ライフサイエンスコーパス: hemolysin

1 ody with a remarkably high affinity to alpha-hemolysin.

2 uctural homology to the staphylococcal alpha-hemolysin.

3 so known as LukAB), leukotoxin DE, and gamma-hemolysin.

4 tivity when they are forced to express alpha-hemolysin.

5 macrophages, in response to Escherichia coli hemolysin.

6 y two protein nanopores: aerolysin and alpha-hemolysin.

7 rulence factors, such as coagulase and alpha-hemolysin.

8 ), and bacterial channel-forming toxin alpha-hemolysin.

9 he expression pattern of coagulase and alpha-hemolysin.

10 of ADAM10 as the cellular receptor for alpha-hemolysin.

11 ion channel nanopore methods employing alpha-hemolysin.

12 o solved the first x-ray structure of a TpsA hemolysin.

13 using a bacterial pore-forming toxin, alpha-hemolysin.

14 he one formed by Staphylococcus aureus alpha-hemolysin.

15 d ASC due to the secreted pore-forming toxin hemolysin.

16 teins classically consists of cytolysins and hemolysins.

17 lonal group positive for sepA and a putative hemolysin; (2) a group harboring the EAST-1 enterotoxin

18 tructure and function of a truncated form of hemolysin A (HpmA265) from Proteus mirabilis using a ser

19 Hemolysin A belongs to the two-partner secretion pathway

20 The truncated hemolysin A formed a right-handed parallel beta-helix wi

21 between HpmA265 and neighboring full-length hemolysin A molecules, facilitated in part by the highly

22 The Escherichia coli hemolysin A secretion system was used to promote the sec

23 activity profile after full-length, inactive hemolysin A was seeded with truncated hemolysin A.

24 aride, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD), phosphoe

25 active hemolysin A was seeded with truncated hemolysin A.

26 nidirectional interconversion of full-length hemolysin A.

27 peptide is facilitated by alpha-toxin (alpha-hemolysin), a pore-forming toxin and virulence factor of

28 These strains produce the pore-forming toxin hemolysin, a characteristic used clinically to distingui

29 This pathogen secretes alpha-hemolysin, a pore-forming cytotoxin that contributes to

30 S. aureus alpha-hemolysin, a pore-forming cytotoxin, is an essential vir

31 We show herein that staphylococcal alpha-hemolysin, a pore-forming cytotoxin, is required for ful

32 li that produce the pore-forming toxin alpha-hemolysin, a response that is markedly attenuated when t

33 oles of two established cytotoxins, the HpmA hemolysin, a secreted cytotoxin, and proteus toxic agglu

34 We show that alpha-hemolysin activates the NLRP3 inflammasome during S. aur

35 Screening by means of assays to detect delta-hemolysin activity and agr autoinducing peptide producti

36 dated via measurement of reconstituted alpha-hemolysin activity and the voltage-gated channel activit

37 h strong blood agar hemolysis and high alpha-hemolysin activity are markers for VAP, but not VAT, and

38 us Sequence Typing and spa-typing, and alpha-hemolysin activity by semiquantitative analysis of hemol

39 cheal aspirates (ETA) for genotype and alpha-hemolysin activity in relation to the development of VAT

40 alpha-Hemolysin activity of S. aureus isolates was predictive

41 patients exhibited significantly lower alpha-hemolysin activity than those from VAP cases; however, n

42 on and in vitro killing, agr function (delta-hemolysin activity), agr group, SCCmec type, and surviva

43 for appropriate regulation of Stk1 function, hemolysin activity, autolysis, and GBS virulence.

44 eins, a peptide chain release factor 1 and a hemolysin acyltransferase, respectively.

45 e barrier, Staphylococcus aureus toxin alpha-hemolysin (aHL) channels have been incorporated into the

46 Mechanistically, alpha- and beta-hemolysins alone did not trigger caspase-1 activation, b

47 ution of operative ion channels (e.g., alpha-hemolysin (alpha-HL) and gramicidin) in the bilayer is o

48 ntact DNA strands with the ion channel alpha-hemolysin (alpha-HL) are limited to single-stranded DNA

49 h region of the wild-type protein pore alpha-hemolysin (alpha-HL) constitutes a sensing zone for indi

50 ough the bacterial protein ion channel alpha-hemolysin (alpha-HL) embedded in a lipid bilayer.

