ライフサイエンスコーパス: hematopoietic system

1 bryo is crucial for development of the adult hematopoietic system.

2 HSCs may underlie many features of the aged hematopoietic system.

3 with support of myeloid lineage cells in the hematopoietic system.

4 ograms and direct cell fate decisions in the hematopoietic system.

5 interactions between mammary cancers and the hematopoietic system.

6 e datasets in high-resolution mapping of the hematopoietic system.

7 inel of cellular stress in the liver and the hematopoietic system.

8 hemogenic endothelium to establish the adult hematopoietic system.

9 we generated mice lacking caspase-9 in their hematopoietic system.

10 e-has been previously developed to study the hematopoietic system.

11 mi1(-/-) mice reconstituted with a wild-type hematopoietic system.

12 odel that acutely deletes Grp78 in the adult hematopoietic system.

13 model with conditional TRF1 deletion in the hematopoietic system.

14 f controls the homeostasis of the Drosophila hematopoietic system.

15 nockout mouse model of GRP78 and PTEN in the hematopoietic system.

16 cellular depletion can reverse aging in the hematopoietic system.

17 esis and a primary target of miR-125b in the hematopoietic system.

18 g developmental defects and breakdown of the hematopoietic system.

19 the mouse and affects the composition of the hematopoietic system.

20 ent that is extensively expressed within the hematopoietic system.

21 escence and expansion/differentiation of the hematopoietic system.

22 significantly to p53-mediated effects on the hematopoietic system.

23 ing the essential autophagy gene Atg7 in the hematopoietic system.

24 ult THS exposure had profound effects on the hematopoietic system.

25 an adaptor protein expressed in cells of the hematopoietic system.

26 (HSCs) with functional consequences for the hematopoietic system.

27 l of HSCs to sustain the highly regenerative hematopoietic system.

28 gene expression to modulate cell fate in the hematopoietic system.

29 t of phagocytes are central functions of the hematopoietic system.

30 rotein selective functions that modulate the hematopoietic system.

31 d carcinogen, especially in reference to the hematopoietic system.

32 unctional defects of individual cells of the hematopoietic system.

33 led the activation of all 3 integrins in the hematopoietic system.

34 deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system.

35 l role for the development of the definitive hematopoietic system.

36 er as well as genetic diseases affecting the hematopoietic system.

37 antigen and other receptors in cells of the hematopoietic system.

38 natally and show profound alterations in the hematopoietic system.

39 aining multiple organ systems, including the hematopoietic system.

40 lly significant consequences of aging of the hematopoietic system.

41 nta in establishing the mammalian definitive hematopoietic system.

42 ells generally requires ablation of the host hematopoietic system.

43 ation of lineage specific alterations in the hematopoietic system.

44 been shown to take on functions outside the hematopoietic system.

45 eins at this point in the development of the hematopoietic system.

46 of potential functions within the developing hematopoietic system.

47 le regulators tailored to the demands of the hematopoietic system.

48 wal, differentiation, and homeostasis of the hematopoietic system.

49 the development of distinct lineages of the hematopoietic system.

50 in many developmental systems, including the hematopoietic system.

51 d on lymphoid and myeloid progenitors in the hematopoietic system.

52 portant role early in the development of the hematopoietic system.

53 ated possible actions of Jak3 outside of the hematopoietic system.

54 d challenges for genetic manipulation of the hematopoietic system.

55 phoid-specific expression pattern within the hematopoietic system.

56 nt HSCs were also unable to reconstitute the hematopoietic system.

57 lular ubH2A level and gene expression in the hematopoietic system.

58 porting myeloid amplification to rebuild the hematopoietic system.

59 the development of several cell types in the hematopoietic system.

60 nesis specifically in the context of an aged hematopoietic system.

61 ney emerges as an important regulator of the hematopoietic system.

62 l for the development and homeostasis of the hematopoietic system.

63 sis, and leads to the formation of the adult hematopoietic system.

64 ol of stem and progenitor cells in the fetal hematopoietic system.

65 unodeficient mice reconstituted with a human hematopoietic system.

66 rstanding of the evolution of the vertebrate hematopoietic system.

67 disease that disrupts normal function of the hematopoietic system.

68 tor cells of the liver, pyloric stomach, and hematopoietic system.

69 at miR-142 is broadly expressed in the adult hematopoietic system.

70 re repopulate large parts of the recipient's hematopoietic system.

71 generate the lineal precursors of the adult hematopoietic system.

72 erful oncogene in the mammary epithelium and hematopoietic system.

73 acts independently from menin (Men1) in the hematopoietic system.

