ライフサイエンスコーパス: hepatectomy

1 ion as the primary energy source early after hepatectomy.

2 nce to the 10-fold volume removal of partial hepatectomy.

3 elated deaths occurred within 365 days after hepatectomy.

4 nefit from adjuvant CIK cell treatment after hepatectomy.

5 nce to the 10-fold volume removal of partial hepatectomy.

6 ferred to surgical teams to be evaluated for hepatectomy.

7 h higher rate of proliferation after partial hepatectomy.

8 e recovery of the living donor after partial hepatectomy.

9 blockade on liver regeneration after partial hepatectomy.

10 luded all adult patients undergoing elective hepatectomy.

11 nalyze surgeons' anticipation of the risk of hepatectomy.

12 fferent time points until 72 h after partial hepatectomy.

13 generation when applied 2 h prior to partial hepatectomy.

14 ion of SB-258719 sixteen hours after partial hepatectomy.

15 (mitotic index in HE sections) after partial hepatectomy.

16 Wistar rats were subjected to 60-70% partial hepatectomy.

17 K-iT/Nor-1(small hairpin RNA)) after partial hepatectomy.

18 splantation, ulcerative colitis, and partial hepatectomy.

19 ents with chronic liver injury who underwent hepatectomy.

20 e phases of liver regeneration after partial hepatectomy.

21 9 are preferentially mobilized after partial hepatectomy.

22 during the waiting period before definitive hepatectomy.

23 ease complications associated with the first hepatectomy.

24 atients with chronic liver injury undergoing hepatectomy.

25 n of liver volume and function after partial hepatectomy.

26 ctivated cell sorting and administered after hepatectomy.

27 ts activation at 3 to 24 hours after partial hepatectomy.

28 with liver metastases who required a 2-stage hepatectomy.

29 atched controls underwent the planned second hepatectomy.

30 but not in regenerating livers after partial hepatectomy.

31 tion and reduced steatosis following partial hepatectomy.

32 ) reduced the hepatocyte proliferation after hepatectomy.

33 minal surgery but this is the first trial in hepatectomy.

34 d for hepatocyte proliferation after partial hepatectomy.

35 e injected with Concanvalin A before partial hepatectomy.

36 cember 2009, 555 patients underwent elective hepatectomy.

37 ndergone retrorsine pretreatment and partial hepatectomy.

38 naling, in a murine model of extensive (85%) hepatectomy.

39 than resident LSEC progenitors after partial hepatectomy.

40 me may be more difficult during laparoscopic hepatectomy.

41 chemotherapy-free interval, age, and type of hepatectomy.

42 for liver failure to develop after extended hepatectomy.

43 ctor of NAFLD and survival following partial hepatectomy.

44 emotherapy treatments, and extent of partial hepatectomy.

45 Patient overall survival after hepatectomy.

46 lates growth and metabolic adaptations after hepatectomy.

47 drinking water of mice subjected to partial hepatectomy.

48 r2 knockout (Itpr2(-/-) ) mice following 67% hepatectomy.

49 eneration in 157 patients undergoing partial hepatectomy.

50 model of 2-acetylaminofluorene with partial hepatectomy.

51 nd HPC-associated biliary regeneration after hepatectomy.

52 MSCs supported survival after partial hepatectomy.

53 PP treatment delayed liver weight gain after hepatectomy.

54 olization, if used, types of transection and hepatectomy.

55 ignaling, was strongly induced after partial hepatectomy.

56 neration and clinical outcomes after partial hepatectomy.

57 decades, morbidity is still high after major hepatectomy.

58 ers and the in vivo activation after partial hepatectomy.

59 n display similar safety and feasibility for hepatectomies.

60 he tumors themselves were the reason for the hepatectomies.

61 liver regeneration after two-thirds partial hepatectomy (2/3 PH).

62 Patients were treated with an extended hepatectomy (202 [39.3%]), a hemihepatectomy (180 [35.0%

63 n hemihepatectomy (48.8%), or hemi-/extended hepatectomy (36.3%).

64 e and Zip14(-/-) mice that underwent partial hepatectomy (70% of liver removed) were used as models o

65 eration was compared with that after partial hepatectomy (70%).

