ライフサイエンスコーパス: hematopoietic stem and progenitor cell

1 iciency in human primary T cells and CD34(+) hematopoietic stem and progenitor cells.

2 ell-mediated destruction of bone marrow (BM) hematopoietic stem and progenitor cells.

3 f gene modification were achieved in CD34(+) hematopoietic stem and progenitor cells.

4 her leukemic cells alter functions of normal hematopoietic stem and progenitor cells.

5 work that regulates the development of adult hematopoietic stem and progenitor cells.

6 ion and differentiation of granulocytes from hematopoietic stem and progenitor cells.

7 0 CD34(+) cells, similar to that of purified hematopoietic stem and progenitor cells.

8 d their preferential elimination over normal hematopoietic stem and progenitor cells.

9 tion of D-cyclins also operates in quiescent hematopoietic stem and progenitor cells.

10 tion triggers activation of Wnt signaling in hematopoietic stem and progenitor cells.

11 umber of circulating Lin(-)/Sca-1(+)/cKit(+) hematopoietic stem and progenitor cells.

12 HSCs with serial transplantation and CIN in hematopoietic stem and progenitor cells.

13 Notch receptor expression and activation in hematopoietic stem and progenitor cells.

14 ch signaling and self-renewal capacity in FA hematopoietic stem and progenitor cells.

15 perturbing the engraftment of normal CD34(+) hematopoietic stem and progenitor cells.

16 Mutation of CALR was detected in hematopoietic stem and progenitor cells.

17 lf-renewal and differentiation efficiency of hematopoietic stem and progenitor cells.

18 ffective at partially rescuing Mll-deficient hematopoietic stem and progenitor cells.

19 as required for efficient DNA replication in hematopoietic stem and progenitor cells.

20 t a useful novel technology to culture human hematopoietic stem and progenitor cells.

21 enes that cooperate with Runx1 in regulating hematopoietic stem and progenitor cells.

22 ore, Runx1 is required for the regulation of hematopoietic stem and progenitor cells.

23 lpha4beta1 integrin cell adhesion complex in hematopoietic stem and progenitor cells.

24 need to be replenished from bone marrow (BM) hematopoietic stem and progenitor cells.

25 ell surface markers consistent with immature hematopoietic stem and progenitor cells.

26 ene, was most repressed by miR-125b in mouse hematopoietic stem and progenitor cells.

27 Tgfbeta2 stimulates proliferation of hematopoietic stem and progenitor cells.

28 ntrol of mRNA stability in the life cycle of hematopoietic stem and progenitor cells.

29 specific "developmental niches" that support hematopoietic stem and progenitor cells.

30 on with G-CSF or AMD3100 for mobilization of hematopoietic stem and progenitor cells.

31 poietic cell transplantation is dependent on hematopoietic stem and progenitor cells.

32 ce migration, survival, and other actions of hematopoietic stem and progenitor cells.

33 significant toxicity was observed for normal hematopoietic stem and progenitor cells.

34 X1 and suppresses RUNX1-induced expansion of hematopoietic stem and progenitor cells.

35 rs using CRISPR-Cas9 genome editing in human hematopoietic stem and progenitor cells.

36 xpressing populations, including the cKit(+) hematopoietic stem and progenitor cells.

37 eration and increased apoptosis of embryonic hematopoietic stem and progenitor cells.

38 cell compartment and enhanced quiescence in hematopoietic stem and progenitor cells.

39 d leukemia (AML) blasts compared with normal hematopoietic stem and progenitor cells.

40 scular endothelium, but Drosha (cKO)-derived hematopoietic stem and progenitor cells accumulate in th

41 n, we mapped expression profiles of purified hematopoietic stem and progenitor cells, adipose tissue

42 iferation, differentiation, and migration of hematopoietic stem and progenitor cells, all aimed at ef

43 We also used our approach to identify hematopoietic stem and progenitor cells and a novel NK-l

44 F384 fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potenti

45 Aging Itpkb(-/-) mice lost hematopoietic stem and progenitor cells and died with se

46 , promotes the survival and proliferation of hematopoietic stem and progenitor cells and drives megak

47 ations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self

48 ein CBFbeta-SMMHC impairs differentiation in hematopoietic stem and progenitor cells and induces AML

49 ansition enhancers, which are established in hematopoietic stem and progenitor cells and maintained i

50 iplex homologous recombination (HR) in human hematopoietic stem and progenitor cells and primary huma