74 lar disease include the immune, nervous, and hematopoietic systems.

75 ariety of phenotypes within the skeletal and hematopoietic systems.

76 e development of both the cardiovascular and hematopoietic systems.

77 ns caused hyperproliferation in lymphoid and hematopoietic systems.

78 ettings, such as stimulating recovery of the hematopoietic system after bone marrow transplantation.

79 stem cells (HSCs) generate all cells of the hematopoietic system, age-associated changes in HSCs may

80 In the human hematopoietic system, aging is associated with decreased

81 As with most tissues, the aged hematopoietic system also exhibits a reduced capacity to

82 uction contributes to homeostasis within the hematopoietic system and appropriate responsiveness to i

83 ietic stem cells are likely derived from the hematopoietic system and are a result not of transdiffer

84 eloid malignancies often arise from an aging hematopoietic system and are currently incurable due to

85 s (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for

86 ling of cancer cells both by stimulating the hematopoietic system and by enhancing CD8(+)-dependent t

87 er, PHD2-deficient HSCs replenish the entire hematopoietic system and display an enhanced self-renewa

88 ates Hox gene expression in the adult murine hematopoietic system and dysregulates Hox genes that are

89 sent study, specific deletion of PIT1 in the hematopoietic system and fetal liver transplantation exp

90 we specifically deleted the PDK1 gene in the hematopoietic system and found that PDK1-deficient HSCs

91 scription factor Myb plays a key role in the hematopoietic system and has been implicated in the deve

92 ce of Fbw7-dependent cyclin E control to the hematopoietic system and highlight CIN as a characterist

93 over 1,500 single cells throughout the mouse hematopoietic system and illustrate its utility for reve

94 ls are prominently expressed in cells of the hematopoietic system and in organs involved in salt and

95 acceleration of tumor formation both in the hematopoietic system and in sarcomas.

96 ts into the cell-cell cross talk between the hematopoietic system and its microenvironment in the bon

97 erized by the accumulation of B cells in the hematopoietic system and lymphoid tissues.

98 en limited to only a few tissues, mainly the hematopoietic system and mammary gland.

99 lly ablated geminin in the developing murine hematopoietic system and observed profound defects in th

100 ulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune r

101 ls (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout

102 ch Scl functions in the establishment of the hematopoietic system and provide evidence that its prima

103 mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and M

104 generated a mouse model lacking Hmgb1 in the hematopoietic system and studied the response to acute s

105 ssential for the functional integrity of the hematopoietic system and that its mutations likely contr

106 he complexity of the embryonic origin of the hematopoietic system and the developmental migration of

107 evere side effects that primarily affect the hematopoietic system and the epithelium of the gastroint

108 y described functional interplay between the hematopoietic system and the SNS extends to the earliest

109 s a disease of the vascular endothelium; the hematopoietic system and the vascular endothelium share

110 applied the technology to dissect the human hematopoietic system and to characterize heterogeneous r

111 stem cells have been shown to repopulate the hematopoietic system and to contribute to skeletal and c

112 genes uniquely expressed in HSCs within the hematopoietic system and to develop a reporter strain th

113 transcriptional control of Elf-4 within the hematopoietic system and, thus, integrate Elf-4 into the

114 it in the maternal brain, rather than in the hematopoietic system, and during gestation was responsib

115 TEL2 is expressed in the hematopoietic system, and its expression is up-regulated

116 ies, such as cancer, loss of function in the hematopoietic system, and low success rate of somatic cl

117 phasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysre

118 cytes, representing the highly proliferative hematopoietic system, and skeletal muscle, a minimally p

119 n revealed fog1 expression in the heart, the hematopoietic system, and the brain, while fog2a and fog

120 sues, such as the intestinal epithelium, the hematopoietic system, and the male germline.

121 Chronic viral infections of the hematopoietic system are associated with bone marrow dys

122 ts treated for proliferative diseases of the hematopoietic system are characterised by a severe, prog

123 We have used the hematopoietic system as a model to investigate whether a

124 We use the Drosophila melanogaster larval hematopoietic system as an in vivo model for the genetic

125 of Nf1 (Nf1(+/-)) and c-kit signaling in the hematopoietic system as required and sufficient for tumo

126 consider the role telomerase may play in the hematopoietic system as well as the effect that over-exp

127 roles in the development and biology of the hematopoietic system, as evidenced by mouse and human ge

128 ong stem cells from different regions of the hematopoietic system at the same time during development

129 patients with malignancies of the kidney or hematopoietic system but are often accompanied by severe

130 lycans (HSPGs), is expressed by cells of the hematopoietic system but its role in leukocyte biology i

131 s selectively rescued in the endothelial and hematopoietic systems but not in the skeleton.