66 Most underwent a major hepatectomy (82%), often accompanied by lymphadenectomy

67 Adult mice received partial (two-thirds) hepatectomy, acute or chronic administration of carbon t

68 After 70% partial hepatectomy, albNS(cko) livers show increased DNA damage

69 w conceptual technique of laparoscopic right hepatectomy allowing for low blood loss and morbidity.

70 ared to 28 and 12 months for patients in the hepatectomy alone group (control).

71 artition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) occurred over time and is associated

72 artition and portal vein ligation for staged hepatectomy (ALPPS), a 2-stage hepatectomy procedure, ha

73 artition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), available after stage-1, either to

74 Moreover, liver regeneration after partial hepatectomy also depended upon the formation of InsP3 in

75 ad impaired liver regeneration after partial hepatectomy and 50% mortality, indicating that NEMO is r

76 gment, crystallizable) to mice after partial hepatectomy and acetaminophen intoxication, and measured

77 egeneration, which is required after partial hepatectomy and acute or chronic liver injury.

78 urs prior to and sixteen hours after partial hepatectomy and by intraperitoneal administration of SB-

79 Regenerative growth was induced by partial hepatectomy and exposure to carbon tetrachloride.

80 better 5-year overall survival from initial hepatectomy and from liver recurrence in the PSH than in

81 -258719 and SB-269970) at 16 h after partial hepatectomy and peaked at 32 h ([(3)H]-thymidine incorpo

82 of liver regeneration after extended partial hepatectomy and portal vein ligation for multiple biloba

83 of liver regeneration after extended partial hepatectomy and portal vein ligation for multiple biloba

84 y augmented liver regeneration after partial hepatectomy and portal vein ligation, and increased the

85 y augmented liver regeneration after partial hepatectomy and portal vein ligation, and increased the

86 mportant to help improve the safety of donor hepatectomy and to provide a database for informed conse

87 s stimulate liver regeneration after partial hepatectomy and toxin-mediated injury.

88 BMI) 30 or higher (Ob group) underwent major hepatectomy and were matched with 42 patients with BMI 2

89 ted 20 years ago, has been described for all hepatectomies, and is considered as the reference techni

90 diofrequency (RF) ablation, partial surgical hepatectomy, and a sham operation and to inhibit HCC rec

91 ogram who underwent pancreaticoduodenectomy, hepatectomy, and colectomy at a single academic institut

92 nd distinctly in tissue regeneration models, hepatectomy, and myeloablation.

93 of portal hypertension, planned extension of hepatectomy, and the MELD score.

94 ression-free survival, conversion to partial hepatectomy, and viable HCC within the tumor specimen.

95 Nonanatomical tissue-sparing hepatectomies are associated with worse DFS in patients

96 We used liver regeneration after partial hepatectomy as a physiological stress response model.

97 Furthermore, applying two-thirds partial hepatectomy as a surgically induced liver regeneration m

98 Before major or extended hepatectomy, assessment of the future liver remnant (FLR

99 h HCC hepatocellular carcinoma who underwent hepatectomy at one institution were evaluated with insti

100 ected from 55 patients who underwent partial hepatectomy at the Royal Infirmary Edinburgh between Dec

101 However, after partial hepatectomy, BM LSEC progenitor proliferation and mobili

102 After partial hepatectomy, BM SPCs provide hepatocyte growth factor, p

103 entially amenable to curative extended right hepatectomy but insufficient size of the future liver re

104 efficient early cytokine response to partial hepatectomy, but is inhibitory to later growth factor ac

105 efficient early cytokine response to partial hepatectomy, but is inhibitory to later growth factor ac

106 nd of hepatocyte proliferation after partial hepatectomy by preventing increases in growth hormone re

107 hepatectomy performed, and hospital type and hepatectomy caseload were retrieved.

108 surgery and the hospital type, location, and hepatectomy caseload were retrieved.

109 tumors and major resections correlated with hepatectomy caseload.

110 s preconditioned with retrorsine and partial hepatectomy, cell transplantation after ETN pretreatment

111 sion-free survival (PFS) for patients in the hepatectomy/CIK combination group were 41 and 16 months,

112 ectomy, pancreatectomy, pulmonary resection, hepatectomy, colectomy, and cystectomy) between 2010 and

113 uperior estimation of patient survival after hepatectomy compared with current staging systems.

