers are arranged in a left-handed helix.
7 finding that human calcitonin forms an alpha-helix.
8 of the microparticles was of a V-type single helix.
9 ide chains arranged along one side of the 14-helix.
10 as if transitioning between the ends of the helix.
11 ond transmembrane segment and major coupling helix.
12 ural and dynamic perturbations in the double helix.
13 tolabeled residues (V954 and E969) in the S6 helix.
15 ing to RcnR orders its N terminus, decreases helix 1 flexibility, and induces conformational changes
17 vealed water penetration along transmembrane helix 1 with the cooperation of a polar residue (Y147 in
18 al aromatic and hydrophobic residues in pore helix 1, helices S5 and S6, and helix S6 of a neighbouri
19 include a distinct movement of transmembrane helix 2 (M2), from its position in the previously report
20 nalysis revealed that the flexibility of the helix 3, 7, and 11 regions represents the most important
21 four lipid-facing residues in transmembrane helix 4 (TM4) that is known to be important for dimeriza
22 a are antimicrobial, we synthesized IFN-beta helix 4 and found that it is sufficient to permeate mode
23 f the IFN-beta molecular surface (especially helix 4) are cationic and amphipathic, both classic char
25 a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular half outward to
27 xes further showed two distinct folds of the helix 6-7 region, classified as "open" and "closed", whi
28 two homologous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence homology to t
31 ere, we identify a structural element, alpha-helix-7, in human Argonaute2 (Ago2) that is required for
33 s the helix-loop transition in transmembrane helix 8, which likely forms the structural basis for CFT
35 on RTA and makes primary contacts with alpha-helix A (residues 18-32), alpha-helix F (182-194), as we
36 haped substrate pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-proline l
38 ngineered TGF-beta monomer, lacking the heel helix, a structural motif essential for binding the TGF-
39 he Swellix program presented here combines a helix abstraction with a combinatorial approach to the R
41 t mutations in loop L1c-FlapI, loop L6c, and helix alpha1c of the RFK module (positions K202, E203, F
44 hPg residues occupied opposite faces of this helix, an arrangement that minimized steric clashing of
45 g events in biogenesis is the formation of a helix, an elementary structure that is ubiquitously pres
47 polycrystalline material in which the alpha-helix and beta-sheet regions of the protein are similar
48 Vps4 subunit to join the growing end of the helix and engage the substrate, while hydrolysis and rel
49 s bound at the channel-periphery near the M4 helix and exerts a long-range allosteric effect on the p
50 t degron, Deg1, also contains an amphipathic helix and exhibits 42% amino acid similarity with SM N10
51 e demonstrate that targeted helix-(pi-sheet)-helix and helix-(pi-sheet)-coil assemblies occur without
52 in intercalates between turns of the dynamin helix and impairs fission by preventing trans interactio
57 the converter, the SH1-SH2 helix, the relay helix, and the lever, abolishes nonmuscle myosin-2 speci
58 rate 2 SMS excitation in transmural myofiber helix angle, mean diffusivity (mean +/- standard deviati
59 ed in the monomeric state but forms an alpha-helix approximately 70 residues long in the self-associa
60 ed and shown to form well-defined helix-turn-helix architectures in which helical and sheet subcompon
61 nce-defined helix-sheet-coil and helix-sheet-helix architectures, are Nature-inspired synthetic mimic
63 nd conformation, instead of forming an alpha-helix as observed in the previously solved structure of
64 D IR spectroscopy, parallel and antiparallel helix associations were identified by vibrational coupli
66 that covers one full turn of the nucleosome helix at seven different SHLs, and that the position of
68 electrostatic interactions near the Cbeta H3 helix at the membrane-proximal face of the TCR, a region
69 es and show that the pore is most probably a helix barrel that contains eight D4 peptides arranged in
71 linearly with the G:C content of the hairpin helix, being 50% longer for hairpins with only A:T base
72 TR structure reveals a previously unresolved helix belonging to the R domain docked inside the intrac
