ライフサイエンスコーパス: henselae

1 erless vector pANT3 and used to transform B. henselae.

2 te-enriched cultures were inoculated with B. henselae.

3 Escherichia coli or the 43-kDa antigen of B. henselae.

4 a homologue of this antigen is present in B. henselae.

5 fied upstream of the htrA gene of Bartonella henselae.

6 s hepatis was associated exclusively with B. henselae.

7 r improve the sensitivity of detection of B. henselae.

8 rs, all eight cats were rechallenged with B. henselae.

9 veterinarian was coinfected with Bartonella henselae.

10 of an antigenic autotransporter gene from B. henselae.

11 ke factor autotransporter gene (cfa) from B. henselae.

12 ed cohemolysin autotransporter protein of B. henselae.

13 and 138 (51%) cats were seropositive for B. henselae.

14 ensis, Rickettsia rickettsii, and Bartonella henselae.

15 s a previously unrecognized reservoir for B. henselae.

16 VirB type IV secretion system of Bartonella henselae.

17 d human THP-1 macrophages exposed to live B. henselae.

18 zabethae, 12.5%; to B. quintana, 9.5%; to B. henselae, 3.5%; to Seoul virus, 0.5%; and to Rickettsia

19 In Bartonella henselae, 8 of the 10 virB operon genes share extensive

20 bacilliformis gene is present in Bartonella henselae, a bacterium that is closely related to B. baci

21 disease is an infection caused by Bartonella henselae, a fastidious gram-negative bacillus acquired f

22 ell lysate fractions from closely related B. henselae, although possessing significant mitogenicity f

23 iosis, 26 (53 percent) were infected with B. henselae and 23 (47 percent) with B. quintana.

24 mpled, 5 cats (1.1%) were coinfected with B. henselae and B. clarridgeiae and 2 cats (0.5%) were coin

25 are it to infections with those caused by B. henselae and B. clarridgeiae.

26 and OMPs from B. koehlerae, compared with B. henselae and B. clarridgeiae.

27 Bartonella henselae and B. koehlerae bacteremia was documented in t

28 Bartonella henselae and B. quintana induce an unusual vascular prol

29 st often responsible for human infection, B. henselae and B. quintana, cause prolonged febrile illnes

30 Two species, B. henselae and B. quintana, have been associated with baci

31 B. henselae and B. quintana, the organisms that cause bacil

32 tosis, but immunohistochemistry ruled out B. henselae and B. quintana.

33 e protein family of proteins from Bartonella henselae and Bartonella quintana, respectively.

34 Rickettsia species, as well as on Bartonella henselae and Escherichia coli, and the assay was found t

35 ce and was reactive with rabbit anti-live B. henselae and mouse anti-Pap31 antibodies by Western blot

36 R), which allowed direct detection of both B henselae and quintana DNA in patient's peripheral blood

37 an tubes containing EDTA for isolation of B. henselae and suggest that, for cat blood, collection in

38 ies (i.e., B. vinsonii subsp. berkhoffii, B. henselae, and B. clarridgeiae) that are currently recogn

39 , 4, and 2 were positive for B. quintana, B. henselae, and C. burnetii, respectively, by the dPCR ass

40 ifferentiate Bartonella quintana, Bartonella henselae, and Coxiella burnetii from surgical heart valv

41 (GFP) gene was expressed on a plasmid in B. henselae, and GFP-expressing bacteria were visualized by

42 lla abortus, Brucella melitensis, Bartonella henselae, and Legionella pneumophila, which are also abl

43 fections, e.g., Brucella abortus, Bartonella henselae, and Legionella pneumophila.

44 lichiosis (HGE), Ehrlichia canis, Bartonella henselae, and Rickettsia rickettsii.

45 en-free cats were inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infected cat bl

46 nts > 4 weeks into illness) and confirmed B. henselae as the causative species.

47 ts developed strong antibody responses to B. henselae, as determined by Western blot analysis and enz

48 role for microglia in the pathogenesis of B. henselae-associated neurological disease.

