ライフサイエンスコーパス: hemozoin

1 s to be a requisite step in the formation of hemozoin.

2 ization pathway, leading to the formation of hemozoin.

3 rasite digestive vacuole as a polymer called hemozoin.

4 edominantly sequestered as inert crystalline hemozoin.

5 arial parasites crystallize heme to nontoxic hemozoin.

6 ded organelle containing the malaria pigment hemozoin.

7 ystallization into physiologically insoluble hemozoin.

8 erization into the chemically inert pigment, hemozoin.

9 ce phagocytosed infected red blood cells and hemozoin.

10 ifferences between the synthetic and natural hemozoin.

11 arum has been implicated in the formation of hemozoin, a detoxified, crystalline form of ferric proto

12 ize of endogenous heme nanoparticles called "hemozoin," a unique component of all blood-stage malaria

13 te that during experimental schistosomiasis, hemozoin accumulating in the mouse liver is taken up by

14 The findings suggest that the influences of hemozoin accumulation and high-density parasitemia on pl

15 Endothelial cells, which encounter hemozoin after schizont rupture, respond to sHz by relea

16 Furthermore, the uptake of hemozoin also coincides with the hepatic expression of m

17 enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibo

18 ing hematophagy, we propose that schistosome hemozoin also provides a potent immunomodulatory functio

19 Malarial pigment (hemozoin) also accumulates in the placenta and may modul

20 part by bioactive parasite products such as hemozoin and infected red blood cell-derived extracellul

21 istinguishable from that of malaria pigment (hemozoin), and single crystal X-ray diffraction confirms

22 dation, heme polymerization into crystalline hemozoin, and antimalarial drug accumulation.

23 t or native HRP II promoted the formation of hemozoin, and chloroquine inhibited the reaction.

24 H]quinoline compounds became associated with hemozoin as assessed by electron microscope autoradiogra

25 physiologic amounts of P. falciparum-derived hemozoin augment NOS type 2 (NOS2) transcripts and NO pr

26 to the cytosolic compartment is mediated by hemozoin, because incubation of purified malaria pigment

27 steps for accurate quantification of de novo hemozoin/beta-hematin formation was verified experimenta

28 trying to unravel the molecular mechanism of hemozoin biosynthesis within the parasite digestive vacu

29 esented here demonstrate that acquisition of hemozoin by monocytes is associated with suppression of

30 sponding fraction of hemoglobin converted to hemozoin, calculated based on the known magnetic suscept

31 decreased hemoglobin concentrations and that hemozoin can induce NOS2-derived NO formation in culture

32 malaria-naive individuals demonstrated that hemozoin caused both increased and decreased MIF product

33 , binding of [3H]quinoline inhibitors to the hemozoin chain depended on the addition of heme substrat

34 The X-ray patterns indicated the presence of hemozoin clusters, each comprising several crystals alig

35 IF when stimulated with the malarial product hemozoin compared with cells carrying low expression MIF

36 sion was associated with increased placental hemozoin concentrations.

37 e parasites, compatible with the increase in hemozoin content and the mechanism used by P. falciparum

38 These results unambiguously demonstrate that hemozoin crystallites are identical to synthetic beta-he

39 s of cellular hemoglobin and convert it into hemozoin crystallites.

40 quinine, amodiaquine) function by preventing hemozoin crystallization.

41 the infected erythrocytes, forming nontoxic hemozoin crystals from large quantities of heme released

42 Hemozoin crystals have been reported to form within lipi

43 n vivo, we probed the mutual orientations of hemozoin crystals in situ within RBCs using synchrotron-

44 id death, the parasite synthesizes insoluble hemozoin crystals in the digestive vacuole through polym

45 y to address the location and orientation of hemozoin crystals within the digestive vacuole (DV), as

46 electron microscopy of a cluster of aligned hemozoin crystals within the parasite digestive vacuole.

47 cells by sequestration into submicron-sized hemozoin crystals.

48 ed alternative activation in the presence of hemozoin developed a phenotype specifically lacking in R

49 that the intact organelle, but not isolated hemozoin, dually activates the alternative complement an

50 ucidate how these drugs inhibit formation of hemozoin during metabolism of heme within the malarial p

51 The ab initio analysis of the hemozoin elementary cell showed that the Fe(3+) ion is i

52 TNF-alpha) abrogates this increase; and that hemozoin enhances HIV production.

53 rding the lack of quinoline association with hemozoin, explain the exaggerated accumulation of quinol

54 etic susceptibilities of hemoglobin heme and hemozoin ferriheme, was 0.50, in agreement with the publ

55 its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-

56 ng and identification of novel inhibitors of hemozoin formation as potential blood schizontocidal ant

57 ng DNA aptamers efficiently inhibit in vitro hemozoin formation catalyzed by either a model lipid sys

58 Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of f

59 Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high

60 n, indicating that the RCQ molecules inhibit hemozoin formation in the parasite's digestive vacuole i

61 a-hematin (synthetic hemozoin) formation and hemozoin formation in the parasite.

62 Inhibition of hemozoin formation possibly contributes to the mechanism

63 rocytes, and electron microscopy showed that hemozoin formation was defective in transgenic mice.

64 ifficult to reconcile with recent reports of hemozoin formation within lipid droplets in the digestiv

65 protein, PfHDP, a major protein involved in hemozoin formation, as a novel drug target.

66 Hemoglobin degradation/hemozoin formation, essential steps in the Plasmodium li

67 ein like MSP3, which does not participate in hemozoin formation, may suggest a protective role agains

68 Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falcip

69 is, HRPs bind the liberated heme and mediate hemozoin formation.

70 mechanisms in addition to the inhibition of hemozoin formation.

