ライフサイエンスコーパス: hemin

1 ze the adverse physiologic effects of Hb and hemin.

2 or RNA G-quadruplexes (G4) and the cofactor hemin.

3 se pulldown assays showed that Abc3 binds to hemin.

4 nd 100 times better than that of unsupported hemin.

5 onferring resistance to the toxic effects of hemin.

6 gastric emptying reversed by the HO1 inducer hemin.

7 e secreted by P. aeruginosa (apo-HasAp) with hemin.

8 77 affected HO-1 levels after induction with hemin.

9 oximately 10(-13) M) of native apoMb (N) for hemin.

10 e HO-1 protein expression in the presence of hemin.

11 sponsive to an environmental signal, such as hemin.

12 its greater ability to acquire host-derived hemin.

13 h other ARE-activating agents ethoxyquin and hemin.

14 tein, spin labeling, and reconstitution with hemin.

15 in hem15Delta cells cultured in supplemental hemin.

16 apoglobin that is capable of rapidly binding hemin.

17 vitro by incubating isolated apoprotein with hemin.

18 o solvent (k transfer = 54.3 s(-1) versus k -hemin = 0.00076 s(-1)).

19 rement among bacteria, but the mechanisms of hemin acquisition are poorly defined.

20 uced by phenylhydrazine-induced hemolysis or hemin administration.

21 uggested that the combination of HNE and low hemin affinity facilitated rapid decomposition of prefor

22 lative importance of apoglobin stability and hemin affinity.

23 to enhance apoglobin stability but decrease hemin affinity.

24 there is little dependence of expression on hemin affinity.

25 overall equilibrium folding constant and not hemin affinity.

26 ngle-molecule redox reaction dynamics at the hemin-Ag interface is primarily driven by thermal fluctu

27 bc3 as vacuolar hemin exporter, results with hemin-agarose pulldown assays showed that Abc3 binds to

28 ther analysis by absorbance spectroscopy and hemin-agarose pulldown assays showed that Shu1 interacts

29 c tumor cell survival assay, SSRBC surrogate hemin, along with H(2)O(2) and ZnPP demonstrate a simila

30 HO-1 induction with hemin also markedly decreased HCV replication in both pa

31 capturing carcinoembryonic antigen (CEA) and hemin, an all-in-one dual-aptasensor with 1,1'-oxalyldii

32 catalyse the NAD(P)H-dependent reduction of hemin, an indication that the protein's role may be to c

33 among all the drugs screened, we found that hemin, an inducer of heme oxygenase, functions as a brea

34 In vivo treatment with hemin, an inducer of HO-1, blocked the vascular hypertro

35 ia and other cell types after treatment with hemin, an iron-containing porphyrin.

36 gic regulator of glomerular DAF and identify hemin analogues as inducers of functional glomerular DAF

37 Hemin analogues differing in either metal or porphyrin r

38 In contrast, HO-1 agonists hemin and cobalt protoporphyrin IX significantly increas

39 d these results with chemical degradation by hemin and FeCl(3).

40 The sensor consists of hemin and functionalized multi-wall carbon nanotubes cov

41 the surface-exposed HtaA protein binds both hemin and Hb and also contributes to the utilization of

42 within the ChtA CR domain were critical for hemin and Hb binding.

43 61 and H412 were critical for the binding to hemin and Hb by the CR2 domain.

44 ve binding studies demonstrated that soluble hemin and Hb were able to inhibit the binding of HtaA an

45 ChtA, ChtB, and ChtC are able to bind hemin and Hb, with ChtA showing the highest affinity.

46 C. diphtheriae that encode factors that bind hemin and Hb.

47 , HtaB, are required for the ability to bind hemin and Hb.

48 red proteins, ChtA and ChtC, which also bind hemin and Hb.

49 Studies with hemin and heme supplemented medium indicated that antisc

50 Corynebacterium diphtheriae utilizes hemin and hemoglobin (Hb) as iron sources during growth

51 athogen Corynebacterium diphtheriae utilizes hemin and hemoglobin as iron sources for growth in iron-

52 ere respiratory disease diphtheria, utilizes hemin and hemoglobin as iron sources for growth in iron-

53 Plasma levels of hemin and hpx (at admission, day 3, and day 14) were ass

54 activity was increased by administration of hemin and inhibited by chromium mesoporphyrin.

55 Because of the toxicity of high levels of hemin and iron, these compounds are often tightly regula

56 We demonstrated that HbpC binds hemin and localizes to the B. henselae outer membrane an

57 formed from the binding interaction between hemin and the dual DNA aptamer.

