ライフサイエンスコーパス: hematopoietic differentiation

1 es, including RUNX1, a critical regulator of hematopoietic differentiation.

2 2 family members have been identified during hematopoietic differentiation.

3 ht to derive from a common progenitor during hematopoietic differentiation.

4 hypermethylation phenotype that dysregulates hematopoietic differentiation.

5 rough interaction with Gfi proteins controls hematopoietic differentiation.

6 ancy and dynamics across different stages of hematopoietic differentiation.

7 context-sensitive roles at defined stages of hematopoietic differentiation.

8 uggest that forced ABCG2 expression prevents hematopoietic differentiation.

9 id not, however, extend to the next level of hematopoietic differentiation.

10 independent of c-Mpl to promote multilineage hematopoietic differentiation.

11 , p300, but not CBP, is essential for proper hematopoietic differentiation.

12 on of genomic instability, and inhibition of hematopoietic differentiation.

13 receptors do not play an instructive role in hematopoietic differentiation.

14 Evi27 expression is tightly regulated during hematopoietic differentiation.

15 of CBP, but not p300, is required for normal hematopoietic differentiation.

16 adult mice contain a remarkable capacity for hematopoietic differentiation.

17 s relatively inefficient at the induction of hematopoietic differentiation.

18 important role in supporting and regulating hematopoietic differentiation.

19 point to an essential role for Ptp gamma in hematopoietic differentiation.

20 l system for the study of various aspects of hematopoietic differentiation.

21 EST recruitment and MYC repression to govern hematopoietic differentiation.

22 of a ventral source of signal(s) controlling hematopoietic differentiation.

23 ne expression pattern for specific stages of hematopoietic differentiation.

24 of growth factors plays an important role in hematopoietic differentiation.

25 ethylation dynamics and normal and malignant hematopoietic differentiation.

26 se-associated phenotypes, including impaired hematopoietic differentiation.

27 d decay, which, in turn, results in impaired hematopoietic differentiation.

28 tic impact of this robust demethylase during hematopoietic differentiation.

29 ator of hematopoiesis, at multiple stages of hematopoietic differentiation.

30 relatively few transcription factors control hematopoietic differentiation.

31 ls, and that its expression increases during hematopoietic differentiation.

32 w cytometry to assess inhibition of mIDH2 on hematopoietic differentiation.

33 expressing Etv2 (ER71) and Tal1 that undergo hematopoietic differentiation.

34 odulating GATA-2 at the protein level during hematopoietic differentiation.

35 , is an indispensible epigenetic governor of hematopoietic differentiation.

36 cellular heterogeneity reflective of normal hematopoietic differentiation.

37 cell (HSPC) gene expression programs during hematopoietic differentiation.

38 were collectively co-regulated during normal hematopoietic differentiation.

39 d epigenetic regulation that is required for hematopoietic differentiation.

40 intain a normal karyotype and are capable of hematopoietic differentiation.

41 gnals that induce early mesoderm to initiate hematopoietic differentiation.

42 ent reveals that methylation is critical for hematopoietic differentiation.

43 vel marker of this and other stages of early hematopoietic differentiation.

44 e regulation during vascular development and hematopoietic differentiation.

45 oietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

46 e-regulated miRs-126/126* and analyzed their hematopoietic differentiation.

47 ay participate in stem cell self-renewal and hematopoietic differentiation.

48 many cell types, including putative roles in hematopoietic differentiation.

49 f healthy donors, and could be redirected to hematopoietic differentiation.

50 mooth muscle cell investment of vessels, and hematopoietic differentiation.

51 ating factor (GM-CSF), which are involved in hematopoietic differentiation and activation of immune c

52 athways, including developmental patterning, hematopoietic differentiation and antiviral defense.

53 his article, we describe the role of TEL2 in hematopoietic differentiation and cellular transformatio

54 he onset of EKLF and GATA1 expression during hematopoietic differentiation and demonstrate that EB di

55 e cell cycle machinery at discrete stages of hematopoietic differentiation and during cytokine-mediat

56 ion that culminates in a failure of terminal hematopoietic differentiation and emphasizes the role of

57 We identify regulators governing hematopoietic differentiation and further show the linea

58 MicroRNAs (miRs) play major roles in normal hematopoietic differentiation and hematopoietic malignan

59 Stat5 plays a key role in the regulation of hematopoietic differentiation and hematopoietic stem cel

60 nulocyte-specific genes that are involved in hematopoietic differentiation and inhibitor of different

61 protein-protein interactions participate in hematopoietic differentiation and leukemogenesis.

62 ur understanding of the role of microRNAs in hematopoietic differentiation and leukemogenesis.