51 XCR4 antagonist, AMD3100 for mobilization of hematopoietic stem and progenitor cells and their use fo

52 tablish a cellular platform for expansion of hematopoietic stem and progenitor cells and treatment of

53 quiescence, blocked PTN-mediated recovery of hematopoietic stem and progenitor cells, and abolished P

54 l maturation, its role in myeloid priming of hematopoietic stem and progenitor cells, and its indispe

55 survival advantage, led to proliferation of hematopoietic stem and progenitor cells, and skewed hema

56 CD26 for enhanced homing and engraftment of hematopoietic stem and progenitor cells, and the use of

57 much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently,

58 The environments that harbor hematopoietic stem and progenitor cells are critical to

59 Although most hematopoietic stem and progenitor cells are found in the

60 keeper of the hematopoietic niche transition.Hematopoietic stem and progenitor cells are generated fi

61 a, complementation group C (FANCC)-deficient hematopoietic stem and progenitor cells are hypersensiti

62 During inflammation and infection, hematopoietic stem and progenitor cells are stimulated t

63 Hematopoietic stem and progenitor cells arise from the v

64 Hematopoietic stem and progenitor cells, as well as nucl

65 bles the robust engraftment of healthy human hematopoietic stem and progenitor cells, as well as prim

66 d cell-intrinsic survival roles for RIPK1 in hematopoietic stem and progenitor cells, because Vav-iCr

67 mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo.

68 Critically, however, PIP4K2A KD in normal hematopoietic stem and progenitor cells, both murine and

69 ncies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells but the mechanis

70 d ROS release, have not been investigated in hematopoietic stem and progenitor cells, but likely have

71 ylphosphatidylinositol (GPI) is disrupted in hematopoietic stem and progenitor cells by a somatic mut

72 epatic transfer of human fetal liver derived hematopoietic stem and progenitor cells (CD34(+)) in hum

73 used simultaneously to differentiate between hematopoietic stem and progenitor cells (CD34(+)/CD31(-)

74 ate in vivo that JAK2 mutations do not alter hematopoietic stem and progenitor cell com-partment size

75 The hematopoietic stem and progenitor cell compartment displ

76 Moreover, the hematopoietic stem-and-progenitor-cell compartment was d

77 ally, miR-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by r

78 in of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in p

79 ion and occurs in conjunction with increased hematopoietic stem and progenitor cell cycling, extramed

80 this enhancer by CRISPR/Cas9 mutagenesis in hematopoietic stem and progenitor cells demonstrated tha

81 with acute myeloid leukemia (AML) but not in hematopoietic stem and progenitor cells derived from nor

82 al contributions to our understanding of how hematopoietic stem and progenitor cells develop from pre

83 r complexes that regulate gene expression in hematopoietic stem and progenitor cell development.

84 In contrast, loss of Itgb3 in normal hematopoietic stem and progenitor cells did not affect e

85 topoietic stem and progenitor cells promoted hematopoietic stem and progenitor cell differentiation t

86 Rev1 hematopoietic stem and progenitor cells displayed compro

87 form is caused by replicative impairment of hematopoietic stem and progenitor cells due to very shor

88 only sufficient to increase the viability of hematopoietic stem and progenitor cells during engraftme

89 We used an ex vivo hematopoietic stem and progenitor cell/EC (HSPC/EC) cocu

90 Sept4-null mice have increased numbers of hematopoietic stem and progenitor cells, elevated XIAP p

91 A similar number of hematopoietic stem and progenitor cells emerge from Dros

92 rgeted suppression of SH2B3 in primary human hematopoietic stem and progenitor cells enhanced the mat

93 ent (Rag(-/-)) mice reconstituted with K/BxN hematopoietic stem and progenitor cells exhibit arthriti

94 We found that PRMT5-deficient hematopoietic stem and progenitor cells exhibited severe

95 UCB-derived hematopoietic stem and progenitor cells expanded in the

96 Several approaches for controlling hematopoietic stem and progenitor cell expansion, lineag

97 Hematopoietic stem and progenitor cells from 3-month-old

98 factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from HFD-fed mic

99 ed many new enhancers and super enhancers in hematopoietic stem and progenitor cells from mouse fetal

100 Using hematopoietic stem and progenitor cells from our conditi

101 al report on the response of splenic-derived hematopoietic stem and progenitor cells from patients wi

102 In summary, Rb is critical for hematopoietic stem and progenitor cell function, localiz

103 We show that hematopoietic stem and progenitor cells give rise to iPS

104 nstrated that cell intrinsic loss of Tp53 in hematopoietic stem and progenitor cells haploinsufficien

105 Fetal liver hematopoietic stem and progenitor cells harboring target

106 These results suggest that nonleukemic hematopoietic stem and progenitor cells, harboring speci

107 Hematopoietic stem and progenitor cells (HPCs) are neces

108 pigenotypes during the expansion of human CB hematopoietic stem and progenitor cells (HPSCs).

