ライフサイエンスコーパス: hemangioblast

1 ells arise from a common precursor cell, the hemangioblast.

2 from a common embryonic precursor termed the hemangioblast.

3 ls (BL-CFCs), the in vitro equivalent of the hemangioblast.

4 K1 and SCL are molecular determinants of the hemangioblast.

5 affecting hematopoiesis at the level of the hemangioblast.

6 of hematopoietic and endothelial cells, the hemangioblast.

7 ges may in fact function at the level of the hemangioblast.

8 es arise from a common precursor, called the hemangioblast.

9 pressing both Flk1 and SCL may represent the hemangioblast.

10 sized to arise from a common progenitor, the hemangioblast.

11 ar cells, the descendents of the presumptive hemangioblast.

12 al cells are derived from a common cell, the hemangioblast.

13 -sac blood island, which originates from the hemangioblast.

14 rs required for earlier specification of the hemangioblast.

15 ve erythroid development at the level of the hemangioblast.

16 cular events leading to the formation of the hemangioblast.

17 originate from a common precursor cell, the hemangioblast.

18 levels in cell populations enriched for the hemangioblast.

19 sidered to be the in vitro equivalent of the hemangioblast.

20 early mesoderm and its differentiation into hemangioblasts.

21 ises primitive Hem and End cells, as well as hemangioblasts.

22 nd colonies are clonally generated by single hemangioblasts.

23 occur simultaneously from common precursors, hemangioblasts.

24 tical factors for the proliferation of human hemangioblasts.

25 nic stem cells and impaired the formation of hemangioblasts.

26 we show that vessel phenotype resulting from hemangioblast activity can be altered by modulation of t

27 blood and blood vessels, provide functional hemangioblast activity during choroidal neovascularizati

28 WT hemangioblast activity in adult iNOS-/- recipients resul

29 scularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.

30 ult hematopoietic stem cells have functional hemangioblast activity, that is, they can clonally diffe

31 ole early in development at the level of the hemangioblast, an embryonic progenitor of the hematopoie

32 leads to the opposite effect, inhibition of hemangioblast and hematopoietic development.

33 addition to mesoderm, these cells expressed hemangioblast and hematopoietic markers.

34 hematopoiesis, including the concepts of the hemangioblast and hemogenic endothelium.

35 GF-beta) superfamily, is required for proper hemangioblast and primitive hematopoietic development.

36 ing is critical for the proliferation of the hemangioblast and that cells expressing both Flk1 and SC

37 iption factor as a negative regulator of the hemangioblast and the endothelial lineage.

38 se ER71 and Etsrp caused strong expansion of hemangioblast and vascular endothelial lineages in a zeb

39 -/-) mouse result from a decreased number of hemangioblasts and a block in their ability to different

40 f ES cell differentiation to mesoderm and to hemangioblasts and acts within the LIF-gp130-Stat3 pathw

41 10% blasts from tertiary ELTC functioned as hemangioblasts and generated macroscopic Hem-End colonie

42 d may represent a common condition shared by hemangioblasts and HSCs.

43 f brachyury and flk-1 and differentiation to hemangioblasts and primitive and definitive hematopoieti

44 expressed gene signatures characteristic of hemangioblasts, and could be expanded, cryopreserved and

45 and functional characteristics of embryonic hemangioblasts, and that these can be used to directly i

46 We demonstrate that ACE+CD45-CD34+/- hemangioblasts are common yolk sac (YS)-like progenitors

47 ferentiate into ECs, suggesting that classic hemangioblasts are rare or nonexistent in Xenopus.

48 Padron-Barthe et al explore the role of the hemangioblast as the cell of origin for yolk sac blood a

49 h the embryologic, developmentally arrested, hemangioblast as the tumor cell of origin for VHL-associ

50 rp1 expression inhibits the specification of hemangioblasts, as shown by decreased expression of the

51 thetically, CD34(+)KDR(+) cells may comprise hemangioblasts bipotent for both lineages.

