ライフサイエンスコーパス: hem

1 from helicopter emergency medical services (HEMS).

2 igration of CR cells arising in the cortical hem.

3 even prior to the formation of the cortical hem.

4 r rhombic lip and the telencephalic cortical hem.

5 eocortical CR cells arises from the cortical hem.

6 cells, we therefore genetically ablated the hem.

7 sed Wnt2b, Wnt3a and Wnt5a expression in the hem.

8 x in mice genetically engineered to lack the hem.

9 d these fibers may remain within the blanket hem.

10 muV; and a hemin degradation/storage enzyme, HemS.

11 teria had a survival benefit associated with HEMS.

12 s an ultra-stable organic cation for polymer HEMs.

13 dioxygenation (NOD) reaction similar to oxy-hemes.

14 hodovulum sulfidophilum SoxAX contains three hemes.

15 ation state of the proximal histidine to the hemes.

16 extends to the electronic properties of the hemes.

17 uction potentials for the high- and low-spin hemes.

18 Q, while being totally inactive, retains the hemes.

19 heme degradation and do not bind additional hemes.

20 N-based nucleophiles on synthetic ferric-NO hemes.

21 n of MauG, the electron equilibrates between hemes.

22 ains one high-spin and three low-spin c-type hemes.

23 spectral contamination from changes in the b hemes.

24 s, arginines, and associated water above the hemes.

25 tions of a diheme system with two equivalent hemes.

26 re a natural consequence of thiolate-ligated hemes.

27 the heme nitrogens than for high-spin ferric hemes.

28 on of hydrogen-bonded water chains above the hemes.

29 ndicated by interactions typical of adjacent hemes.

30 hose of closely related compounds containing hemes.

31 ling oxidation states of the His/His ligated hemes.

32 nd intermonomer Coulombic effects between bL hemes.

33 IV) state without direct contact between the hemes.

34 e redox and chemical properties of the SoxAX hemes.

35 The closeness of hemes 3 and 8 from different enzyme subunits allows redi

36 2b expression appears to define the cortical hem, a dorsal signaling center previously characterized

37 In particular, the cortical hem, a region of high bone morphogenetic proteins (BMPs)

38 The cortical hem, a source of Wingless-related (WNT) and bone morphog

39 that neocortical layers would be inverted in hem-ablated animals, as in reeler mice, deficient in ree

40 anizer, yet the FGF8 source was unchanged in hem-ablated brains.

41 neocortex, was reduced in size in late-stage hem-ablated embryos, whereas cortex ventrolateral to the

42 n control mice, but were virtually absent in hem-ablated mice from embryonic day (E) 10.5 until birth

43 Unexpectedly, hem ablation also perturbed regional patterning along th

44 HEM accounts for heterogeneous error variability in an o

45 In subjects triaged to HEMS, actual transport by HEMS was associated with an in

46 ows separate monitoring of the alpha or beta hemes along the allosteric pathway.

47 r path, with respect to the distance between hemes, along the polypeptide chain is exactly the same i

48 e course at 3 mus for beta but not for alpha hemes, an interval previously shown to be the first step

49 ed Wnt3a and Lef1 expression in the cortical hem and adjacent hippocampal promordium and consequent i

50 CD34+KDR+ cell fraction comprises primitive Hem and End cells, as well as hemangioblasts.

51 In humans, the potential therapeutic role of Hem and End progenitors in ischemic heart disease is sub

52 The performance of HEM and its F-like statistic was examined with simulated

53 ubstantially recovered WNT expression in the hem and partially rescued hippocampal development.

54 rain signalling centres-the septum, cortical hem and the pallial-subpallial boundary-known to generat

55 Since Hem and WAVE normally form a complex, our data argues th

56 affects RP2 migration in a similar manner as Hem and WAVE, and appears to operate via WAVE.

57 diencephalic signaling centers, the cortical hem and zona limitans intrathalamica (ZLI), are merged,

58 tions between (i) the propionates of the two hemes and (ii) the heme of each protein with the polypep

59 s as a mixture of populations with nonplanar hemes and electronic structures that place significant s

60 ified cytochrome was confirmed to contain 10 hemes and exhibited Fe(III)-NTA reductase activity.

