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1 is a type II transmembrane component of the hemidesmosome.
2 ane via a multimolecular junction called the hemidesmosome.
3 BTB dynamics directly and/or indirectly via hemidesmosome.
4 180 into the cell surface at the site of the hemidesmosome.
5 els formed ample numbers of normal appearing hemidesmosomes.
6 beling, and there was variable hypoplasia of hemidesmosomes.
7 expressed in the lens, but in the absence of hemidesmosomes.
8 presence of junctional blisters and abnormal hemidesmosomes.
9 nced by less abundant and irregularly spaced hemidesmosomes.
10 ning the same peptide, they fail to assemble hemidesmosomes.
11 so becomes competent to nucleate assembly of hemidesmosomes.
12 ha6 beta4 integrin, an integral component of hemidesmosomes.
13 e epidermis to the basement membrane through hemidesmosomes.
14 s pathway, and with cytoskeletal elements of hemidesmosomes.
15 the failure to form anchoring filaments and hemidesmosomes.
16 e in adherence, even though they do not form hemidesmosomes.
17 ion components cause incomplete formation of hemidesmosomes.
18 normal alpha6beta4 integrin clustering into hemidesmosomes.
19 ckout mice, leading to restored formation of hemidesmosomes.
20 ing that the defect was in reassembly of the hemidesmosomes.
21 herin to adherens junctions and myotactin to hemidesmosomes.
22 1109) that is unable to assemble into mature hemidesmosomes.
23 s critical for the ability of EGF to disrupt hemidesmosomes.
24 ve mua-6 null allele localizes to hypodermal hemidesmosomes.
25 signaling, alpha6beta4 mediates assembly of hemidesmosomes.
26 alpha6beta4-mediated adhesion or assembly of hemidesmosomes.
27 scopy revealed rudimentary, poorly developed hemidesmosomes.
28 d muscle-induced tension transmitted through hemidesmosomes.
29 pha 6 beta 4 is involved in BM anchorage via hemidesmosomes.
30 phosphorylation of beta4 and disassembly of hemidesmosomes.
31 tained beta3 expression and the formation of hemidesmosomes.
32 e beta4 cytoplasmic domain and disruption of hemidesmosomes.
33 hc and signaling to ERK but not formation of hemidesmosomes.
34 K14(+) cells were enriched for desmosome and hemidesmosome adhesion complex genes, and were depleted
35 in prevents reassembly of the BMZ and mature hemidesmosomes after keratectomy in beta6(-/-) mice.
36 and bullous pemphigoid antigen 2 within the hemidesmosomes along the basolateral surface of the epit
39 required for keratin filament linkage to the hemidesmosome, an adhesion complex in epithelial basal c
42 ly, basal cell markers, including integrins, hemidesmosome and extracellular matrix components, are s
43 dermal blister formation at the level of the hemidesmosome and is associated with a myopathy of unkno
44 rs gamma-tubulin and NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongatio
45 ermis of these mice contains well-structured hemidesmosomes and adheres stably to the basement membra
48 alpha6beta4 integrin, decreased formation of hemidesmosomes and decreased assembly of the actomyosin
49 ysis of superficial cells, but the number of hemidesmosomes and desmosomes are normal in basal and su
50 alpha 6 beta 4 in the formation of complete hemidesmosomes and in stable adhesion of basal keratinoc
51 ous cell carcinoma cells, which have reduced hemidesmosomes and increased beta4 phosphorylation, an i
52 e that this mobilization of alpha6beta4 from hemidesmosomes and its redistribution to cell protrusion
53 sing dominant negative Fyn display increased hemidesmosomes and migrate poorly in vitro in response t
54 at specialized adhesive structures known as hemidesmosomes and plays a critical role in diverse epit
55 in-a laminin-5 receptor-mediates assembly of hemidesmosomes and recruitment of Shc and phosphoinositi
56 n, bradykinin, or acetylcholine can increase hemidesmosomes and reduce beta4 phosphorylation in a cal
57 aling of the skin, keratinocytes disassemble hemidesmosomes and reorganize their actin cytoskeletons
58 (1364) reduced the ability of EGF to disrupt hemidesmosomes and that this effect appears to involve c
60 GFP-beta4WT) into 804G cells, which assemble hemidesmosomes, and human endothelial cells, which expre
61 in the basal keratinocytes that connected to hemidesmosomes, and on the dermal side both collagen fil
62 , as seen by a nearly complete lamina densa, hemidesmosomes, and the polarized, linear distribution o
63 d keratinocytes reveals abundant desmosomes, hemidesmosomes, and the production of a basal lamina.