52 iogenesis, and has been postulated to induce hemangioblasts, bipotential precursors for blood and end

53 Significantly, proliferation of embryonic hemangioblasts (BL-CFCs) is regulated by hypoxia, as Arn

54 les between embryonic stem (ES) cell-derived hemangioblasts (Blast-Colony-Forming Cells, BL-CFCs) and

55 Hemangioblast, blood cell, cardiomyocyte, and vascular d

56 derive from a common progenitor, termed the hemangioblast, but the factor(s) specifying the developm

57 s arise from a common clonal progenitor, the hemangioblast, but this hypothesis has not been tested d

58 oderm, by measuring brachyury expression, to hemangioblasts, by measuring blast colony-forming cell (

59 dpc) represents an optimal window from which hemangioblasts can be isolated.

60 ells originate from embryologically-arrested hemangioblasts capable of blood and endothelial cell dif

61 ony-forming cell (BL-CFC), a progenitor with hemangioblast characteristics generated in embryonic ste

62 mesendoderm populations and were enriched in hemangioblast colony-forming cells (Bl-CFC).

63 ever, we discovered that LDN treatment after hemangioblast commitment enhanced primitive myeloid pote

64 on of Smad1 in embryoid body cultures before hemangioblast commitment limits hematopoietic potential

65 pleted in FlK1(+) mesoderm, at a stage after hemangioblast commitment, the pool of hematopoietic prog

66 1 and Gata2 are not observed at the onset of hemangioblast commitment.

67 topoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution

68 from that found in the previously described hemangioblast-derived blast cell colonies in that they t

69 d by the transient expression of Numb in the hemangioblast-derived blast cell colonies.

70 sults indicate that ALK-1 signaling promotes hemangioblast development and hematopoiesis, as evidence

71 Hemangioblast development from ES cells was reduced 2- t

72 ule methoxyamine, affected cytokine-mediated hemangioblast development in vitro.

73 a (SCL), a transcription factor that directs hemangioblast development into blood cell precursors, re

74 ) ES cells, ALK-1 rescued both the defective hemangioblast development, and primitive erythropoiesis,

75 Our results show that in addition to delayed hemangioblast development, Hhex(-/-) ES-derived progeny

76 ) cells, to further define events leading to hemangioblast development.

77 acts upstream of scl and etsrp in zebrafish hemangioblast development.

78 c and endothelial development, downstream of hemangioblast development.

79 well as endothelial genes, in the definitive hemangioblasts (DHs).

80 lammation, is a novel marker for identifying hemangioblasts differentiating from human embryonic stem

81 ion of mesoderm: as a negative regulator for hemangioblast differentiation and hematopoiesis but alte

82 Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endot

83 er integrate the molecular events regulating hemangioblast differentiation.

84 ogenesis, including the pathways controlling hemangioblast differentiation.

85 wing that definitive HSCs do not function as hemangioblasts during normal development.

86 n-angiotensin system (RAS) directly regulate hemangioblast expansion and differentiation via signalin

87 ACE enzymatic activity is required for hemangioblast expansion, and differentiation toward eith

88 ficient to enhance commitment of mesoderm to hemangioblast fate.

89 to expand the number of cells that commit to hemangioblast fate.

90 iation of these mesodermal precursors to the hemangioblast fate; and VEGF is required for the product

91 ignaling molecule derived from PC, regulated hemangioblast formation and primitive hematopoiesis.

92 h, LPA functioned as a developmental cue for hemangioblast formation and primitive hematopoiesis.

93 Our results showed a profound reduction in hemangioblast frequency in the absence of endoglin.

94 rs of these bipotential progenitors-known as hemangioblasts-from human embryonic stem (hES) cells usi

95 he idea that a common progenitor, termed the hemangioblast, generates both hematopoietic and endothel

96 lved in insulin sensitivity, erythropoiesis, hemangioblast generation, and cellular redox control was

97 resulted in a temporal-sensitive increase in hemangioblast generation, precocious commitment to eryth

98 ut is dispensable for HE specification after hemangioblasts have been formed.

99 The roles of scl, ets and gata factors in hemangioblasts have been well defined, but the significa

100 These studies identified postnatal hemangioblasts in a CD34(+)KDR(+) cell subset, endowed w

101 ment and the specific signaling occurring in hemangioblasts in contrast to more advanced hematopoieti

102 vels of transcripts encoding markers for the hemangioblast, including Runx1, Scl, and Gata2.

