ライフサイエンスコーパス: hemocyte

1 ifferentiation into specialized blood cells (hemocytes).

2 f leukemic clam hemocytes (and not in normal hemocytes).

3 , which comprise the vast majority of mature hemocytes.

4 to coordinate trans-epithelial migration of hemocytes.

5 induces plasmatocyte maturation in adjacent hemocytes.

6 with prodigious production of differentiated hemocytes.

7 tions as an opsonin favoring phagocytosis by hemocytes.

8 in blood cell progenitors and differentiated hemocytes.

9 calization in the cytoplasm of leukemic clam hemocytes.

10 3, and results in apoptosis of leukemic clam hemocytes.

11 s expressing tetraspanin mediate adhesion of hemocytes.

12 ual hemocytes or encapsulated by interacting hemocytes.

13 s accompanied by abnormal differentiation of hemocytes.

14 n mechanism to passively gain entry into the hemocytes.

15 ranscript abundance usually being highest in hemocytes.

16 vely charged nature makes it unattractive to hemocytes.

17 rosine phosphatase activity than noninfected hemocytes.

18 o melanizations that are not encapsulated by hemocytes.

19 the host fat body and those that target host hemocytes.

20 um ookinetes and in circulating and attached hemocytes.

21 r signaling center for specialized signaling hemocytes.

22 rescue the differentiation defects in mutant hemocytes.

23 tetraspanin Tsp68C and its effect on larval hemocytes.

24 0 nm, completely blocked binding of label to hemocytes.

25 ands (LGs) and have an excess of circulating hemocytes.

26 tathione, can be studied functionally within hemocytes.

27 strain to overexpress Ras(V12) in Drosophila hemocytes.

28 hitin in macrophage-like immune cells called hemocytes.

29 lular signal-regulated kinase (ERK) in naive hemocytes.

30 the basis of mutual repulsion in Drosophila hemocytes.

31 pact on the cytoskeleton, and stimulation of hemocytes.

32 the production of reactive oxygen species by hemocytes.

33 born neurons in crayfish can be derived from hemocytes.

34 regulates the proliferation and adhesion of hemocytes.

35 une responses in immune cells, in particular hemocytes.

36 ance between prohemocytes and differentiated hemocytes.

37 tinct patterns, but were mainly expressed in hemocytes.

38 2 and Pvf3 to the Pvr trophic maintenance of hemocytes.

39 onses in other insects, and immune-competent hemocytes.

40 a CvGal1 glycoprotein ligand associated with hemocytes.

41 and the plasma membrane of a subset of snail hemocytes (60%), it was not detected in cell-free plasma

42 ia the DOP1 receptor may contribute to early hemocyte activation.

43 As demonstrated with a hemocyte adhesion assay and a surface plasmon resonance

44 pase inhibitor p35 in Pvr mutants eliminates hemocyte aggregates and restores blood cell counts and m

45 MdBV-infected hemocytes also exhibited higher levels of tyrosine phosp

46 t prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling cent

47 MdBV infects primarily host hemocytes and also infects a hemocyte-derived cell line

48 ons, show a progressive apoptotic decline in hemocytes and an incomplete resident hemocyte pattern, w

49 P transcripts are expressed primarily in the hemocytes and are increased at 24 h after pathogenic bac

50 s characterized by the absence of phagocytic hemocytes and atypical expression of immunity-related ge

51 glycoproteins, hemocyte extracts, and intact hemocytes and by surface plasmon resonance analysis.

52 lts in a leukemia-like over-proliferation of hemocytes and copious differentiation of lamellocytes du

53 itutively expressed at a low level in larval hemocytes and fat body and increased dramatically upon b

54 -regulated during parasite challenge in both hemocytes and gills.

55 gon and w1118 flies possess more circulating hemocytes and higher levels of phenoloxidase activity th

56 in the larval lymph gland and in circulating hemocytes and interacts with Asrij.

57 that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endoso

58 , and weight) and immune response (number of hemocytes and phenoloxidase activity) of the nonbiting m

59 asdhA mutant caused a transient depletion of hemocytes and reduced mortality.