64 structural functions, invertebrate and human hemidesmosomes are actively monitored by the cell as a n
67 alized cell junctions such as desmosomes and hemidesmosomes are mediated through the so-called plakin
70 , the alpha6beta4 integrin is mobilized from hemidesmosomes as evidenced by indirect immunofluorescen
72 alpha6beta4 integrin plays a crucial role in hemidesmosome assembly by binding to laminin-5 in the ba
73 ilitates basement membrane assembly, but not hemidesmosome assembly, in the laminin 5-rich dermal-epi
75 LAMB3, and LAMC2), in the gene encoding the hemidesmosome-associated beta4 integrin (ITGB4), and in
79 beta 4 couple with BPAG1-e and BPAG2 to form hemidesmosomes, attaching externally to laminin and inte
81 rin alpha6beta4 is an essential component of hemidesmosomes but it also plays a dynamic role in invas
82 atment does not induce increased assembly of hemidesmosomes, but instead causes a deterioration of th
83 suggest that the EGF-R causes disassembly of hemidesmosomes by activating Fyn, which in turn phosphor
85 80 and certain cytoplasmic components of the hemidesmosome colocalize in the peptide-treated cells, t
89 s is the first crystal structure of either a hemidesmosome component or an integrin cytoplasmic domai
90 olecule and compared it to the transmembrane hemidesmosome component, alpha 6 beta 4 integrin, and to
93 d by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the under
96 s BP230) is a member of the plakin family of hemidesmosome cytoskeletal linker proteins that is encod
97 cells produce lamellae, their basal type II hemidesmosomes disappear and the alpha6 integrins appear
98 Epidermal growth factor (EGF) can induce hemidesmosome disassembly by a mechanism that involves s
99 the mechanism and functional significance of hemidesmosome disassembly during normal epithelial cell
100 siRNA increase beta4 phosphorylation, induce hemidesmosome disassembly, and increase migration in HaC
101 serine phosphorylation in regulating type II hemidesmosome disassembly, implicate a cluster of serine
105 reduces beta4 phosphorylation and stabilizes hemidesmosomes, effects that are reversed by CsA, indica
106 lation of alpha6 or beta4 results in loss of hemidesmosomes, epidermal polarity, and basement membran
108 partic acid mutation of beta4 T1736 impaired hemidesmosome formation in junctional epidermolysis asso
111 luated by immunofluorescence microscopy, and hemidesmosome formation was assessed by electron microsc
112 Accordingly, clint1 mutants show impaired hemidesmosome formation, loss of cell-cell contacts and
123 ent adhesion molecules, whereas those in the hemidesmosome include the integrin class of cell matrix
125 massive failure of BM assembly/organization, hemidesmosome instability, and a failure of hair follicl
126 c migration of carcinoma cells that assemble hemidesmosomes involves the activation of a signaling pa
128 6beta4, the primary transmembrane protein of hemidesmosomes, is also expressed in the lens, but in th
129 ds to assess certain morphologic features of hemidesmosome-keratin intermediate filaments interaction
130 further assess the role of beta1-integrin in hemidesmosome, knockdown of beta1-integrin in Sertoli ce
132 ion of adhesion molecule BP180 and defective hemidesmosomes, leading to detachment of corneal epithel
134 rich in mitochondria and had desmosome- and hemidesmosome-like junctions with other axons and retina
136 IL-8 production and decreasing the number of hemidesmosomes localized at the basement membrane zone.
137 These results suggest that disruption of hemidesmosomes mediated by Fyn is a prerequisite for nor
138 lexes and a decrease of 44% in the number of hemidesmosomes/microm of membrane from samples prepared
139 ne phosphorylation of beta4 and disrupts the hemidesmosomes of 804G cells expressing recombinant wild
141 rts a decreasing degree of inhibition on the hemidesmosomes of cells expressing versions of beta(4) c
142 that traverses the lamina lucida beneath the hemidesmosomes of epidermal cells and functions to link
143 UNC-52/Perlecan linked the dense body to the hemidesmosome on the hypodermal cells, which in turn ins
145 rotubules were essential for elongation when hemidesmosomes or the activity of the Rho kinase LET-502
148 14 days of age, although the total number of hemidesmosomes per microm of epithelial plasmalemma was
152 the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cel
153 P-beta4WT and GFP-beta4V284E colocalize with hemidesmosome proteins, whereas hemidesmosomal component
156 ajor epidermal integrins are alpha3beta1 and hemidesmosome-specific alpha6beta4; both share laminin 5
158 primarily on its role in the organization of hemidesmosomes, stable adhesive structures that associat
159 nding of autoantibodies to components of the hemidesmosome structure, resulting in an inflammatory re
161 certain critical intracellular functions of hemidesmosomes, such as the normal connections with kera
162 toward a pathogenic epitope on the epidermal hemidesmosome that anchors basal keratinocytes to the ba
163 o those interactions of the molecules of the hemidesmosome that are necessary for its function in int
164 rix protein integral to the formation of the hemidesmosomes that attach normal basal cells to the und
165 surface in structures referred to as type II hemidesmosomes that persist throughout this early stage.
166 lpha 6 beta 4 integrin is a component of the hemidesmosome, the anchoring structure in the basal memb
168 thogenic rabbit antibody directed toward the hemidesmosome to beta2m-deficient mice and to normal con
170 atrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of integrins with fibr
171 ioned whether this intracellular function of hemidesmosomes was also perturbed in junctional epidermo
173 h prominent microvilli, tight junctions, and hemidesmosomes were more pronounced in air-lifted cultur
175 mbly of cell- matrix adhesive devices called hemidesmosomes when other cells are plated upon them.
176 somes), and pemphigoid antigens are found in hemidesmosomes (which mediate adhesion to the basement m
177 hin keratinocytes; alpha6beta4 is present in hemidesmosomes, while alpha3beta1 is recruited into foca
178 id (BP), is a transmembrane component of the hemidesmosome with a collagen-like extracellular domain.
179 phosphorylation of beta4 and disassembly of hemidesmosomes without interfering with the activation o
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