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1 iverdin requires oxygen for its synthesis by heme oxygenase.
2 d to the upstream gene hemO, which encodes a heme oxygenase.
3 m-positive bacteria that possess IsdG-family heme oxygenases.
4 al cytochrome P450 (P450) monooxygenases and heme oxygenases.
5 ikely common intermediate with the canonical heme oxygenases.
6 cts differ from those generated by canonical heme oxygenases.
8 We showed that variation in basal levels of heme oxygenase 1 (HMOX1) contribute to the response to O
9 ed reduced progesterone levels and placental heme oxygenase 1 (Hmox1) expression and increased methyl
11 nscriptional repressor, negatively regulates heme oxygenase 1 (HMOX1), a key cytoprotective enzyme th
12 h regulates the expression of genes encoding heme oxygenase 1 (Hmox1), glutamate-cysteine ligase cata
14 ctivated protein (MAP) kinase, expression of heme oxygenase 1 (HO-1) and cyclooxygenase 2 (COX-2), an
15 ession of heat-shock protein 70 (HSP-70) and heme oxygenase 1 (HO-1) and promoted cell survival after
17 ctor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues
18 investigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanism by us
20 (hIL-10R) by cmvIL-10 led to upregulation of heme oxygenase 1 (HO-1), an enzyme linked with suppressi
21 overexpression of the heme-degrading enzyme, heme oxygenase 1 (HO-1), has been shown to protect mice
22 NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical chemoprotective gene pr
24 on a key enzyme involved in heme catabolism, heme oxygenase 1 (HO-1), which, ironically, has been poo
30 kers (matrix metalloproteinase 1 [MMP-1] and heme oxygenase 1 [HO-1]), and proinflammatory cytokines
31 The carboxyhemoglobin level (a measure of heme oxygenase 1 activity) has not been assessed in adul
33 orresponded with increases in cytoprotective heme oxygenase 1 and IL-10 mRNAs, selective reductions i
34 ential for linked antioxidant protection via heme oxygenase 1 and reduced foam cell formation via liv
36 ion, hypoxia-inducible factor 1alpha-induced heme oxygenase 1 expression resulting in improved surviv
37 athione S-transferase (GST) genes as well as heme oxygenase 1 gene (HMOX1) encode enzymes that detoxi
38 med a systematic review and meta-analysis of heme oxygenase 1 gene (HO-1) promoter polymorphisms and
39 ssion of hypoxia-inducible factor 1alpha and heme oxygenase 1 in the hippocampus was increased in the
40 Cobalt protoporphyrin (CoPP), a well known heme oxygenase 1 inducer, has been used to promote endog
42 ples for hypoxia-inducible factor 1alpha and heme oxygenase 1, and 4) immunohistochemistry of hippoca
43 H(2)O(2), concomitant with up-regulation of heme oxygenase 1, COX-2, and anti-apoptotic proteins (BC
46 most robustly increased genes and proteins, heme oxygenase 1, NADPH-quinone oxidoreductase 1, and gr
47 ulation of H2A histone family, member X, and heme oxygenase 1, which were experimentally validated as
49 ncreased inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased MDA and plasm
50 ncreased inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased plasma creati
51 f Bcl-2 (5.5-folds), Bcl-xl (5.5-folds), and heme oxygenase-1 (4.4-folds); decreased expression of IC
53 adenoassociated virus (rAAV)-encoding human heme oxygenase-1 (hHO-1) in attenuating post-ischemic in
54 n (HP), cluster of differentiation (CD) 163, heme oxygenase-1 (HMOX1), and biliverdin reductase A (BL
55 genes increased in the DKO liver, including heme oxygenase-1 (Hmox1), which disrupts complex III and
57 per-zinc superoxide dismutase (CuZnSOD), and heme oxygenase-1 (HO-1) (antioxidant enzymes) were reduc
60 f2, NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax.
61 production of antioxidant enzymes, including heme oxygenase-1 (HO-1) and glutathione peroxidase 1 (Gp
66 nd to oxidative stress-induced expression of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreducta
67 cells by the regulations of novel molecules heme oxygenase-1 (HO-1) and programmed death-1 ligand 1
69 a hypoxia-inducible plasmid expressing both heme oxygenase-1 (HO-1) and the Src homology domain-2 co
71 AC and selected reaction monitoring revealed heme oxygenase-1 (HO-1) as the most significantly up-reg
72 he cytoprotective and antiapoptotic molecule heme oxygenase-1 (HO-1) at the transcriptional level.