132 cacious for multiple genetic diseases of the hematopoietic system, but roughly half of clinical gene

133 facilitates postinjury recovery of the mouse hematopoietic system by promoting proliferation and faci

134 titutive or reversible ablation of A1 in the hematopoietic system by RNA interference.

135 nockdown of all A1 isoforms expressed in the hematopoietic system by RNA interference.

136 em cell fate decisions in the blood-forming (hematopoietic) system by providing a simple and broadly

137 ed both in the (micro)environment and in the hematopoietic system can accelerate thymic involution; h

138 adult angiogenic responses suggest that the hematopoietic system can be a source of endothelial cell

139 hat various tissues, especially parts of the hematopoietic system, can be rejuvenated.

140 aster regulatory transcription factor in the hematopoietic system, can result in a differentiation bl

141 induced by CpG in mice with a Stat3-ablated hematopoietic system cause potent antitumor effects, lea

142 RHAU deletion in hematopoietic system caused hemolytic anemia and differe

143 ere, we show that a deficiency of A20 in the hematopoietic system causes anemia, lymphopenia, and pos

144 Within the hematopoietic system, CD85j is expressed with cell-speci

145 ct its genomic and functional integrity, the hematopoietic system critically depends on the combined

146 The hematopoietic system declines with age, resulting in dec

147 The hematopoietic system declines with age.

148 IN can function as a tumor suppressor in the hematopoietic system: deletion of Atmin under the contro

149 Lineage specification in the hematopoietic system depends on the expression of lineag

150 nges and downregulation of genes involved in hematopoietic system development and function.

151 The hematopoietic system develops during embryogenesis at te

152 Correspondingly, mice lacking Sphk2 in the hematopoietic system display thrombocytopenia.

153 ) mouse model, BMT mice with a reconstituted hematopoietic system displayed increased susceptibility

154 imeric wild-type mice with a CG/NE-deficient hematopoietic system displayed significantly increased l

155 arction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic

156 ic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter.

157 icated in the establishment of the primitive hematopoietic system during mouse embryonic development.

158 Within the human hematopoietic system, expression of HDAC9 is biased towa

159 In mice, specific knockdown of SHIP1 in the hematopoietic system following retroviral delivery of a

160 LTR HSC can reconstitute the hematopoietic system for life, whereas STR HSC can susta

161 he ability of stem cells to reconstitute the hematopoietic system for many decades after the administ

162 athway represents a leading model within the hematopoietic system for the analysis of genetic network

163 critical factors that govern recovery of the hematopoietic system from stress, such as during antican

164 Within the hematopoietic system, Ghr is expressed in a highly HSC-s

165 ectively in the development of the mammalian hematopoietic system has been difficult to ascertain bec

166 ole of the tyrosine phosphatase SHP-1 in the hematopoietic system has been well studied; however, its

167 me time during development suggests that the hematopoietic system has evolved mechanisms to prevent t

168 a general role for the lipocalin 24p3 in the hematopoietic system has not been tested in vivo.

169 Therefore, strategies to rejuvenate the hematopoietic system have important clinical implication

170 ces in the understanding of the cells of the hematopoietic system have provided a rich basis for impr

171 velopment as well as normal functions of the hematopoietic system, heart, and kidney in adults.

172 In the adult hematopoietic system, HH signaling regulates intrathymic

173 such as the skin, gastrointestinal tract and hematopoietic system, homeostasis is dependent on the co

174 associated with degenerative diseases of the hematopoietic system, immunodeficiency, and neoplasia.

175 ems, make only a minimal contribution to the hematopoietic system in chimeras, indicating that hemato

176 marrow cells prior to reconstitution of the hematopoietic system in lethally irradiated mice.

177 by E2F transcription factors in a BM-derived hematopoietic system in mice, we uncovered a functional

178 ich aging of the stem cell population of the hematopoietic system in particular can create conditions

179 re, we review recent studies implicating the hematopoietic system in plexiform neurofibroma genesis,

180 s a juxtacrine homeostatic adaptation of the hematopoietic system in stress myelopoiesis.

181 nce for fractionation-induced sparing of the hematopoietic system in this study.

182 e Vav promoter to express MYC throughout the hematopoietic system in transgenic mice.

183 as warranted a therapeutic potential for the hematopoietic system in treating diseases of the CNS.

184 6 is expressed during the development of the hematopoietic system in vivo and in vitro and that its e

185 s that are able to initiate and maintain the hematopoietic system in vivo.