49 A cosmid library of B. henselae ATCC 49793 was constructed using SuperCos1 in E

50 known to be infected with either Bartonella henselae, B. clarridgeiae, or B. vinsonii subsp. berkhof

51 B. henselae, B. quintana, and C. burnetii seropositivity wa

52 artonella species and subspecies: Bartonella henselae, B. quintana, B. washoensis, and B. vinsonii su

53 inarian were not reactive against Bartonella henselae, B. quintana, or B. elizabethae antigens but we

54 station was a significant risk factor for B. henselae bacteremia (odds ratio = 2.82, 95% confidence i

55 B. henselae bacteremia was detected in 89% of the 47 natura

56 Sixty-five (24%) cats had Bartonella henselae bacteremia, and 138 (51%) cats were seropositiv

57 determine the longitudinal prevalence of B. henselae bacteremia, the prevalence of B. henselae in th

58 blood and serum were negative for Bartonella henselae, Bartonella quintana, and B. bacilliformis.

59 complex isolates and one each of Bartonella henselae, Bartonella quintana, Shigella flexneri, Klebsi

60 cloned fragment of Bartonella (Rochalimaea) henselae (Bh) DNA was found to direct synthesis of an im

61 (GFP) gene (gfpmut3) and transformed into B. henselae by electroporation.

62 Cats were readily infected with B. henselae by intravenous inoculation, developed histopath

63 B. henselae can be difficult to culture axenically, and as

64 parenchymal peliosis, and in the case of B. henselae cat-scratch disease.

65 Bartonella (Rochalimaea) henselae causes cat-scratch disease, bacillary angiomato

66 Promoter fusions of B. henselae chromosomal DNA to gfp were examined by flow cy

67 rozen blood yielded the largest number of B. henselae colonies for any of the schedules tested.

68 Cats bacteremic with B. henselae constitute a large reservoir from which humans

69 sive antibody to the homologous strain of B. henselae did not prevent bacteremia.

70 e tested individually for the presence of B. henselae DNA by PCR.

71 lenic cat scratch disease by detection of B. henselae DNA in the orbital abscess fluid.

72 B. henselae DNA was detected in 34% of 132 fleas, with seas

73 for Bartonella serology was positive, and B henselae DNA was identified by PCR in the peripheral blo

74 B. henselae DNA was identified in 27 of 42 (64%) histologic

75 Herein, we report a case of Bartonella henselae endocarditis involving prosthetic mitral and ao

76 e report the first feline case of Bartonella henselae endocarditis.

77 should elucidate the mechanisms by which B. henselae establishes persistent bacteremic infections wi

78 ilitated the primary isolation of Bartonella henselae from blood and aqueous fluid of naturally infec

79 xicity, implicating HbpC in protection of B. henselae from the toxic levels of heme present in the gu

80 Bartonella henselae fur gene expression complemented a Vibrio chole

81 cular microbiological evidence of Bartonella henselae genotype San Antonio 2 (SA2) infection in four

82 fp were examined by flow cytometry, and a B. henselae groEL promoter fusion which induced expression

83 Bartonella henselae has only recently been isolated, characterized,

84 In the wild-type strain, transcription of B. henselae hbpC was upregulated at arthropod temperature (

85 detella pertussis, Brucella spp., Bartonella henselae, Helicobacter pylori and Legionella pneumophila

86 sposon mutagenesis to screen for genes in B. henselae heme binding and uptake pathways.

87 i subsp. berkhoffii, B. clarridgeiae, and B. henselae), highly suggestive of Bartonella endocarditis.

88 31 is an Fn-binding protein mediating the B. henselae-host interaction(s), and they implicate the 13F

89 21.2% of sera from patients positive for B. henselae immunoglobulin G antibodies by indirect immunof

90 We designed a study to detect B. henselae in archival biopsies by polymerase chain reacti

91 B. henselae LSU16 is a virulent strain of B. henselae in cats and propose that the virulence of B. he

92 in cats and propose that the virulence of B. henselae in cats is strain dependent.

93 derstand better the long-term survival of B. henselae in cats, we examined the feline humoral immune

94 tribution of antibodies to the control of B. henselae in cats.

95 ting reports describe the pathogenesis of B. henselae in the cat.

96 contributes to the persistence of Bartonella henselae in the chronically infected vascular endotheliu

97 B. henselae bacteremia, the prevalence of B. henselae in the fleas infesting these cats, and whether

98 ng to explore the population structure of B. henselae in the United Kingdom and to determine the dist

99 Overexpression of hbpC in B. henselae increased resistance to heme toxicity, implicat

100 62%) also had titers > or = 64 to Bartonella henselae, indicating serologic cross-reactivity between

101 In the immunocompromised individual, B. henselae-induced angiogenesis, or bacillary angiomatosis

102 We also investigated the role of IL-8 in B. henselae-induced endothelial cell proliferation and capi

103 I found that B. henselae induces long-term endothelial survival and tubu

104 B. henselae induction of VEGF, IL-1beta, and IL-8 outlines

105 Blood specimens from B. henselae-infected cats were collected in both EDTA and I

106 re was determined with blood samples from B. henselae-infected cats.

