ライフサイエンスコーパス: heparan sulfate

1 degradation pathway of dermatan sulfate and heparan sulfate.

2 glycan (GAG) adhesion molecules and binds to heparan sulfate.

3 ls, binding of FH is generally attributed to heparan sulfate.

4 ls is influenced by the sulfation pattern of heparan sulfate.

5 U), deficiency of NAGLU, and accumulation of heparan sulfate.

6 of AMD, reduces the binding of FHL-1 to this heparan sulfate.

7 blocks binding to scavenger receptor B1 and heparan sulfate.

8 minal AgRP, not the N-terminal domain, binds heparan sulfate.

9 peptides with glycosaminoglycans, including heparan sulfate.

10 al glycocalyx coverage, with preservation of heparan sulfate.

11 Hpa2 function does not rely on heparanase or heparan sulfate.

12 glycosaminoglycans, particularly heparin and heparan sulfate.

13 heparin or enzymatic removal of cell surface heparan sulfates.

14 evidence suggested the role of 3-O-sulfated heparan sulfate (3-OS HS) during HCMV-mediated entry and

15 oprotein D (gD) to the receptor 3-O-sulfated heparan sulfate (3-OS HS) mediates viral entry.

16 Further, lower levels of heparan sulfate (3.41 +/- 5.6 pg/mL [study group] vs 43.

17 of twenty-three experimental measurements on heparan sulfate, a mixture of linear chains of disacchar

18 lysosomal enzymes that specifically degrade heparan sulfate, a sulfated glycosaminoglycan.

19 Heparan sulfate, a sulfated linear polysaccharide modifi

20 ely charged glycans, such as sialic acid and heparan sulfate, abundant on cell surface membranes.

21 Heparan sulfate accelerated AL-12, AL-09, kappaI Y87H, a

22 ntration of thrombomodulin and the degree of heparan-sulfate accelerated antithrombin activity on tho

23 r the activity of major inhibitors including heparan-sulfate-accelerated antithrombin and activated p

24 e only enzyme in mammals capable of cleaving heparan sulfate, an activity implicated in tumor inflamm

25 We observed a 3-fold elevation in CSF heparan sulfate and a 3-8 fold increase in MPS-IH specif

26 SLIT3, but not ROBO4, binding to endothelial heparan sulfate and attenuated EC migration and in vivo

27 so appeared in liver cells, where it reduced heparan sulfate and beta-hexosaminidase accumulation to

28 normal levels of attachment to cell surface heparan sulfate and binding to nectin-1 receptor.

29 gosaccharide acceptors resembling unmodified heparan sulfate and chondroitin sulfate precursor molecu

30 BMP-2, as well as glycosaminoglycans such as heparan sulfate and chondroitin sulfate.

31 Binding was reduced after the removal of heparan sulfate and following the inhibition of glycosam

32 es corresponded with augmented extracellular heparan sulfate and glypican 4 levels.

33 Cell surface anionic glycosaminoglycans heparan sulfate and HA protect the cells against histone

34 ral pieces of evidence that demonstrate that heparan sulfate and other closely related glycosaminogly

35 ween the alpha-synuclein amyloid fibrils and heparan sulfate and show that overall sulfation of the h

36 E is likely responsible for virus binding to heparan sulfate and that N- and 6-O-sulfation of the hep

37 Our data also implicate NCX-9 in a LON-2/heparan sulfate and UNC-6/netrin-mediated, RAC-dependent

38 ted two native GAGs (chondroitin sulfate and heparan sulfate) and compared our results to chemically

39 nthesized chondroitin, unsulfated heparosan, heparan sulfate, and alginate.

40 Heparan sulfate, and especially disease-specific heparan

41 o Bruch's membrane through interactions with heparan sulfate, and we show that the common Y402H polym

42 Heparan sulfates are implicated in a wide range of biolo

43 an), and glycosaminoglycans (eg, hyaluronan, heparan sulfate) are upregulated on cardiac injury and r

44 ionic glycosaminoglycans hyaluronic acid and heparan sulfate as two key macromolecules that establish

45 Recently, syndecan-1 (SDC1), a transmembrane heparan sulfate-bearing proteoglycan, was also speculate

46 cause fibroblast growth factor 22 (FGF22), a heparan sulfate binding growth factor, has been shown to