186 The hematopoietic systems in the irradiated recipients were

187 ion for innate and specific immunity, in the hematopoietic system, in cellular growth regulation, and

188 Many age-related changes in the hematopoietic system, in particular the clonal myeloid b

189 Human CMV (HCMV) uses members of the hematopoietic system including neutrophils for dissemina

190 S exposure induces persistent changes in the hematopoietic system independent of age at exposure.

191 e that P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitor

192 of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and

193 The development of the hematopoietic system is a dynamic process that is contro

194 Aging of the hematopoietic system is associated with an increased inc

195 Aging of the hematopoietic system is associated with myeloid malignan

196 The Drosophila hematopoietic system is composed of at least three class

197 However, the role of Dmtf1 in the hematopoietic system is entirely unknown.

198 Moreover, development of the hematopoietic system is exquisitely sensitive to the lev

199 The Drosophila larval hematopoietic system is founded by differentiated hemocy

200 neages and developmental stages of the adult hematopoietic system is lacking.

201 the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level.

202 on and physiological relevance in the murine hematopoietic system is nevertheless elusive.

203 Although the kinetics of recovery of the hematopoietic system is normal, HSCs in a SPARC-deficien

204 s, but the regulation of this process in the hematopoietic system is poorly understood.

205 in different tissues, its expression in the hematopoietic system is restricted to CD34+ stem cells.

206 the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S

207 cell fraction at the foundation of the adult hematopoietic system, is currently of great interest and

208 lays an important role in the development of hematopoietic system, it is less well understood whether

209 and p21 and to induce MDM2 expression in the hematopoietic system, its downstream targets in TNBC are

210 tion of Lis1 (also known as Pafah1b1) in the hematopoietic system led to a severe bloodless phenotype

211 turation of the various cell lineages of the hematopoietic system, less is known about factors that g

212 h beta-arrestin1 and -2 are expressed in the hematopoietic system, loss of beta-arrestin2 preferentia

213 The hematopoietic system matures from the fetal state, chara

214 that age-related changes in HSCs and in the hematopoietic system may not entirely be due to a degene

215 lopment of the cardiovascular, excretory and hematopoietic systems may be more closely related than p

216 Within the hematopoietic system, members of the Kruppel-like family

217 Overexpressing Lin28A in the mouse hematopoietic system mimicked the phenotype observed on

218 The fetal/neonatal hematopoietic system must generate enough blood cells to

219 In the hematopoietic system, mutations in IDH1 at arginine (R)

220 aracterized by the presence in the patient's hematopoietic system of a large cell population with a m

221 oietic cells lacking WT1 will repopulate the hematopoietic system of an irradiated adult recipient in

222 There are now numerous examples in the hematopoietic system of genes that are critical for norm

223 is their ability to reconstitute the entire hematopoietic system of hemoablated recipients.

224 riments showing that genetic deletion in the hematopoietic system of Janus kinase 2 (JAK2) abrogates

225 ficient LSK cells failed to reconstitute the hematopoietic system of lethally irradiated mice.

226 self-renewal and ability to reconstitute the hematopoietic system of lethally irradiated mice.

227 s were unable to adequately reconstitute the hematopoietic system of lethally irradiated recipients.

228 dressed these questions by investigating the hematopoietic system of mice deficient for Rev1, a core

229 The hematopoietic system of mice is established during the e

230 Analysis of the hematopoietic system of mice with the Apc(min) allele th

231 ifferentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time.

232 has enabled HSCs to be used to replenish the hematopoietic system of patients after chemotherapy or r

233 the leukemogenic potential of SET-CAN in the hematopoietic system of transgenic mice.

234 sage on adult hematopoiesis, we compared the hematopoietic systems of AML1+/- and AML1+/+ mice.

235 The hematopoietic system offers many advantages as a model f

236 NF can be effectively supplied by either the hematopoietic system or the CNS, but the essential TNFR1

237 D88 deletion, predominantly in the liver and hematopoietic system, or were crossed with Akr1b7 Cre tr

238 idence indicates that cells derived from the hematopoietic system participate in angiogenesis.

239 egulate cell fate decisions in the mammalian hematopoietic system, playing crucial roles in stem cell

240 The hematopoietic system plays a major role in human health.

241 We show here that, within the hematopoietic system, Prdm16 is expressed very selective

242 nown role in defense and debris removal, the hematopoietic system provides critical regenerative driv

243 The hematopoietic system provides numerous examples attestin

244 e find that inhibition of let-7 in the adult hematopoietic system recapitulates fetal erythroid-domin

245 We find that deletion of SPPL3 in the hematopoietic system reduces numbers of peripheral NK ce

246 angiopoietin-like proteins (Angptls) in the hematopoietic system remain unknown.