60 are expressed constitutively in fat body and hemocytes and secreted into plasma, where they are activ

61 ant disrupted in Mcl1 is rapidly attacked by hemocytes and shows a corresponding reduction of virulen

62 PLL exhibited an ability to bind to insect hemocytes and the cuticular surface of a nematode, H. ba

63 developmental defects, overproliferation of hemocytes and the formation of melanotic tumors or nodul

64 ted to the loss of lwr function primarily in hemocytes and the lymph glands, a hematopoietic organ in

65 related sugar, lacNAc, and strongly binds to hemocytes and the tegument of S. mansoni sporocysts in a

66 we report an in vivo transfer of sorted live hemocytes and their successful reanalysis on retrieval f

67 complexed in the cytoplasm of leukemic clam hemocytes (and not in normal hemocytes).

68 rtical remodeling of Drosophila blood cells (hemocytes) and mouse macrophages.

69 ent transcription factor that controls glia, hemocyte, and tendon cell differentiation in Drosophila.

70 evels were specifically elevated in diseased hemocytes, and high expression was correlated with disea

71 t BgGRN induces proliferation of B. glabrata hemocytes, and specifically drives the production of an

72 n in the nucleus were observed in lwr mutant hemocytes, and the dl and Dorsal-related immunity factor

73 s: the deposition of extracellular matrix by hemocytes, and the onset of central nervous system activ

74 Hemocytes appear involved in debris removal and seem to

75 the mechanism(s) for parasite entry into the hemocyte are unknown.

76 Gated live hemocytes are analyzed and sorted at will based on preci

77 We investigated whether insect hemocytes are capable of de novo DA production.

78 Hemocytes are observed at the mineralization front using

79 During late larval stages three types of hemocytes are produced, plasmatocytes, crystal cells, an

80 sensory neurons, epidermal cells rather than hemocytes are the primary phagocytes in clearing degener

81 These studies identify hemocytes as a source of adult-born neurons in crayfish

82 d respond to parasite infection, implicating hemocytes as critical modulators of the late-phase immun

83 ed on these data, we introduce leukemic clam hemocytes as novel and easily accessible, in vivo and in

84 significantly increased in gills at 4h, and hemocytes at 0 h and 4 h, while HdHIF-1beta expression s

85 gulated in gills at 4h, 24h and 96 h, and in hemocytes at 24h and 96 h, while HdHIF-1beta remained re

86 were altered and the density of circulating hemocytes (blood cell analog) was significantly reduced,

87 Drosophila hemocytes (blood cells) have emerged as a powerful syste

88 increase in the number of circulating larval hemocytes (blood cells), which is caused by cellular ove

89 mpered by the lack of single-cell assays for hemocytes (blood cells).

90 in a sugar-inhibitable fashion suggest that hemocyte-bound galectin may be serving as a pattern reco

91 Interestingly, CanA1 RNAi in hemocytes but not the fat body was sufficient to block i

92 e not required for the directed migration of hemocytes, but act locally in epithelial cells to coordi

93 isoforms were expressed at similar levels in hemocytes, but in fat body isoform B mRNA was present at

94 onstruct was not restricted to ytr-deficient hemocytes, but was also observed in hemocytes expressing

95 and forth between epithelial disc cells and hemocytes by extracellular ROSs and TNF/Eiger drives ove

96 novel MT isoform (CvMT-IV) was isolated from hemocytes by subtractive hybridization techniques follow

97 rrounding the egg with layers of specialized hemocytes called lamellocytes.

98 Host hemocytes can recognize and ingest its conidia, but this

99 in multiple migratory cell types, including hemocytes, caudal visceral mesoderm (CVM), the visceral

100 ate that PVR directly controls survival of a hemocyte cell line.

101 h concentrations of plasmatocytes, the major hemocyte class in uninfected control larvae.

102 Hemocyte collision and subsequent repulsion involves a s

103 ecessive mutations that also affected normal hemocyte composition in larvae.

