ライフサイエンスコーパス: hepacivirus

1 ntification in domestic dogs of a nonprimate hepacivirus.

2 longing to the family flaviviridae and genus hepacivirus.

3 ce of ancient recombination with these other hepaciviruses.

4 t on the genetic diversity and host range of hepaciviruses.

5 es has resulted in escape from antagonism by hepaciviruses.

6 s) of the RNA genomes of Flaviviridae of the Hepacivirus and Pestivirus genera contain internal ribos

7 four cysteine residues, conserved among the Hepacivirus and Pestivirus genera, fitting the formula o

8 data highlight the similarities between the Hepacivirus and Pestivirus NS5A proteins and suggest tha

9 on the natural history and evolution of the hepaciviruses and on the extent of structural variation

10 major and ancient natural reservoir for both hepaciviruses and pegiviruses and provide insights into

11 Hepaciviruses and pegiviruses constitute two closely rel

12 erse group of bat-derived viruses related to hepaciviruses and pegiviruses within the family Flavirid

13 volutionary analyses revealed that all known hepaciviruses and pegiviruses, including those previousl

14 about the origin and evolution of the animal hepaciviruses as well as their potential usage as surrog

15 tics, the IRES of hepatitis C virus (HCV), a Hepacivirus belonging to Flaviviridae, cannot as yet be

16 of HCV include a recently discovered canine hepacivirus (CHV) and GB virus B (GBV-B), both viruses w

17 parative phylogenetic analysis of the canine hepacivirus (CHV) confirmed it to be the most geneticall

18 Here we show that an HCV-related hepacivirus discovered in Norway rats can establish high

19 Equine hepacivirus (EHCV; nonprimate hepacivirus) is a hepatotr

20 gy caused by another, more rapidly resolving hepacivirus, GB virus B (GBV-B), in infections of common

21 nnate immunity in resolving infection with a hepacivirus, GBV-B, in common marmosets.

22 ars, the known phylogenetic diversity of the hepacivirus genera has absolutely exploded.

23 of hepatitis C virus (HCV), a member of the Hepacivirus genus of the family Flaviviridae, has been d

24 The new virus, guereza hepacivirus (GHV), clusters phylogenetically with GBV-B

25 xpanded the previously mammal-only pegivirus-hepacivirus group to include a virus from the graceful c

26 B virus B (GBV-B; family Flaviviridae, genus Hepacivirus) has been studied in New World primates as a

27 ry, pathogenesis, and immunity of this novel hepacivirus in its natural host.

28 The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to

29 ow that NS3 proteases from all other primate hepaciviruses, including the highly divergent GBV-A and

30 enetically with GBV-B and recently described hepaciviruses infecting African bats and North American

31 netic and biological characterization of new hepaciviruses infecting animals contributes to our under

32 st that NK cell and DC mobilization in acute hepacivirus infection can dampen virus replication but a

33 vention, and treatment of diseases caused by hepacivirus infection.

34 and thus represents an animal model to study hepacivirus infections in their natural hosts.

35 ile GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primates (tamarins

36 Equine hepacivirus (EHCV; nonprimate hepacivirus) is a hepatotropic member of the Flavivirida

37 Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver

38 ch primates might clear infections by extant hepaciviruses like HCV.

39 aled that the genetic distance between these hepaciviruses likely prevented virus morphogenesis.

40 Nonprimate hepacivirus (NPHV) is the closest known relative of hepa

41 he natural host of the only known nonprimate hepacivirus (NPHV), CHV, which is also the closest phylo

42 sest homolog of HCV is the equine nonprimate hepacivirus (NPHV), which shares similar features with H

43 Among these novel viruses, the nonprimate hepaciviruses (NPHV) that infect horses are the closest

44 l for deciphering virus-host interactions in hepacivirus pathogenesis.

45 The mechanism of translation initiation on hepacivirus/pestivirus (HP) IRESs, which involves factor

46 n the closest genetic relatives of the human hepaciviruses, providing an intriguing clue to the zoono

47 animal and primate hepaciviruses, the equine hepaciviruses remain the closest genetic relatives of th

48 l NPHV cDNA clones and other novel tools for hepacivirus studies.

49 inants between HCV and GB virus B (GBV-B), a hepacivirus that infects small New World primates (tamar

50 ntification of these many animal and primate hepaciviruses, the equine hepaciviruses remain the close