80 a, urine, and tissues, which in turn induces heme oxygenase-1 (HO-1) expression in the colonic epithe
82 vitro study showed that adiponectin induced heme oxygenase-1 (HO-1) expression through the peroxisom
84 ase expression, nitric oxide production, and heme oxygenase-1 (HO-1) expression, which was associated
86 al injury, and inhibited RPTC Nrf2, Agt, and heme oxygenase-1 (HO-1) gene expression in Akita Cat tra
89 lective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of novel GFAP.HMOX
90 the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implic
91 of NO induce the anti-inflammatory effector heme oxygenase-1 (HO-1) in gastric epithelial cells thro
92 of the cytoprotective, heme-degrading enzyme heme oxygenase-1 (HO-1) in neutrophil progenitors in bon
93 e antioxidative and anti-inflammatory enzyme heme oxygenase-1 (HO-1) in the brains of individuals wit
94 ed a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic
95 uanosine (8OHG), 4-hydroxynonenal (HNE), and heme oxygenase-1 (HO-1) in the pyramidal neurons of the
112 The stress-inducible cytoprotective enzyme heme oxygenase-1 (HO-1) may play a critical role in the
114 ukin-8 (IL-8), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) mRNA was measured in BEAS-2B cel
115 Treatment with CRA at nontoxic doses induced heme oxygenase-1 (HO-1) mRNA/protein expression and HO-1
116 of inducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogen
118 overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the grow
121 Only overexpression of the gene encoding heme oxygenase-1 (HO-1) significantly correlated with in
123 y amplified in human breast cancers, induced heme oxygenase-1 (HO-1) through Nrf2 transactivation in
125 erythroid 2p45-related factor-2 (Nrf2), and heme oxygenase-1 (HO-1) was tested in both in vitro and
126 up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1) which is capable of mitigating a
127 amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP
128 d that PRRSV downregulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme
132 ter antioxidant transcription factor, and of heme oxygenase-1 (HO-1), one of its main target genes, i
133 ome solid tumors and myeloid leukemia cells, heme oxygenase-1 (HO-1), the anti-oxidant, anti-inflamma
134 attention as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the c
136 ported in a human patient and mice that lack heme oxygenase-1 (HO-1), we studied iron distribution an
137 Many cancer cells constitutively express heme oxygenase-1 (HO-1), which catabolizes heme to gener
138 is the up-regulation of the inducible enzyme heme oxygenase-1 (HO-1), which catabolizes heme to gener
139 Intracellular heme levels are regulated by heme oxygenase-1 (HO-1), which catalyzes the degradation
141 ng expression of the stress response protein heme oxygenase-1 (HO-1), which interacts with and thereb
150 is generated by the stress-responsive enzyme heme oxygenase-1 (HO-1, encoded by Hmox1), which is high
154 quality control is regulated in part by the heme oxygenase-1 (HO-1; Hmox1) system through the redox-
157 ranofin displayed synergistic lethality with heme oxygenase-1 and glutamate-cysteine ligase inhibitor
159 e discuss here new insights into the role of heme oxygenase-1 and heme on cardiovascular health, and
160 ontractility rather than passive stretch via heme oxygenase-1 and histone deacetylase signalling.
161 d4 to Nrf2-binding sites on the promoters of heme oxygenase-1 and NADPH quinone oxidoreductase 1.
162 rf2 or DJ-1 attenuated Cu((II))ATSM-mediated heme oxygenase-1 and NADPH quinone oxidoreductase-1 indu
163 into the nucleus to induce transcription of heme oxygenase-1 and other cytoprotective enzymes throug
166 arkable cardioprotective effects ascribed to heme oxygenase-1 are best evidenced by its ability to re
168 le to upregulate the atheroprotective enzyme heme oxygenase-1 at the RNA and protein level in respons
169 nhancing expression of the IL-10 target gene heme oxygenase-1 by mechanisms dependent on p38 MAPK act
172 enhances its paracine effects on RIII via a heme oxygenase-1 dependent mechanism, which may help us
174 s, whereas treatment with carbon monoxide, a heme oxygenase-1 enzymatic product, abrogated this effec
175 als treated with tin protoporphyrin (SnPP, a heme oxygenase-1 enzyme inhibitor), even after Ad.Trx1 t
178 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coro
179 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with cardio
180 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with higher
184 duced expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-i
185 vivo and IRAK-M(-/-) AECs in vitro with the heme oxygenase-1 inhibitor, tin protoporphyrin, substant
186 a 7-day doxycycline treatment sustained high heme oxygenase-1 levels during the entire period of hypo
190 related with CO in the breath were levels of heme oxygenase-1 protein in serum and HMOX1 transcripts
191 ted bitransgenic mice that overexpress human heme oxygenase-1 under doxycycline control in an inducib
196 ated protein 78), and the antioxidant enzyme heme oxygenase-1 were decreased, whereas levels of infla
197 tide phosphate:quinone oxidoreductase 1, and heme oxygenase-1 were lower in group 2 than group 3.
198 ioxidant enzymes peroxiredoxin-2 (Prdx2) and heme oxygenase-1 were upregulated in cd36-/- VSMCs.