104 vations were linked to changes in the larval hemocyte composition, showing changes in cell types impo

105 We report a significant correlation between hemocyte concentration and encapsulation capacity among

106 Our results suggest that circulating hemocyte concentration and lamellocyte differentiation c

107 The relative contributions of hemocyte concentration vs. lamellocyte differentiation t

108 mph gland hypertrophy, increased circulating hemocyte concentration, and abundant production of lamel

109 genes (including Toll and tube) have reduced hemocyte concentrations, whereas larvae deficient in Hop

110 Surface proteins of hemocytes control the abrupt transition of hemocytes fro

111 Hemocytes coordinate a robust and specific immunological

112 in crayfish is tightly correlated with total hemocyte counts (THCs) and can be manipulated by raising

113 e internalizing amnioserosa tissue by mutant hemocytes coupled with impaired midline zippering of mut

114 EBP levels within peripheral differentiating hemocytes, culminating in their premature release into c

115 ins of host larvae harboring a wide range of hemocyte densities.

116 heral neurons and we demonstrate that larval hemocytes depend on the PNS as an attractive and trophic

117 ing Drosophila embryogenesis depends on both hemocyte-deposited extracellular matrix and neural activ

118 primarily host hemocytes and also infects a hemocyte-derived cell line from P. includens called CiE1

119 rescence-activated cell sorting approach for hemocyte detection, analysis, and sorting, which is effi

120 arallel glycomic study carried out on oyster hemocytes determined the structures of oligosaccharides

121 Different stages of hemocyte development have been classified according to m

122 know nothing about the endogenous control of hemocyte development in any gastropod model.

123 We further find that inhibition of hemocyte development or of Croquemort, a receptor requir

124 for spatial and temporal events that govern hemocyte development.

125 regulate the cytoskeleton during a subset of hemocyte developmental migrations.

126 However, circulating hemocytes did aggregate over the needle-puncture wound t

127 Correlatively, no hemocytes differentiate.

128 the choice between progenitor quiescence and hemocyte differentiation [the posterior signaling center

129 that were associated with severe defects in hemocyte differentiation and proliferation; ytr is predo

130 lood cell precursor maintenance and prevents hemocyte differentiation during larval hematopoiesis.

131 One regulatory network known to control hemocyte differentiation is the Janus kinase (JAK)/Signa

132 lvement of this pathway in the regulation of hemocyte differentiation through its action in the hemat

133 l-autonomous and non-autonomous functions in hemocyte differentiation.

134 ogenitor population and preventing premature hemocyte differentiation.

135 matopoietic precursor state while preventing hemocyte differentiation.

136 cells in the lymph gland results in abnormal hemocyte differentiation.

137 Consequently, hemocytes disrupted for autophagy were impaired in their

138 leted hemocyte population and a breakdown in hemocyte distribution.

139 use the Drosophila embryo to investigate how hemocytes (Drosophila macrophages), are able to prioriti

140 require secretion by migrating macrophages (hemocytes) during their developmental dispersal, which i

141 required in muscles, but not in fat body or hemocytes, during larval development for an efficient en

142 Layers of hemocytes encapsulated larvae immediately after infectio

143 Hemocytes express a larger range of glycans, including c

144 eficient hemocytes, but was also observed in hemocytes expressing the oncogenic forms of Raf or Ras p

145 ecific expression, as well as early and late hemocyte expression.

146 ith intact and deglycosylated glycoproteins, hemocyte extracts, and intact hemocytes and by surface p

147 fob hemocytes (fly macrophages) engulf bacteria but fail to

148 they increase in abundance relative to other hemocytes following experimentally induced shell regener

149 ue, but confirm the essential role of Pvr in hemocytes for embryonic survival.

150 dy (three genes) and those expressed in host hemocytes (four genes).

151 d lymph gland development, while Dm-Myb(-/-) hemocytes from mosaic larvae reveal a phagocytosis defec

152 f hemocytes control the abrupt transition of hemocytes from resting, nonadherent cells to activated,

153 do not appear to be able to take shelter in hemocytes from the action of the Toll pathway, the effec

154 bles the selective gating of live Drosophila hemocytes from the lymph glands (larval hematopoietic or

155 e proteins H2A, H2B, H3 and H4 were found in hemocytes from the Pacific white shrimp, Litopenaeus van

156 ntal steps in the maturation of blood cells (hemocytes) from their precursors.