73 s (PIFs) are members of the basic helix-loop-helix (bHLH) family of transcription factors in Arabidop
74 e transcription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, development,
76 known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hopkins syndro
77 n anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tapetal d
78 ns in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase seam cell nu
80 ential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effect
81 enile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel
82 e maturation protein, which, with just a six-helix bundle and a six-stranded beta-sheet, forms a geno
83 rom the C112R substitution in the N-terminal helix bundle and likely relate to a reduced ability of a
84 wo interhelical loops of the C-terminal four-helix bundle appear to penetrate the membrane bilayer, s
87 r to Polalpha, p261C of Pol contains a three-helix bundle in the middle and zinc-binding modules on e
88 o heptad-repeat regions refold to form a six-helix bundle structure that can be specifically targeted
90 nds to model the formation of the SNARE four-helix bundle that mediates synaptic vesicle fusion and u
91 ported water-soluble self-assembled foldamer helix bundle to encapsulate simple guest molecules withi
95 of WhiB1 reveals that Wbl proteins are four-helix bundles with a core of three alpha-helices held to
97 In contrast, mutants lacking the TAD alpha-helix but retaining the most distal C-terminal residues
98 s in K2hPg Further, the adoption of an alpha-helix by VKK38 upon binding to K2hPg sterically optimize
100 ructure of StnA can be described as an alpha-helix cap domain on top of a common alpha/beta hydrolase
103 we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acc
105 etween these potassium and water sites and a helix controlling the cytoplasmic gate of KdpA is linked
106 trate, while hydrolysis and release promotes helix disassembly and substrate release at the lagging e
107 in the A. thaliana kinome found that alphaC helix disorder may be a common feature of plant kinases.
109 epair (BER) recognizes and repairs minimally helix-distorting DNA base lesions induced by both endoge
110 proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukar
111 rial outer membrane via its N-terminal alpha helix domain and hosts a redox-active [2Fe-2S] cluster i
112 egion consists of a zinc domain and a winged helix domain and plays an important role in enzyme activ
113 domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlapping location.
116 raphy, we show that Cdt1 contains two winged-helix domains in the C-terminal half of the protein and
117 que secondary structure that we term an "eta-helix" due to its repeating turns, which are highly remi
120 fferences that alter the conformation of the helix F through helix G region in the upper portion of t
121 of At2g44920 as a representative of the beta-helix family to determine if it had exceptional global s
122 ion factors, members of the basic helix-loop-helix family, play crucial roles in mesoderm development
123 rties of mutations within an overlooked hERG helix, finding important contributions to channel functi
125 selectivity, which correlates strongly with helix folding, the system we report here is also highly
127 ally, the N- and C-terminal halves of the TM helix form trimeric cores of opposite nature (hydrophobi
128 ngaged on cellulose, as models predict alpha-helix formation and decreased cellulose interaction for
133 rwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, whereas pept
134 esistant to conformational collapse or alpha-helix formation upon the addition of the osmolyte trimet
135 cle binding via membrane-induced amphipathic helix formation, and '3K' further enhances this effect.
136 oupling between membrane partitioning, alpha-helix formation, and electrostatic repulsions between ac
138 s (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wide range of ex
140 domains induces protection of the Nef alphaB-helix from deuterium uptake, consistent with a role for
141 gest that the formation of an extended alpha-helix from the disordered carboxy-terminal region of nuc
142 lter the conformation of the helix F through helix G region in the upper portion of the cavity and io
143 to a transient unfolding and dissociation of helix H that becomes more prominent at higher temperatur