109 is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions

110 Expansion of hematopoietic stem and progenitor cells (HSC/HPC) in ex

111 of these complexes in fate determination of hematopoietic stem and progenitor cells (HSCs and HPCs)

112 rs are shared between AML blasts and healthy hematopoietic stem and progenitor cells (HSCs), we evalu

113 d reduce the risk of activating oncogenes in hematopoietic stem and progenitor cells (HSCs).

114 Definitive hematopoietic stem and progenitor cells (HSCs/Ps) origin

115 for endogenous homeobox (Hox) genes in adult hematopoietic stem and progenitor cell (HSPC) activity h

116 y progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition.

117 icroenvironment is an important regulator of hematopoietic stem and progenitor cell (HSPC) biology.

118 The hematopoietic stem and progenitor cell (HSPC) compartmen

119 , we show that adenosine signaling regulates hematopoietic stem and progenitor cell (HSPC) developmen

120 In zebrafish, Ak2 deficiency affected hematopoietic stem and progenitor cell (HSPC) developmen

121 Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftmen

122 blast growth factor (FGF) signaling promotes hematopoietic stem and progenitor cell (HSPC) expansion

123 Hematopoietic stem and progenitor cell (HSPC) expansion

124 (dnmt3bb.1) is essential for maintenance of hematopoietic stem and progenitor cell (HSPC) fate as pa

125 The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choic

126 Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation

127 Genetic control of hematopoietic stem and progenitor cell (HSPC) function i

128 The consequences of loss of RB on hematopoietic stem and progenitor cell (HSPC) function i

129 Rac and Cdc42 are known regulators of hematopoietic stem and progenitor cell (HSPC) function,

130 ressive complex 2 (PRC2) plays a key role in hematopoietic stem and progenitor cell (HSPC) function.

131 Hematopoietic stem and progenitor cell (HSPC) functions

132 However, their roles in hematopoiesis and hematopoietic stem and progenitor cell (HSPC) functions

133 ssion profiling, reveals that Lsd1 represses hematopoietic stem and progenitor cell (HSPC) gene expre

134 hematopoietic microenvironment and regulate hematopoietic stem and progenitor cell (HSPC) homeostasi

135 in adult mice resulted in marked changes in hematopoietic stem and progenitor cell (HSPC) localizati

136 is a co-receptor in the CXCL12/CXCR4 axis of hematopoietic stem and progenitor cell (HSPC) migration

137 The mechanisms mediating hematopoietic stem and progenitor cell (HSPC) mobilizati

138 he prototypical mobilizing cytokine, induces hematopoietic stem and progenitor cell (HSPC) mobilizati

139 Quantitative alterations in hematopoietic stem and progenitor cell (HSPC) numbers ar

140 Hematopoietic stem and progenitor cell (HSPC) phenotype

141 roliferating leukemia cells inhibited normal hematopoietic stem and progenitor cell (HSPC) proliferat

142 38MAPK family isoform p38alpha in initiating hematopoietic stem and progenitor cell (HSPC) proliferat

143 ignaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention

144 Tet2 restoration reverses aberrant hematopoietic stem and progenitor cell (HSPC) self-renew

145 Hematopoietic stem and progenitor cell (HSPC) specificat

146 Regulation of hematopoietic stem and progenitor cell (HSPC) steady-sta

147 Using a hematopoietic stem and progenitor cell (HSPC)-specific c

148 We previously identified a hematopoietic stem and progenitor cell (HSPC)-specific s

149 Primary hematopoietic stem and progenitor cells (HSPC) co-expres

150 Engraftment and maintenance of hematopoietic stem and progenitor cells (HSPC) depend on

151 Here, we tracked the developmental fate of hematopoietic stem and progenitor cells (HSPC) in tumor-

152 such as self-renewal and differentiation in hematopoietic stem and progenitor cells (HSPC) remain po

153 the accumulation of DNA damage in primitive hematopoietic stem and progenitor cells (HSPC), associat

154 s CSC models, we used Sca-1(+)/lin(-) murine hematopoietic stem and progenitor cells (HSPC), which we

155 olitogenic T cell program regulates upstream hematopoietic stem and progenitor cells (HSPC).