61 by the process of coupled oxidation of model hemes and hemoproteins not involved in heme catabolism,

62 which pairs of conserved histidine-chelating hemes and one experimentally determined salt bridge were

63 operties: availability of unliganded ferrous hemes and R-state character of the hemoglobin tetramer.

64 CymA is limited by electron transfer to the hemes and that complex formation with Fcc3 facilitates t

65 to change the EPR spectra of both the cyt b hemes and the [2Fe-2S] cluster of the Fe/S protein.

66 oscopic properties of each of the two c-type hemes and the overall redox properties of MauG are descr

67 We hypothesize that the two hemes and their axial ligands in cyt b561 are integral p

68 atively assigned to redox-sensitive modes of hemes and ubiquinone and changes in the surrounding prot

69 photopigment rhodopsin [11] is expressed in HEMs and contributes to UVR phototransduction.

70 analysis of lightly versus darkly pigmented HEMs and found 16 genes differentially expressed in the

71 Hematopoietic (Hem) and endothelial (End) lineages derive from a common

72 1.5 cm were created in the assessed lesions (HEM) and in the uninvolved liver parenchyma (liv).

73 ncephalon Lmx1a is expressed in the cortical hem, and in its absence cortical hem progenitors contrib

74 ce due to a migratory defect in the cortical hem, and is accompanied by upregulation of Ebf3 in this

75 p a dorsal telencephalic midline, a cortical hem, and two cortical hemispheres.

76 In oxygenic phototrophs, chlorophylls, hemes, and bilins are synthesized by a common branched p

77 lls exhibited WT levels of Fe/S clusters and hemes, and they did not hyperaccumulate Fe.

78 Inhibition of hem- and lymphangiogenesis (afferent and efferent arm of

79 performed and occurrence and time course of hem- and lymphangiogenesis after keratoplasty was observ

80 There is concurrent, VEGF-A-dependent hem- and lymphangiogenesis after normal-risk keratoplast

81 rapping of VEGF-A significantly reduced both hem- and lymphangiogenesis and significantly improved lo

82 t survival, establishing early postoperative hem- and lymphangiogenesis as novel risk factors for gra

83 antation in either donor or host cornea, but hem- and lymphangiogenesis were clearly visible at day 3

84 s to repress the generation of both cortical hem- and PSB-derived CR cells.

85 line signaling in the production of cortical hem- and PSB-derived CR cells.

86 ping studies, as a novel marker for cortical hem- and septum-derived CR cells.

87 mal expression is restricted to the cortical hem are completely absent in Gli3(Xt/Xt) embryos, but so

88 ellar rhombic lip and telencephalic cortical hem are dorsally located germinal zones which contribute

89 the Soret peaks of the oxidized and reduced hemes are 403 and 418 nm for the low-spin heme and 389 a

90 In MV.CO the spectra of both hemes are almost independent of pH between 5.7 and 11.0.

91 be markedly decreased to the point that two hemes are almost isopotential, yet the enzyme retains ca

92 Typically, c hemes are bound to the protein through two thioether bon

93 The reduction potentials of the hemes are different and are cross-assigned to fast and s

94 supporting the idea that ferric-hydroperoxo hemes are indeed the precursors of the reactive ferryl i

95 Cysteine-bound hemes are key components of many enzymes and biological

96 e(III) oxidation state, the nuclear receptor hemes are low spin and 6-coordinate with cysteine(thiola

97 ical globins to the parent red Lbs but their hemes are nitrated.

98 As the two hemes are physically separated by 14.5 A, a hole-hopping

99 heme, and four low-spin, bis-his coordinated hemes are positioned to facilitate intra- and intermolec

100 lts as well as more complex siderophores and hemes are potential carriers to deliver Ga(III) to the m

101 Hemes are prosthetic groups that participate in diverse

102 Although the beta hemes are relatively near the IHP binding site, a linkag

103 HEMS are resource intensive, and the most efficient geog

104 Hydroxide (OH(-))-exchange membranes (HEMs) are important polymer electrolytes enabling the us

105 d Boundary and Homogenous Equilibrium Model (HEM), are employed to describe the claw motion and cavit

106 olves laser flash-quench oxidation of ferric hemes, as demonstrated by our work on the ferryl (compou

107 e viability, and release CO to intracellular hemes, as predicted, but their actions are more complex,

108 tivity and can result in the loss of the two hemes at the active site, hemes d and b595.