144 Polymerization assays using Lmod2 mutants of helix h1 and the WH2 domain support this conclusion.
145 rms were observed on the heme-proximal side (helix H5), at the dimerization interface (helices H6 and
146 haracterize the substrate preferences of the helix-hairpin-helix (HhH) domains of XPF and ERCC-XPF an
147 conformational transitions in the C-terminal helix have specific functional involvements in PtdIns tr
148 ubiquitination-resistance were positioned at helix-helix interfaces, likely preventing the hepcidin-i
150 e substrate preferences of the helix-hairpin-helix (HhH) domains of XPF and ERCC-XPF and show that th
152 Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators controlled by MYT
153 x/loop regions, as well as of the C-terminal helix; (iii) the energy barrier of phospholipid extracti
155 at fibrillar exon1 has a partly mobile alpha-helix in its aggregation-accelerating N terminus, and se
156 ults support a model whereby the amphipathic helix in SM N100 attaches reversibly to the ER membrane
157 ed a deletion mutant lacking only this alpha-helix in stable cell lines and Xenopus laevis photorecep
158 Furthermore, we showed that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a mem
159 res of these three factors revealed an alpha-helix in the C-terminal inhibitory domain that packs aga
162 G530 stabilizes the cognate codon-anticodon helix, initiating step-wise 'latching' of the decoding c
164 mall molecule stabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ri
165 ecific factors such as Cwc25 lock the branch helix into position for nucleophilic attack of the branc
166 due volume at the Phe position in the alpha1-helix is critical for alphaLbeta2 activation because tri
167 ding on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic pa
170 the cleft closes, and the amphipathic alpha-helix is released to bind to the carrier domain via its
171 econdary structure with a low content of PII helix is remarkably efficient at promoting calcium adsor
174 y residues in the S5, S6, and the first pore helix; isoflurane competitively disrupts A-967079 antago
175 l parameters of adjacent rungs in the triple-helix ladder and developed statistical potentials by ext
176 cription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein.
177 ein, Gp5.7, which adopts a winged helix-turn-helix-like structure and specifically represses transcri
178 CFTR from all other ABC transporters is the helix-loop transition in transmembrane helix 8, which li
179 TING FACTORs (PIFs) are members of the basic helix-loop-helix (bHLH) family of transcription factors
182 (TCF4 also known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hop
183 encoding an anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required fo
184 hat mutations in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase s
186 the differential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predi
187 insect juvenile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain prote
190 transcription factors, members of the basic helix-loop-helix family, play crucial roles in mesoderm
191 almia transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding p
193 HAIR DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future root h
194 roaches, we discovered that the Id family of helix-loop-helix proteins is both necessary and sufficie
195 nd 5' RACE identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IRE1alph
196 p1 Inhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an impo
197 PK3 and MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the
199 is accompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix;
203 at least a factor of 60, confirming that TM helix motions are linked to the citrate-binding event.
205 in the protein where the intersection of two helix N-termini creates a region with a strong, localize
206 th POTRA2 containing an additional elongated helix not observed previously in other POTRA domains.
207 ithin the hydrophobic half of the stabilized helix not only reversed the strong membrane interaction
208 lly conserved bulged uridine (U51) in the P4 helix of circularly permuted Bacillus subtilis P RNA wit
210 Delta60) suggested that an 'accessory' alpha-helix of Complexin-I inhibits release by inserting into
212 olved for any linear peptoid, revealed a PPI helix of great regularity despite the presence of only 5
214 talytically important interactions of the P4 helix of P RNA with metal ions, demonstrating that the b
215 substitutions, locating to the transmembrane helix of TatB that restored transport activity to Tat si
220 The three-way junction and the P1 switch helix of the two apo conformers are notably different fr
221 the U2AF-homology motif (UHM) and the alpha6 helix of U2AF35, and was fine-tuned by exon Ab/3 variant
222 last 16 CCD residues, composing an "overlap helix" (OH), have been crystallized in two mutually excl
224 lated DNA local parameters, step parameters, helix parameters, and major/minor groove widths to exami
227 the robust autophagy activity of the Kalpha2-helix peptide, the present study showed that treatment w
228 antiviral activities of synthesized Kalpha2-helix peptide, which was derived from the viral FLICE-li
229 ate that targeted helix-(pi-sheet)-helix and helix-(pi-sheet)-coil assemblies occur without compromis
231 ane proteins with a single membrane-spanning helix play a plethora of vital roles in the cellular pro
232 SECM/optical microscope, generating a double helix point spread function at the image plane, which al
233 ing module, a membrane-inducible amphipathic helix present in a previously undescribed location in At
235 as previously been employed to measure alpha-helix propensities among proteinogenic alpha-amino acid
236 rrounded by IDRs, individual intrinsic alpha-helix propensities varied as shown by CD spectroscopy.