51 taining DNA duplexes was studied in an alpha-hemolysin (alpha-HL) nanopore.

52 translocation of proteins through the alpha-hemolysin (alpha-HL) pore using the AAA+ unfoldase ClpX.

53 he presence of an applied voltage, the alpha-hemolysin (alpha-HL) protein ion channel can produce uni

54 e for capture in the nanocavity of the alpha-hemolysin (alpha-HL) protein pore under an electrophoret

55 e prototypic transmembrane beta-barrel alpha-hemolysin (alpha-HL) reconstituted on immobilized single

56 n) and one static biological nanopore (alpha-hemolysin (alpha-HL)) were successfully incorporated int

57 old NPs using the biological nanopores alpha-hemolysin (alphaHL) and its M113N mutant equipped with a

58 alently coupled a DNA polymerase to an alpha-hemolysin (alphaHL) heptamer using the SpyCatcher/SpyTag

59 ecule resolution with the protein pore alpha-hemolysin (alphaHL) is presented.

60 ctric field applied across a wild-type alpha-hemolysin (alphaHL) nanopore provides structural informa

61 (SG)18 metallic cluster is bound to an alpha-hemolysin (alphaHL) nanopore, the mean residence time of

62 lyethylene glycol (PEG) molecules with alpha-hemolysin (alphaHL) nanopores.

63 means to monitor the conductance of an alpha-hemolysin (alphaHL) pore as a DNA hairpin with a polydeo

64 rated an unnatural amino acid into the alpha-hemolysin (alphaHL) pore by using solid-phase peptide sy

65 , we describe a chip in which a single alpha-hemolysin (alphaHL) pore in a planar phospholipid bilaye

66 re was formed by Staphylococcus aureus alpha-hemolysin (alphaHL) protein and contained electrostatic

67 ilize the well-studied protein channel alpha-hemolysin (alphaHL) to map the presence of beta-cyclodex

68 anslocation through the staphylococcal alpha-hemolysin (alphaHL) transmembrane pore, a robust, tracta

69 ed of phosphocholine using the protein alpha-hemolysin (alphaHL), to demonstrate osmotically-driven m

70 ure the conductance of the ion channel alpha-hemolysin (alphaHL), while simultaneously applying a dir

71 inflammasome required GBS expression of beta-hemolysin, an important virulence factor.

72 f this conjecture by using two toxins, alpha-hemolysin and aerolysin, which differ in their shape, si

73 sion of many virulence factors such as alpha-hemolysin and coagulase; however, the molecular mechanis

74 nal reporters, direct protein outputs (alpha-hemolysin and delta-toxin), and an in vivo skin challeng

75 nalysis using the biological nanopores alpha-hemolysin and its E111A mutant is presented here as a pr

76 These data suggest that hemolysin and MARTX toxin contribute to vaccine reactoge

77 To study the contribution of hemolysin and other accessory toxins to pathogenesis, we

78 secretory virulence factors (S. aureus beta-hemolysin and P. acnes CAMP (Christie, Atkins, Munch-Pet

79 uppress production of key MRSA toxins (alpha-hemolysin and Panton-Valentine leucocidin) that impair h

80 alpha-Hemolysin and protein A were maximally expressed 4 h aft

81 thoadaptation, we measured the rate of alpha-hemolysin and staphyloxanthin inactivation during serial

82 Detection of increased rates of alpha-hemolysin and staphyloxanthin inactivation in GO and MMR

83 CV with heme, but not iron, restored growth, hemolysin and staphyloxanthin production, and sensitivit

84 er of the two major subtypes of TPS systems (hemolysins and adhesins) based on their sequences.

85 In particular, S. aureus produces potent hemolysins and leukotoxins.

86 coccus aureus, controlling the production of hemolysins and other virulence factors.