47 Despite the large number of heparin and heparan sulfate binding proteins, the molecular mechanis

48 tructurally equivalent residues from AAV2, a heparan sulfate binding serotype, followed by cell bindi

49 otective antibody that binds adjacent to the heparan sulfate binding site of A27, likely affecting li

50 proach specifically designed to identify HEP/heparan sulfate binding sites in proteins were first car

51 stablish structure activity relationships of heparan sulfate binding with its receptor, the synthesiz

52 s, we identify exosomal fibronectin as a key heparan sulfate-binding ligand and mediator of exosome-c

53 a provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical r

54 s, they are more appropriately classified as heparan sulfate-binding proteins (HSBPs).

55 mice that lack Ext1, an enzyme required for heparan sulfate biosynthesis, in hepatocytes.

56 n this study, we report that ablation of the heparan sulfate biosynthetic enzyme NDST1 in murine endo

57 the nucleus along with sSDC1, and removal of heparan sulfate-bound cargo from sSDC1 abolished its tra

58 in/dermatan sulfate by approximately 50-60%, heparan sulfate by approximately 35%), N-acetyl-d-glucos

59 e + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrated significantly higher

60 we further investigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and o

61 To study in more detail the role of EXTL2 in heparan sulfate chain elongation, we tested the ability

62 stimulates elongation resulting in increased heparan sulfate chain length.

63 he same cell line had little or no effect on heparan sulfate chain length.

64 Interestingly, cargo bound to sSDC1 heparan sulfate chains (i.e. hepatocyte growth factor) w

65 in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear transloc

66 the balance between chondroitin sulfate and heparan sulfate chains in dictating ligand responses wit

67 In conclusion, the lack of Sdc4 heparan sulfate chains in the kidneys of Sdc4-null mice

68 The negatively charged heparan sulfate chains interact with a multitude of diff

69 lfate and show that overall sulfation of the heparan sulfate chains is more important than sulfation

70 st GPC3, which preferentially recognized the heparan sulfate chains of GPC3, both the sulfated and no

71 ns these proteins actually interact with the heparan sulfate chains of one or more membrane or extrac

72 ing that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signa

73 er affinity for endothelial-derived perlecan heparan sulfate chains than serglycin GAG chains.

74 d of lipid bilayer, proteoglycan dimers, and heparan sulfate chains with realistic sequences.

75 the core LON-2/glypican protein, lacking its heparan sulfate chains, and secreted forms of LON-2/glyp

76 family glycopeptide containing two different heparan sulfate chains, namely the extracellular domain

77 ransferase activity related to elongation of heparan sulfate chains.

78 related to the initiation and termination of heparan sulfate chains.

79 ectodomain and the extended conformation of heparan sulfate chains.

80 yx, a layer of glycosaminoglycans (including heparan sulfate, chondroitin sulfate, and hyaluronic aci

81 ctrometry on urine samples to determine GAG (heparan sulfate, chondroitin sulfate, and hyaluronic aci

82 acid) concentrations as well as patterns of heparan sulfate/chondroitin sulfate disaccharide sulfati

83 Heparitinase I, which selectively cleaves heparan sulfate, completely abolished extracellular TG2

84 f ions and proteins with the chondroitin and heparan sulfate components of the extracellular matrix;

85 Plasma heparan sulfate concentrations directly correlated with

86 data support the idea that abnormalities in heparan sulfate content and distribution contribute to a

87 lfate synthesized was confirmed by analyzing heparan sulfate content in tissues isolated from Ndst2(-

88 sing cells alone could explain the increased heparan sulfate content.

89 chondroitin sulfate/dermatan sulfate nor the heparan sulfate derived from CCD-1095Sk cells primed on

90 ammalian heparanase digestion of heparin and heparan sulfate exposes a cryptic motif on the non-reduc

91 paranase expression, consequent reduction in heparan sulfate expression and endothelial glycocalyx th

92 phragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT3-ROBO4 signa

93 Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathoge

94 We propose that heparan sulfate facilitates the formation of transient a

95 AFM pulling on glypican-1 and heparan sulfate for 10 min caused significantly increase

96 n mature viruses specifically interacts with heparan sulfate for cell surface attachment.

