ライフサイエンスコーパス: hepatic

1 cyte apoptosis in association with increased hepatic 13-HODE.

2 livers of Plasmodium berghei-infected mice; hepatic activin B was also upregulated at peak parasitem

3 d transcription factor known to regulate the hepatic acute-phase response and lipid homeostasis.

4 creased glucagon and up-regulated markers of hepatic amino acid catabolism without affecting muscle w

5 Here, we sought to test the role of hepatic AMPK in the regulation of in vivo glucose-produc

6 In summary, activation of hepatic AMPK/sirtuin-1 and FGF21/beta-klotho signaling p

7 uman cytochrome P450 3A4 (CYP3A4) is a major hepatic and intestinal enzyme that oxidizes more than 60

8 isms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system

9 ncy, phenotype and anti-fibrotic function of hepatic and peripheral NK subsets in 43 HBV-LC patients.

10 Additionally, hepatic and plasma PTX3 levels were increased in patient

11 d imaging uncovered extrinsic compression of hepatic and portal veins, resulting in functional Budd-C

12 eat, due to mechanisms of drug metabolism in hepatic and renal failure, as well as posttransplant dru

13 ce had the most severe steatosis and highest hepatic and serum lipids as well as insulin resistance a

14 lic acid and beta-muricholic acid as well as hepatic and serum lipids.

15 Encephalopathy, hepatic, and renal dysfunction manifested later than car

16 Rat brain and renal, hepatic, and splenic tissues were harvested 7 days after

17 with a hepatic metastasis, one patient had a hepatic angioma, one patient had an extraadrenal pheochr

18 Purpose To investigate whether perioperative hepatic arterial infusion pump chemotherapy (HAI) was as

19 ed placebo-controlled trial, whether maximal hepatic arterial phase breath-holding duration is affect

20 Conclusion Maximal hepatic arterial phase breath-holding duration is reduce

21 liver metastases include chemoinfusion via a hepatic arterial pump or port, irinotecan-loaded drug-el

22 ng beads (DEB-TACE), which was given via the hepatic artery 2-5 weeks after randomisation and accordi

23 Hepatic artery aneurysms represent a significant risk fo

24 epatic homeostasis and contributes to unique hepatic attributes such as metabolic zonation and regene

25 diates postprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase LSD1

26 Hepatic autophagy is triggered in vivo by hyperammonemia

27 stance is due, in part, to the compromise of hepatic autophagy, a process that leads to lysosomal deg

28 Hepatic bile acid and lipid content was elevated in WT m

29 s a positive correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (omega6) and

30 ochondria by autophagy, positively regulates hepatic cancer stem cells (CSCs) by suppressing the tumo

31 onsible for highly penetrant male-restricted hepatic carcinogenesis.

32 in the HEK293-RXFP1 cAMP assay and the human hepatic cell line LX-2.

33 fferential in-gel electrophoresis to analyze hepatic cells in early response to virosome-induced memb

34 licular and basolateral domains of polarized hepatic cells, respectively.

35 tic steatosis and serum AST level as well as hepatic cellular NF-kappaB activation.

36 n vivo cholesterol challenges induce massive hepatic cholesterol accumulation and damage, which is re

37 High hepatic cholesterol causes non-alcoholic steatohepatitis

38 iles for interpreting effects of dietary and hepatic cholesterol in human non-obese NAFLD/NASH patien

39 C mice had decreased lipogenesis mediated by hepatic cholesterol responsive element-binding protein a

40 t protein 1 (MCP-1), TNF-alpha, and IL-6 and hepatic cleaved caspase 3 in mice fed either a normal ch

41 Moreover, hepatic collagen FSR correlates with established risks f

42 Hepatic collagen FSR in NAFLD increased with advancing d

43 NASH, and plasma lumican FSR correlates with hepatic collagen FSR, suggesting applications as direct

44 Loss of hepatic collectrin expression leads to the diminished cr

45 rived suppressor cells (MO-MDSCs) within the hepatic compartment suppress inflammation and impair imm

46 processing in brown adipose tissue (BAT) and hepatic conversion of cholesterol to bile acids via the

47 red, and expanded from eight 20-mm, 18-gauge hepatic core samples to 50 x 10(6) autologous cells per

48 , assemble into hierarchical combinations at hepatic CRMs.

49 is that identified a crucial overlap between hepatic Cyp51(-/-) and Rorc(-/-) expression profiles.

50 polycystic kidney rats by 35%; in contrast, hepatic cystic areas were decreased by 45% in TGR5-defic

51 TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing ch

52 Hepatic de novo lipogenesis (DNL) converts carbohydrates

53 y) yet developed steatosis upon induction of hepatic de novo lipogenesis with fructose feeding.

54 Clinical endpoints defined as hepatic decompensation (ascites, encephalopathy, and var

55 ence interval [CI], 0.19-0.43; P < .001) and hepatic decompensation (HR, 0.26; 95% CI, 0.17-0.39; P <

56 was found to be independently predictive of hepatic decompensation.

