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1 immunized with trinitrophenyl-keyhole limpet hemocyanin.
2 -fold) after conjugation with keyhole limpet hemocyanin.
3 2) mimics the spectroscopic signature of oxy-hemocyanin.
4 -dependent Ag, phosphocholine-keyhole limpet hemocyanin.
5 g dose groups challenged with keyhole limpet hemocyanin.
6 ow insect hexamerins might have evolved from hemocyanin.
7 ization of male SJL mice with keyhole limpet hemocyanin.
8 nserved copper-binding histidine residues of hemocyanin.
9 reased by conjugating them to keyhole limpet hemocyanin.
10 ITC-labeled tetanus, OVA, and keyhole limpet hemocyanin.
11 equenced lepidopteran hexamerin or arthropod hemocyanin.
12 host-restricted responses to keyhole limpet hemocyanin.
13 against 2,4,6 trinitro-phenyl-keyhole limpet hemocyanin.
14 hed control Ig, conjugated to keyhole limpet hemocyanin.
15 o oligosaccharides present on keyhole limpet hemocyanin.
16 A, as well as to the model Ag keyhole limpet hemocyanin.
17 T cell-dependent (TD) Ag DNP-keyhole limpet hemocyanin.
18 r after immunization with DNP-keyhole limpet hemocyanin.
19 T cell-dependent antigen TNP-keyhole limpet hemocyanin.
20 h UO(2)(2+)-DCP conjugated to keyhole limpet hemocyanin.
21 immunoglobulin conjugated to keyhole limpet hemocyanin.
22 ell and chemically coupled to keyhole limpet hemocyanin.
23 hapten, conjugated to BSA or keyhole limpet hemocyanin.
24 icant homology to the sequences of arthropod hemocyanins.
26 nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide-contain
27 mmunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-dependent Ig classes,
28 a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L Ab treatment,
29 r, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase were better st
31 ion of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasiliensis infecti
32 nation with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (GMK) for 96 week
33 hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin, which was char
34 CD4+ T cell sensitization to keyhole limpet hemocyanin and CD8+ T cell sensitization to MART-1 melan
35 ykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OHKYN-modified am
38 f tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunologic adjuvant.
39 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal allograft reje
40 okine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-restricted tumor-
41 fferent immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-bis(palmitoyloxy
42 ponses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag-specific B cel
43 duction of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL
44 ponse to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Ltg+ mice
45 n or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent Ags TNP-Ficoll o
47 cyanin is closely associated with crustacean hemocyanins and suggests that cryptocyanin arose as a re
48 en synthesized, conjugated to keyhole limpet hemocyanin, and administered with the immunologic adjuva
49 caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody techniques were use
51 nd immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhibited glucose-in
52 L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wild-type control
54 Il5 Collectively, our data demonstrate that hemocyanins are able to trigger the release of proinflam
57 ed after immunization with PC-keyhole limpet hemocyanin but at significantly lower levels than those
58 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produced normal amoun
60 m plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-immunized mice, we
61 din L-733,560 was conjugated to succinylated hemocyanin by water-soluble carbodiimide and was used as
62 ounterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect adhesion to fibro
63 CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of allogeneic or syng
64 phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in number and s
65 ere defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated phagocytosis, and
66 MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequent experiment
69 cinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease in CD19(+) sple
71 ty of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuvant QS-2
73 hetic model that structurally mimics the oxy-hemocyanin core, whereas the Cu(II)(2) protein reacted w
74 ltiple members of the hemocyanin gene family-hemocyanin, cryptocyanin, phenoloxidase, and hexamerins-
75 mmunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce significantly increas
76 immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1 cytokine-depen
78 unized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1/13,000), but l
82 ptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that completely
85 mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and cellula
87 ture of a high molecular weight protein, the hemocyanin from Octopus vulgaris, under solution conditi
89 ural and immunological properties, including hemocyanins from Concholepas concholepas, Fissurella lat
91 rphae in order to infer the evolution of the hemocyanin gene family and estimate spider relationships
92 etween cryptocyanin and other members of the hemocyanin gene family shows that cryptocyanin is closel
93 results suggest that multiple members of the hemocyanin gene family-hemocyanin, cryptocyanin, phenolo
96 the last number of years, the oxygen carrier hemocyanin, has demonstrated several immune- and physiol
97 muscle of Macrobrachium rosenbergii whereas, hemocyanin (HC) was identified as an allergen in Macrobr
98 tertiary, and quaternary structures of squid hemocyanin (Hc) were characterised, and the relationship
99 led binuclear "type 3" Cu sites are found in hemocyanin (Hc), tyrosinase (Tyr), and the multicopper o
102 n, aggrecan, collagen, entactin, fibrinogen, hemocyanin, heparan sulphate, laminin, myosin, proteogly
106 h2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allograft
107 en-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+) T-cell CD40L e
110 -hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall responses were also
111 lper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-depende
112 fter immunization with OVA or keyhole limpet hemocyanin in CFA, NK cell-deficient (NK-T+) mice develo
113 roinflammatory response for F. latimarginata hemocyanin in comparison with keyhole limpet hemocyanin
114 0,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant intranasal diese
116 e to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was found to be signi
118 s preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloantigen-induced T c
120 TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemic
121 ulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and
123 ) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monoc