156 h allogeneic NK cells generated from CD34(+) hematopoietic stem and progenitor cells (HSPC-NK cells)

157 amplin et al. (2015) perform live imaging of hematopoietic stem and progenitor cells (HSPCs) and find

158 AHR is highly expressed in hematopoietic stem and progenitor cells (HSPCs) and inhi

159 It is highly expressed in hematopoietic stem and progenitor cells (HSPCs) and is d

160 nd released into circulation, targets marrow hematopoietic stem and progenitor cells (HSPCs) and medi

161 However, the role of endocannabinoids in hematopoietic stem and progenitor cells (HSPCs) and thei

162 e have developed a technique to expand human hematopoietic stem and progenitor cells (HSPCs) and use

163 Hematopoietic stem and progenitor cells (HSPCs) are expo

164 tions: in some anatomical locations specific hematopoietic stem and progenitor cells (HSPCs) are gene

165 Hematopoietic stem and progenitor cells (HSPCs) are vuln

166 ethodology for tracing the clonal history of hematopoietic stem and progenitor cells (HSPCs) behavior

167 rosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its

168 TNF-alpha and Fas-induced death signaling in hematopoietic stem and progenitor cells (HSPCs) by exami

169 Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be a

170 Hematopoietic stem and progenitor cells (HSPCs) can reco

171 Despite convincing evidence that hematopoietic stem and progenitor cells (HSPCs) can sens

172 ugh insertional mutagenesis in primary human hematopoietic stem and progenitor cells (HSPCs) derived

173 Importantly, aged hematopoietic stem and progenitor cells (HSPCs) differ f

174 During bacterial infection, hematopoietic stem and progenitor cells (HSPCs) differen

175 GFbeta signaling is transiently activated in hematopoietic stem and progenitor cells (HSPCs) during h

176 Hematopoietic stem and progenitor cells (HSPCs) emerge a

177 ent in lineage choice, we transplanted human hematopoietic stem and progenitor cells (HSPCs) expressi

178 The demand for human hematopoietic stem and progenitor cells (HSPCs) for tran

179 Mobilization of hematopoietic stem and progenitor cells (HSPCs) from bon

180 to demonstrate engraftment of gene-corrected hematopoietic stem and progenitor cells (HSPCs) from FA

181 Generation of functional hematopoietic stem and progenitor cells (HSPCs) from hum

182 occurring X-linked somatic PIGA mutations in hematopoietic stem and progenitor cells (HSPCs) from pat

183 Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the

184 Hematopoietic stem and progenitor cells (HSPCs) function

185 r, the inability to derive engraftable human hematopoietic stem and progenitor cells (HSPCs) has limi

186 Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has prov

187 roving the ex vivo and in vivo production of hematopoietic stem and progenitor cells (HSPCs) has the

188 ow, counterintuitively, that Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a s

189 We depleted hematopoietic stem and progenitor cells (HSPCs) in adult

190 The low frequency of hematopoietic stem and progenitor cells (HSPCs) in human

191 el fragments (BVFs) and CD34(+) and CD117(+) hematopoietic stem and progenitor cells (HSPCs) in human

192 this issue through tracking of thousands of hematopoietic stem and progenitor cells (HSPCs) in rhesu

193 tical role in the retention and migration of hematopoietic stem and progenitor cells (HSPCs) in the b

194 of polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) in the b

195 GFP(+) (cd41:GFP(+)) thrombocytes as well as hematopoietic stem and progenitor cells (HSPCs) in the z

196 esin proteins block differentiation of human hematopoietic stem and progenitor cells (HSPCs) in vitro

197 the function and transcriptional program of hematopoietic stem and progenitor cells (HSPCs) in vivo.

