ライフサイエンスコーパス: henipavirus

1 ic and highly pathogenic paramyxovirus genus Henipavirus.

2 lso utilized as a dissemination mechanism by henipaviruses.

3 l surface, including HIV, parainfluenza, and henipaviruses.

4 gent for the treatment of diseases caused by henipaviruses.

5 potential subunit vaccine immunogens against henipaviruses and also establish important tools for fur

6 iple serological assays reveal antibodies to henipaviruses and Lagos bat virus in all locations, incl

7 a new efficient vaccination strategy against henipaviruses and opens novel perspectives on the use of

8 mbrane fusion-triggering mechanism(s) of the henipaviruses and the paramyxoviruses.

9 The broad tropism of the henipaviruses and the unavailability of therapeutics thr

10 ute respiratory syndrome-like coronaviruses, henipaviruses, and Ebola virus.

11 viruses, including SARS-like corona viruses, henipaviruses, and lyssaviruses, understanding how patho

12 To this end, we followed henipavirus antibody levels of >100 individual E. helvum

13 Henipaviruses are zoonotic viruses that can cause severe

14 sults advance our basic understanding of the henipavirus assembly process and provide a novel model f

15 ractions with host cell machinery.IMPORTANCE Henipaviruses can cause deadly infections of medical, ve

16 are unknown, as are the mechanisms by which henipaviruses can cause disease.

17 ruses, influenza A viruses, hantaviruses, or henipaviruses, can result in profound pathology in human

18 Henipaviruses cause deadly infections in humans, with a

19 of a changing climate on the future risk for Henipavirus emergence.

20 After attaching to the host cell receptor, henipaviruses enter the target cell via direct viral-cel

21 To estimate the likelihood of henipaviruses entering the UK, a qualitative release ass

22 to cognate ephrinB receptors, indicate that henipavirus entry and fusion could differ mechanisticall

23 hrinB3 have been identified as receptors for henipavirus entry.

24 Emerging viruses in the paramyxovirus genus Henipavirus evade host antiviral responses via protein i

25 Here, several soluble forms of henipavirus F (sF) were engineered and characterized.

26 for most paramyxoviruses, activation of the henipavirus fusion protein occurs in recycling endosomal

27 hat ephrinB2 and -B3 binding determinants on henipavirus G are distinct and dissociable.

28 Henipavirus G chimeric protein analysis implicated resid

29 The henipavirus G glycoproteins lack both hemagglutinating a

30 for the highly specific interactions of the henipavirus G glycoproteins with only two members (ephri

31 ently published data for morbillivirus H and henipavirus G proteins, we extend our recently proposed

32 , recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerabl

33 h virus (NiV) and Hendra virus belong to the Henipavirus genus in the Paramyxoviridae family.

34 s (HeV) and Nipah virus (NiV) constitute the Henipavirus genus of paramyxoviruses, both fatal in huma

35 s one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designat

36 sely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae, which are dist

37 sely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae.

38 to a proline-rich microdomain unique to the Henipavirus genus.

39 ah virus (NiV), a paramyxovirus in the genus Henipavirus, has a mortality rate in humans of approxima

40 ximity to other countries where incidents of henipaviruses have occurred and the distribution of Pter

41 man metapneumovirus, and the deadly zoonotic henipaviruses Hendra and Nipah virus (NiV).

42 The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV),

43 The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV),

44 ly been shown to have antiviral activity for henipaviruses highlights the validity of this new screen

45 miners prompted the isolation of a rat-borne henipavirus (HNV), Mojiang virus (MojV).

46 Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reserv

47 The discovery of African henipaviruses (HNVs) related to pathogenic Hendra virus

48 ation among climate models to estimate where Henipavirus host distribution is most likely to expand,

49 e immune response in bats and indicates that henipavirus IFN antagonist mechanisms are likely active

50 (HeV) and Nipah virus (NiV) are in the genus Henipavirus in the family Paramyxoviridae.