58 diates high affinity binding to ferric heme (hemin) and that its N- and C-terminal domains interact w

59 in binding aptamer recognition complex binds hemin, and the resulting catalytic complex activates the

60 release, and molecular signaling effects of hemin appear to be the most critical.

61 7) autoxidize approximately 8 times and lose hemin approximately 200 times more rapidly than native a

62 ng a dual DNA aptamer (CEA aptamer linked to hemin aptamer), capable of rapidly capturing carcinoembr

63 It is also known that P. gingivalis requires hemin as an iron source for its growth.

64 V genes resulted in a reduced ability to use hemin as an iron source, while deletion of htaB had no e

65 em was not involved in the uptake and use of hemin as an iron source.

66 ells being unable to grow in the presence of hemin as the sole iron source.

67 The insertion of hemin b into the asymmetric environment of a protein poc

68 uadruplex structures and when complexed with hemin become functional DNAzymes.

69 )) and Pseudomonas aeruginosa (HasA(p)) bind hemin between two loops, which harbor the axial ligands

70 to the natural biochromophores chlorophyll, hemin, bilirubin, and biliverdin and to high mass fluoro

71 path for the closing of the His32 loop upon hemin binding and identified molecular motions that are

72 To elucidate the mechanism of hemin binding by Hbp2, we determined crystal structures

73 ion proteins (GST-CR1 and GST-CR2) to assess hemin binding by UV-visual spectroscopy.

74 uctures reveal an unprecedented mechanism of hemin binding in which Hbp2(N2) undergoes a major confor

75 ht previously unrecognized plasticity in the hemin binding mechanism of NEAT domains and provide insi

76 conserved sequences are responsible for the hemin binding property previously ascribed to HtaA.

77 son mutant that constitutively expresses the hemin binding protein C (hbpC) gene.

78 hemin transporter, and the surface-anchored hemin binding proteins HtaA and HtaB.

79 Hemin binding proteins, secretion systems, response regu

80 Hemin binding studies demonstrated that HtaA and HtaB ar

81 Hemin binding to the Y75 loop triggers closing of the H3

82 326-D660 with a Y642A mutation that prevents hemin binding).

83 the formation of DNA concatemers containing hemin-binding aptamers through a modified hybridization

84 In this reaction, hemin-binding peroxidase-mimicking DNAzymes ("peroxidyme

85 R) domains within HtaA and in the associated hemin-binding protein, HtaB, are required for the abilit

86 ody of HBs (Ab1) immobilized on the MNPs and hemin bio-bar-coded AuNPs probe labeled antibody (Ab2).

87 (2) The partially unfolded intermediate with hemin bound (IH) has a hemichrome spectrum indicative of

88 A was able to acquire hemin from Hb and that hemin bound to HtaA could be transferred to HtaB.

89 , and unfolded (U) states of apoMb and their hemin-bound counterparts, NH (holoMb), IH, and UH, respe

90 (Hbp2(N2); residues 183-303) in its free and hemin-bound states.

91 hese attacks involves i.v. administration of hemin, but a faster-acting, more effective, and safer th

92 e tumor necrosis factor-alpha receptors, and hemin by abolishing both sEng and soluble fms-like tyros

93 d lower than that for the native state, free hemin can bind to it and promote the assembly of the hol

94 axial ligand-bearing loops in the process of hemin capture we investigated the H32A mutant, which was

95 Infusion of a low dose of hemin caused acute intravascular hemolysis and autoampli

96 Furthermore, excess NTBI and hemin caused aggregation of PrP(C) to a detergent-insolu

97 Py17XNL, phenylhydrazine and hemin caused premature mobilization of granulocytes from

98 d single-molecule redox reaction dynamics of hemin (chloride) adsorbed on Ag nanoparticle surfaces by

99 , serves as a redox moiety when bound with a hemin cofactor.

100 CEA and hemin competitively bound with the dual DNA aptamer whil

101 unfavored and where the noncovalent DNAzyme-hemin complex has no activity.

102 The G4/hemin complexes catalyze the H(2)O(2)-mediated oxidation

103 ted that formation of synthetic MF6p/FhHDM-1.hemin complexes inhibited hemin degradation by hydrogen

104 on of oxidative-stress-related genes by this hemin concentration-dependent pathway.

105 nt, a decreased temperature and an increased hemin concentration.