198 rculation, can induce the differentiation of hematopoietic stem and progenitor cells (HSPCs) into fun

199 We transplanted hematopoietic stem and progenitor cells (HSPCs) into ret

200 titutive egress of bone marrow (BM)-resident hematopoietic stem and progenitor cells (HSPCs) into the

201 Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a pro

202 Cytoskeletal remodeling of hematopoietic stem and progenitor cells (HSPCs) is essen

203 Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not f

204 PU.1 downregulation within hematopoietic stem and progenitor cells (HSPCs) is the p

205 rapy with genetically modified human CD34(+) hematopoietic stem and progenitor cells (HSPCs) may be s

206 ranscription factors, is highly expressed by hematopoietic stem and progenitor cells (HSPCs) of murin

207 Independent of genotype, MDS hematopoietic stem and progenitor cells (HSPCs) overexpr

208 We show that Sirt1 ablation in adult hematopoietic stem and progenitor cells (HSPCs) promotes

209 constitute a supportive microenvironment for hematopoietic stem and progenitor cells (HSPCs) released

210 Hematopoietic stem and progenitor cells (HSPCs) reside i

211 he circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that als

212 pitulate the full span of thymopoiesis, from hematopoietic stem and progenitor cells (HSPCs) through

213 The homing and egress of hematopoietic stem and progenitor cells (HSPCs) to and f

214 of these myeloid cells, and the response of hematopoietic stem and progenitor cells (HSPCs) to MI, h

215 t Nras allele, we analyzed hematopoiesis and hematopoietic stem and progenitor cells (HSPCs) under no

216 iple types of blood and immune cells renders hematopoietic stem and progenitor cells (HSPCs) valuable

217 In vivo imaging of transplanted hematopoietic stem and progenitor cells (HSPCs) was deve

218 In this model, hematopoietic stem and progenitor cells (HSPCs) were dec

219 Normal hematopoietic stem and progenitor cells (HSPCs) were rel

220 Fs) have not been reported for primary human hematopoietic stem and progenitor cells (HSPCs), and hav

221 bout factors that govern the self-renewal of hematopoietic stem and progenitor cells (HSPCs), and our

222 e break site has proven challenging in human hematopoietic stem and progenitor cells (HSPCs), and par

223 -1 bicistron results in decreased numbers of hematopoietic stem and progenitor cells (HSPCs), decreas

224 Here we report that in adult human hematopoietic stem and progenitor cells (HSPCs), H3K9me2

225 We show that hematopoietic stem and progenitor cells (HSPCs), in part

226 adult and umbilical cord blood CD34(+) human hematopoietic stem and progenitor cells (HSPCs), the cel

227 In addition to well-characterized CD34(+) hematopoietic stem and progenitor cells (HSPCs), the hum

228 attempt to discover novel growth factors for hematopoietic stem and progenitor cells (HSPCs), we have

229 in the BM when cotransplanted with wild-type hematopoietic stem and progenitor cells (HSPCs), whereas

230 ent infections in resting memory T cells and hematopoietic stem and progenitor cells (HSPCs), which a

231 able of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs).

232 ells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs).

233 CR5, in primary human CD4+ T cells and CD34+ hematopoietic stem and progenitor cells (HSPCs).

234 operties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs).

235 cy of these niches can be rivaled by healthy hematopoietic stem and progenitor cells (HSPCs).

236 factor kappaB (NF-kappaB) pathways in mouse hematopoietic stem and progenitor cells (HSPCs).

237 , results in hyperactivity of Raf/Mek/Erk in hematopoietic stem and progenitor cells (HSPCs).

238 tes, monocytes, and macrophages (mphis) from hematopoietic stem and progenitor cells (HSPCs).

239 g a growth advantage to genetically modified hematopoietic stem and progenitor cells (HSPCs).

240 l role in modulating the physiology of adult hematopoietic stem and progenitor cells (HSPCs).

241 he maintenance and regenerative expansion of hematopoietic stem and progenitor cells (HSPCs).

242 niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs).

243 matopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells (HSPCs).

244 tem requires balanced cell fate decisions by hematopoietic stem and progenitor cells (HSPCs).

245 s from 200 000 highly purified primary mouse hematopoietic stem and progenitor cells (HSPCs).

246 Gs-coupled receptors enhances engraftment of hematopoietic stem and progenitor cells (HSPCs).

247 Hematopoietic stem and progenitors cells (HSPCs) are act

248 cells, and T cells from a polyclonal pool of hematopoietic stem and progenitor cells in 4 macaques ob

249 The small number of hematopoietic stem and progenitor cells in cord blood un

250 oid differentiation of primary human CD34(+) hematopoietic stem and progenitor cells in culture ex vi

251 The engineered bone marrow (eBM) retains hematopoietic stem and progenitor cells in normal in viv

252 thways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to c

253 eration of macrophages in aortic lesions and hematopoietic stem and progenitor cells in the spleen an

254 survival by accelerating the recovery of BM hematopoietic stem and progenitor cells in vivo.