114 In rats, after 70% partial hepatectomy, daily administration of 1K1 for 5 days sign

115 Thus, after two-thirds partial hepatectomy, DeltaEGFR livers displayed lower and delaye

116 This study shows that hepatectomies done with intermittent clamping exceeding

117 es for pancreaticoduodenectomy (PD) or major hepatectomy due to periampullary or proximal bile duct n

118 Extended (86%) hepatectomy (eHx) was modified to minimize collateral da

119 ALPPS is a novel 2-stage hepatectomy enabling resection of extensive hepatic tumo

120 by applying the 2-acetaminofluorene/partial hepatectomy experimental model.

121 evels improve survival of mice after partial hepatectomy, FGF19 mitogenic activity is associated with

122 esponse to loss of liver mass due to partial hepatectomy followed by regeneration.

123 ortality was similar to conventional 2-stage hepatectomies for CRLM.

124 in 2 expert centers practicing 1- or 2-stage hepatectomy for bCRLM.

125 by next-generation sequencing who underwent hepatectomy for CLM (2005-2015).

126 o stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRLM).

127 o stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRLM).

128 nd morbidity and mortality rates after major hepatectomy for colorectal metastases in patients having

129 anuary 1992 and December 2012, who underwent hepatectomy for CRLM and resection of synchronous EHD.

130 anuary 1992 and December 2012, who underwent hepatectomy for CRLM and resection of synchronous EHD.

131 Hepatectomy for HCC in cirrhosis is affected by the risk

132 endent prognostic factor for mortality after hepatectomy for HCC in European patients and could be us

133 All consecutive patients who underwent hepatectomy for HCC in our institution, between February

134 Ninety-two patients undergoing hepatectomy for HCC were prospectively evaluated with pr

135 Among 198 patients who underwent hepatectomy for HCC, 109 patients had an available compu

136 ia could be used to evaluate patients before hepatectomy for HCC.

137 for prediction of PLF in patients undergoing hepatectomy for HCC.

138 liver metastases and inferior outcomes after hepatectomy for metachronous CLM.

139 luded patients subjected to PVE before major hepatectomy for metastatic colorectal cancer.

140 ALPPS is a two-stage hepatectomy for patients with extensive liver tumors wit

141 escriptions of liver anatomical division and hepatectomies have been made, causing some confusion amo

142 on-PSH was a risk of noncandidacy for repeat hepatectomy (hazard ratio: 8.18, confidence interval: 1.

143 om the hepatic vein during pure laparoscopic hepatectomy; however, there is a risk of pulmonary gas e

144 95% CI: 1.141-6.024; P = 0.024), right-sided hepatectomy (HR: 2.143, 95% CI: 1.544-2.975; P < 0.001),

145 del) that underwent RF ablation, 35% partial hepatectomy (ie, left lobectomy), or a sham operation (c

146 to include all patients undergoing elective hepatectomies in an observational study.

147 We performed partial hepatectomies in mice with hepatocyte-specific disruptio

148 nsecutive adult patients undergoing elective hepatectomy in 9 HPB centers.

149 in normal and steatotic livers after partial hepatectomy in a rodent model.

150 Hepatectomy in G6PD-deficient donors is associated with

151 hed literature regarding the safety of donor hepatectomy in G6PDd individuals.

152 Right hepatectomy in LDLT induces a more severe deprivation of

153 on liver regeneration following 70% partial hepatectomy in mice lacking the Cip/Kip inhibitors p21(C

154 target genes during liver regeneration after hepatectomy in mice, and in hepatocellular carcinoma (HC

155 nalization also occurred following a partial hepatectomy in mice.

156 We have shown that partial hepatectomy in multidrug resistance 2 knockout (Mdr2(-/-

157 apacity and postoperative course after major hepatectomy in obese patients through a case-matched stu

158 n intention-to-treat analysis 1- and 2-stage hepatectomy in patients with bCRLM achieve comparable OS

159 Survival after hepatectomy in patients with double mutation of APC and

160 rity of adhesions and facilitated the second hepatectomy in patients with liver metastases who requir

161 tation of 2-acetylaminofluorene with partial hepatectomy in rats or on feeding a 3,5-diethoxycarbonyl

162 models of 2-acetylaminofluorene with partial hepatectomy in rats, and 3,5-diethoxycarbonyl-1,4-dihydr

163 iferation that can be observed after partial hepatectomy in rats.