106 criptional repressor of the hut locus at all hemin concentrations tested.

107 lizes to the cell surface in response to low hemin concentrations, but under high hemin concentration

108 to low hemin concentrations, but under high hemin concentrations, Shu1-HA4 re-localizes to the vacuo

109 diating the tolerance of B. quintana to high hemin concentrations.

110 gulated when B. quintana was exposed to high hemin concentrations.

111 hemin-limited conditions compared to excess-hemin conditions.

112 The efficiencies of hemin transfer from hemin-containing donors (holo-protein) to different hemi

113 Here we report hemin transfer from hemin-containing IsdA (holo-IsdA) to hemin-free IsdC (ap

114 d by variation in fatty acid composition and hemin content of the meat, while protein-bound peroxide

115 e Stern-Volmer quenching constants (Ksv) for hemin, cytochrome c, hemoglobin, and myoglobin were 5.6x

116 hetic MF6p/FhHDM-1.hemin complexes inhibited hemin degradation by hydrogen peroxide and hemin peroxid

117 three proteins, HutB, HutC, and HmuV; and a hemin degradation/storage enzyme, HemS.

118 e hcp promoter sequence, and the binding was hemin dependent.

119 Hemin-dependent activation is mediated primarily by the

120 (DPP)Fe(III) cofactor and the zinc metal ion hemin derivative [(PPIX)Zn], underscoring the exquisite

121 ound O2, promotes autoxidation, and enhances hemin dissociation by inhibiting water coordination to t

122 70,000 times greater than the rate of simple hemin dissociation from holo-IsdA into solvent (k transf

123 containing aniline, H2O2, and a G-qudraplex-hemin DNAzyme.

124 Because the hemin-doped serum albumin mats have both biocompatibilit

125 the hypothesis that the hemolysis byproduct hemin elicits events that induce ACS.

126 s that the central NEAT domain in Hbp2 binds hemin even though its primary sequence lacks a highly co

127 Consistent with a role for Abc3 as vacuolar hemin exporter, results with hemin-agarose pulldown assa

128 etection of a signal produced in response to hemin exposure.

129 d of the four arms which, in the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with p

130 ontaining donors (holo-protein) to different hemin-free acceptors (apo-protein) were examined, and th

131 er from hemin-containing IsdA (holo-IsdA) to hemin-free IsdC (apo-IsdC).

132 s demonstrated that HtaA was able to acquire hemin from Hb and that hemin bound to HtaA could be tran

133 t to apo-IsdE; 3) apo-IsdE directly acquires hemin from holo-IsdC, but not from holo-IsdB and holo-Is

134 ogens secrete a hemophore (HasA) to scavenge hemin from its host and deliver it to a receptor (HasR)

135 were compared with that of indirect loss of hemin from the relevant donor to H64Y/V68F apomyoglobin.

136 pture and extract the oxidized form of heme (hemin) from Hb, IsdH and IsdB.

137 new design of nitric oxide sensors based on hemin-functionalized graphene field-effect transistors.

138 for probing sensing processes that yield the hemin/G-quadruplex as a functional label.

139 nd sensing platform implements the resulting hemin/G-quadruplex as an electrocatalytic label that cat

140 Then, porous Au@Pd nanoparticles and hemin/G-quadruplex as the peroxidase mimics efficiently

141 tasensor based on VEGF-induced assembly of a hemin/G-quadruplex catalyst (detection limit 18 nM).

142 ed assembly of two aptamer subunits into the hemin/G-quadruplex catalyst (detection limit 2.6 nM).

143 ing to the generation of catalytic telomeric hemin/G-quadruplex chains that control the l-cysteine-me

144 anoparticles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for deter

145 arget DNA present in a sample, by exposing a hemin/G-quadruplex DNAzyme, which then catalyzes the gen

146 This study describes the novel hemin/G-quadruplex DNAzyme-catalyzed aerobic oxidation o

147 Finally, the hemin/G-quadruplex DNAzyme/Amplex Red system was used to

148 ch, in the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with peroxidase activity.

149 zation of electroactive toluidine blue (Tb), hemin/G-quadruplex formed by intercalating hemin into th

150 n of DNA is further implemented to yield the hemin/G-quadruplex horseradish peroxidase (HRP)-mimickin

151 surface as a result of the formation of the hemin/G-quadruplex label using SPR.

152 The hemin/G-quadruplex nanostructure and the Pb(2+)-dependen

153 the complex and to the self-assembly of the hemin/G-quadruplex on the Au support.