109 semble of conformations with nearly parallel hemes, at a metal-metal distance approximately 18-19 A.

110 c-type cytochrome domains wrapped around two hemes axially coordinated by His(53)/Cys(96) and His(164

111 ase activity, indicating that the cofactors (hemes b and copper for CcoN and cytochromes c for CcoO a

112 tral signals characteristic of the high-spin hemes b and d of these oxidases.

113 lue of 3.35 comparable to those obtained for hemes b of cytochrome bc(1) (3.79 and 3.44).

114 g an electron transfer complex consisting of hemes b(n), c(n), and PQ, and the pathway of n-side redu

115 Hemes b, o, o+16, and heme a, those involved in the bios

116 in the R391A mutant is consistent with these hemes being physically close together on the periplasmic

117 orate intramonomer Coulombic effects between hemes bL and bH and intermonomer Coulombic effects betwe

118 udo first-order reduction rate constants for hemes bL and bH in H111N and H198N, by ubiquiniol, are 1

119 The Em values for hemes bL and bH in the H111N and H198N complexes are -95

120 that electron transfer between inter-monomer hemes bL-bL may occur during bc1 catalysis.

121 It contains two covalently attached c-type hemes but exhibits unusual properties compared to c-type

122 ibrium with facile electron transfer between hemes but with only one binding nitric oxide.

123 do not describe redox properties of distinct hemes, but the first and second one-electron reductions

124 R spectrum attributed to interaction between hemes c(n) and b(n).

125 eased, and the redox potential of one of the hemes can stay above the level of quinone pool, or Delta

126 Many HEM cations exist, featuring desirable properties, but n

127 the telencephalon (for example, the cortical hem (CH)) to populate the entire cortical surface.

128 maquette demonstrate the tight affinity for hemes containing the C-2 hydroxyethylfarnesyl group in b

129 he loss of the two hemes at the active site, hemes d and b595.

130 that, although the specification of cortical hem-derived CR cells is dependent on signaling from the

131 mutants results in the loss of the cortical hem-derived CR character but does not affect the specifi

132 nsistent with its dependence for growth on a hem-derived WNT signal.

133 often involves an assembly of two hemesb The hemes display a large difference in redox midpoint poten

134 Oxidation-reduction of both hemes displays an unusually low midpoint potential (-248

135 n pattern of Frizzled10 mRNA in the cortical hem, dorsal thalamus and dorsal neural tube.

136 lineage marker for CR cells derived from the hem during embryonic life.

137 primary sterol Delta(14)-reductase and that HEM dysplasia and ichthyosis are inborn errors of choles

138 th respect to cholesterol synthesis and that HEM dysplasia and ichthyosis are laminopathies rather th

139 in B receptor (LBR) have been shown to cause HEM dysplasia in humans and ichthyosis in mice.

140 tion may be useful in designing more durable HEM electrochemical devices.

141 y-conversion devices such as HEM fuel cells, HEM electrolyzers, and HEM solar hydrogen generators.

142 tion of electron transfer between the two bL hemes enhances electron leakage to oxygen and thus decre

143 que has been used to study copper complexes, hemes, enzyme mechanisms, micellar water content, and wa

144 genes under multiple conditions based on the HEM estimation.

145 oxidation of bis-ferric MauG, the two c-type hemes exist as a spin-uncoupled bis-Fe(IV) species with

146 In the cortical hem, expression of LacZ mRNA was confined to the ventric

147 a hematopoietic cell-specific member of the Hem family of cytoplasmic adaptor proteins.

148 hromes contain a number of His/His ligated c-hemes for electron transfer and a structurally different

149 the MhuD-diheme complex reveals two stacked hemes forming extensive contacts with residues in the ac

150 rochemical energy-conversion devices such as HEM fuel cells, HEM electrolyzers, and HEM solar hydroge

151 so show that during the degradation of WAVE, Hem function is opposite to that of and downstream of Ab

152 igh-copy suppressor screen for regulators of hem gene expression resulted in the identification of an

153 We demonstrate that the expression of hem genes in Rhodobacter capsulatus is transcriptionally

154 ons in LBR result in Pelger-Huet anomaly and HEM-Greenberg skeletal dysplasia, whereas in mice Lbr mu

155 set to determine whether subjects triaged to HEMS had a survival benefit when actually transported by

156 positioned between the D-propionates of the hemes, had been mutated in vivo to lysine and showed to