164 ld-type (WT) rats that had undergone partial hepatectomy in the presence of 2-acetylaminofluorene (2A

165 We performed partial hepatectomy in WT and liver-specific Sirt1-deficient mic

166 e 2000 terms "right and left hemihepatectomy/hepatectomy" increased dramatically versus the use of th

167 sts that AhR functionality following partial hepatectomy is dependent on a p21(Cip1)-regulated signal

168 ial for retrievability, and graft removal by hepatectomy is impractical.

169 A second-stage hepatectomy is performed as soon as the graft has regene

170 Two-stage hepatectomy is the surgical strategy mostly chosen for t

171 ious consequences for normal livers, partial hepatectomy leads to severe liver necrosis and reduced h

172 derwent PSH and 144 patients underwent right hepatectomy, left hepatectomy, or left lateral sectionec

173 has enabled extensive liver resection, post-hepatectomy liver failure remains one of the most lethal

174 mathematical framework which described post-hepatectomy liver regeneration in each patient by incorp

175 When irradiated rats underwent partial hepatectomy, liver regeneration was compromised, but inf

176 The pure laparoscopic approach in right hepatectomy (LRH) for living donor liver transplantation

177 Diabetes, repeat-hepatectomy, major-hepatectomy, synchronous-major-proced

178 may be achieved and a simple terminology of hepatectomies may be proposed.

179 KRAS-mutated CRLM, more extensive anatomical hepatectomies may be warranted.

180 atomical description and this terminology of hepatectomies may find a consensus among the liver surgi

181 we hypothesized that the outcome after major hepatectomy may be influenced by posthepatectomy PVP.

182 ent studies of complications following donor hepatectomy may not be generalizable to all hospitals pe

183 l vein revascularization who underwent lobar hepatectomy, median OS was not reached yet exceeded 24.5

184 ergone major (n = 135) or extended (n = 108) hepatectomies met the inclusion criteria.

185 To prevent drops in oxygen after hepatectomy, mice were pretreated with inositol trispyro

186 The retrorsine-partial hepatectomy model was used for liver repopulation studie

187 After two-thirds partial hepatectomy, mutant mice (n = 5) displayed increased liv

188 65 postoperative days in patients undergoing hepatectomy (n = 2811) and/or pancreatectomy (n = 1092)

189 dent association with LD was found for major hepatectomy (odds ratio [OR], 2.41; 95% CI, 1.17-4.30; P

190 Partial hepatectomy of the adult mammalian liver activates compe

191 Two-stage hepatectomy offers the possibility of long-term survival

192 We performed partial hepatectomies on wild-type C57BL/6, CD45.1, Tcrd(-/-), o

193 More specifically, we have performed partial hepatectomy on mice with genetic deficiency in C3, the m

194 reased innate immunity in mice after partial hepatectomy or acetaminophen-induced injury, with reside

195 , such as rodent LR after two-thirds partial hepatectomy or administration of damaging chemicals (CCl

196 regeneration/repair after either 70% partial hepatectomy or carbon tetrachloride-induced liver injury

197 ional replicative capacity following partial hepatectomy or chemical injuries.

198 tocyte proliferation following liver partial hepatectomy or damage resulting from carbon tetrachlorid

199 Thirty-nine patients undergoing partial hepatectomy or liver transplantation for HCC were consen

200 or patients' >/=18 years who underwent wedge hepatectomy or lobectomy from 2000 to 2014.

201 ical more limited resections such as central hepatectomy or sectionectomies may provide an alternativ

202 did not regenerate following either partial hepatectomy or treatment with certain nuclear receptor a

203 4 patients underwent right hepatectomy, left hepatectomy, or left lateral sectionectomy (non-PSH grou

204 re it with a successive cohort of open right hepatectomies (ORH) for LDLT.

205 e represents a promising strategy to improve hepatectomy outcomes in patients with liver fibrosis.