87 ted genes encoding virulence factors such as hemolysins and proteases were lowered in the presence of

88 S. aureus required alpha-, beta-, and gamma-hemolysins and the host Nlrp3 inflammasome.

89 (protein A) and downregulation of hla (alpha-hemolysin) and sspA (V8 protease) transcripts when compa

90 phasis on Panton-Valentine leukocidin, alpha-hemolysin, and the recently discovered alpha-type phenol

91 putative roles in virulence (e.g., ctx, tcp, hemolysin, and type VI secretion genes) were upregulated

92 ce genes for the biosynthesis of O antigens, hemolysins, and exonucleases as well as others for sugar

93 ncluded those for enterotoxins, leukocidins, hemolysins, and surface proteins and several newly ident

94 odels, the therapeutic efficacy of the alpha-hemolysin antibody appeared additive to the antibiotic l

95 we solved the crystal structure of the alpha-hemolysin:antibody complex.

96 These results emphasize the utility of alpha-hemolysin as a model system to study biologically releva

97 ovide insights into the application of alpha-hemolysin as a molecular sieve to differentiate nanostru

98 tion and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets mult

99 complex shows that the antibody binds alpha-hemolysin between the cap and the rim domains.

100 The alpha-hemolysin binding to its receptor A-disintegrin and meta

101 s to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism.

102 The observation that alpha-hemolysin can usurp the metalloprotease activity of its

103 alentine leukocidin LukSF-PV (PVL) and gamma-hemolysin CB (HlgCB) target human phagocytes through int

104 ution to the alpha-hemolysin pore, the alpha-hemolysin channel can be controlled open or closed by ad

105 eported earlier for OmpF porin and the alpha-Hemolysin channel, we estimate the radii of cis and tran

106 scopy shows that Staphylococcus aureus alpha-hemolysin channels in membranes tethered to gold have th

107 These results indicate that S. aureus hemolysins circumvent the requirement of ATP and the P2X

108 en, genetic fusion of GFP with the bacterial hemolysin ClyA resulted in a chimeric protein that elici

109 the secretion of the T6SS hallmark protein, hemolysin-coregulated protein (Hcp).

110 secretion signal sequences but are linked to hemolysin-coregulated protein and valine-glycine repeat

111 roduction of its associated effectors, e.g., hemolysin-coregulated protein.

112 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immune evasion and

113 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in the virulence of Bo

114 erial invasion and the GBS pore-forming beta-hemolysin/cytolysin (beta-h/c) trigger autophagic activa

115 in covR and related factors, including beta-hemolysin/cytolysin (beta-h/c), surface-anchored adhesin

116 he contribution of the pore-forming GBS beta-hemolysin/cytolysin (betaH/C) to vaginal colonization, a

117 systemic infections, exhibit decreased beta-hemolysin/cytolysin activity, and show increased sensiti

118 gh transcription of genes important for beta-hemolysin/cytolysin expression and export is similar to

119 ponse with serine hydroxamate increased beta-hemolysin/cytolysin expression.

120 ns demonstrated decreased expression of beta-hemolysin/cytolysin, an important cytotoxin implicated i

121 tivated when BMDCs were infected with a live hemolysin deficient (Deltahly) strain.

122 flamed skin and indicate that S. aureus uses hemolysin-dependent killing of these cells as an immune

123 ved in GBS-infected human PMNs in vitro in a hemolysin-dependent manner, appeared to be part of this

124 and penetrate chorioamniotic membranes in a hemolysin-dependent manner.

125 lation of mRNAs encoding multiple toxins and hemolysins (e.g., hlgA, hlgB, hlgC, hla, lukS-PV, lukF-P

126 One such protein is the hemolysin encoded by hlyA.

127 ermines the presence of both the tdh and trh hemolysin-encoding genes, which are also present in ST36

128 in vitro data on the cytolytic activities of hemolysin exist, the connection of hemolysin to virulenc

129 did not differ between mice inoculated with hemolysin-expressing strains and those infected with non

130 pressing strains and those infected with non-hemolysin-expressing strains.

