ライフサイエンスコーパス: hemidesmosomal

1 ted with autoantibodies directed against the hemidesmosomal Ags BP180 and BP230.

2 Hemidesmosomal alpha3- and beta4-integrin levels were no

3 n cytoskeleton and reduced the expression of hemidesmosomal alpha6/beta4-integrins.

4 diseases in which autoantibodies target the hemidesmosomal antigen BP180 and desmosomal antigens Dsg

5 BP was induced in mice by antibodies to the hemidesmosomal antigen BP180.

6 ted with autoantibodies directed against the hemidesmosomal antigens anti-BP230 and anti-B180.

7 -bound and circulating autoantibodies to the hemidesmosomal antigens BP180 and BP230.

8 Previous sequence analyses of hemidesmosomal BP 180/collagen XVII cDNA from human skin

9 We have shown that these hemidesmosomal complexes are lost in prostate carcinoma,

10 of intermediate keratin filament network to hemidesmosomal complexes.

11 py using mAbs specific for this integrin and hemidesmosomal components and its loss from a cytokerati

12 ocalize with hemidesmosome proteins, whereas hemidesmosomal components in cells expressing GFP-beta4K

13 ed no major abnormalities in localization of hemidesmosomal components, but desmosomal components org

14 asal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, fr

15 rescued the alterations in the deposition of hemidesmosomal components, such as plectin, collagen typ

16 Many desmosomal and hemidesmosomal constituents are phosphoproteins and in c

17 4 subunit mediates both association with the hemidesmosomal cytoskeleton and recruitment of the signa

18 ibutes to failure of anchoring filaments and hemidesmosomal formation.

19 s, is known to be caused by mutations in the hemidesmosomal genes ITGA6 and ITGB4, which encode the a

20 l electrophoresis, co-migrated with BP180, a hemidesmosomal glycoprotein associated with two other au

21 n occurs intracellularly at the level of the hemidesmosomal inner plaque, which contains plectin, a h

22 e mutation, p.Gln1124X, leads to the loss of hemidesmosomal inner plaques and a complete absence of s

23 isoform that led to ultrastructural loss of hemidesmosomal inner plaques and clinical features of tr

24 on of EGF receptor (EGF-R) combines with the hemidesmosomal integrin alpha6beta4 in both normal and n

25 family, was shown to form a complex with the hemidesmosomal integrin alpha6beta4.

26 either the beta 4 integrin subunit or HD1, a hemidesmosomal plaque component, showed that in control

27 s in the ITGA6 and ITGB4 genes, encoding the hemidesmosomal protein alpha6beta4-integrin, have been i

28 characterized by autoantibodies against the hemidesmosomal protein BP180 (BPAg2, type XVII collagen)

29 mediated by antibodies directed against the hemidesmosomal protein BP180 (collagen XVII, BPAG2), and

30 al separation triggered by antibodies to the hemidesmosomal protein BP180 (collagen XVII, BPAG2).

31 characterized by autoantibodies against the hemidesmosomal protein BP180.

32 iated with an IgG autoimmune response to the hemidesmosomal protein BP180.

33 sociated autoimmune skin disease, target the hemidesmosomal protein BP180.

34 ssion of type XVII collagen, a transmembrane hemidesmosomal protein encoded by COL17A1.

35 Laminin 5 is a pivotal hemidesmosomal protein involved in cell stability, migra

36 The quest for the function of BPAG1, a major hemidesmosomal protein of skin keratinocytes, has led to

37 n the plectin gene (PLEC1), encoding another hemidesmosomal protein previously linked to EB with musc

38 A hemidesmosomal protein regulates actin dynamics and trac

39 a4 integrin (ITGB4), and in the gene for the hemidesmosomal protein type XVII collagen (COL17A1/BPAG2

40 iated with an IgG autoimmune response to the hemidesmosomal protein, BP180.

41 ted with autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 and inflammation

42 y the presence of autoantibodies against the hemidesmosomal proteins BP230 and BP180.

43 e associated with autoantibodies against two hemidesmosomal proteins, BP180 and BP230.

44 e does not affect expression levels of other hemidesmosomal proteins, nor the amount of beta4 integri

45 ntified in the BPAG2/COL17A1 gene encoding a hemidesmosomal transmembrane protein, the 180 kDa bullou

46 h late-onset muscular dystrophy (EB-MD) is a hemidesmosomal variant of EB due to mutations in the ple