206 male sex (P = .03), and no history of prior hepatectomy (P = .04) or hepatic arterial infusion chemo

207 Following partial hepatectomy, p53(-/-) hepatocytes exhibited early entry

208 At second hepatectomy, patients in the HA membrane arm required 33

209 er the second procedure, with extended right hepatectomy performed at day 23 after transplantation.

210 sociated conditions, indication for surgery, hepatectomy performed, and hospital type and hepatectomy

211 Recent studies using partial hepatectomy (PH) and other experimental models of liver

212 nd Cdk2 for liver regeneration after partial hepatectomy (PH) by generating corresponding double- and

213 Mice subjected to partial hepatectomy (PH) develop hypoglycemia, followed by incre

214 e of cell proliferation that follows partial hepatectomy (PH) identified approximately 1,400 mammalia

215 ), standard (60%), or extended (80%) partial hepatectomy (PH) in mice with and without liver steatosi

216 Extended partial hepatectomy (PH) in patients is leading to portal hyperp

217 intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pattern of

218 ells undergo phenotypic changes post-partial hepatectomy (PH) in vivo, including increased cytotoxici

219 UND & AIMS: Liver regeneration after partial hepatectomy (PH) increases the protein folding burden at

220 during liver regeneration (LR) after partial hepatectomy (PH) is observed in several species.

221 g liver regeneration using the mouse partial hepatectomy (PH) model.

222 involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells

223 We performed partial hepatectomy (PH) to transgenic mice that overexpress SIR

224 groups) weeks of treatment with G49, partial hepatectomy (PH) was performed, and all mice were mainta

225 iating liver regeneration (LR) after partial hepatectomy (PH), by regulating expression of Cyclin-D1.

226 involved in liver regeneration after partial hepatectomy (PH), to initiate growth, protect liver cell

227 In conjunction with partial hepatectomy (PH), transplanted stem/progenitor cells eng

228 e display delayed regeneration after partial hepatectomy (PH).

229 arly in liver regeneration following partial hepatectomy (PH).

230 to retrorsine treatment followed by partial hepatectomy (PH).

231 tentials of cholangiocytes after 70% partial hepatectomy (PH).

232 ells during liver regeneration after partial hepatectomy (PH).

233 injury and regeneration induced by a partial hepatectomy (PHx) could have different effects on HBV re

234 ompared with those of standard (68%) partial hepatectomy (pHx) in mice.

235 aKlf6), cell proliferation following partial hepatectomy (PHx) was increased compared to controls.

236 Seventy percent partial hepatectomy (PHx) was performed in C57Bl/6 mice with or

237 In the present study, partial hepatectomy (PHx) was used to study liver regeneration.

238 ytes in culture, rat liver following partial hepatectomy (PHx), and hepatoma cell lines.

239 a pneumoniae or Escherichia coli) or partial hepatectomy (PHx).

240 hibition of liver regeneration after partial hepatectomy (PHX).

241 liver regeneration after two-thirds partial hepatectomy (PHx).

242 Partial hepatectomy (PHx, 70% resection) was performed in male w

243 urrently used in preclinical models: partial hepatectomy, portal ligature or embolization, and radiot

244 on for staged hepatectomy (ALPPS), a 2-stage hepatectomy procedure, has revolutionized the surgical m

245 PTEN down-regulation after hepatectomy promotes the burning of TRAS-derived lipids

246 Use of 4 HA membranes at the end of first hepatectomy reduced the extent and severity of adhesions

247 cal parenchymal resections including central hepatectomy (resection of segments 4, 5, and 8), right a

248 ificantly between patients in 1- and 2-stage hepatectomy, respectively: 37.2 and 34.5 months (P=0.6),

249 e and inhibition of cell proliferation after hepatectomy, resulting in liver failure.