51 There is new evidence for the presence of henipaviruses in African bats.

52 in geographical and species distribution of henipaviruses in Australasia which will contribute to pl

53 his study was to determine the occurrence of henipaviruses in fruit bat (Family Pteropodidae) populat

54 ey indicate the presence of non-NiV, non-HeV henipaviruses in fruit bat populations of Sulawesi and S

55 Evidence was obtained for the presence henipaviruses in the non-Pteropid species R. amplexicaud

56 The genus Henipavirus includes Hendra virus (HeV) and Nipah virus

57 Henipavirus infection causes severe respiratory illness

58 The host response to henipavirus infection in NHBE and SAEC highlighted a dif

59 virus entry receptors, mice are resistant to henipavirus infection.

60 ype I interferon signaling in the control of henipavirus infection.

61 l entry into host cells is the first step of henipavirus infections, which ultimately cause syncytium

62 have a Low annual probability of release of henipaviruses into the UK.

63 The emergence of this and other henipaviruses involves interactions among a suite of ant

64 Henipavirus is a new genus of Paramyxoviridae that uses

65 rategies to prevent lethal infections due to henipaviruses is highly desirable.

66 Nipah virus (NiV) (Genus Henipavirus) is a recently emerged zoonotic virus that c

67 zones according to location of outbreaks of henipaviruses, isolation of henipaviruses, proximity to

68 may have some antiviral activity against the henipaviruses, its use as an effective standalone therap

69 stigations into the growing numbers of novel henipavirus-like viruses.

70 ple emerging viruses, including filoviruses, henipaviruses, lyssaviruses, and zoonotic coronaviruses.

71 y highly pathogenic human viruses, including henipaviruses, lyssaviruses, severe acute respiratory sy

72 first time, host factors that interact with henipavirus M proteins and contribute to viral particle

73 , but where this bat species is absent other henipaviruses may be present, as on Sulawesi and Sumba.

74 ructs (sF(GCNt)) could elicit cross-reactive henipavirus-neutralizing antibody in mice.

75 re, we highlight the emergence of a zoonotic Henipavirus, Nipah virus, to demonstrate the interdiscip

76 The henipaviruses, Nipah virus (NiV) and Hendra virus (HeV),

77 The recognition of henipaviruses occurring across a wider geographic and ho

78 V) and Nipah virus (NiV) belong to the genus Henipavirus of the family Paramyxoviridae and are unique

79 ) and Hendra virus (HeV) are closely related henipaviruses of the Paramyxovirinae.

80 e of a conserved mechanism of retrovirus and henipavirus parasitization of cell-to-cell recognition p

81 cted trafficking processes are important for henipavirus particle production and identify a new host

82 cial new information in the understanding of henipavirus pathogenesis in the human respiratory tract

83 In this study, we characterized henipavirus pathogenesis using primary cells derived fro

84 ore, to facilitate spatiotemporal studies on henipavirus pathogenesis, we generated a firefly lucifer

85 -B3 usage will further our understanding of henipavirus pathogenesis.

86 ccine candidate in areas where both RABV and henipaviruses pose a threat to human health.

87 of outbreaks of henipaviruses, isolation of henipaviruses, proximity to other countries where incide

88 We show that the distribution of Henipavirus reservoirs, and therefore henipaviruses, wil

89 This optimized henipavirus reverse genetics system will facilitate futu

90 , and tested for the presence of HeV, NiV or henipavirus RNA by PCR.

91 Recent evidence identified multiple Henipavirus species in Africa distinct from those in Sou

92 nism that is a general property of the known Henipavirus species.

93 Henipavirus-specific vaccines are still commercially una

94 ogy and PCR also suggested the presence of a henipavirus that was neither HeV nor NiV in Pteropus ale

95 irus (TPMV), a relative of the morbilli- and henipaviruses that neither infects humans nor has cross-

96 cally related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin recepto

97 within the Paramyxovirinae subfamily called HENIPAVIRUS: These viruses are most closely related to m

98 dy was to develop candidate vaccines against henipaviruses utilizing two well-established rhabdoviral

99 findings characterize essential regions for Henipavirus V proteins that represent potential targets

100 GSL incorporation in henipaviruses was also dependent on the viral capsid (M)

101 of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease

102 ion of Henipavirus reservoirs, and therefore henipaviruses, will likely change under climate change s