ライフサイエンスコーパス: hematopoietic

1 This hypersensitivity to hematopoietic ablation was completely rescued by inactiv

2 for BM endothelial cells (ECs) in regulating hematopoietic aging and support further research to iden

3 BM microenvironment, was sufficient to drive hematopoietic aging phenotypes in young HSCs.

4 oncogenic and tumor-suppressor functions and hematopoietic and cardiac differentiation.

5 Here, we describe two brothers with hematopoietic and immunologic symptoms reminiscent of Wi

6 e marrow chimeras, we demonstrated that both hematopoietic and nonhematopoietic cell DREAMs are requi

7 amma causes ECM by signaling within both the hematopoietic and nonhematopoietic compartments.

8 id cell-dependent killing of a collection of hematopoietic and nonhematopoietic human tumor-derived c

9 ic environment contained within endosomes of hematopoietic and parenchymal cells, whereupon IgG is di

10 iption factor that is recurrently mutated in hematopoietic and solid tumors.

11 Finally, we show that hematopoietic AR expression limits IL-33-driven lung inf

12 noculated NSG-SGM3 mice engrafted with human hematopoietic CD34+ stem cells with low-passage CCHF vir

13 nalysis of tumoral epigenetic alterations in hematopoietic CDRs points to sets of genes that are tigh

14 safely induces immune tolerance to combined hematopoietic cell and organ allografts in humans.

15 cytotoxic agents in C57BL/6 mice in vivo and hematopoietic cell lines.

16 We used both an experimental hematopoietic cell model of latency and cells from natur

17 and preventing disseminated viral disease in hematopoietic cell transplant (HCT) recipients but does

18 Allogeneic hematopoietic cell transplantation (allo-HCT) is indicat

19 which is the main complication of allogeneic hematopoietic cell transplantation (allo-HCT).

20 sus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (allo-HCT).

21 tranded DNA (dsDNA) viruses after allogeneic hematopoietic cell transplantation (HCT) are limited by

22 st disease (GVHD) is higher after allogeneic hematopoietic cell transplantation (HCT) from unrelated

23 Hematopoietic cell transplantation (HCT) has been consid

24 Hematopoietic cell transplantation (HCT) has now been sh

25 Hematopoietic cell transplantation (HCT) is curative for

26 prophylaxis after matched-related allogeneic hematopoietic cell transplantation (HCT) recently showed

27 ll-recognized after myeloablative allogeneic hematopoietic cell transplantation (HCT).

28 Ss) are life-threatening complications after hematopoietic cell transplantation (HCT).

29 depletion of donor CD4+ T cells early after hematopoietic cell transplantation effectively prevents

30 of morbidity and mortality after allogeneic hematopoietic cell transplantation.

31 -Class to analyze 32 datasets from different hematopoietic cell types from the Blueprint Epigenome pr

32 which is unresponsive to transplant due to a hematopoietic cell-extrinsic mechanism.

33 inib use, but its cytomegalovirus risk after hematopoietic-cell transplantation (HCT) is not known.

34 In these models, Nf1 haploinsufficiency in hematopoietic cells accelerated tumor onset and increase

35 -/-) mice have decreased MHC-I expression on hematopoietic cells and fewer CD8(+) T cells prior to in

36 ppressor, which regulates the homeostasis of hematopoietic cells and immune responses.

37 e substantially greater in baboons receiving hematopoietic cells from a pig expressing high levels of

38 However, RAS activation in hematopoietic cells has immunologic effects that diverge

39 itional deletion of Bmal1 in endothelium and hematopoietic cells in murine models of microvascular an

40 Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; howev

41 fferentially interacts with murine and human hematopoietic cells in these mouse models and how these

42 rrent Tet2 loss and Nras(G12D) expression in hematopoietic cells induced myeloid transformation, with

43 focused on the molecular mechanisms by which hematopoietic cells initiate and maintain innate and ada

44 Thus, activation of NLRP3 in hematopoietic cells initiates IL-1beta-driven paracrine

45 analyses suggest that CD70 expressed by host hematopoietic cells is involved in the control of allore

46 ypes could be complemented by wild-type (WT) hematopoietic cells or administration of exosomes produc

47 ted by RIPK1, RIPK3, and MLKL kinases but in hematopoietic cells RIPK1 has anti-inflammatory roles an

48 Non-leukemic hematopoietic cells with DNMT3A(R882H) displayed focal m

49 t ZIKV infection was particularly evident in hematopoietic cells with microglia, the brain-resident m

50 Constitutive activation of beta-catenin in hematopoietic cells yielded lethal myeloid disease in a

51 esis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, place

52 e is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase f

53 Here we show that in hematopoietic cells, Nup98 binds predominantly to transc

54 stem cells, but not in normal CD34(+)CD38(-) hematopoietic cells, T cells, or vital tissues.