103 its absence, primitive myeloid cells retain hemangioblast-like characteristics and fail to migrate.

104 argeted deletion of MAP2 specifically in the hemangioblast lineage resulted in abnormal vascular deve

105 composed of mesenchymal cells that expressed hemangioblast markers (CD31, CD34, C-kit, CXCR4, Runx1,

106 otent markers Oct4, SSEA-1, Rex1, and AP and hemangioblast markers CD133, Flk1, and c-kit.

107 sts, as shown by decreased expression of the hemangioblast markers, etsrp, fli1a, and scl; blocks pri

108 We developed a heuristic model of hemangioblast maturation, in part, to be explicit about

109 eries of experiments, which suggest that the hemangioblast may be a state of competence rather than a

110 Although exceedingly rare, hemangioblasts may represent the lifetime source/reservo

111 experiments revealed that endoglin marks the hemangioblast on day 3 of EB differentiation.

112 cells develop from a common progenitor, the hemangioblast, or directly from mesodermal cells.

113 and conclude that embryonic progenitors with hemangioblast potential represent a possible cytologic e

114 lls in the embryo from a putative definitive hemangioblast precursor.

115 akaryocyte lineage initially originates from hemangioblast precursors during early gastrulation and i

116 We found that a majority of hemangioblast precursors during early gastrulation conta

117 this region, HSCs are thought to arise from hemangioblast precursors located in the ventral wall of

118 In Xenopus, the definitive hemangioblast precursors of the HSC lineage have been id

119 1+ cardiovascular progenitors, distinct from hemangioblast precursors, represents a mesodermal precur

120 eneration of Flk-1+ mesoderm, the Flk-1+Scl+ hemangioblast, primitive erythroid and endothelial cells

121 ine yolk sac, including overlapping waves of hemangioblast, primitive, erythroid, and definitive eryt

122 Moreover, contribution by individual hemangioblast progenitors to both endothelial and hemato

123 ouble-negative gate unlocking entry into the hemangioblast program, in part by inhibiting TGFbeta sig

124 al gene regulatory network (GRN) controlling hemangioblast programming has been elucidated.

125 EBs during the appearance of precursors with hemangioblast properties, the blast colony-forming cells

126 ematopoiesis as well as a novel mechanism of hemangioblast regulation.

127 Sibling cells generated by a hemangioblast, replated in unicellular culture, produce

128 h the genome-wide binding pattern of Ldb1 in hemangioblasts revealed a number of direct-target genes

129 es, to evaluate the self-renewal capacity of hemangioblasts, single CD34(+)KDR(+) cells were grown in

130 es derive from a common progenitor cell, the hemangioblast: specifically, the human cord blood (CB) C

131 indings point to a role for endoglin in both hemangioblast specification and hematopoietic commitment

132 demonstrated previously that Smad1 promotes hemangioblast specification, but then subsequently restr

133 ily responsible for initiation of definitive hemangioblast specification.

134 mon origin from mesodermal precursors called hemangioblasts, specified in the primitive streak during

135 e demonstrate a role for Runx1 (AML1) at the hemangioblast stage of hematopoietic and endothelial dev

136 Clonal analysis provided evidence for a hemangioblast that can give rise to two daughter cells:

137 orming cell represents the long-hypothesized hemangioblast, the common precursor of the hematopoietic

138 expression of Flk1 and Tal1, markers for the hemangioblast, the precursor of both blood and endotheli

139 omoting growth factor) and FLK1 (a marker of hemangioblasts, the bipotential progenitor of endothelia

140 apex of the hierarchy programming the adult hemangioblast, thus illustrating that miRNAs can act as

141 opoietic or endothelial fate of hESC-derived hemangioblasts, thus providing novel opportunities for h

142 t Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic prog

143 des that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are

144 the Notch pathway can efficiently respecify hemangioblasts to a cardiac fate, resulting in the gener

145 Differentiation to both mesoderm and hemangioblasts was lower in Shp-2Delta46-110 cells compa

146 ive documentation of proepicardially derived hemangioblasts, which can differentiate into erythrocyte

147 The existence of hemangioblasts, which serve as common progenitors for he

148 arise from a pool of pluripotential cells ("hemangioblasts") within the Drosophila embryonic mesoder