157 Proteomic analysis of the hemocyte glycoproteins identified beta-integrin and domi

158 We show that leukemic clam hemocytes have an intact p53 pathway, and that maintenan

159 ta indicate, for the first time, that shrimp hemocyte histone proteins possess antimicrobial activity

160 ogether, our data show that Collier controls hemocyte homeostasis via coordinate regulation of PSC ce

161 ed that L. pneumophila resided within insect hemocytes in a vacuole that ultrastructurally resembled

162 n and trophic maintenance of macrophage-like hemocytes in Drosophila melanogaster embryos.

163 bnormal proliferation and differentiation of hemocytes in the context of specific lesions, such as ov

164 Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of

165 ion regulates the production of blood cells (hemocytes) in Drosophila larvae.

166 HP12 mRNA levels in the larval fat body and hemocytes increased after a bacterial challenge.

167 resent at enormously high levels in diseased hemocytes, indicative of extensive reverse transcription

168 tantly, oyster ETs were evidenced in vivo in hemocyte-infiltrated interstitial tissues surrounding wo

169 e migration and highlight novel Pvf roles in hemocyte invasive migration.

170 LL3 expression in the midgut and hemocytes is activated by ookinete midgut invasion and i

171 This overproduction of hemocytes is attributed to the loss of lwr function prim

172 Drosophila lymph gland, the source of adult hemocytes, is established by mid-embryogenesis.

173 electron transport chain complex assays, and hemocyte isolation from Drosophila larvae.

174 and, despite successful phagocytosis by host hemocytes, killed caterpillars both at 37 degrees C and

175 r of 5-ethynyl-2'-deoxyuridine (EdU)-labeled hemocytes, labeled cells populate the neurogenic niche c

176 Hemocytes lacking Stat fail to differentiate into plasma

177 ST) sequences from immune response-activated hemocyte libraries.

178 irus (MdBV) causes a loss of adhesion by two hemocyte-like cell lines, namely, High Five cells from t

179 Here, we use insect plasmatocytes and hemocyte-like Drosophila S2 cells to characterize mechan

180 embers and conducted functional studies with hemocyte-like Drosophila S2 cells.

181 tion of macrophages, and is expressed in the hemocyte lineage.

182 intenance and some cell fate choices between hemocyte lineages.

183 The removal of panulirin from the lobster hemocyte lysate leads to an increase in phenoloxidase re

184 ing concentrations of panulirin to a lobster hemocyte lysate, previously depleted of trypsin-inhibito

185 progenitors (IPs) expressing prohemocyte and hemocyte markers.

186 In particular, distinct zones of hemocyte maturation, signaling and proliferation in the

187 DA synthesized and released from hemocytes may act in an autocrine mechanism to stimulate

188 bdivided into melanotic nodules engaging the hemocyte-mediated encapsulation and into melanizations t

189 elanotic masses were generally linked to the hemocyte-mediated immune response.

190 We show here that, just before dusk, hemocytes migrate from the vasculature into the symbioti

191 ntal migrations in which posteriorly located hemocytes migrate toward the head.

192 In the absence of hemocytes migrating adjacent to the developing VNC, the

193 Our findings redefine Pvf roles in hemocyte migration and highlight novel Pvf roles in hemo

194 We find that preventing hemocyte migration by removing the function of the Droso

195 Finally, Ena rescues hemocyte migration defects caused by activated Dia.

196 Indeed, hemocyte migration is essential to deliver a subset of E

197 Failure of hemocyte migration, loss of collagen IV, or abrogation o

198 ligands, Pvf2 and Pvf3 in the regulation of hemocyte migration, proliferation, and size.

199 of the PDGF/VEGF family that is required for hemocyte migration.

200 Studies with staining reagents and hemocyte monolayers showed that MCL1 functions as an ant

201 that Rac-mediated lamellae are essential for hemocyte motility and Rho signaling is necessary for cel

202 utility of G(PA)C is exemplified by tracking hemocyte movements using a versatile transgenic Drosophi

203 ect or block in differentiation of precursor hemocytes: mutant larvae have enlarged lymph glands (LGs

204 The primary features of the oyster whole hemocyte N-glycome were also found in dominin, the major

205 fic Abs localized to 3-day p.p. fat-body and hemocyte nuclei, suggesting a role for vankyrin proteins

206 of NAC, a delay in the recovery rate of the hemocyte number was observed.