154 Hemin/G-quadruplex structure as HRP mimicking-DNAzyme si

155 e of K(+) ions and hemin, into the telomeric hemin/G-quadruplex structure, exhibiting horseradish per

156 The telomeric hemin/G-quadruplex structures catalyze the oxidation of

157 g recognition events that form the catalytic hemin/G-quadruplex structures.

158 VEGF-induced assembly of a semiconductor QDs-hemin/G-quadruplex supramolecular structure (detection l

159 The hemin/G-quadruplex-aptamer nucleoapzyme also stimulates

160 xy-L-arginine to L-citrulline by a series of hemin/G-quadruplex-arginine aptamer conjugated nucleoapz

161 f the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thioch

162 The coupling of a concomitant H2O2-mediated hemin/G-quadruplex-catalyzed oxidation of Amplex Red to

163 of dopamine to aminochrome using a series of hemin/G-quadruplex-dopamine aptamer nucleoapzymes.

164 Well supported: stable hemin-graphene conjugates formed by immobilization of mo

165 HtaA was unable to bind to Hb from which the hemin had been chemically removed.

166 In cell cultures, this microbe secretes hemin/hemoglobin-binding protein 2 (Hbp2; Lmo2185) prote

167 s better than that of the recently developed hemin-hydrogel system and 100 times better than that of

168 y focuses on how doping the protein mat with hemin improves charge-transport.

169 round signal associated with the use of free hemin in histochemical studies.

170 tion, but no residue from the Q32 loop binds hemin in holo-HasA(yp).

171 ystem and the iron center in the biomolecule hemin in nanometer proximity in a bio-organic/semiconduc

172 ted with the competitive reaction of CEA and hemin in the presence of the dual aptamer, was exponenti

173 ly important in transmitting the presence of hemin in the Tyr75 loop to the His32 loop to initiate it

174 lysis and autoamplification of extracellular hemin in transgenic sickle mice, but not in sickle-trait

175 binding ability of the synthetic protein to hemin in vitro.

176 biomolecule and a solid-state system in the hemin/InAs hybrid structure.

177 Exposure to hemin induced a significant reduction in miR-217 express

178 moglobin-AS) sickle mouse model, intravenous hemin induced cardiovascular collapse and mortality with

179 Exogenous hemin induced Treg polarization in purified T cell/monoc

180 wild-type rats, the natural Hmox substrate, hemin, induced glomerular DAF.

181 egakaryocyte differentiation, but not during hemin-induced erythrocyte differentiation.

182 Furthermore, L3MBTL1 levels decrease during hemin-induced erythroid differentiation or erythropoieti

183 p66Shc knockdown inhibits hemin-induced erythroid differentiation, in which reacti

184 Hemin-induced expression of PlGF is abolished in EKLF-de

185 lterations in leukocyte recruitment, whereas hemin-induced inflammation occurred over a longer time f

186 these results show that Shu1 undergoes rapid hemin-induced internalization from the cell surface to t

187 We now demonstrate heme-bound iron (hemin) induces PlGF mRNA >200-fold in a dose- and time-d

188 n renal epithelial (HK-2) cells demonstrated hemin-inducible chromatin looping between the intronic e

189 4 and hemopexin replacement therapy prior to hemin infusion protected sickle mice from developing ACS

190 , more rapidly and effectively than a single hemin infusion.

191 Heme oxygenase (HO) cleaves hemin into biliverdin, iron, and CO.

192 The incorporation of hemin into the G-quadruplex structure of DNAzyme yields

193 , hemin/G-quadruplex formed by intercalating hemin into the TB aptamer (TBA) and glucose oxidase (GOx

194 that fold, in the presence of K(+) ions and hemin, into the telomeric hemin/G-quadruplex structure,

195 The use of hemin iron by Corynebacterium diphtheriae requires the D

196 The use of hemin iron in C. diphtheriae involves the dtxR- and iron

197 le mutant exhibits a significant decrease in hemin iron use, indicating a role in hemin transport for

198 Hemin iron utilization assays using various C. diphtheri

199 ssays showed that Y361 was essential for the hemin iron utilization function of HtaA.

200 rce, while deletion of htaB had no effect on hemin iron utilization in C. diphtheriae.

201 b and also contributes to the utilization of hemin iron.

202 The binding of free hemin is characterized by an initial rapid phase forming

203 echanism of lung injury due to extracellular hemin is independent of SCD.