55 RA in nonhematopoietic cells, but not in the hematopoietic cells, was required for the development of

56 transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 overexpression

57 The Y chromosome is frequently lost in hematopoietic cells, which represents the most common so

58 esis pathway expression compared with normal hematopoietic cells.

59 minant of HCMV tropism for select subsets of hematopoietic cells.

60 mage, is compromised in Foxo3(-/-) primitive hematopoietic cells.

61 ase Atad3a hyperactivated mitophagy in mouse hematopoietic cells.

62 Stromal, but not hematopoietic, cells were the essential source of Notch

63 Hematopoietic changes were associated with a significant

64 n embryos, adults, and Rag2(-/-) gammac(-/-) hematopoietic chimeras reconstituted with cd69(-/-) stem

65 Recent reports have identified hematopoietic colony-stimulating factors as important re

66 thology of chimeric mice lacking TLR2 in the hematopoietic compartment (TLR2KO-->WT) was comparable t

67 s profound reduction of proliferation in the hematopoietic compartments that is rapidly lethal in adu

68 pregulation of IRF8 expression driven by the hematopoietic cytokine FLT3L during cell division.

69 NOD2, ligand induced expression of multiple hematopoietic cytokines (interleukin-7 [IL-7], Flt3L, st

70 evealed that arthritis resistance reflects a hematopoietic defect in addition to mast cell deficiency

71 drial respiration) caused lethal fetal liver hematopoietic defects and hematopoietic stem cell (HSC)

72 g Rho family protein Cdc42 and accounted for hematopoietic defects in TRAF6-expressing HSPCs.

73 cytokine receptor and RAS signaling (62.2%), hematopoietic development (29.7%), and chemical modifica

74 sed as a template for the integration of new hematopoietic differentiation and transdifferentiation d

75 nvolving transcription factors important for hematopoietic differentiation and/or signaling molecules

76 These included genes in familial hematopoietic disorders (GATA2, RUNX1), telomeropathies

77 This review focuses on hematopoietic disorders that are associated with mutatio

78 EAM knockout (KO) mice, DREAM KO control and hematopoietic DREAM KO mice showed a significant delay i

79 1 to stimulate hematopoiesis is critical, as hematopoietic dysfunction results from a range of ionizi

80 RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell) and mesenchymal (osteo

81 Non-hematopoietic expression of TREM2 was found to be respon

82 2 transcription factor play central roles in hematopoietic fate establishment.

83 e cells concomitant with their transition to hematopoietic fate.

84 c stem cells (HSCs) reside at the top of the hematopoietic hierarchy and are the origin of all blood

85 to 15 weeks of gestation, these cells lacked hematopoietic in vivo engraftment potential.

86 ans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this

87 was expressed exclusively within definitive hematopoietic KDR(+)CD235a(-) mesoderm in a WNT- and fib

88 ssues prone to oncogenic transformation: the hematopoietic lineage and the intestinal epithelium.

89 y regulate signaling pathways in a number of hematopoietic lineages, including T lymphocytes.

90 whether and how dietary restriction affects hematopoietic malignancies is unknown.

91 e recent discovery of rare STAT mutations in hematopoietic malignancies suggests that STAT mutants ma

92 c myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that may deserve specific manag

93 increased risk of subsequently developing a hematopoietic malignancy, suggesting that these mutation

94 on WNT-dependent KDR(+)CD235a(-) definitive hematopoietic mesoderm and WNT-independent KDR(+)CD235a(

95 nd WNT-independent KDR(+)CD235a(+) primitive hematopoietic mesoderm revealed strong CDX gene expressi

96 strong CDX gene expression within definitive hematopoietic mesoderm.