57 that may be altered in acetaminophen-induced hepatic depolarization.

58 ent polyamine production during Plasmodium's hepatic development and pave the way to the exploitation

59 nterference of Hnf4a with Foxa2, and reduced hepatic differentiation in Mgp-null lungs.

60 s utility for treating metabolically-related hepatic disease.

61 However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause (

62 econdary" LF (n = 5) which resulted from non-hepatic diseases such as sepsis.

63 pid development of liver cancer in mice with hepatic disruption of Pten.

64 Hepatic DPP4 expression is elevated in subjects with ect

65 re studied the transcriptional regulation of hepatic Dpp4 in young mice prone to diet-induced obesity

66 Already at 6 weeks of age, expression of hepatic Dpp4 was increased in mice with high weight gain

67 in mouse liver, imparting sex differences in hepatic drug/lipid metabolism and disease risk.

68 t is becoming increasingly accepted that the hepatic ECM proteome (i.e., matrisome) responds dynamica

69 lysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumi

70 ratio [HR] 1.59 [95% CI 1.13-2.20]; p=0.01), hepatic encephalopathy (2.81 [1.72-4.42]; p=0.0004), dia

71 BACKGROUND & AIMS: Hepatic encephalopathy (HE) is a serious complication of

72 Screening for hepatic encephalopathy (HE) that does not cause obvious

73 an immune-mediated encephalopathy; lymphoma, hepatic encephalopathy and progressive multifocal leukoe

74 Hemodynamic changes, incidence of hepatic encephalopathy, and long-term (>3 months) need f

75 ) and reduced VWF synthesis, specifically in hepatic endothelial cells, as a critical factor that is

76 expand the role of SLC13A5 from facilitating hepatic energy homeostasis to influencing hepatoma cell

77 The exception was hepatic enhancement results calculated for a uniphasic i

78 ncy of PDA on ARG2 rather than the principal hepatic enzyme ARG1 opens a therapeutic window for obesi

79 Hepatic epithelioid hemangioendothelioma (HEHE) is a rar

80 However, a role for zinc during hepatic ER stress is largely unknown despite important r

81 ress apoptosis and steatosis associated with hepatic ER stress.

82 isms were genotyped; and IFN-stimulated gene hepatic expression (n = 16) was tested by TaqMan assays.

83 In normoglycemic wild-type mice, hepatic expression of Ad36E4ORF1 lowered nonfasting bloo

84 Similar results are reproduced by hepatic expression of ectopic CCDC3 in mice on HFD.

85 d LXRE-LXRalpha binding, and broadly altered hepatic expression of LXRalpha-regulated lipid metabolic

86 cebo group, including two patients (1%) with hepatic failure in the placebo group.

87 ces, including the development of cirrhosis, hepatic failure, and hepatocellular carcinoma.

88 mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation.

89 These properties allow hepatic FcRn to mediate albumin delivery and maintenance

90 ble tool for studying the dynamic changes in hepatic FFA flux in models of liver disease.

91 irect or surrogate markers, respectively, of hepatic fibrogenesis in humans.

92 Finally, TANGO1(+/-) mice displayed less hepatic fibrosis compared to WT mice in two separate mur

93 R-200b axis may be key for the management of hepatic fibrosis during the progression of PSC.

94 imaging techniques to more accurately stage hepatic fibrosis in a rat model.

95 ient elastography (VCTE) in the detection of hepatic fibrosis in patients with severe to morbid obesi

96 dark therapy or melatonin administration on hepatic fibrosis in the multidrug resistance gene 2-knoc

97 Hepatic fibrosis occurs during the progression of primar

98 otoxic effects, and monitor for worsening of hepatic fibrosis scores during MTX therapy.

99 HSCs mediate hepatic fibrosis through their activation from a quiesce

100 HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differen

101 We investigated changes in hepatic fibrosis, based on transient elastography (TE),

102 for nonalcoholic steatohepatitis (NASH) and hepatic fibrosis, can be used for patients with psoriasi

103 ographics, lifestyle, metabolic factors, and hepatic fibrosis.

104 e currently no therapies to directly inhibit hepatic fibrosis.

105 ffect, or deliver drugs systemically without hepatic first pass metabolism.

106 sively absorbed into portal circulation, and hepatic flavin-dependent monooxygenases (FMOs) efficient

107 At the molecular levels, hepatic Foxo1/3/4 deficiency triggered a significant inc

108 Alterations in hepatic free fatty acid (FFA) uptake and metabolism cont

109 MARS therapy successfully replaced hepatic function in ALF allowing time for spontaneous re

110 tween these new regulatory RNA molecules and hepatic function in men has not been investigated.

111 the cellular and molecular machinery driving hepatic functions is of utmost relevance.

112 lamus play a large role in the regulation of hepatic functions via the autonomic nervous system.