237 d in nonphotochemical quenching, and the one-helix proteins and their cyanobacterial homologs designa
238 TIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future root hair cells (
239 discovered that the Id family of helix-loop-helix proteins is both necessary and sufficient to direc
241 esulting in a rearrangement of the substrate helix register into a so-called "shifted" conformation t
243 ge in a specific interaction with post-relay helix residue Glu-469, which affects the mechanics of th
245 onal amplitudes of the Tsr HAMP coupled with helix rotations and movements toward a two-helix packing
246 dues in pore helix 1, helices S5 and S6, and helix S6 of a neighbouring subunit, form a hydrophobic c
247 n to Survivin and Borealin, the single alpha-helix (SAH) domain of INCENP supports CPC localization t
248 ha1 and alpha2 helices are consistent with a helix scissors motion or a gearbox rotational model of H
250 rgeted assemblies, a mix of sequence-defined helix-sheet-coil and helix-sheet-helix architectures, ar
251 mix of sequence-defined helix-sheet-coil and helix-sheet-helix architectures, are Nature-inspired syn
252 transcription are sufficient to give M2-seq helix signatures; these signals were previously overlook
253 amaterial consisting of interconnected metal helix slat structures with four-fold symmetry, which exh
254 The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play important
256 Studies of F103 in the hinge of the inner helix suggest an important role for its bulky sidechain
257 mely Kite dimers (Kleisin interacting winged-helix tandem elements), interact with Smc-kleisin rings
258 secondary structural element is one turn of helix that binds the central portion of the CRM1 groove.
259 occurs at the N-terminus and the first alpha-helix that connects the HlyIIC domain to the HlyII-core
260 e six VAT subunits to constrict into a tight helix that grips an 80 A stretch of unfolded protein.
261 e the extended loop prior to the penultimate helix, the extended Omega-loop, and a beta-hairpin turn
262 ctions connecting the converter, the SH1-SH2 helix, the relay helix, and the lever, abolishes nonmusc
265 ositively charged residues in the C-terminal helix to engage in DNA binding, triggering a major repro
266 helix-turn-helix (wHTH) motifs use an alpha helix to read the base sequence in the major groove whil
267 ain (LBD) of hPXR, interacting with the AF-2 helix to stabilize the LBD for coactivator binding.
268 target RNA and extends a newly-formed alpha helix to the distal loop where it forms protein interact
269 identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IRE1alpha RNase tar
270 r of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an important role
271 6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the expression
273 The functionally relevant random-coil-alpha-helix transition associated with Ca(2+) uptake that invo
274 duced Circulating LncRNA) partakes in triple helix (triplex) formation, is transiently elevated follo
279 n synthesized and shown to form well-defined helix-turn-helix architectures in which helical and shee
281 kDa T7 protein, Gp5.7, which adopts a winged helix-turn-helix-like structure and specifically repress
282 s suggest that a likely mechanism for triple helix unfolding is intermolecular shearing of collagen a
283 analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central
287 exposed conformation stacked within the DNA helix, where it effectively blocks nucleotide incorporat
288 sing site is located on the face of the beta-helix whereas the C-terminal domain is likely involved i
289 to GPP, until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity
290 ructurally blocked by the HECT domain alpha1-helix, which further undergoes ubiquitylation on a conse
291 sis suggests that it can form an amphipathic helix, which is ideal for lipid membrane interaction.
292 des extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight
293 ith an antiparallel motion of the C-terminal helix, which may alter the native-state structural ensem
296 es possess an unstructured beta-domain and C-helix with the rest of the alpha-domain remaining native
299 1, can spontaneously assemble into a double helix without the need for a covalently connected linear
300 nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypi
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