97 We used the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV) as a model to study

98 reincubated with our model virus, infectious hematopoietic necrosis virus (IHNV), infectivity was sig

99 7)Lu-DOTATATE: 8 patients (2.9%) developed a hematopoietic neoplasm (4 MDS, 1 AML, 1 MPN, and 2 MDS/M

100 generative ability of the disease-associated hematopoietic niche.

101 marizes several aspects related to the human hematopoietic niche: (1) its anatomical structure, compo

102 collagen-producing fibroblasts derived from hematopoietic or bone marrow lineages in hearts subjecte

103 esis, and up-regulation of genes involved in hematopoietic organ development, lymphoid development, a

104 In the Drosophila hematopoietic organ, the lymph gland, the posterior sign

105 transplanted OS mice in peripheral blood and hematopoietic organs, such as the BM, thymus, and spleen

106 These studies are consistent with a hematopoietic origin and >1 immediate cellular precursor

107 Upon their differentiation, we found hematopoietic phenotypes of graded severity and/or stage

108 uitment to these microenvironments, known as Hematopoietic Pockets.

109 undergo fewer transitions and are reduced in hematopoietic potential.

110 volution of CD31 expression from the CD34(+) hematopoietic precursor to the CD45RA(+) mature CD4(+) a

111 SP/Cas9 to reduce alpha-globin expression in hematopoietic precursors, and show effectiveness in xeno

112 scontinuous sinusoids also allow circulating hematopoietic progenitor and stem cells to populate the

113 reviously shown that HCMV infection of human hematopoietic progenitor cells engrafted in immune defic

114 These features prevented hematopoietic progenitor cells from transmigrating into

115 Murine hematopoietic progenitor cells overexpressing MPP1 acqui

116 t-like or a replicative infection in CD34(+) hematopoietic progenitor cells, we defined classes of lo

117 ochondria compared with nonmalignant CD34(+) hematopoietic progenitor cells.

118 activated in AML cells compared with normal hematopoietic progenitor cells.

119 n the cell population positive for the early hematopoietic progenitor marker CD41.

120 A population of cells displaying a hematopoietic progenitor phenotype (CD34(++) CD45(low))

121 for occluding-junctions in regulating niche-hematopoietic progenitor signalling and link this mechan

122 We show that Hdac8-deficient hematopoietic progenitors are compromised in colony-form

123 Flt3Cre+ KrasG12D fetal liver hematopoietic progenitors give rise to a myeloid disease

124 is SCF variant elicited biased activation of hematopoietic progenitors over mast cells in vitro and i

125 nitial activation of the Gata1 gene in early hematopoietic progenitors remains to be elucidated.

126 ts lineage choice in differentiating primary hematopoietic progenitors using image patches from brigh

127 iota is known to influence the generation of hematopoietic progenitors, although the pathways underly

128 ression, enhanced self-renewal, expansion of hematopoietic progenitors, and myeloid differentiation b

129 udied erythropoiesis using knockout mice and hematopoietic progenitors.

130 y in the absence of PRC1, to fully transform hematopoietic progenitors.

131 a therapeutic target to accelerate balanced hematopoietic reconstitution after myelosuppression.

132 ge cells and endothelial cells in regulating hematopoietic reconstitution following injury.

133 evidence for clonal succession after initial hematopoietic reconstitution.

134 essel regeneration and increase survival and hematopoietic recovery after HSC transplantation.

135 tivates Notch2 signaling in HSPCs to promote hematopoietic recovery and has potential as a therapeuti

136 tration of Dkk1 to irradiated mice increased hematopoietic recovery and improved survival.

137 Dramatically compromised hematopoietic recovery and increased lethality were seen

138 es to enhance HSC engraftment and accelerate hematopoietic recovery in the elderly population followi

139 Results Hematopoietic recovery was similar after transplantation

140 hematopoietic stem cells providing potential hematopoietic recovery.

141 These data identify Dkk1 as a regulator of hematopoietic regeneration and demonstrate paracrine cro

142 granulocytes promote blood vessel growth and hematopoietic regeneration.

143 process is thought to impair osteogenic and hematopoietic regeneration.