97 We found that circulating heparan sulfate fragments were significantly (23-fold) e

98 ether, our data provide strong evidence that heparan sulfate from both neutrophils and the endotheliu

99 howed no major structural difference between heparan sulfate from control and Ndst2(-/-) tissues, wit

100 nd Ndst2(-/-) tissues, with the exception of heparan sulfate from spleen where the relative amount of

101 Heparan sulfate from the cerebral cortex of MPS IIIA mic

102 Removal of heparan sulfate from the exosome surface releases fibron

103 ration-dependent manner by the XylNap-primed heparan sulfate GAGs.

104 -Delta20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs) but not to the

105 ns that couple a membrane-docking peptide to heparan sulfate glycosaminoglycans (GAGs) with a PTD.

106 3-O-sulfated N-sulfoglucosamine residues of heparan sulfate glycosaminoglycans.

107 affinities in the following order: heparin > heparan sulfate > chondroitin sulfate = dermatan sulfate

108 ncluding cello-oligosaccharides, hyaluronan, heparan sulfate, heparin, and chondroitin sulfate, and c

109 s of the glycosaminoglycans-hyaluronan (HA), heparan sulfate/heparin (HS/HP), chondroitin/dermatan su

110 ract with CCL5 with the highest affinity are heparan sulfates/heparin.

111 omputational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare seq

112 Heparan sulfate (HS) 3-O-sulfation determines the bindin

113 Heparan sulfate (HS) and chondroitin sulfate (CS) glycos

114 Heparan sulfate (HS) and HS proteoglycans (HSPGs) coloca

115 he host glycosaminoglycans heparin (Hep) and heparan sulfate (HS) are high-priority carbohydrates for

116 Heparin and heparan sulfate (HS) are linear polysaccharides that are

117 scribed to establish ligand requirements for heparan sulfate (HS) binding proteins based on a workflo

118 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.

119 Four well-defined heparan sulfate (HS) block copolymers containing S-domai

120 Heparin and heparan sulfate (HS) by nature contain multiple isomeric

121 physiological glycosaminoglycan (GAG) target heparan sulfate (HS) by single molecule force spectrosco

122 various tissue injury factors through their heparan sulfate (HS) chains, but the importance of HSPGs

123 , and overexpression approaches identified a heparan sulfate (HS) component of proteoglycans as an im

124 Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypi

125 mplex virus-1 (HSV-1) attach to cell surface heparan sulfate (HS) for entry into host cells.

126 marine sponges, chondroitin sulfate (CS) and heparan sulfate (HS) have been identified in Cnidarians,

127 are correlated with the expression level of heparan sulfate (HS) in human skin.

128 Heparan sulfate (HS) is a complex oligosaccharide that i

129 Heparan sulfate (HS) is a component of cell surface and

130 Heparan sulfate (HS) is a linear sulfated polysaccharide

131 Heparan sulfate (HS) is a polysaccharide known to modula

132 Heparan sulfate (HS) is a sulfated polysaccharide that d

133 Heparan sulfate (HS) is an abundant polysaccharide in th

134 Heparan sulfate (HS) is an essential component of the ex

135 quisite control of growth factor function by heparan sulfate (HS) is dictated by tremendous structura

136 ional entity composed of a complex synthetic heparan sulfate (HS) oligosaccharide and biotin.

137 By controlling the sulfation patterns of heparan sulfate (HS) on pluripotent embryonic stem cell

138 Heparan sulfate (HS) plays a crucial role in the fibrosi

139 Heparan sulfate (HS) polysaccharides are ubiquitous in a

140 A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatica

141 Heparan sulfate (HS) proteoglycan chains are key compone

142 We find that SDN-1 is the predominant heparan sulfate (HS) proteoglycan in the early C. elegan

143 Expression of the heparan sulfate (HS) proteoglycan syndecan-1 is a hallma

144 ow that raised level of SDC4, a cell-surface heparan sulfate (HS) proteoglycan, plays a role in patho

145 membrane (ILM), a basement membrane rich in heparan sulfate (HS) proteoglycan.

146 Heparan sulfate (HS) proteoglycans are found on the cell

147 cosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an ac

148 s growth factors and angiogenic factors from heparan sulfate (HS) storage sites and alters the integr

149 (HCV) entry involves binding to cell surface heparan sulfate (HS) structures.