157 In addition, one of the hemes has an atypical His-Tyr axial ligation.

158 The hemes have positive reduction potentials that allow down

159 This indicates that the high- and low-spin hemes have similar intrinsic E(m) values but exhibit neg

160 and redox reactivity of the model Cys-bound hemes highlight the critical role of the protein scaffol

161 In the absence of Nf2, NPCs of the cortical hem, hippocampal primordium and neocortical primordium o

162 orsal midline structures, including cortical hem, hippocampus and choroid plexus, either failed to fo

163 ng PFGE and MLST of seven genes, aroC, dnaN, hemD, hisD, purE, sucA, and thrA.

164 a a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemI

165 anule release in response to stimulation of (hem) immunoreceptor tyrosine-based activation motif (ITA

166 elets prevent inflammatory bleeding through (hem) immunoreceptor tyrosine-based activation motif-depe

167 nflammatory disease, which signal through a (hem)immunoreceptor tyrosine-based activation motif (ITAM

168 gered by 2 receptors that signal through an (hem)immunoreceptor tyrosine-based activation motif (ITAM

169 reveal an important contribution of Grb2 in (hem)immunoreceptor tyrosine-based activation motif signa

170 s that Grb2 is a crucial adapter protein in (hem)immunoreceptor tyrosine-based activation motif signa

171 In vivo, this selective (hem)immunoreceptor tyrosine-based activation motif signa

172 LEC-2 mediates platelet activation through a hem-immunoreceptor tyrosine-based activation motif (hemI

173 findings reveal a much broader role for the hem in cortical development than previously recognized,

174 ydrogen-bonded network is observed above the hemes in all of the high-resolution crystal structures o

175 ditions, carbon monoxide binds to the Fe(II)-hemes in approximately 15 ms.

176 of reversible electron transfer between the hemes in bis-Fe(IV) MauG.

177 We identified the axial ligands to hemes in cyt b561 by mutating four conserved histidines

178 mine that the midpoint potentials of the two hemes in cytochrome c(4) are 240 and 340 mV (vs standard

179 the basis of sequence alignments, one of the hemes in each of the cytochrome c(7)-type domains does n

180 cuit comprising seven His/His-ligated c-type hemes in each subunit.

181 In vitro, ferrous deoxy-hemes in hemoglobin (Hb) react with nitrite to generate

182 , CO-inhibited (carboxy), and O2-bound (oxy) hemes in myoglobin (MB) and hemoglobin (HB) solutions an

183 do the Soret peaks of the low- and high-spin hemes in the absorption spectrum.

184 electron equilibration between the two b(H) hemes in the dimer through the two b(L) hemes is possibl

185 the stability of the Chl a and one or both b hemes in the monomer of the b 6 f complex, and (b) Phe r

186 The electronic properties of the hemes in the reduced state of TDO change significantly u

187 e 46% identical, but the arrangements of the hemes in the two structures differ; the rms deviation of

188 he aromatic pairs present between the two bL hemes in the two symmetry-related monomers.

189 Our HEM inference is based on Markov chain Monte Carlo to es

190 Hemes (iron porphyrins) are involved in a range of funct

191 Whether the hem is a major regulator of cortical patterning outside

192 When the hem is ablated a necessary balance is perturbed, and cer

193 The cortical hem is an embryonic signaling center that generates bone

194 The software for the HEM is available from the authors upon request.

195 ious finding that in these mice the cortical hem is expanded leading to increased production of CR ce

196 b(H) hemes in the dimer through the two b(L) hemes is possible upon reduction through one center N de

197 lation of five coordinated histidine-ligated hemes is present in the ferrous state at a physiological

198 ich a tryptophan residue located between the hemes is reversibly oxidized and reduced to increase the

199 nd SLAP2 as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis

200 ity, and thrombin generation in response to (hem)ITAM-coupled, but not G protein-coupled, receptor ac

201 e PIG3V and the normal human melanocyte line HEM-l by RNA sequencing, targeted metabolomics, and shot

202 s functionally redesigned to accommodate two hemes ligated to histidines and to retain the strong cou

203 Two lesions with HEM/liv 1.42 and 1.46 were classified as benign foci oth

204 The HEM/liv quotients were calculated for each mass.

205 One lesion with HEM/liv ratio equal to 1.21 was classified as metastasis

206 adiologically typical for hemangiomas, their HEM/liv ratios were at least 1.6 (smaller masses) or 1.8

207 hemangiomas and in normal liver parenchyma (HEM/liv), and to verify, whether the quotient could be p

208 about 45 residues at the N terminus with the hemes located between the two monomers.