247 the mechanistic basis for its impact on the hematopoietic system remains largely unresolved.

248 represent the most primitive elements of the hematopoietic system, responsible for long-term maintena

249 Widespread inactivation of RB in the murine hematopoietic system resulted in profound myeloprolifera

250 Dpy30 loss in the adult hematopoietic system results in severe pancytopenia but

251 gp96/grp94 deletion in the murine hematopoietic system results in thrombocytopenia, prolon

252 The hematopoietic system's myeloid bias was reflected by inc

253 n highly proliferative organs, including the hematopoietic system, small intestine, and testes.

254 nt a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, pr

255 gp96 is also essential for expression of 14 hematopoietic system-specific integrins.

256 l vector HSPC gene therapy generates a human hematopoietic system stably marked at the clonal level b

257 As extensively demonstrated in the hematopoietic system, stem cell repopulation is hierarch

258 In the hematopoietic system, stem cells are characterized by us

259 The hematopoietic system sustains regeneration throughout li

260 In the hematopoietic system, TGF-beta signaling controls a wide

261 To identify the principal components of the hematopoietic system that are radioprotective, we transp

262 nvolves a tumor/stromal interaction with the hematopoietic system that depends, at the molecular leve

263 Macrophages are versatile cells of the hematopoietic system that display remarkable functional

264 ata annotate developmental mechanisms in the hematopoietic system that enable a decision to be made e

265 n stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is beli

266 CSF) is an endogenous peptide hormone of the hematopoietic system that has been shown to be neuroprot

267 CSF) is an endogenous peptide hormone of the hematopoietic system that has entered Phase I/II clinica

268 ically significant conditions arising in the hematopoietic system that include: diminution and decrea

269 hich can be alleviated by restoration of the hematopoietic system that is also defective in E2f1-/-E2

270 ochromic, microcytic anemia intrinsic to the hematopoietic system that is associated with a decreased

271 AML) is an autosomal dominant disease of the hematopoietic system that is caused by heterozygous muta

272 To elucidate the properties of an aged human hematopoietic system that may predispose to age-associat

273 The only cells of the hematopoietic system that undergo self-renewal for the l

274 In the hematopoietic system, the ANS regulates stem cell niche

275 dicate that although widely expressed in the hematopoietic system, the expression of Runx1 is regulat

276 n, differentiation, and proliferation in the hematopoietic system, the intestine, the pancreas, and t

277 nd because they are broadly expressed in the hematopoietic system, their targeting may have unwanted

278 nerating immunocompromised mice with a human hematopoietic system, there are still several shortcomin

279 patterns of stem cell divisions in the human hematopoietic system throughout life.

280 s to assess activity and distribution of the hematopoietic system throughout the whole skeleton of re

281 receptor nuclear translocator (ARNT) in the hematopoietic system to ablate activity of both HIF-1alp

282 homeostasis and highlight the ability of the hematopoietic system to respond to stress without signif

283 ctional genomic approaches in the Drosophila hematopoietic system to systematically identify oncogene

284 d with deficits in neurodevelopment and with hematopoietic system toxicity.

285 ding of the accumulation of mutations in the hematopoietic system upon aging.

286 xpressed from its endogenous promoter in the hematopoietic system using a conditional allele and IFN-

287 determined that CFU-ECs are derived from the hematopoietic system using progenitor assays, and analys

288 rs (CMPs) by deletion of Atmin in the entire hematopoietic system using Vav-Cre.

289 Beyond the hematopoietic system, Usp3Delta/Delta animals spontaneou

290 xposure and bone marrow transplantation, the hematopoietic system was successfully reconstituted over

291 In the hematopoietic system, we defined critical decision point

292 ne the role of MLL in the development of the hematopoietic system, we examined the potential of cells

293 manull (NSG) mice reconstituted with a human hematopoietic system, we were able to discriminate the r

294 d that the effects of TCDD on the developing hematopoietic system were mediated by direct AHR activat

295 This is particularly true of the hematopoietic system, where demands on host defenses can

296 TL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle repr

297 erated telomere shortening restricted to the hematopoietic system, which affects the baseline TL of a

298 defects in the development of the zebrafish hematopoietic system, which could be partially rescued b

299 Thus, Mi-2beta provides the hematopoietic system with immune cell capabilities as we

300 R/R) mice display altered development of the hematopoietic system without enhanced tumor susceptibili