150 n by 2.5-fold, whereas cell surface SDC4 and heparan sulfate (HS) were reduced by 36 and 30%, respect

151 Here we show that heparan sulfate (HS), a class of glycosaminoglycan chain

152 of the undegraded glycosaminoglycans (GAGs) heparan sulfate (HS), and dermatan sulfate (DS), progres

153 Heparan sulfate (HS), critical to establish CCL21 gradie

154 EXTL3 regulates the biosynthesis of heparan sulfate (HS), important for both skeletal develo

155 saminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous

156 (EXT1), which is involved in biosynthesis of heparan sulfate (HS), plays a role in filovirus entry.

157 isaccharides of chondroitin sulfate (CS) and heparan sulfate (HS), which are representatives of two m

158 Heparanase, a heparan sulfate (HS)--specific endoglucuronidase, mediat

159 OPG is known to be a high-affinity heparan sulfate (HS)-binding protein.

160 al delivery of AAV serotype 2 (AAV2) and its heparan sulfate (HS)-binding-deficient capsid led to sim

161 patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2,

162 tein domains 19 and 20, which also recognize heparan sulfate (HS).

163 ated by cell type-specific interactions with heparan sulfate (HS).

164 Heparan sulfates (HS) are linear sulfated polysaccharide

165 Here, we investigated the role of heparan sulfates (HS) in mediating this interaction and

166 Accumulation of heparan sulfate in cultured astrocytes corresponded with

167 Specifically, altered sulfation of heparan sulfate in mutant neutrophils affected formation

168 ) mutant mice exhibit an 8-fold reduction of heparan sulfate in primary hepatocytes and a 5-fold redu

169 rimary hepatocytes and a 5-fold reduction of heparan sulfate in whole liver tissue.

170 teracts with cell surface receptors, such as heparan sulfate, integrins (alpha3beta1, alphaVbeta3, an

171 y that therapeutic disruption of fibronectin-heparan sulfate interactions will negatively impact myel

172 known mammalian endoglycosidase that cleaves heparan sulfate) is essentially involved in DN pathogene

173 Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin

174 Surface expression of CD138 increased heparan sulfate levels on ASCs, which are known to bind

175 tility for the assembly of both heparin- and heparan sulfate-like oligosaccharides.

176 e first evidence that fibronectin binding to heparan sulfate mediates exosome-cell interactions, reve

177 odels, we utilized sulfated polysaccharides, heparan sulfate mimetics, and occluding compounds.

178 y features of this binding interaction using heparan sulfate mimetics, identify an important sulfate

179 Further, pharmacologic inhibition of heparan sulfate mobilized qualitatively more potent and

180 Heparan sulfate modulates the activity and distribution

181 Through heparan sulfate moieties, syndecans are thought to ancho

182 heterogeneous glycosaminoglycans heparin and heparan sulfate occurring in N-acetylated and N-sulfated

183 An antibody directed against the heparan sulfate of a proteoglycan shows efficacy in bloc

184 In fibroblasts, ligand interactions with heparan sulfate of syndecan-4 recruit cytoplasmic protei

185 the synthetic difficulties to access diverse heparan sulfate oligosaccharides with well-defined sulfa

186 ays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on

187 ptors for exosome uptake, but the ligand for heparan sulfate on exosomes has not been identified.

188 s more sensitive than CCL2 to the density of heparan sulfate on the SPR surfaces; this is likely due

189 eviously shown that HMPV requires binding to heparan sulfate on the surfaces of target cells for atta

190 ly exclusive interactions with PI(4,5)P2 and heparan sulfates on opposing sides of the membrane.

191 Heparan sulfates on target cell surfaces can act as rece

192 We discovered that heparan sulfate plays a dual role in exosome-cell intera

193 ) family of genes contains five members: the heparan sulfate polymerizing enzymes, EXT1 and EXT2, and

194 In vivo transcript expression levels of the heparan sulfate-polymerizing enzymes Ext1 and Ext2 were

195 Size estimation of heparan sulfate polysaccharide chains indicated that inc

196 ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2

197 Together, these data suggest that heparan sulfate presentation of SLIT3 to ROBO4 facilitat

198 blocked by addition of exogenous heparin or heparan sulfate, pretreatment of conditioned medium with

199 Therefore, inhibiting heparan sulfate production may provide a means for avoid

200 osyltransferase gene, Ext1, is essential for heparan sulfate production.