207 in the rapid restoration of the circulating hemocyte number.

208 Consequently, total hemocyte numbers drop dramatically during embryogenesis,

209 9, 12, 13, 25, 27, 32 and 34 in fat body and hemocytes of larvae injected with bacteria.

210 that integrins perform diverse functions in hemocytes of silkworm.

211 heet antimicrobial peptide isolated from the hemocytes of Tachypleus tridentatus.

212 opoietic system is founded by differentiated hemocytes of the embryo, which colonize segmentally repe

213 The HP14 mRNA exists in fat body and hemocytes of the naive larvae, and its level increases s

214 We found here that the hemocytes of the oyster Crassostrea gigas release antimi

215 d PEN2, PEN3, and PEN4, are expressed in the hemocytes of the Pacific white shrimp, Litopenaeus vanna

216 an embryonic cell line (Bge) and circulating hemocytes of the snail Biomphalaria glabrata, intermedia

217 nhibitor, named panulirin, isolated from the hemocytes of the spiny lobster Panulirus argus with regu

218 The immune cells (hemocytes) of a snail are sentinels that act as a crucia

219 runcated variant, 620-fold above normal clam hemocytes) of human mortalin, an Hsp70 family protein.

220 but many must be phagocytosed by individual hemocytes or encapsulated by interacting hemocytes.

221 f the highly conserved ortholog, cut, led to hemocyte overgrowth and tumor formation in Drosophila me

222 In untreated leukemic clam hemocytes, p53 is complexed throughout the cytoplasm wit

223 line in hemocytes and an incomplete resident hemocyte pattern, whereas supernumerary peripheral neuro

224 Hemocytes phagocytosed bacteria after injection, and ant

225 his study, we found that DA modulates insect hemocyte phagocytosis using hemocytes prepared from the

226 1 receptor with antagonist SCH23390 impaired hemocyte phagocytosis.

227 al role that circulating blood cells (called hemocytes) play in immunity by generating a total of 11,

228 pvr mutants have a depleted hemocyte population and a breakdown in hemocyte distribu

229 r mutants, a large fraction of the embryonic hemocyte population undergoes apoptosis, and the remaini

230 ins failed to prevent overproduction of this hemocyte population.

231 he GATA factor Serpent (Srp) is required for hemocyte precursor formation during Drosophila hematopoi

232 f hemocytes, whereas the other was active in hemocyte precursors and plasmatocytes only.

233 During larval stages, a pool of pluripotent hemocyte precursors differentiate into hemocytes that ar

234 the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to mul

235 modulates insect hemocyte phagocytosis using hemocytes prepared from the rice stem borer (RSB), Chilo

236 s, a niche regulates prohemocytes to control hemocyte production.

237 Hemocyte proliferation and differentiation are influence

238 hila Myb (Dm-Myb) causes a failure of larval hemocyte proliferation and lymph gland development, whil

239 nstrate that U-shaped acts to control larval hemocyte proliferation and suppress lamellocyte differen

240 ebrate A-Myb nor c-Myb, can complement these hemocyte proliferation defects in Drosophila.

241 infection with S. mansoni by first inducing hemocyte proliferation with BgGRN.

242 At least one isoform of serpin-1 can inhibit hemocyte proteinase 1, another M. sexta blood proteinase

243 In this study, we show that oyster hemocytes recognize P. marinus via a novel galectin (C.

244 expressed at high levels by tumor-associated hemocytes recruited from the circulation.

245 progenitor cells in the tissue and to reduce hemocyte release.

246 The hemocyte-released DNA was found to surround and entangle

247 Here, we show that Drosophila hemocytes require a precisely orchestrated CIL response

248 heral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recrui

249 These hemocyte responses depend on PNS activity, as shown by a

250 ression of mutant Idh in larval blood cells (hemocytes) resulted in higher numbers of circulating blo

251 The mutant hemocytes retain the ability to phagocytose bacteria as

252 ound that in the absence of SdhA, the LCV in hemocytes showed signs of instability and leakage.