209 the neocortical primordium to compensate for hem loss.

210 e calculated from the oxidation state of the hemes measured with multi-wavelength cell spectroscopy.

211 t be a consequence of growth in the cortical hem (medial patterning center), which produces morphogen

212 to [Fe4S4](2+) clusters and low-spin Fe(II) hemes, most of which were associated with mitochondrial

213 High-resolution primer extension analysis of hem mRNA reveals the presence of numerous putative RegA,

214 The Hem-o-lok and other surgical clips must not be used to c

215 in 2006, have continued due to postoperative Hem-o-lok clip failure with sudden, massive bleeding.

216 hile the FDA issued a Class II recall of the Hem-o-lok clip for laparoscopic donor nephrectomies in 2

217 e plan, funded by oversight agencies and the Hem-o-lok manufacturer, is proposed.

218 A February 2011 survey disclosed that Hem-o-lok or other clips are still used by some surgeons

219 re found to represent the only two authentic hemes of cyt b561; models that propose smaller or greate

220 ly ordered for a favorable reaction with the hemes of DHC showing potentials of -310 and -240 mV, res

221 ms a trimer or tetramer in solution; the two hemes of each monomer are hexacoordinated by histidine a

222 lts raise the question of how the prosthetic hemes of MPO and EPO, whose function is to produce oxidi

223 The iron hemes of MtrA are bound to its polypeptide chain via pro

224 ns to compute the redox potentials of the 10 hemes of MtrF in aqueous solution.

225 real-time oxidation state of NAD(H) and the hemes of the electron transport chain and oxygen consump

226 e pump site is coupled to ET between the two hemes of the enzyme, while transfer of a chemical proton

227 The redox potentials of the hemes of the mitochondrial bc(1) complex are dependent o

228 TGFbeta signaling in explants from cortical hems of wild-type mice altered p21 expression and the pr

229 In Hem or WAVE mutants, RP2 neuron either abnormally migrat

230 ower heme redox potential of R-state ferrous hemes or could reflect the high ligand affinity geometry

231 with established HNO targets such as Fe(III) hemes or Ph3P.

232 ve cohort study of subjects undergoing scene HEMS or ground emergency medical services (GEMS) in the

233 A), a dimeric enzyme that houses five c-type hemes per protomer, conducts the six-electron reduction

234 antially lower than that of the 5-coordinate hemes present in myoglobin and hemoglobin.

235 he cortical hem, and in its absence cortical hem progenitors contribute excessively to the adjacent h

236 RegA, FnrL and CrtJ binding sites in several hem promoter regions.

237 ional regulator, called HbrL, that regulates hem promoters in response to the availability of heme.

238 Here, we show that the Hem protein, via the WAVE complex, regulates migration o

239 herol quinone (aTQ), and other constituents (hemes, proteins, DNA, and surfactant lipids).

240 Because human epidermal melanocytes (HEMs) provide critical protection against skin cancer, s

241 f HAS alters the total level of farnesylated hemes, providing further evidence that HOS and HAS inter

242 Human and DmCBS Fe(II) hemes react relatively slowly with CO and NO, and the ra

243 Indicating that the hem regulates dorsoventral patterning in the cortical he

244 We report that Hem regulates neuronal migration through stabilizing WAV

245 underlying the higher reactivity of R-state hemes remains elusive.

246 n of the promoter regions of hutA, tonB, and hemS reveals consensus sequence promoters that encompass

247 identified interactions between the cortical hem, rich in Wingless-Int (WNT) proteins and bone morpho

248 [Fe(4)S(4)](2+) clusters, low- and high-spin hemes, S = (1)/(2) [Fe(2)S(2)](+) clusters, NHHS Fe(II)

249 Hemes sequester NO, whereas thiols deploy NO bioactivity

250 ed midpoint potentials (E(m,7)) of the two b hemes similar to those in the wild type.

251 in previous spectroscopic studies, the four hemes sites have been presumed to be equivalent.

252 ch as HEM fuel cells, HEM electrolyzers, and HEM solar hydrogen generators.