144 center (PSC) acts as a niche to regulate the hematopoietic response to immune stress such as wasp par

145 ith 4 components: (1) a TCR specific for the hematopoietic-restricted, leukemia-associated minor H an

146 During Drosophila larval development, hematopoietic sites are in direct contact with sensory n

147 Here we report that hematopoietic-specific genetic inactivation of Sin3B, an

148 echanistic basis for WNT-mediated definitive hematopoietic specification from hPSCs.

149 factor in the regulation of human definitive hematopoietic specification, and provides a mechanistic

150 icroenvironment is an important regulator of hematopoietic stem and progenitor cell (HSPC) biology.

151 The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choic

152 in of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in p

153 Mutant mice have altered hematopoietic stem and progenitor cell populations in th

154 We used an ex vivo hematopoietic stem and progenitor cell/EC (HSPC/EC) cocu

155 tions: in some anatomical locations specific hematopoietic stem and progenitor cells (HSPCs) are gene

156 Hematopoietic stem and progenitor cells (HSPCs) are vuln

157 ent in lineage choice, we transplanted human hematopoietic stem and progenitor cells (HSPCs) expressi

158 to demonstrate engraftment of gene-corrected hematopoietic stem and progenitor cells (HSPCs) from FA

159 occurring X-linked somatic PIGA mutations in hematopoietic stem and progenitor cells (HSPCs) from pat

160 tical role in the retention and migration of hematopoietic stem and progenitor cells (HSPCs) in the b

161 pitulate the full span of thymopoiesis, from hematopoietic stem and progenitor cells (HSPCs) through

162 ells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs).

163 operties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs).

164 F384 fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potenti

165 Rev1 hematopoietic stem and progenitor cells displayed compro

166 only sufficient to increase the viability of hematopoietic stem and progenitor cells during engraftme

167 Transplantation of human hematopoietic stem and progenitor cells into SRG-15 mice

168 Autologous transplantation of hematopoietic stem and progenitor cells lentivirally lab

169 se fetal liver erythroblasts, and in CD34(+) hematopoietic stem and progenitor cells, with increased

170 xpressing populations, including the cKit(+) hematopoietic stem and progenitor cells.

171 th persistence of mIDH2 and normalization of hematopoietic stem and progenitor compartments with emer

172 e tracked back to the phenotypically defined hematopoietic stem cell (HSC) compartment in all investi

173 (GFs) that together promote quiescent human hematopoietic stem cell (HSC) expansion ex vivo have bee

174 lethal fetal liver hematopoietic defects and hematopoietic stem cell (HSC) failure.

175 linically to treat leukopenia and to enforce hematopoietic stem cell (HSC) mobilization to the periph

176 ulations that express characteristics of the hematopoietic stem cell (HSC) niche contain precursors t

177 le bone marrow cells that regulate different hematopoietic stem cell (HSC) properties such as prolife

178 eptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171

179 em declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, mye

180 dent transformation in MLL-CSCs derived from hematopoietic stem cell (HSC)-enriched LSK population bu

181 ch, we identify ZNF521/Zfp521 as a conserved hematopoietic stem cell (HSC)-enriched transcription fac

182 itive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis

183 ansfer genes specifically into the primitive hematopoietic stem cell compartment through the utilizat

184 se group of bone marrow disorders and clonal hematopoietic stem cell disorders characterized by abnor

185 As p53 is central to hematopoietic stem cell functions, its aberrations affec

186 Transplantation of a single hematopoietic stem cell is an important method for its f

187 lood cells is derived from a single dominant hematopoietic stem cell lineage.

188 bility, indicating that Erf is necessary for hematopoietic stem cell maintenance or differentiation.

189 Adhesion is a key component of hematopoietic stem cell regulation mediating homing and

190 the blood program during development, adult hematopoietic stem cell survival and quiescence, and ter

191 immunogenicity results of MVA in allogeneic hematopoietic stem cell transplant (HCT) recipients and

192 sease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients.

193 ific T cells and viral control in allogeneic hematopoietic stem cell transplant recipients.

194 versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplant reflects a complex im

195 intestinal toxemia botulism in an allogeneic hematopoietic stem cell transplantation (allo-HCT) recip

196 has not been investigated during allogeneic hematopoietic stem cell transplantation (allo-HSCT).