131 However, sAIP did not promote hemolysin expression in hemB mutant strains or S. aureus

132 after infection, with higher levels of alpha-hemolysin expression in mice infected with bacteria alon

133 d a similar overall fold to Escherichia coli hemolysin expression modulating protein Hha; however, st

134 sion of type I and P fimbriae, modulation of hemolysin expression, and expression of a novel pathogen

135 tein nanopores, such as those based on alpha-hemolysin from Staphylococcus aureus have shown great pr

136 emonstrating that the rtx operon is a second hemolysin gene cluster in V. anguillarum M93Sm.

137 The two hemolysin gene clusters previously identified in Vibrio

138 Previously, two hemolysin gene clusters responsible for the hemolysis an

139 IL-1beta production dependent on CT when the hemolysin gene was deleted.

140 A probe designed for the virulence hemolysin gene, hlyA, was immobilized on the gold-coated

141 One hemolysin gene, vah1, has been previously identified but

142 -PCR) were used to examine expression of the hemolysin genes under exponential and stationary-phase c

143 rries genes associated with virulence (e.g., hemolysin genes) and conjugation (tra and trb genes) but

144 Hemolysin had the predominant role in lethality, with a

145 2) conjugated to a non-toxic mutant of alpha-hemolysin (Hla H35L), CP5 conjugated to clumping factor

146 sponses to 2 staphylococcal exotoxins, alpha-hemolysin (Hla) and Panton-Valentine leukocidin (PVL; Lu

147 We tested the hypothesis that alpha-hemolysin (Hla) contributes to the severity of USA300 sk

148 rt now shows that immunization against alpha-hemolysin (Hla), a cytolytic toxin secreted by most S. a

149 Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus,

150 alpha-Hemolysin (Hla), a pore-forming toxin secreted by S. aur

151 Staphylococcus aureus alpha-hemolysin (Hla), a potent cytotoxin, plays an important

152 Alpha-hemolysin (Hla), a secreted pore-forming toxin, is an es

153 Panton-Valentine leukocidin (PVL) and alpha-hemolysin (Hla), although supporting evidence is lacking

154 ents with higher levels of IgG against alpha-hemolysin (Hla), delta-hemolysin (Hld), Panton Valentine

155 They include the secreted factors alpha-hemolysin (Hla), ess extracellular A (EsxA), and ess ext

156 ors, including the abundantly produced alpha-hemolysin (Hla), failed to induce eosinophil death.

157 establishment in immunocompetent hosts-alpha-hemolysin (Hla), iron-regulated surface determinants (Is

158 ll-established virulence determinants: alpha-hemolysin (Hla), phenol-soluble modulin-alpha peptides (

159 e factors, including protein A and the alpha-hemolysin (Hla), which cause pathology by activating hos

160 accessory gene regulator C (agrC) and alpha-hemolysin (hla)--molecules important for S. aureus virul

161 Panton-Valentine leukocidin (PVL)- and alpha-hemolysin (Hla)-negative isogenic derivatives (LACDeltap

162 he S. aureus-secreted virulence factor alpha-hemolysin (Hla).

163 as well as the gene encoding the toxin alpha-hemolysin (hla).

164 s dependent on S. aureus expression of alpha-hemolysin (Hla).

165 of IgG against alpha-hemolysin (Hla), delta-hemolysin (Hld), Panton Valentine leukocidin (PVL), stap

166 The gamma-hemolysins (HlgAB and HlgCB) and Panton-Valentine leukoc

167 Escherichia coli (UPEC) strains produce both hemolysin (Hly) and cytotoxic necrotizing factor type 1

168 Cytotoxic necrotizing factor 1 (CNF1) and hemolysin (Hly) are toxins made by approximately 50% of

169 al toxins including the two RTX toxins alpha-hemolysin (HlyA) from Escherichia coli and leukotoxin A

170 We show that UPEC alpha-hemolysin (HlyA) induces Caspase-1/Caspase-4-dependent i

171 m-negative bacteria such as Escherichia coli hemolysin (HlyA) insert into host-cell membranes to subv

172 facilitated by the pore-forming toxin alpha-hemolysin (HlyA), which is expressed and secreted by man

173 ract infections are commonly caused by alpha-hemolysin (HlyA)-producing Escherichia coli.