253 Nitrite is reduced by deoxygenated ferrous hemes, such that heme deoxygenation increases the rate o

254 e, a linkage between that site and the alpha hemes, such that the binding of a single oxygen molecule

255 ajal-Retzius cells derived from the cortical hem that guide migration of progenitors and neurons to t

256 hromes of c-type contain covalently attached hemes that are formed via thioether bonds between the vi

257 plitting of the redox potentials of adjacent hemes that leads to differential heme binding affinities

258 analogs, diacetyl, monoformyl, and diformyl hemes, that posses electron-withdrawing groups, resulted

259 rizzled10 gene in order to mark the cortical hem (the most caudomedial edge of the telencephalic neur

260 Next to the hem, the hippocampus was shrunken, consistent with its d

261 her links to the porphyrin typical of c-type hemes, there is a third proteinaceous link involving a c

262 on transfer from the cytochrome b(L) to b(H) hemes, thereby promoting the formation of a ubisemiquino

263 protolytic residue that interacts with both hemes through a hydrogen-bonding network.

264 strated that MsrQ is able to bind two b-type hemes through the histidine residues conserved between t

265 e remaining proton is transferred toward the hemes to a so-called "pump site." Thus, this proton may

266 me that utilizes two covalently bound c-type hemes to catalyze the biosynthesis of the protein-derive

267 lead from E286 through the region above the hemes to the Mg(2+), and from E286 to the heme a(3) D-pr

268 the repulsion between propionates of partner hemes to the reactive binding free energy to be surprisi

269 y we performed high throughput sequencing of HEMs to obtain a complete data set of transcript sizes,

270 propose a Bayesian hierarchical error model (HEM) to overcome the above restrictions.

271 sure of primary human epidermal melanocytes (HEMs) to UVA causes calcium mobilization and early melan

272 es patients with improved survival following HEMS transport and should be considered in air medical t

273 tion of patients most likely to benefit from HEMS transport is imperative to justify the risks and co

274 rns demonstrating NO and nitrite with ferric hemes under near physiological conditions yield an inter

275 ld be measured from the redox poise of the b-hemes under physiological conditions assuming the redox

276 ytochrome b reduced corresponded to two b(H) hemes undergoing reduction through one center P per dime

277 e movement of protons to the vicinity of the hemes upon reduction, to favor charge neutrality.

278 ully oxidized enzyme and its transfer to the hemes using time-resolved absorption spectroscopy and pH

279 HEM was also compared with ANOVA using simulated data.

280 The optimal cutoff for triage to HEMS was >/=2 points.

281 ubjects triaged to HEMS, actual transport by HEMS was associated with an increased odds of survival (

282 plex, our data argues that in the absence of Hem, WAVE, which is presumably no longer in a complex, b

283 of diminished BMP signaling on the cortical hem were at least partly responsible for these defects i

284 yr-199, and Phe-203), located between two bL hemes, were generated and characterized.

285 the region between and above the a and a(3) hemes where well-defined water chains have not been iden

286 h expresses Fgf8 and Fgf17, and the cortical hem, which expresses Bmps and Wnts.

287 fibroblast growth factors, and the cortical hem, which expresses bone morphogenetic proteins and ver

288 ncephalic structures, including the cortical hem, which normally expresses a number of Wnt molecules

289 ructures, including hippocampus and cortical hem, while the ventral telencephalon appears to expand.

290 with a subpopulation of beta-subunit ferric hemes whose population is influenced by quaternary state

291 h a peak at 553 nm, similar to that of other hemes with a single thioether linkage.

292 , this tetraheme cytochrome c contains three hemes with axial His/Met ligation, whereas heme 3 exhibi

293 e interaction between five-coordinate ferric hemes with bound axial imidazole ligands and nitric oxid

294 Thus, the two hemes with distinct spectral properties are reduced and

295 Each tetramer binds two hemes with high affinity at low micromolar concentration

296 utes to the high reactivity of R-state deoxy-hemes with nitrite.

297 Equilibrium binding studies of the hemes with the maquette demonstrate the tight affinity f

298 the protein evolved to harbor low-potential hemes without slowing down electron flow.

299 Rather we found that hem WNT or BMP signals, or both, have opposite effects t

300 Maintenance of hem WNT signaling and hippocampal development thus requi