107 Furthermore, supernatants from B. henselae-infected HMEC-1 were able to induce chemotaxis

108 ll is recruited to the endothelium during B. henselae infection and then contributes to bacterial-ind

109 ributing to the angiogenic process during B. henselae infection by infiltrating BA lesions and secret

110 Previously, it has been shown that B. henselae infection can result in production of the chemo

111 peliosis hepatis due to systemic Bartonella henselae infection in a patient after kidney transplant.

112 port the first case of HLH due to Bartonella henselae infection in a patient with human immunodeficie

113 Bartonella henselae infection was established in eight cats of vari

114 Patients with B. henselae infection were identified throughout the study

115 arditis of the aortic valve due to Bartonell henselae infection.

116 , high-dose androgen therapy, and Bartonella henselae infection.

117 d hepatocytes produce IL-8 in response to B. henselae infection.

118 ization that promote the establishment of B. henselae infections in vivo.

119 tern of ocular disease in AIDS-associated B. henselae infections is poorly delineated; unusual manife

120 cin may prove useful for the treatment of B. henselae infections.

121 study was undertaken to determine whether B. henselae infects feline fetal brain cells in vitro.

122 All B. henselae-inoculated cats were bacteremic by 2 weeks afte

123 The ability to model B. henselae invasion of feline RBC in vitro should permit i

124 Bartonella henselae is a gram-negative pathogen that causes angioge

125 Bartonella henselae is a recently recognized pathogenic bacterium a

126 Bartonella henselae is an emerging bacterial pathogen, causing cat

127 The gram-negative bacterium Bartonella henselae is capable of causing angiogenic lesions as a r

128 Bartonella henselae is increasingly associated with a variety of pa

129 Thus, expression of the virB genes of B. henselae is induced in bacteria, which have invaded host

130 Bartonella henselae is known to cause central nervous system (CNS)

131 Bartonella henselae is one of the most common zoonotic agents acqui

132 A hallmark of Bartonella henselae is persistent bacteremia in cats despite the pr

133 Bartonella henselae is responsible for various disease syndromes th

134 Bartonella henselae is the causative agent of human cat scratch dis

135 s demonstrated that Bartonella (Rochalimaea) henselae is the definitive agent of cat-scratch disease.

136 demiological studies suggest that Bartonella henselae is the etiological agent of cat scratch disease

137 ye by Parinaud's oculoglandular syndrome; B. henselae is the most common cause.

138 e fleas infesting these cats, and whether B. henselae is transmitted experimentally to cats via fleas

139 cultative intracellular bacterium Bartonella henselae, is characterized by angiogenic lesions.

140 Using Bartonella henselae isolates from cats and a human, the activity of

141 Vector-mediated transmission of B.henselae isolates was evaluated by removing fleas from t

142 The 16S rRNA type was determined for 49 B. henselae isolates.

143 intracellular pathogens, such as Bartonella henselae, Listeria monocytogenes, Legionella pneumophila

144 wo-dimensional immunoblots indicated that B. henselae LPS and members of the Hbp family of proteins d

145 We conclude that B. henselae LSU16 is a virulent strain of B. henselae in ca

146 ciens and similar pathogens (e.g. Bartonella henselae) may also be able to transform human cells.

147 B. henselae-mediated inhibition of apoptosis, as indicated

148 We hypothesize that B. henselae-mediated interaction with immune cells, namely,

149 ery disease and seropositivity to Bartonella henselae (odds ratio [OR], 0.852; 95% confidence interva

150 ucted, eight were seroreactive to Bartonella henselae, one to E. chaffeensis, and one to R. rickettsi

151 This study indicates that B. henselae or B. clarridgeiae can induce chronic infection

152 epitope expression during infection with B. henselae or B. quintana.

153 pitope conservation during infection with B. henselae or B. quintana.

154 cted infection with a Bartonella species (B. henselae or B. vinsonii subsp. berkhoffii) in blood samp

155 Bartonella henselae or Bartonella elizabethae DNA from EDTA-anticoa

156 p 1), 10(8) (group 2), or 10(6) (group 3) B. henselae or with saline (group 4) or were not inoculated

157 nella vinsonii subsp. berkhoffii, Bartonella henselae, or DNA of both organisms was amplified and seq

158 ned the feline humoral immune response to B. henselae outer membrane (OM) proteins in naturally and e

159 hat HbpC binds hemin and localizes to the B. henselae outer membrane and outer membrane vesicles.