124 tive was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA) to fo
125 lsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT), as well as an
126 on with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) with the
127 pic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given with Bacillus Ca
130 ty, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-(N-maleimidomet
131 generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive carbonyl r
132 on of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparati
133 jugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone Cys re
134 ns plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were increasingly poten
135 To solve this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series of GM3 derivativ
136 1-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced no symptoms or
137 olunteers were immunized with keyhole limpet hemocyanin (KLH) first orally and then parenterally or o
140 6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of-efficacy in ro
142 initrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-free environment
143 ith the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administrati
145 Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated a KLH-specific
146 n cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC92H2 we
147 sing Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colony-stim
148 ed to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor challenge with
149 hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunogen, which was su
150 e of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG
151 s of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis
152 ds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the blockade of PI
154 genic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown promisin
156 and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by their ability to
158 mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde developed Abs to GX
160 Following challenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these mice was hapten
161 onjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjugates ar
163 n exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in the microenvironm
164 of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tumor lysa
165 ith a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immunization with KLH
167 eeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted influen
168 response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% of the s
169 Ab immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus (BCG), an auto
171 ultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone) in the presenc
179 nant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer molecule) and d
180 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clusters of Ars-sp
181 C with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*KLH and
182 immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding to the prominen
185 Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated that administratio
186 tibodies were raised by using keyhole limpet hemocyanin modified in vitro by 4-hydroxynonenal (4-HNE)
188 -nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with HSV-1, and the
189 -hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ectopic l
190 phenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337) peptide, using
192 ata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal macrophages.
193 h a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by intranasal rIL
194 immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency virus-1 p24 gag pri
196 condary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippostrongylus larva
197 ee cell type cluster complex, keyhole limpit hemocyanin or tetanus toxoid-reactive Th cells promoted
198 Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) keyhole limpet he
200 and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminished IL-2 produc
202 ared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS-21) that consi
203 phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a quick IgM Ab re
204 h the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral delivery and combining
205 ginal tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain variable fragmen
207 an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide phosphorylated
208 CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced proliferation and cytoki
209 , a comparison of Octopus and horseshoe crab hemocyanin reveals a similar active site, in a striking
212 eptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary eosinophilia (39
214 nation with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral responses were ind
215 unization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolated from all immu
216 on protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation and 2,4,6-trin
217 ce, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersensitivity inflam
218 A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of spleen cells was al
219 r upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in the presence of A
220 ncubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S8 T cells (dini
221 reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitrophenyl-specifi
223 similar in sequence, size, and structure to hemocyanin, the copper-containing oxygen-transport prote
224 nse to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severely impaired seco
226 ease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibiting (anti-CD3)
228 tratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generated splenic HY-sp
231 to the coupled binuclear Cu active sites in hemocyanin, tyrosinase, and catechol oxidase, in O(2) ac
233 ensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human nasal allergic
236 coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both IgM and IgG antib
237 llowing immunization with DNP-keyhole limpet hemocyanin was significantly decreased for all IgG subcl
240 nant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from uninfected, nonat
241 gh-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even after adoptive t
244 (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(null) mice.
245 inistered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were treated with pe
246 h or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myeloma cells
247 keyhole limpet hemocyanin and C. concholepas hemocyanin, which was characterized by an increase in th
248 e, the biophysical interactions of shellfish hemocyanin with known phenoloxidase inhibitors are prese
249 nse, we investigated the effects of mollusks hemocyanins with varying structural and immunological pr
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