204 m of hemin uptake in C. diphtheriae in which hemin is initially obtained from Hb by HtaA and then tra

205 stability of the N state or its affinity for hemin is reduced.

206 lthough the affinity of the intermediate for hemin (K(d) approximately 10(-11) M) is approximately 10

207 me (either intrinsic or added in the form of hemin) led to a further enhancement of thiol-stimulated

208 ne was enhanced in P. gingivalis grown under hemin-limited conditions compared to excess-hemin condit

209 In this study, we found that a hemin-limited growth environment significantly enhanced

210 Hence, to investigate the effect of hemin loading on the topology of the His32 loop we also

211 direct experimental evidence indicating that hemin loads onto the Tyr75 loop of apo-HasAp, which trig

212 exhibit different rates of autoxidation and hemin loss.

213 n intron 1 of the HO-1 gene, which regulates hemin-mediated HO-1 gene expression.

214 r of the redox state of the iron center in a hemin molecule.

215 rized NEAT domains to coordinate iron in the hemin molecule.

216 s are linked by cofacial interactions of two hemin molecules and that the conformation of the Ala32 l

217 nteraction allows reliable immobilization of hemin molecules on graphene without damaging the graphen

218 ution from electron hopping between adjacent hemin molecules to be isolated.

219 0-fold via electron hopping between adjacent hemin molecules, resulting in the highest measured condu

220 -mimicking DNAzymes was stimulated by adding hemin molecules.

221 hat in response to the RBC breakdown product hemin, monocyte control of T cell polarization will diff

222 of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as bio-bar-coded na

223 ugates formed by immobilization of monomeric hemin on graphene, showed excellent catalytic activity,

224 The interference quantifies the influence of hemin on the spin decoherence properties of the surface

225 on between the apo- and holo-structures, the hemin on-rate is too fast to detect by conventional stop

226 icant degradation when incubated with either hemin or FeCl(3).

227 fect on the ability of C. diphtheriae to use hemin or Hb as iron sources; however, a chtB htaB double

228 iron and activated by a heme source, such as hemin or Hb.

229 vated by the ChrAS system in the presence of hemin or hemoglobin, and mutations in the chrSA genes ab

230 However, the presence of excess hemin or iron reversed this dominance.

231 tly pirate plant iron compounds such as heme/hemin or iron-nicotianamine, and our data indicate that

232 be cells, their ability to acquire exogenous hemin or the fluorescent heme analog zinc mesoporphyrin

233 d hemin degradation by hydrogen peroxide and hemin peroxidase-like activity in vitro.

234 Reduced hemin, (PPIX)Fe(II), was also employed to highlight the

235 M-1 interact in vitro with cell membranes in hemin-preconditioned erythrocytes.

236 Importantly, hemin primarily through its effect on CD16+ monocytes in

237 For mammalian HOs, both native hemin propionates are required for substrate binding and

238 Hemin, prototypical for the heme group in hemoglobin, is

239 chia coli hemA show that HutA functions as a hemin receptor, and complementation analyses with E. col

240 hemin utilization (hut) encoding a putative hemin receptor, HutA; a TonB-like energy transducer; an

241 these proteins may function as cell surface hemin receptors in C. diphtheriae.

242 t alpha chain folding intermediates prior to hemin reduction and incorporation into adult Hemoglobin

243 and induced-fit mechanisms that may promote hemin release from Hb by altering the position of its F

244 space, oxidative and nitric oxide reactions, hemin release, and molecular signaling effects of hemin

245 This was ascribed to hemin, released from metHb, promoting lipid oxidation mo

246 B. quintana has the highest known hemin requirement among bacteria, but the mechanisms of

247 w that hut locus transcription is subject to hemin-responsive regulation, which is mediated primarily

248 ious cycle, B. quintana transitions from the hemin-restricted human bloodstream to the hemin-rich bod

249 role in the adaptation of B. quintana to the hemin-rich arthropod vector environment.

250 he hemin-restricted human bloodstream to the hemin-rich body louse vector.

251 studies suggest that the natural Hb and the hemin-scavenger proteins Hp and hemopexin have a strong

252 ore, in vitro studies show that the graphene-hemin sensors can be used for the detection of nitric ox

253 Our studies demonstrate that the graphene-hemin sensors can respond rapidly to nitric oxide in phy

254 Our work supports a model in which hemin serves as a signal for the regulation of OxyR acti

255 emistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band n

256 is found to increase with temperature due to hemin, signifying a spin exchange between the iron cente

257 nzyme activity compared with non-transfected hemin-stimulated controls.