201 ply the number of sulfates, is important for heparan sulfate protein binding.

202 Binding of AAV to heparan sulfate proteoglycan (HSPG) at the ILM may allow

203 ce lacking lipoprotein lipase (LPL), hepatic heparan sulfate proteoglycan (HSPG) receptors, LDLR, or

204 l synaptogenesis, including the GPI-anchored heparan sulfate proteoglycan (HSPG) Wnt co-receptor Dall

205 attachment factors (HAFs), such as DC-SIGN, heparan sulfate proteoglycan (HSPG), and alpha4beta7 int

206 To confirm this finding, we prepared heparan sulfate proteoglycan (HSPG)-knockout (KO) cells

207 its receptors, the proto-oncogene c-Met and heparan sulfate proteoglycan (HSPG).

208 Here, we identified heparan sulfate proteoglycan as a major cellular attachm

209 activity, GAG incorporation of (35)SO4, and heparan sulfate proteoglycan assembly.

210 monstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes W

211 The heparan sulfate proteoglycan Glypican 4 (Gpc4) is strong

212 vate EGL-mediated NO production and that the heparan sulfate proteoglycan glypican-1 is a primary mec

213 Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatoc

214 Glypican-1 (Gpc1) is the predominant heparan sulfate proteoglycan in the developing and adult

215 Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, possesses angiost

216 Syndecan-1 is a cell surface heparan sulfate proteoglycan primarily expressed in the

217 d, Saez et al demonstrate that inhibition of heparan sulfate proteoglycan production by bone marrow o

218 es the interaction between TGF-beta1 and its heparan sulfate proteoglycan sequestration receptor, TGF

219 Furthermore, we identified the heparan sulfate proteoglycan syndecan-1 in complexes wit

220 The heparan sulfate proteoglycan syndecan-1 is proteolytical

221 s have shown that postsynaptic expression of heparan sulfate proteoglycan syndecan-2 (SDC2) induces d

222 The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates

223 olecule-3-grabbing nonintegrin (DC-SIGN) and heparan sulfate proteoglycan were implicated as corecept

224 hanosensitive complex contains an endogenous heparan sulfate proteoglycan with HS chains that is crit

225 Heparan sulfate proteoglycan(s) is present in neutrophil

226 in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin sig

227 ered that the dendritic cell (DC)-associated heparan sulfate proteoglycan-dependent integrin ligand (

228 a patients express dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand,

229 Expression of SP-Tatm3x in heparan sulfate proteoglycan-negative cells further impr

230 accumulation is mediated through binding to heparan sulfate proteoglycans (HSPG) allowing for possib

231 Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in the adaptive res

232 Heparan sulfate proteoglycans (HSPG) play a critical rol

233 step of virus-cell interaction by mimicking heparan sulfate proteoglycans (HSPG), the highly conserv

234 We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV bind

235 Heparan sulfate proteoglycans (HSPGs) are ubiquitously e

236 Heparan sulfate proteoglycans (HSPGs) bind to and regula

237 Heparan sulfate proteoglycans (HSPGs) critically modulat

238 matosensory neurons as a model, we show that heparan sulfate proteoglycans (HSPGs) Dally and Syndecan

239 Heparan sulfate proteoglycans (HSPGs) function as corece

240 Heparan sulfate proteoglycans (HSPGs) have been attribut

241 Heparan sulfate proteoglycans (HSPGs) have long been imp

242 transferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to

243 We demonstrated that expression of heparan sulfate proteoglycans (HSPGs), including TbetaRI

244 We found levels of mRNAs encoding heparan sulfate proteoglycans (HSPGs), particularly SDC1

245 ter hepatocytes in vivo through cell surface heparan sulfate proteoglycans (HSPGs).

246 thought to enter hepatocytes in vivo through heparan sulfate proteoglycans (HSPGs).

247 s with their receptors are often mediated by heparan sulfate proteoglycans (HSPGs).