160 his study we examined the interactions of B. henselae Pap31 with fibronectin (Fn), heparin (Hep), and

161 hogens were identified, including Bartonella henselae Pap31, Brucella Omp31, Agrobacterium tumefacien

162 sest homologs to HbpA include the Bartonella henselae phage-associated membrane protein, Pap31 (58.4%

163 in A (BepA) of vasculotumorigenic Bartonella henselae protects the infected human endothelial cells a

164 s were variable, one approximately 83-kDa B. henselae protein (Bh83) was immunoreactive with all CSD

165 lI-EcoRI DNA fragment expresses a 120-kDa B. henselae protein immunoreactive with 21.2% of sera from

166 Bartonella have been found to infect humans, henselae, quintana, elizabethae, bacilliformis, and vins

167 crovascular endothelial cells (HMEC-1) by B. henselae resulted in the formation of well-defined vacuo

168 Infection of human endothelial cells by B. henselae resulting in IL-8 production likely plays a cen

169 gens have emerged recently (e.g., Bartonella henselae, Rickettsia felis), and their mechanisms of tra

170 ifornia were significant risk factors for B. henselae seropositivity.

171 y made on the basis of increasing Bartonella henselae serum antibody titers.

172 Heterogeneous B. henselae-specific IgG reactivity with numerous protein b

173 more, infection of endothelial cells with B. henselae stimulated upregulation of the IL-8 chemokine r

174 Experimental inoculation of cats with B. henselae strains demonstrated that both constitutive exp

175 e hypothesis for this discrepancy is that B. henselae strains vary in their zoonotic potential.

176 A total of 118 B. henselae strains were delineated into 12 sequence types

177 B. henselae target DNA was amplified from 100% of samples w

178 this study, we characterized a strain of B. henselae termed LSU16.

179 B. koehlerae was more closely related to B. henselae than to B. clarridgeiae by protein profile, and

180 arridgeiae and several strains of Bartonella henselae, the agent of cat scratch disease, with variati

181 erica are Bartonella quintana and Bartonella henselae, the agents of trench fever, bacillary angiomat

182 patients who had a high titer for Bartonella henselae, the causative agent of bacillary angiomatosis

183 Bartonella henselae, the causative agent of cat scratch disease, es

184 Early recognition of HLH and B. henselae through liver biopsy and serological tests led

185 the cat were reactive against antigens of B. henselae (titer, 1,024), B. quintana (titer, 128), and t

186 trate that the cat flea readily transmits B. henselae to cats.

187 to antibody-positive queens with Bartonella henselae to determine the contribution of antibodies to

188 from bacteremic cattery cats transmitted B. henselae to five SPF kittens in two separate experiments

189 Adherence of intact B. henselae to HUVECs was inhibited by increasing concentra

190 nd deletion of hbpC affect the ability of B. henselae to infect the cat host.

191 sion appears to be a strategy employed by B. henselae to survive in the arthropod vector and the mamm

192 his study, we investigated the ability of B. henselae to upregulate MCP-1 gene expression and protein

193 naturally infected cats was used to probe B. henselae total membranes to detect commonly recognized a

194 We identified a B. henselae transposon mutant that constitutively expresses

195 lae with variations in the 16S rRNA gene, B. henselae type I and type II.

196 t had high Bartonella antibody titers and B. henselae type I DNA was detected in the damaged aortic v

197 Sequencing of the region upstream of the B. henselae virB2 gene revealed a region with sequence homo

198 ith the bacteriophage harbored in Bartonella henselae was cloned and sequenced.

199 bserved a CAMP-like reaction when Bartonella henselae was grown in close proximity to S. aureus on 5%

200 B. henselae was identified in 8 of 10 serologically positiv

201 er revealed similar banding patterns when B. henselae was reacted against the Ig isotypes IgG and IgG

202 kDa antigen gene, which replaces virB5 in B. henselae, was also demonstrated at the protein level usi

203 - and serum antibody-negative for Bartonella henselae, were randomly allocated to groups and were int

204 class-specific reactivity against Bartonella henselae whole-cell antigen.

205 Our study strongly associates B. henselae with cat scratch disease, suggesting that it ma

206 0.5%) were coinfected with two strains of B. henselae with variations in the 16S rRNA gene, B. hensel

207 Bartonella henselae wound-associated infections suggest involvement