174 e a labile pore-forming toxin known as alpha-hemolysin (HlyA).

175 ve hemagglutinin (MSHA), and enterotoxigenic hemolysin (HlyA); C-II encodes a variant of Vibrio patho

176 Cytotoxic necrotizing factor 1 (CNF1) and hemolysin (HlyA1) are toxins produced by uropathogenic E

177 infections, secretes the pore-forming toxin hemolysin II (HlyII).

178 ation of CAMP factor neutralization and beta-hemolysin immunization cooperatively suppressed the skin

179 reus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes to cause di

180 crobe, Elsen and colleagues identify a novel hemolysin in a highly virulent Pseudomonas aeruginosa st

181 There was a higher abundance of alpha-hemolysin in culture supernatants among ACME-positive is

182 eexisting antibodies against S. aureus alpha-hemolysin in the serum of human individuals by isolating

183 The activity of an ion channel, alpha-hemolysin, incorporated into bis-DenPC BLMs prior to pol

184 creased production of cholera toxin (CT) and hemolysin, increased motility, and a reduced ability to

185 inhibition as a strategy to attenuate alpha-hemolysin-induced disease.

186 findings suggest a role for S. aureus alpha-hemolysin-induced PNA formation in alveolar capillary de

187 not driven by this mechanism; rather, alpha-hemolysin-induced PNA formation was solely platelet P-se

188 alpha-hemolysin injures epithelial cells in vitro by interacti

189 this report, we demonstrate use of the alpha-hemolysin ion channel to analyze these subtle topologica

190 inkage and capturing the DNA inside an alpha-hemolysin ion channel.

191 ne glycol) (PEG) molecules in a single alpha-hemolysin ion channel.

192 astic detection using between 1 and 26 alpha-hemolysin ion channels reconstituted in a lipid bilayer,

193 Staphylococcal alpha-hemolysin is an essential virulence factor in severe S.

194 The wild-type protein nanopore alpha-hemolysin is used to capture individual DNA duplexes con

195 This large, hemolysin-like protein was found in the supernatant of a

196 GBS expression of the cytolytic toxin, beta-hemolysin, lysosomal acidification, and leakage.

197 We sought to determine the role of alpha-hemolysin-mediated activation of NLRP3 in the pathogenes

198 the mechanism of action for the two-partner hemolysin members is not fully understood.

199 Upon interaction of its C-terminal hemolysin moiety with the cell surface receptor alphaMbe

200 rt the generation of two distinct anti-alpha-hemolysin monoclonal antibodies that antagonize toxin ac

201 report of the crystal structure of the alpha-hemolysin monomer.

202 polymers to perform nanopore SBS on an alpha-hemolysin nanopore array platform.

203 The blocking of the alpha-hemolysin nanopore by rhodamines could be utilized in DN

204 atcheting of DNA templates through the alpha-hemolysin nanopore controlled by phi29 DNA polymerase wi

205 ecules are initially pulled through an alpha-hemolysin nanopore from the cis to the trans side of a l

206 vidual complexes are captured atop the alpha-hemolysin nanopore in an applied electric field.

207 mplitude states when captured atop the alpha-hemolysin nanopore in an applied field.

208 vidual complexes are captured atop the alpha-hemolysin nanopore in an electric field.

209 Detection using the alpha-hemolysin nanopore is also developed to analyse the mark

210 Using an alpha-hemolysin nanopore, we measured the dwell time for compl

211 Utilizing the alpha-hemolysin nanopore, we show that in the presence of Ag(+

212 captured in an electric field atop the alpha-hemolysin nanopore.

213 e concentration gradients applied over alpha-hemolysin nanopores.