253 The conserved hemocyte-specific endosomal protein Asrij is essential f

254 Hemocyte-specific expression of the pan-caspase inhibito

255 We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a

256 ween the large extracellular loop domain and hemocyte-specific integrin is interrupted not only by a

257 acellular loop of tetraspanin D76 binds to a hemocyte-specific integrin of Manduca sexta.

258 of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency

259 autophagy was required for integrin-mediated hemocyte spreading and Rho1-induced cell protrusions.

260 hould critically enhance in vivo and ex vivo hemocyte studies in Drosophila and other species, notabl

261 fically drives the production of an adherent hemocyte subset that participates centrally in the anti-

262 scriminate and sort plasmatocytes, the major hemocyte subset, from lamellocytes, an activated subset

263 ChIP) localizes NURF to Ken-binding sites in hemocytes, suggesting that Ken recruits NURF to repress

264 om the blood group A oligosaccharides on the hemocyte surface may function as potentially effective l

265 oss-linking to beta-integrin, located on the hemocyte surface, leading to cell activation, phagocytos

266 lood group moieties on oyster dominin and on hemocyte surfaces can account in part for their affinity

267 s interaction of integrin and tetraspanin on hemocyte surfaces.

268 , ligand-independent mechanism that promotes hemocyte survival during both normal hematopoietic devel

269 d enhance the phenoloxidase (PO) activity of hemocyte suspensions in the presence of LPS or beta-1,3-

270 otent hemocyte precursors differentiate into hemocytes that are released into circulation upon metamo

271 bundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and

272 We report a class of granulocytic hemocytes that may be directly involved in shell crystal

273 with extracellular DNA networks released by hemocytes, the circulating immune cells of invertebrates

274 ncrease in proliferation of undifferentiated hemocytes throughout development and is accompanied by a

275 Importantly, we show that these resident hemocytes tightly colocalize with peripheral neurons and

276 silencing abrogates the ability of mosquito hemocytes to differentiate and respond to parasite infec

277 Attachment and spreading of hemocytes to foreign surfaces induced localization of Cv

278 Here we show that exposing hemocytes to lipopolysaccharide (LPS) led to induction o

279 a DA-dependent signaling system operates in hemocytes to mediate phagocytotic functions.

280 Exposure of hemocytes to Perkinsus spp. trophozoites enhanced this p

281 h-promoted immune responses and functions in hemocytes to promote a tissue-to-tissue signaling cascad

282 n of the proneural gene scute (sc) misdirect hemocytes to these ectopic locations.

283 rvae with fluorescently labeled blood cells (hemocytes) to investigate the circulatory dynamics of la

284 po) adults can be reversed when they receive hemocytes transplanted from wild-type donor flies prior

285 Inside oyster hemocytes, trophozoites resist oxidative killing, prolif

286 Yet, throughout larval development, both hemocyte types increase in numbers.

287 Drosophila immune cells, the hemocytes, undergo four stereotypical developmental migr

288 The expression of TNF by hemocytes was both necessary and sufficient to trigger T

289 In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate

290 Most MdBV genes expressed in hemocytes were persistently expressed in CiE1 cells, inc

291 is expressed in circulating and lymph gland hemocytes, where it plays a critical role in controlling

292 One enhancer was active in all classes of hemocytes, whereas the other was active in hemocyte prec

293 formation and activates the proliferation of hemocytes which invade the lesion site.

294 llular ROSs activate Drosophila macrophages (hemocytes), which in turn trigger JNK activity in epithe

295 mors is due to a large number of circulating hemocytes, which is approximately 10 times higher than t

296 VEGF/PDGF ligands from the tubules attract hemocytes, which secrete components of the basement memb

297 study, we examined the N-glycans of both the hemocytes, which via CvGal1 are the target of the parasi

298 In leukemic clam hemocytes, wild-type p53 and mortalin proteins co-locali

299 e partially inhibited by pretreatment of the hemocytes with anti-CvGal Abs.

300 In addition, treatment of leukemic clam hemocytes with MKT-077, a cationic inhibitor of mortalin