255 hese rescued neonates have severely depleted hematopoietic stem and progenitor cells, indicating that

256 Transplantation of human hematopoietic stem and progenitor cells into SRG-15 mice

257 The developmental fate of hematopoietic stem and progenitor cells is influenced by

258 l in vitro model of HIV-1 latency in primary hematopoietic stem and progenitor cells isolated from hu

259 Autologous transplantation of hematopoietic stem and progenitor cells lentivirally lab

260 changes induced by the oncogenes in isolated hematopoietic stem and progenitor cells (lineage(-)Sca-1

261 ostasis, as reflected by marked expansion of hematopoietic stem and progenitor cells, MK hyperplasia,

262 ic red pulp of typically rare extramedullary hematopoietic stem and progenitor cells, notably granulo

263 d quickly knock down c-kit and PU.1 genes in hematopoietic stem and progenitor cells of recipient mic

264 ut of transplanted autologous rhesus macaque hematopoietic stem and progenitor cells over a time peri

265 iencies in the murine Fancc(-/-) fetal liver hematopoietic stem and progenitor cell pool.

266 Mutant mice have altered hematopoietic stem and progenitor cell populations in th

267 topoietic tissues alters the distribution of hematopoietic stem and progenitor cell populations, and

268 results confirm that the spatial gradient of hematopoietic stem and progenitor cells previously measu

269 is and fate-mapping approaches, we show that hematopoietic stem and progenitor cells progressively re

270 Significantly, coculture of MkMPs with hematopoietic stem and progenitor cells promoted hematop

271 he purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative resp

272 e-editing technologies in autologous CD34(+) hematopoietic stem and progenitor cells represents a pro

273 Fancc(-/-) fetal liver hematopoietic stem and progenitor cells revealed a signi

274 ingle cells belonging to rare populations of hematopoietic stem and progenitor cells (Sca1(+)c-Kit(+)

275 contrast, healthy B6.g7 recipients of K/BxN hematopoietic stem and progenitor cells show only mild a

276 ssion of the C/EBPalpha target gene GFI-1 in hematopoietic stem and progenitor cells, suggesting a me

277 ls, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.

278 Acute myeloid leukemia (AML) originates from hematopoietic stem and progenitor cells that acquire som

279 w in different cell types, including CD34(+) hematopoietic stem and progenitor cells, that inhibition

280 quired for the proliferation and survival of hematopoietic stem and progenitor cells, the extent to w

281 uct eupalinilide E promotes the expansion of hematopoietic stem and progenitor cells; the development

282 eatment with dmPGE2 enhances the function of hematopoietic stem and progenitor cells; these data also

283 we design a stochastic mathematical model of hematopoietic stem and progenitor cells to study the evo

284 ues maturation and migration of Drosha (cKO) hematopoietic stem and progenitor cells to the fetal liv

285 oiesis is important for enhanced efficacy of hematopoietic stem and progenitor cell transplantation.

286 d reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells, unraveling nove

287 In hematopoietic stem and progenitor cells, up to 28% of st

288 Hematopoietic stem and progenitor cells upregulate the T

289 rt on a forward RNAi screen in primary human hematopoietic stem and progenitor cells, using pooled le

290 nogenic and repopulating potential of normal hematopoietic stem and progenitor cells was spared.

291 ot develop autoimmunity, and the function of hematopoietic stem and progenitor cells was unimpaired.

292 geted knockdown experiments in primary human hematopoietic stem and progenitor cells, we demonstrate

293 Hematopoietic stem and progenitor cells were previously

294 to maintain the immature characteristics of hematopoietic stem and progenitor cells, which could res

295 ciency also led to the loss of quiescence of hematopoietic stem and progenitor cells, which dramatica

296 Hematopoietic stem and progenitor cells with inactivated

297 have demonstrated a spatial gradient for the hematopoietic stem and progenitor cells, with higher con

298 se fetal liver erythroblasts, and in CD34(+) hematopoietic stem and progenitor cells, with increased

299 myosin-II isoforms sense matrix stiffness in hematopoietic stem and progenitor cells, with polarized

300 s article, we show that PTK7 is expressed by hematopoietic stem and progenitor cells, with the highes