214 and a mutation in an rtx gene resulted in a hemolysin-negative mutant, demonstrating that the rtx op

215 s performed with a vah1 mutant resulted in a hemolysin-negative mutant.

216 e mutations in rtx genes did not result in a hemolysin-negative phenotype.

217 P. acnes CAMP factor was neutralized or beta-hemolysin of S. aureus was mutated.

218 Hemolysins of V. anguillarum have been considered virule

219 and blocked the formation of a stable alpha-hemolysin oligomer on the target cell surface.

220 Pulmonary injury induced by isolated alpha-hemolysin or live S. aureus is independent of interleuki

221 biotype strains, which do not produce either hemolysin or the MARTX toxin, activated low-level IL-1be

222 t), iroN (salmochelin receptor), hlyA (alpha-hemolysin), or entF (enterobactin synthetase subunit).

223 cific bacterial clone, (iii) levels of alpha-hemolysin, or (iv) delta-hemolysin production were ident

224 oduce virulence factors such as leukocidins, hemolysins, or the antioxidant staphyloxanthin.

225 hly-encoded alpha hemolysin partially accounted for these effects by eleva

226 Because all strains had a similar beta-hemolysin phenotype, we surmise that thermostable direct

227 in mutualistic or hostile interactions (i.e. hemolysins, pilins, adhesins), and exoenzymes with a pot

228 glycol) molecules that enter a single alpha-hemolysin pore cause distinct mass-dependent conductance

229 es within the lumen of the stem of the alpha-hemolysin pore for the C4R1 dimer, but only one binding

230 les include purified proteins from the alpha-hemolysin pore from Staphylococcus aureus, the anthrax t

231 The transmembrane protein alpha-hemolysin pore has been used to develop ultrasensitive b

232 easurements of ion conductance through alpha-hemolysin pore in a bilayer lipid membrane revealed bloc

233 tion of the chelating agent through an alpha-hemolysin pore in the absence and presence of target ana

234 examined mutants of the staphylococcal alpha-hemolysin pore so severely truncated that the protein ca

235 ed sensors based on the staphylococcal alpha-hemolysin pore to allow the single-molecule detection an

236 -stranded DNA movement through a model alpha-hemolysin pore under an applied electric field.

237 EG copolymer threaded through a single alpha-hemolysin pore was induced by a combination of DNA stran

238 es of the temperature in and around an alpha-hemolysin pore, and we use this to explore melting prope

239 e protein unfolds and moves through an alpha-hemolysin pore, enables the distinction between unphosph

240 l)phosphonium chloride solution to the alpha-hemolysin pore, the alpha-hemolysin channel can be contr

241 s of polynucleotide folding: 1), Using alpha-hemolysin pores and a diverse set of different DNA hairp

242 gether, backward translocation through alpha-hemolysin pores combined with mesoscopic theoretical mod

243 pores with pore sizes smaller than the alpha-hemolysin pores have been prepared, primarily by electro

244 ngs, we detect the insertion of single alpha-hemolysin pores into the bilayer membrane, demonstrating

245 Two heptameric staphylococcal alpha-hemolysin pores were covalently linked in an aligned cap

246 il antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the a

247 anslocation of polynucleotides through alpha-hemolysin pores.

248 yclodextrin in multiple staphylococcal alpha-hemolysin pores.

249 Here we report evidence that alpha-hemolysin-positive (hly(+)) type I Escherichia coli (E.

250 The virulence factor alpha-hemolysin produced by S. aureus lyses perivascular macro

251 Hemolysins produced by Vibrio anguillarum have been impl

252 bated with pathogenic E coli including alpha-hemolysin producing strains.

253 bronectin binding in SCVs, it cannot promote hemolysin production in the absence of a functional elec

254 her pvl presence nor in vitro level of alpha-hemolysin production is the primary determinant of outco

255 delta hemolysin production was also inhibited, suggesting the

256 In vivo alpha-hemolysin production was reduced in both L and V-treated

257 ii) levels of alpha-hemolysin, or (iv) delta-hemolysin production were identified.