250 inhibited in DeltaEGFR livers after partial hepatectomy, revealing a new function for EGFR kinase ac

251 responsible for donor morbidity after right hepatectomy (RH) for adult-to-adult living donor liver t

252 Hepatectomy specimen ex vivo MR imaging assisted in matc

253 Diabetes, repeat-hepatectomy, major-hepatectomy, synchronous-major-procedure, inflow-occlusi

254 play a smaller role in recovery from partial hepatectomy than BM LSEC progenitors, but, when infused

255 Following partial hepatectomy, the liver initiates a regenerative program

256 Following partial hepatectomy, the liver initiates a regenerative programm

257 generation was not influenced by the type of hepatectomy, the number of courses of chemotherapy, or a

258 (4.9 [3.5-5.9] vs 6.4 [4.3-12]; P < 0.001), hepatectomy time (70 [42-120] vs 81 [58-207]; P = 0.02),

259 allowed for an increased percentage of major hepatectomies to be performed in a purely minimally inva

260 milieu of chronic inflammation links partial hepatectomy to accelerated hepatocarcinogenesis; this su

261 may be applicable to patients scheduled for hepatectomy to estimate perioperative complications.

262 anvalin A was injected 4 days before partial hepatectomy to natural killer T cells- deficient mice or

263 ral types and rounds of injury, ranging from hepatectomy to toxin-mediated damage.

264 In mice, partial hepatectomy up-regulated expression of CCL20 and ligands

265 We studied a murine model of partial hepatectomy using immunodeficient mice to determine the

266 Laparoscopic hepatectomy was associated with lower intraoperative blo

267 A new conceptual technique of right hepatectomy was designed using evidence-based facts and

268 A left hepatectomy was done and dilated bile ducts filled with

269 ion of patients with complications at second hepatectomy was higher in the control group (55% vs 23%

270 Most important, LR after partial hepatectomy was impaired in caNrf2-transgenic mice as a

271 Repeat hepatectomy was more frequently performed in the PSH gro

272 Concurrent hepatectomy was performed in 178 patients (38%), and whe

273 Partial hepatectomy was performed in C57BL/6 wild-type, Cd39 ect

274 The number of patient conversions to hepatectomy was seven for ACE and three for cTACE.

275 pacity of Ercc1(-/Delta) liver after partial hepatectomy was significantly reduced.

276 nths (7.4-57.2) scheduled for extended right hepatectomy, we compared a preconditioned group with PVE

277 d hepatic PC/PE could predict survival after hepatectomy, we used mouse models lacking key enzymes in

278 Between 2007 and 2012, a total of 680 hepatectomies were analyzed from a prospective database.

279 Between January 2013 and September 2013, 651 hepatectomies were included.

280 Overall, 28,708 hepatectomies were performed.

281 e 3- and 5-year overall survival rates after hepatectomy were 48.7% and 33.8%, respectively.

282 ed with modern preoperative chemotherapy and hepatectomy were analyzed.

283 ancreaticoduodenectomy, subtotal and partial hepatectomy were analyzed.

284 Complications after donor hepatectomy were categorized using International Classif

285 al and overall outcomes after extended right hepatectomy were evaluated.

286 roliferation that occurred following partial hepatectomy were not observed in Zip14(-/-) mice.

287 Fifty-four candidates for 2-stage hepatectomy were randomized at the end of the first proc

288 secutive patients who underwent laparoscopic hepatectomy were reviewed.

289 the collaborative study period, outcomes for hepatectomy were similar for LV and HV (85 vs 507 cases)

290 rvival (RFS) and overall survival (OS) after hepatectomy were worse in patients with double mutation

291 icantly different in the first 2 years after hepatectomy when the interval was extended from 3 months

292 tocellular carcinomas 6 months after partial hepatectomy, whereas Nemo(Deltahepa) mice fed the BHA di

293 ALPPS is a 2-stage hepatectomy, which incorporates parenchymal transection

294 ses and AKT activation 3 hours after partial hepatectomy, which, however, is alleviated by temporal c

295 Moreover, 2 reduced blood loss during liver hepatectomy, while 1 and aprotinin had no effect.

296 93-4.62; P < .001), followed by extension of hepatectomy with (OR, 2.76; 95% CI, 1.85-4.77; P = .03)

297 Mice died at 15-18 days after hepatectomy with ascites, increased plasma ammonia, and

298 way were rapidly upregulated after two-third hepatectomy, with the ubiquitin ligase Nedd4-1 being a t

299 ally impedes tumorigenesis following partial hepatectomy without compromising survival or liver mass

300 ateral sectionectomy, and 3 underwent a left hepatectomy without middle hepatic vein procurement.

301 is widely used to minimize blood loss during hepatectomy, without an established time limit.