197 t-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation (alloSCT) is pot

198 Autologous hematopoietic stem cell transplantation (HSCT) and mesen

199 common and poorly recognized complication of hematopoietic stem cell transplantation (HSCT) associate

200 Allogeneic hematopoietic stem cell transplantation (HSCT) from an H

201 anti-HBc)-positive patients after allogeneic hematopoietic stem cell transplantation (HSCT) has not b

202 Allogeneic hematopoietic stem cell transplantation (HSCT) is a crit

203 Allogeneic hematopoietic stem cell transplantation (HSCT) is used a

204 Autologous hematopoietic stem cell transplantation (HSCT) of gene-m

205 Allogeneic hematopoietic stem cell transplantation (HSCT) remains t

206 The outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was monit

207 is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and upda

208 t and devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT), posing a

209 sease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT).

210 cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT).

211 Trials of hematopoietic stem cell transplantation and gene therapy

212 systemic mastocytosis, including allogeneic hematopoietic stem cell transplantation and multikinase

213 Hematopoietic stem cell transplantation is a potential c

214 Allogeneic hematopoietic stem cell transplantation is hampered by c

215 ntrol in severely affected patients for whom hematopoietic stem cell transplantation is not available

216 n of protoporphyrin in the liver, LT without hematopoietic stem cell transplantation leaves the new l

217 signaling assays of 30 primary samples from hematopoietic stem cell transplantation patients with an

218 The success of allogeneic hematopoietic stem cell transplantation, a key treatment

219 dation involved chemotherapy with or without hematopoietic stem cell transplantation.

220 vival may only be achievable with allogeneic hematopoietic stem cell transplantation.

221 uartile range, 27-321) days after allogeneic hematopoietic stem cell transplantation.

222 gh-throughput integration site analysis in a hematopoietic stem cell-transplanted humanized mouse mod

223 axis is involved in the interaction between hematopoietic stem cells (as well as hematologic and sol

224 ns of genes of interest from primary CD34(+) hematopoietic stem cells (cRBCs).

225 scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 se

226 Accumulation of damaged DNA in hematopoietic stem cells (HSC) is associated with chromo

227 erved microRNAs that are highly expressed in hematopoietic stem cells (HSCs) and acute myeloid leukem

228 o investigate the role of DDT in maintaining hematopoietic stem cells (HSCs) and progenitors, we used

229 Hematopoietic stem cells (HSCs) are mobilized from niche

230 ould be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from

231 In the developing embryo, hematopoietic stem cells (HSCs) emerge from the aorta-go

232 nals that enhance the retention or egress of hematopoietic stem cells (HSCs) from bone marrow (BM).

233 Single hematopoietic stem cells (HSCs) have been functionally s

234 Hematopoietic stem cells (HSCs) in the bone marrow (BM)

235 Prolonged exit from quiescence by hematopoietic stem cells (HSCs) progressively impairs th

236 Hematopoietic stem cells (HSCs) remain mostly quiescent

237 Hematopoietic stem cells (HSCs) reside at the top of the

238 r humanized through the engraftment of human hematopoietic stem cells (HSCs) that can lead to human h

239 Hematopoietic stem cells (HSCs) that sustain lifelong bl

240 e occurred in parallel with specification of hematopoietic stem cells (HSCs) to the myeloid and lymph

241 The use of allogeneic hematopoietic stem cells (HSCs) to treat genetic blood c

242 Upon aging, hematopoietic stem cells (HSCs) undergo changes in funct

243 Inflammatory signals can activate hematopoietic stem cells (HSCs), but how HSCs regain qui

244 is not known if adult LCH or ECD arises from hematopoietic stem cells (HSCs), nor which potential blo

245 increased numbers of phenotypically defined hematopoietic stem cells (HSCs).