258 n-binding protein (FnBP) and greatly reduced hemolysin production, although the basis for this is unc

259 ell walls, significantly reduced capsule and hemolysin production, and restoration of the phenotypes

260 Furthermore, these studies revealed that hemolysins promote in the presence of lipoproteins the a

261 l for the binding of the enzyme to the alpha-hemolysin promoter.

262 cretion signal of the Escherichia coli alpha-hemolysin protein (HlyA) on a low-copy-number plasmid.

263 strate how peptide passage through the alpha-hemolysin protein can be sufficiently slowed down to obs

264 Here, a wild-type alpha-hemolysin protein nanopore was used to monitor DNA repai

265 of DNA through different mutations of alpha-hemolysin protein nanopores.

266 The sensing element is a wild-type alpha-hemolysin protein pore with boromycin as a molecular ada

267 strand of DNA-PEG copolymer inside an alpha-hemolysin protein pore.

268 re electrophoretically driven into the alpha-hemolysin protein pore.

269 The severe deficiency in alpha-hemolysin protein secretion in DeltafakA and DeltafakB1

270 through pores of wild-type and mutant alpha-hemolysin proteins.

271 Like alpha-hemolysin, purified alpha-toxin readily degrades Bcl-x(L

272 20-mer) through a protein ion channel (alpha-hemolysin) reconstituted in a DPhPC bilayer suspended ac

273 , we use a robust beta-barrel channel, alpha-hemolysin, reconstituted into planar lipid bilayers.

274 e used degenerate PCR to identify a positive hemolysin regulatory gene, hlyU, from the unsequenced V.

275 at GBS invades hAECs and strains lacking the hemolysin repressor CovR/S accelerate amniotic barrier f

276 reviously unrecognized sensing zone in alpha-hemolysin specific for dsDNA structure.

277 also regulates virulence genes, including a hemolysin, superantigen-like protein, and phenol-soluble

278 Among them are the thermostable direct hemolysin (TDH) and the TDH-related hemolysin (TRH), whi

279 enotype, we surmise that thermostable direct hemolysin (TDH) plays a limited role in these models.

280 ion was associated with the accessory toxins hemolysin, the multifunctional autoprocessing RTX toxin,

281 increased transcription of the thermolabile hemolysin (tlh).

282 vities of hemolysin exist, the connection of hemolysin to virulence in vivo is not well characterized

283 we identified in all a homologue of the beta-hemolysin toxin gene shared by Brachyspira hyodysenteria

284 riptional regulatory RNA important for alpha-hemolysin translation, suggesting that VfrB may function

285 The alpha-Hemolysin transmembrane channel interacts with a translo

286 e direct hemolysin (TDH) and the TDH-related hemolysin (TRH), which share amino acid similarities to

287 enes known to affect the production of alpha-hemolysin, two of them were associated with an apparent

288 e expression patterns of coagulase and alpha-hemolysin, two well-known sae target genes.

289 opore and the transmembrane pore of an alpha-hemolysin-under both equilibrium and nonequilibrium cond

290 toxin-receptor function revealed that alpha-hemolysin upregulates ADAM10 metalloprotease activity in

291 Vibrio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa beta-pore-formi

292 humans, secretes a PFT called V. vulnificus hemolysin (VVH), which contains a single C-terminal targ

293 y phase but not log phase CA-MRSA, and alpha-hemolysin was singularly identified as the mediator of t

294 vidual cells to the pore-forming agent alpha-hemolysin, we have controlled the membrane permeability,

295 hemolysis and cytolysis of recombinant beta-hemolysin were markedly enhanced by recombinant CAMP fac

296 ich dominated the response to S aureus alpha-hemolysin, were of low concentration or absent.

297 ranscription of the hla gene, encoding alpha-hemolysin, when grown in broth, as well as on RNAIII, a

298 h is held at the latch constriction of alpha-hemolysin, which is used to monitor the kinetics of base

299 upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signal

300 of the protein ion channel, wild-type alpha-hemolysin (WTalphaHL), and stochastic detection of a sma