63 in cultured AGM cells significantly induces hematopoietic differentiation and loss of the progenitor

64 rstanding novel regulatory circuits in early hematopoietic differentiation and malignant transformati

65 ient and mouse hematopoietic cells and alter hematopoietic differentiation and maturation in animal m

66 ase in serum levels of cytokines involved in hematopoietic differentiation and maturation.

67 d changes in this compartment that impact on hematopoietic differentiation and mobilization of a vari

68 y that contributes to cytokine regulation of hematopoietic differentiation and offer a potential mech

69 tential mechanisms for stromal inhibition of hematopoietic differentiation and possibly for the poor

70 shown that this oncoprotein interferes with hematopoietic differentiation and proliferation and part

71 trong evidence that miRNAs modulate not only hematopoietic differentiation and proliferation but also

72 r fumarate metabolism in HSC maintenance and hematopoietic differentiation and reveal a differential

73 ineage commitment to facilitate multilineage hematopoietic differentiation and thus identify their no

74 sed as a template for the integration of new hematopoietic differentiation and transdifferentiation d

75 op highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, a

76 nvolving transcription factors important for hematopoietic differentiation and/or signaling molecules

77 evaluated ESC-derived LKS cells for in vitro hematopoietic-differentiation and colony formation (CFU

78 n factors that function in immune responses, hematopoietic differentiation, and cell growth regulatio

79 IDH1 and IDH2 affect the leukemia epigenome, hematopoietic differentiation, and clinical outcome.

80 apacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferatio

81 inding factor (CBF), resulting in a block of hematopoietic differentiation, and induces leukemia upon

82 ll cycle control, DNA repair, cell division, hematopoietic differentiation, and near many ESTs and no

83 istribution, regulation of expression during hematopoietic differentiation, and subcellular localizat

84 iption factors, which play a pivotal role in hematopoietic differentiation, and their inappropriate e

85 whereas CREBBP is essential for neurulation, hematopoietic differentiation, angiogenesis and skeletal

86 conjugated monoclonal antibodies that target hematopoietic differentiation antigens have been develop

87 oiesis in which many of the genes specifying hematopoietic differentiation are expressed by HSPCs, bu

88 by their expression of genes associated with hematopoietic differentiation, as well as morphologic as

89 Gene expression profiling and hematopoietic differentiation assays showed that indepen

90 olite R-2-hydroxyglutarate (2-HG) and induce hematopoietic differentiation block.

91 GATA1 is a master regulator of hematopoietic differentiation, but Gata1 expression is i

92 MicroRNAs influence hematopoietic differentiation, but little is known about

93 ression by ETO, as well as for inhibition of hematopoietic differentiation by AML1-ETO.

94 omprises three major steps: (i) induction of hematopoietic differentiation by coculture of hPSCs with

95 hat RUNX1 exists as a monomer that regulates hematopoietic differentiation by interacting with tissue

96 rescence Cre reporter allele, largely normal hematopoietic differentiation capacity of Hdac8-deficien

97 s in heterologous genes; and (v) ES in vitro hematopoietic differentiation coupled with regulated BCR

98 Hematopoietic differentiation critically depends on comb

99 differentiation, suggesting that AME induces hematopoietic differentiation defects through at least t

100 machine learning to derive a model of human hematopoietic differentiation directly from DNA methylat

101 Interleukin-5 (IL-5) is a hematopoietic differentiation factor that promotes the d

102 clusters that suggest novel hypotheses about hematopoietic differentiation-for example, highlighting

103 s in cellular reprogramming technologies and hematopoietic differentiation from human pluripotent ste

104 ild-type FLT3 (FLT3-WT) completely abrogates hematopoietic differentiation from MLL-AF4-expressing hE

105 ad is necessary for normal activation of the hematopoietic differentiation gene serpent in the same a

106 scription factors that cooperate to activate hematopoietic differentiation genes.

107 On hematopoietic differentiation, genetically corrected or

108 Specifically, no perturbation of hematopoietic differentiation, globin gene expression, o

109 transcriptional inactivation of HOXA9 during hematopoietic differentiation has been established, litt

110 tic manipulation of intrinsic factors during hematopoietic differentiation has proven a suitable appr

111 lineage restriction from HSCs, this model of hematopoietic differentiation has recently been challeng

112 o general models for the cytokine control of hematopoietic differentiation have been proposed.

113 he percentage of pig-a- embryoid bodies with hematopoietic differentiation, however, were significant

114 itted progenitors are mostly associated with hematopoietic differentiation, immune regulation, and me

115 population during human embryonic stem cell hematopoietic differentiation in a Notch-dependent manne

116 DNA hypermethylation and impaired hematopoietic differentiation in AML after isocitrate de

117 of such analysis, the approach is applied to hematopoietic differentiation in four well studied model

118 Analysis of hematopoietic differentiation in homozygous mutant anima

119 pathway genes at critical stages of myeloid hematopoietic differentiation in LCH patients supports r

120 expression was observed in these HSCs after hematopoietic differentiation in the NSI mice.