71 f chloroquine and involves the inhibition of hemozoin formation.

72 All inhibited both beta-hematin (synthetic hemozoin) formation and hemozoin formation in the parasi

73 n vitro beta-hematin (synthetic identical to hemozoin) formation by these laboratories has led to inc

74 r effects on the inhibition of beta-hematin (hemozoin) formation, and the results were compared with

75 ecific growth sites may be a general mode of hemozoin growth inhibition for the quinoline antimalaria

76 of action of antimalarial drugs that inhibit hemozoin growth.

77 get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-

78 for monomeric vs dimeric heme, and quantify hemozoin (Hz) formation inhibition in vitro.

79 Hemozoin (HZ) is an insoluble crystal formed in the food

80 malarial parasites and use those to quantify hemozoin (Hz) produced within the living parasite digest

81 s a role for Plasmodium products, especially hemozoin (Hz), in suppressed erythropoiesis during malar

82 a second parasite factor, malaria pigment or hemozoin (Hz), signals NOS induction through ERK- and nu

83 The mutants produce little or no hemozoin (Hz), the detoxification by-product of Hb degra

84 tic stage, during which heme is converted to hemozoin (Hz).

85 e donors revealed that P. falciparum-derived hemozoin (Hz; malarial pigment) and synthetic Hz (beta-h

86 Since deposition of malarial pigment (hemozoin [Hz]) contributes to suppression of erythropoie

87 enzamidines interfered with the formation of hemozoin in cell-free systems.

88 rythrocytes in the intervillous space but no hemozoin in macrophages nor increased intervillous infla

89 ve for P. falciparum presented parasites and hemozoin in macrophages or fibrin as well as intervillou

90 enerates a transient vapor nanobubble around hemozoin in response to a short and safe near-infrared p

91 Formation of hemozoin in the malaria parasite, due to its unique natu

92 i-infected erythrocytes or malarial pigment (hemozoin) induces the release of macrophage migration in

93 ably detailed investigations exist for other hemozoin inhibiting chemotypes.

94 e-binding aptamers recapitulate the in vitro hemozoin inhibition activity and induce parasite toxicit

95 uirement for compounds with similar in vitro hemozoin inhibitory potency to preconcentrate within the

96 Hemozoin is a crystalline metabolite of hemoglobin diges

97 Hemozoin is neither a TLR9 ligand for DCs nor functions

98 The heme polymer hemozoin is produced in the food vacuole (fv) of the par

99 malaria-infected placentas: some but not all hemozoin-laden maternal macrophages produced MIP-1 beta

100 V production by 40%-50% (P < .001), and that hemozoin-laden monocytes/macrophages that were preincuba

101 and IL-8 were produced by maternally derived hemozoin-laden placental macrophages.

102 trends as a function of parasite density and hemozoin level.

103 se in HIV-seropositive women with increasing hemozoin levels.

104 to ongoing stimulation of CD4(+) T cells by hemozoin-loaded antigen-presenting cells within lymphoid

105 s, with direct measurements of the synthetic hemozoin magnetization.

106 Hemozoin (malaria pigment) has been implicated in the mo

107 We report that hemozoin nanocrystals demonstrate superparamagnetic prop

108 lysis of the diffusion separation of natural hemozoin nanocrystals in the magnetic field gradient, wi

109 nce that acylglycerol lipids are involved in hemozoin nucleation in vivo, and nucleation of beta-hema

110 In order to ascertain the nature of hemozoin nucleation in vivo, we probed the mutual orient

111 We find that hemozoin nucleation occurs at the DV inner membrane, wit

112 Their analysis supports a model of hemozoin nucleation primarily in the DV.

113 Templated hemozoin nucleation was envisaged to explain a classic o

114 loroquine transport, and in association with hemozoin of the digestive vacuole, where chloroquine inh

115 In this study, the impact of hemozoin on cytokine production by intervillous blood mo

116 was a dose-dependent, suppressive effect of hemozoin on production of gamma interferon (IFN-gamma),

117 designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic

118 e production dysregulated by accumulation of hemozoin or high-density parasitemia may induce patholog

119 y large paramagnetic susceptibility of these hemozoin particles, which induce substantial changes in

120 owing the ingestion of Plasmodium falciparum hemozoin (pfHz; malarial pigment) by peripheral blood mo

121 tion of naturally acquired malarial pigment (hemozoin [PfHz]) by monocytes promoted the overproductio

122 ysregulated in response to malarial pigment (hemozoin [PfHz]) revealed that stem cell growth factor (

123 Yet these cells show a minor reduction in hemozoin production and IC(50) for chloroquine.

124 immunostimulatory activity of pure synthetic hemozoin (sHz) in vitro and in vivo.

125 has been implicated in (i) the production of hemozoin, the black pigment associated with disease, as

126 DV may serve a useful function in directing hemozoin to phagocytic cells for safe disposal.

127 erve to augment the initial host response to hemozoin via activation of the NALP3 inflammasome.

128 ature, and the quantity of extraerythrocytic hemozoin was higher, compared with mild MR cases (n = 5)

129 atically explore this hypothesis, S. mansoni hemozoin was purified and added to in vitro bone marrow-

130 n of beta-hematin, the synthetic analogue of hemozoin, was consistently induced at an acylglycerol-wa

131 h protection against schistosomiasis, making hemozoin well placed to play an important immunomodulato

132 e, thereby increasing the levels of heme and hemozoin, which are lethal to the parasite.

133 somes detoxify heme via crystallization into hemozoin, which is subsequently regurgitated into the ho

134 nd its initial application to DIC imaging of hemozoin within live, synchronized, intraerythrocytic Pl