248 nalization of Tat requires interactions with heparan sulfate proteoglycans and cholesterol-enriched l

249 Heparan sulfate proteoglycans and heparin derivatives fu

250 eins, thereby increasing viral attachment to heparan sulfate proteoglycans and inducing cell migratio

251 Heparin/heparan sulfate proteoglycans and neuropilin-1 (NRP-1) h

252 tion of haptotactic gradients on endothelial heparan sulfate proteoglycans and, hence, integrin-media

253 Heparan sulfate proteoglycans are ubiquitously located o

254 Conducted research showed that heparan sulfate proteoglycans function as adhesion molec

255 sulfate and that N- and 6-O-sulfation of the heparan sulfate proteoglycans is required for HCV infect

256 d ones bind heparin - a structural analog of heparan sulfate proteoglycans known to mediate exosome e

257 and Tec kinase, as well as membrane-proximal heparan sulfate proteoglycans on cell surfaces.

258 ) extracellular trapping of FGF2 mediated by heparan sulfate proteoglycans on cell surfaces.

259 All recombinant Tau assemblies bound heparan sulfate proteoglycans on the cell surface, which

260 L protein mediates attachment of virions to heparan sulfate proteoglycans on the surface of hepatocy

261 t or dynamin activity or remove cell surface heparan sulfate proteoglycans reduced infection efficien

262 Transmembrane heparan sulfate proteoglycans regulate multiple aspects

263 Heparin, an analog of the heparan sulfate proteoglycans that are receptors for den

264 In addition, eliminating heparan sulfate proteoglycans using heparinase completel

265 ary domains: a charged N terminus that binds heparan sulfate proteoglycans, a central NANP repeat dom

266 the enzyme heparanase (HPSE), which degrades heparan sulfate proteoglycans, the main components of EC

267 leagues show that dendritic cell-associated, heparan sulfate proteoglycans-dependent integrin ligand

268 lular trapping mediated by membrane-proximal heparan sulfate proteoglycans.

269 sistent with a previously described role for heparan sulfate proteoglycans.

270 the endothelial receptors for IE binding are heparan sulfate proteoglycans.

271 cells requires its interaction with surface heparan sulfate proteoglycans.

272 by glycosaminoglycans and were reduced after heparan sulfate removal or inhibition of glycosaminoglyc

273 We found that the binding of HS20 to heparan sulfate required sulfation at both the C2 positi

274 The accumulation of heparan sulfate results in neurological symptoms, culmin

275 s address the difficult challenge of heparin/heparan sulfate saccharide separation and will enhance s

276 The complexity of heparin and heparan sulfate saccharides makes their purification, in

277 eparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting

278 These studies support heparan sulfate signaling intermediates as prognostic an

279 In addition, the well-defined heparan sulfate structures helped shine light on the fin

280 ell surface, or even the enzymes involved in heparan sulfate substitution in the Golgi apparatus.

281 ms and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate dev

282 own to interact with diverse targets such as heparan sulfates, sulfatides, and integrins on cell surf

283 R1 led to RVFV resistance as well as reduced heparan sulfate surface levels, consistent with recent o

284 cantly less tightly to low than high density heparan sulfate surfaces compared with CCL2.

285 periments presented herein, in which hepatic heparan sulfate synthesis was genetically abolished, dem

286 Analysis of heparan sulfate synthesized by HEK 293 cells overexpress

287 he role of NDST2 in regulating the amount of heparan sulfate synthesized was confirmed by analyzing h

288 st sequencing method of a complex mixture of heparan sulfate tetrasaccharides by LC-MS/MS.

289 ularly SDC1 mRNA, and cell surface levels of heparan sulfate to be reduced in cells after SMAD6 knock

290 The pre-binding of heparan sulfate to VLPs inhibited the binding of both N-

291 Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in n

292 Accumulation of heparan sulfate was also detected in primary cultures of

293 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1

294 In contrast, binding of HCoV-NL63 to heparan sulfates was required for viral attachment and i

295 ran sulfate, and especially disease-specific heparan sulfate, was reduced to control level.

296 s chondroitin sulfate but that are devoid of heparan sulfate, whereas 181/25 did not.

297 brils in neuroblastoma cells is dependent on heparan sulfate, whereas internalization of smaller non-

298 ocyte-like cell line is equally dependent on heparan sulfate, while astrocyte- and microglia-like cel

299 These changes coincide with accumulation of heparan sulfate with characteristic non-reducing ends, w

300 ure-activity relationship studies of heparin/heparan sulfate with their diverse binding partners such