246 EXTL3 was most abundant in hematopoietic stem cells and early progenitor T cells, w

247 ow progenitor analysis revealed depletion of hematopoietic stem cells and multipotent progenitors acr

248 ( + ) mice, which conditionally lack ET-1 in hematopoietic stem cells and vascular endothelial cells,

249 ently add new copies of the relevant gene to hematopoietic stem cells have led to safe and effective

250 , reduced regeneration of leukemic long-term hematopoietic stem cells in secondary transplant recipie

251 transferring a GFP reporter gene into adult hematopoietic stem cells in vivo, which are predominantl

252 mbination with other cell therapies (such as hematopoietic stem cells or bone marrow-derived MSC or d

253 such as CD33 and CD123, is not expressed on hematopoietic stem cells providing potential hematopoiet

254 able to engraft murine recipients with human hematopoietic stem cells that develop into functional hu

255 d, we show how mRNA nanocarriers can program hematopoietic stem cells with improved self-renewal prop

256 NK cells develop from hematopoietic stem cells, and few monogenic errors that

257 vity of innate immune cells, mesenchymal and hematopoietic stem cells, and insulin-releasing pancreat

258 atopoiesis results from somatic mutations in hematopoietic stem cells, which give an advantage to mut

259 e was reproducible in in vitro cultured cDKO-hematopoietic stem cells, which were significantly rescu

260 The platform was used to deliver single hematopoietic stem cells.

261 ent, possibly directly stemming from infused hematopoietic stem cells.

262 drift acting on a small population of active hematopoietic stem cells.

263 l factor transgene were engrafted with human hematopoietic stem cells.

264 ntisickling beta-globin gene into autologous hematopoietic stem cells.

265 ogical effects of Runx1 in the generation of hematopoietic stem cells.

266 ted genes, commonly occurs among aging human hematopoietic stem cells.

267 concept is being used clinically to harvest hematopoietic stem or progenitor cells from bone marrow

268 ents receive myeloablative chemotherapy with hematopoietic stem-cell transplant followed by adjuvant

269 e rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will requ

270 ven responders (44%) proceeded to allogeneic hematopoietic stem-cell transplantation, including 55% (

271 he clonal architecture of the CD34(+)CD38(-) hematopoietic stem/progenitor cell (HSPC) compartment an

272 erase complex, is highly expressed in normal hematopoietic stem/progenitor cells (HSPCs) and acute my

273 of the m(6)A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cel

274 Ub) ligase activity, is overexpressed in MDS hematopoietic stem/progenitor cells (HSPCs).

275 iferation, although the presence of resident hematopoietic stem/progenitor cells (Lin-/Sca+/c-Kit+; L

276 tremely low immortalization of primary mouse hematopoietic stem/progenitor cells compared to analogou

277 veloped myeloid skewing over time, and their hematopoietic stem/progenitor cells exhibited a long-ter

278 Hematopoietic stem/progenitor cells in the adult mammali

279 genes in precursor cells, and suggests that hematopoietic stress changes the balance of renewal and

280 ut switch to a proliferative state following hematopoietic stress, e.g., bone marrow (BM) injury, tra

281 compartment and its activity in response to hematopoietic stress.

282 and increased apoptosis under genotoxic and hematopoietic stress.

283 Rather, distinct hematopoietic stressors result in the selective expansio

284 The hematopoietic system declines with age, resulting in dec

285 s a juxtacrine homeostatic adaptation of the hematopoietic system in stress myelopoiesis.

286 S exposure induces persistent changes in the hematopoietic system independent of age at exposure.

287 Aging of the hematopoietic system is associated with an increased inc

288 d with deficits in neurodevelopment and with hematopoietic system toxicity.

289 TL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle repr

290 gene expression to modulate cell fate in the hematopoietic system.

291 nt HSCs were also unable to reconstitute the hematopoietic system.

292 rstanding of the evolution of the vertebrate hematopoietic system.

293 This review focuses on alterations in hematopoietic TFs in the pathobiology of inherited plate

294 ese results suggest that MoMLV spread within hematopoietic tissues and cell monolayers involves cell-

295 ophil count-associated locus near the master hematopoietic transcription factor CEBPA The fine-mapped

296 xpression in cells undergoing endothelial-to-hematopoietic transition.

297 pose T-cell-replete HLA-haploidentical donor hematopoietic transplantation using post-transplant cycl

298 equently related complications of allogeneic hematopoietic transplantation.

299 Whereas H-Ras(G12V) elicited papillomas and hematopoietic tumors, K-Ras(G12V) induced lung tumors an

300 cular beds, but its expression is induced in hematopoietic vascular niches after myelosuppressive inj