121 EGFP expression was monitored during hematopoietic differentiation in vitro using flow cytome

122 manifest deficits in exocrine pancreatic and hematopoietic differentiation in vitro, enhanced apoptos

123 ly, telomerase-mutant iPSCs showed defective hematopoietic differentiation in vitro, mirroring the cl

124 ng the splicing factor SRSF2 directly impair hematopoietic differentiation in vivo, which is not due

125 ic iPSCs using the CRISPR/Cas9 tool promotes hematopoietic differentiation in vivo.

126 ological processes, such as neurogenesis and hematopoietic differentiation, in animals.

127 support a model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL degr

128 er binding proteins (C/EBPs) are involved in hematopoietic differentiation, including myelopoiesis an

129 Increased expression of ASB2 during hematopoietic differentiation is associated with decreas

130 The biochemistry of early stages of hematopoietic differentiation is difficult to study beca

131 Hematopoietic differentiation is governed by a complex r

132 The molecular program controlling hematopoietic differentiation is not fully understood.

133 Hematopoietic differentiation is regulated by RARalpha,

134 s participate in B lymphopoiesis and whether hematopoietic differentiation is skewed toward specific

135 transcription factors are known to regulate hematopoietic differentiation, major aspects of the glob

136 Additional mutations that impair hematopoietic differentiation may be required for the de

137 fforts are directed toward adapting in vitro hematopoietic differentiation methods developed for muri

138 y identifying several compounds that improve hematopoietic differentiation of FA-iPSCs.

139 e assays and modulates its ability to induce hematopoietic differentiation of hematopoietic cell line

140 xpression levels of HOXA9 may be crucial for hematopoietic differentiation of hESC.

141 -function studies reveal that HOXA9 enhances hematopoietic differentiation of hESCs by specifically p

142 ulating factor CDX4 These data indicate that hematopoietic differentiation of hESCs models the earlie

143 Here we show that during hematopoietic differentiation of hESCs, HOXA9 expression

144 ding the first evidence for a role of miR in hematopoietic differentiation of hESCs.

145 During hematopoietic differentiation of human embryonic stem ce

146 In this paper, we describe a protocol for hematopoietic differentiation of human pluripotent stem

147 andin-E2 (PGE2), and StemRegenin 1 (SR1) for hematopoietic differentiation of Mn iPSCs.

148 ase that catalyzes LPA production, inhibited hematopoietic differentiation of mouse embryonic stem ce

149 upplemented with cytokines was developed for hematopoietic differentiation of rhesus monkey embryonic

150 Hematopoietic differentiation of these iPSC clones demon

151 id elf-1-like factor/ELF4-deficient mice) or hematopoietic differentiation (p21- and p27-deficient mi

152 y, we performed integration analyses between hematopoietic differentiation performance and molecular

153 Studies of PML function in hematopoietic differentiation previously focused princip

154 ontaining proto-oncogene TLX1/HOX11 inhibits hematopoietic differentiation programs in a number of mu

155 in kinase C-betaII, a factor associated with hematopoietic differentiation-proliferation.

156 formation in an embryonic stem cell model of hematopoietic differentiation provided biological eviden

157 itively regulates expression of mesoderm and hematopoietic differentiation-related factors, including

158 further demonstrate a marked enhancement of hematopoietic differentiation relative to wild-type hESC

159 This hematopoietic differentiation requires fetal bovine seru

160 Correct hematopoietic differentiation requires the tightly regul

161 In a defined hematopoietic differentiation system, ectopic expression

162 ion of Hox genes, resulting in a blockage of hematopoietic differentiation that ultimately leads to l

163 After directed hematopoietic differentiation, the MPD-iPS cell-derived

164 raction Database pointed to miRNA control of hematopoietic differentiation through translational cont

165 strate that SHP-1 acts at multiple stages of hematopoietic differentiation to alter lineage balance.

166 shifts the balance between smooth muscle and hematopoietic differentiation towards blood.

167 defects, are the foundation for the current hematopoietic differentiation tree.

168 andscape and gene expression dynamics during hematopoietic differentiation using DNase-seq, histone m

169 To confirm that the pertubation of hematopoietic differentiation was a result of Ptp gamma

170 isogenic trisomic counterparts, but in vitro hematopoietic differentiation was not consistently alter

171 igate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a

172 vestigate the role of GPI-linked proteins in hematopoietic differentiation, we have inactivated the p

173 tumor suppressors and genes associated with hematopoietic differentiation were repressed at later ti

174 ginally affected T-lineage specification and hematopoietic differentiation with a slight increase in

175 C/EBPalpha(-/-) mice show a block in hematopoietic differentiation, with an accumulation of m

176 alance can lead to hematopoietic failure, as hematopoietic differentiation without self-renewal leads