200 based proteomics screen, we identified HO-1 (heme oxygenase-1), the rate-limiting enzyme in the degra
201 ) mice have increased expression/activity of heme oxygenase-1, a phase II antioxidant, and NF (erythr
202 aimed to investigate the mechanisms by which heme oxygenase-1, an anti-inflammatory enzyme, is protec
203 , despite significantly higher expression of heme oxygenase-1, an antioxidant and cytoprotective enzy
204 ntioxidant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including
205 ed anti-inflammatory factors interleukin-10, heme oxygenase-1, and Hsp70 in macrophages stimulated or
206 ing IL-1ra, IL-10, and PGE(2), but not IL-6, heme oxygenase-1, and NO, attenuated 5-FU-MSC-induced im
208 lation of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-kappaB inh
210 ation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE f
211 expression of Nrf2-dependent genes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic su
212 tor-kappaB, hypoxia-inducible factor-1alpha, heme oxygenase-1, inducible nitric oxide synthase, B-cel
213 ction, by overcoming its negative regulator, heme oxygenase-1, is a key underlying mechanism responsi
214 itochondrial superoxide dismutase (SOD), and heme oxygenase-1, mucosal receptors such as the Toll-lik
215 e regulation of key Nrf2 target genes (i.e., heme oxygenase-1, NAD(P)H dehydrogenase, quinone 1, glut
216 ificantly upregulates Nrf2-responsive genes, heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and
217 n and expression of the antioxidant proteins heme oxygenase-1, NADPH quinone oxidoreductase 1, and gl
218 such as superoxide dismutase, nitric oxide, heme oxygenase-1, neutrophil infiltration, cysteamine, m
219 -dependent gene and protein markers, such as heme oxygenase-1, occurred, whereas Nrf2-deficient fibro
220 es that impair liver regeneration, including heme oxygenase-1, programmed cell death 4, and the cycli
221 myocardial overexpression of thioredoxin-1, heme oxygenase-1, vascular endothelial growth factor, an
222 pression levels of survival genes, Bcl-2 and heme oxygenase-1, were analyzed by gene array analysis a
231 the CX3CR1 receptor induced upregulation of heme-oxygenase-1 (HMOX-1), an antioxidant and anti-infla
232 Q61L) mutant induced the anti-oxidant enzyme heme-oxygenase-1 (HO-1) through activation of NRF2.
235 ntrol animals, and inhibiting the HIF target heme-oxygenase-1 before IR reduced GFR in STN animals.
236 with higher substrate affinity of the enzyme heme oxygenase 2, whereas SH rats present lower substrat
238 Furthermore, evidence suggests that human heme oxygenase-2 (HO2) acts as an oxygen sensor and CO d
239 ate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myrist
244 s sp. strain PCC 7002 comprises two enzymes: heme oxygenase and phycocyanobilin synthase (PcyA).
245 Tetrapyrrole substrates and products of heme oxygenase are potent inhibitors of hepatitis C viru
246 xide synthase, type 1 heme oxygenase, type 2 heme oxygenase, Bax, and Bcl-2 protein and mRNA expressi
247 , homologs of which have been proposed to be heme oxygenases, did not eliminate (13)C-BV IXdelta and
250 antibacterial effects while CO, generated by heme oxygenases, enhances phagocytosis of macrophages.
251 acquires the following characteristics of a heme oxygenase enzyme: (a) donation by His429 of an addi
254 screened, we found that hemin, an inducer of heme oxygenase, functions as a break to control AT(1)-AA
255 her outbreak isolates were found to harbor a heme oxygenase gene (hemO)-containing gene cluster.
256 ve previously shown the catalytic actions of heme oxygenase (HemO) along with the cytoplasmic heme tr
257 stant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to
261 ies production and upregulated expression of heme oxygenase HO-1 (HMOX1), an indicator of oxidative s
262 We hypothesize that in beta-thalassemia heme oxygenase (HO) 1 could play a pathogenic role in th
263 ibited activity of the renoprotective enzyme heme oxygenase (HO) and determined the effects on renal
269 n), astrocyte activation, IgG extravasation, heme oxygenase (HO), iron deposition, oxidative end prod
272 At the molecular level, the expression of heme oxygenase (HO)-1 and the secretion of stromal cell-
273 cold-ischemic transplant injury, but whether heme oxygenase (HO)-1 induction is an underlying mechani
275 the expression of antioxidant genes, such as heme oxygenase (HO)-1, that protect parasites from oxida
276 , IL-4, and IL-6 and oxidative stress marker heme oxygenase (HO)-1, were higher in WD+VDD versus WD a
280 embrane potential and increases in cytosolic heme oxygenase (HO-1) expression and mitochondrial coloc
282 s that interact with HIV-1 MA, we found that heme oxygenase (HO-2) specifically binds the myristate m
283 nduces expression of the CO-producing enzyme heme oxygenase (HO1) and that CO is sensed by M. tubercu
286 CO scavenger oxyhemoglobin (20 muM) and the heme oxygenase inhibitor chromium mesoporphyrin IX (CrMP
287 used by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-
288 mparable in both types of donors, the type 1 heme oxygenase mRNA expression and antioxidant enzyme ac
289 flux of extracellular heme through the HemO heme oxygenase, resulting in more-efficient heme utiliza
293 HO-1 inhibits autophagy, suggesting that the heme oxygenase system may contain therapeutic targets fo
296 that B. abortus 2308 has at least one other heme oxygenase that works in concert with BhuQ to allow
298 ase, inducible nitric oxide synthase, type 1 heme oxygenase, type 2 heme oxygenase, Bax, and Bcl-2 pr
300 n the kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies.
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