258 he use of an alternative iron source such as hemin, suggesting an additional inhibitory mechanism ind

259 s showed that both domains were able to bind hemin, suggesting that the conserved sequences are respo

260 nstrated that HtaA and HtaB are able to bind hemin, suggesting that these proteins may function as ce

261 O, wild-type V. fischeri grew more slowly on hemin than a hnoX deletion mutant.

262 IsdC has a higher affinity for hemin than IsdA.

263 (b) The addition of hemin to antiparallel G-quadruplex DNAzymes lead to a bl

264 nd apo-IsdE; 2) holo-IsdB directly transfers hemin to apo-IsdA and apo-IsdC, but not to apo-IsdE; 3)

265 emonstrate that: 1) metHb directly transfers hemin to apo-IsdB, but not to apo-IsdA, apo-IsdC, and ap

266 ing as an Hb-binding hemophore that delivers hemin to other Hbp2 proteins that are attached to the ce

267 n transfer from the Fe(III)/Fe(II) couple of hemin to the carbon surface at -0.370 V and -0.305 V vs.

268 y linked to its catalytically active moiety, hemin, to avoid the high background signal associated wi

269 HrtAB system is required for protection from hemin toxicity and that expression of the hrtAB genes is

270 e reviews the principal mechanisms of Hb and hemin toxicity in different disease states, updates how

271 ved in the protection of C. diphtheriae from hemin toxicity.

272 isition by this system, we have investigated hemin transfer between the various couples of human meth

273 The results of hemin transfer experiments are consistent with Hbp2 func

274 Hemin transfer experiments demonstrated that HtaA was ab

275 The efficiencies of hemin transfer from hemin-containing donors (holo-protei

276 Here we report hemin transfer from hemin-containing IsdA (holo-IsdA) to

277 and holo-IsdA; and 4) IsdB and IsdC enhance hemin transfer from metHb to apo-IsdC and from holo-IsdB

278 ease in hemin iron use, indicating a role in hemin transport for HtaB and ChtB.

279 s study, we examined the Corynebacterium hmu hemin transport region, a genetic cluster that contains

280 1 Type 3 Secretion System and its effectors, hemin transport, and the two-component system PhoPQ.

281 nes encoding a previously described ABC-type hemin transporter and three additional genes, which we h

282 ae requires the DtxR- and iron-regulated ABC hemin transporter HmuTUV and the secreted Hb-binding pro

283 hmu hemin uptake locus, which encodes an ABC hemin transporter, and the surface-anchored hemin bindin

284 (low Treg/high Th1) in SCD, was dampened in hemin-treated stimulated monocytes from non-alloimmunize

285 mitochondrial localization, is increased by hemin treatment, but p66Shc remains exclusively in the c

286 leukemia cells treated with the HbF inducers hemin, trichostatin A, and sodium butyrate had significa

287 rred between surface-anchored proteins, with hemin ultimately transported into the cytosol by an ABC

288 en the 11-MUA-Au NDs and the Fe(II) atoms of hemin units, was supported by an increase in the signals

289 are consistent with a proposed mechanism of hemin uptake in C. diphtheriae in which hemin is initial

290 ae involves the dtxR- and iron-regulated hmu hemin uptake locus, which encodes an ABC hemin transport

291 onses in P. gingivalis include regulation of hemin uptake systems and gingipain activity, processes t

292 Both receptors rapidly extract hemin using a conserved tri-domain unit consisting of tw

293 yses revealed a potential locus dedicated to hemin utilization (hut) encoding a putative hemin recept

294 Ten of these, including hemin-utilization genes, have a promoter with a putative

295 tolerance of H(2)O(2) was also enhanced when hemin was limited in the growth medium of P. gingivalis.

296 y the affinities of the apoglobin states for hemin were allowed to vary.

297 nscription of tonB in the presence of excess hemin, whereas overexpression of the rhizobial iron regu

298 iphtheriae produced increased sensitivity to hemin, which was complemented by a plasmid harboring the

299 bserved that synthetic MF6p/FhHDM-1 binds to hemin with 1:1 stoichiometry and an apparent Kd of 1.14

300 een replaced with Ala residues fails to bind hemin with high affinity.

301 sional (1)H NMR of NmHO azide complexes with hemins with selectively deleted or rearranged propionate

302 ldown assays showed that Shu1 interacts with hemin, with a KD of approximately 2.2 mum.