113 Mice expressing 3-22% of normal hepatic G6PT activity exhibited higher insulin sensitivi

114 xpression of beta-arrestin 2 greatly reduced hepatic GCGR signaling and protected mice against the me

115 Here we show that hepatic GCN5L1 ablation reduces fasting glucose levels a

116 contrast, autophagy enhancement by means of hepatic gene transfer of the master regulator of autopha

117 d PEPCK levels during fasting, and decreased hepatic gluconeogenesis in response to a pyruvate challe

118 on reduces fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemic gluco

119 tabolic regulator that promotes FOXO1-driven hepatic gluconeogenesis.

120 We found 17beta-estradiol (E2) inhibited hepatic gluconeogenic genes such as phosphoenolpyruvate

121 -) mice) and performed real-time analysis of hepatic glucose fluxes and glycogen metabolism in L-G6pc

122 s) act centrally to decrease food intake and hepatic glucose production and alter hypothalamic neuron

123 Insulin inhibits hepatic glucose production and promotes lipogenesis by s

124 minute-to-minute regulation of postprandial hepatic glucose production, although conditions of gluca

125 effectiveness to suppress EGP and stimulate hepatic glucose uptake; activation of glucokinase was re

126 ise performance, presumably because of lower hepatic glycogen stores.

127 frequently skin related, GI, endocrine, and hepatic; grade 3 to 4 select AEs occurred in 4% of patie

128 d Tgr5(-/-) mice had increased activation of hepatic growth hormone-signal transducer and activator o

129 llular stress with liver injury in the human hepatic HepaRG cell line, and primary hepatocytes.

130 -2 (MT2) is a protease and key suppressor of hepatic hepcidin expression and cleaves HJV.

131 lucose and (14)C-deoxy-D-glucose uptake into hepatic HepG2 cells.These data indicate that pomegranate

132 y is one such signaling cascade that enables hepatic homeostasis and contributes to unique hepatic at

133 In summary, hepatic ILC2s are poised to respond to the release of IL

134 lease were responsible for the activation of hepatic ILC2s that produced the type 2 cytokines IL-5 an

135 Results from this study show that hepatic ILK deletion has no effect on insulin action in

136 d to better elucidate the pathophysiology of hepatic immune-mediated diseases and to develop new ther

137 e (CHF), or chronic liver disease (CLD) with hepatic impairment.

138 al role in regulation of immune responses to hepatic infection and regeneration of tissue.

139 that palmitate-stimulated CD11b(+)F4/80(low) hepatic infiltrating macrophages, but not CD11b(+)F4/80(

140 , fibrosis stage, fibrosis progression rate, hepatic infiltration of immune cells, IFN-lambda3 expres

141 t loss of this transcription factor leads to hepatic inflammation and early signs of fibrosis.

142 secretion, which plays a significant role in hepatic inflammation and fibrosis.

143 the factors crucial for Mvarphi in limiting hepatic inflammation or resolving liver damage have not

144 We demonstrate that hepatic inflammation, fibrosis stage, fibrosis progressi

145 ses with a varying combination and extent of hepatic inflammation, fibrosis, congestion, and portal h

146 rging findings on Gal-9 in the regulation of hepatic inflammation.

147 nduces global regulatory changes that impact hepatic inflammatory and lipid metabolic pathways, provi

148 uantify transcription factor activity during hepatic injury and repair.

149 We investigated Geniposide-induced hepatic injury in male Sprague-Dawley rats after 3-day i

150 nse play in the pathogenesis of this form of hepatic injury.

151 To determine the role of ILK in hepatic insulin action in vivo, male C57BL/6J ILK(lox/lo

152 ndent protein kinase II, which promoted both hepatic insulin resistance and gluconeogenesis.

153 Hepatic insulin resistance, synergistically with lowered

154 om diet-induced liver steatosis and improves hepatic insulin resistance.

155 n signaling remained intact despite profound hepatic insulin resistance.

156 hepatic steatosis and severe whole-body and hepatic insulin resistance.

157 ic beta-arrestin 2 deficiency did not affect hepatic insulin sensitivity or beta-adrenergic signaling

158 ernal insulin sensitivity in late pregnancy; hepatic insulin sensitivity was higher, whereas sensitiv

159 ard fat synthesis, correlating with impaired hepatic insulin signaling and glucose disposal.

160 attenuated in JAK2L adipose tissue, whereas hepatic insulin signaling remained intact despite profou

161 Phosphorylation of components of the hepatic insulin-signaling pathway, namely IRS1, Akt, and

162 lled trial in nondiabetic DIOS patients with hepatic iron >50 mumol/g at magnetic resonance imaging t

163 etween quantitative MRI relaxation times and hepatic iron content.

164 pocampus, and midbrain) and reduction of the hepatic iron store without anemia.

165 (multidrug resistance gene 2 knockout), the hepatic knockdown of GnRH decreased IBDM and liver fibro

166 or advanced glycation end products (RAGE) on hepatic Kupffer cells, resulting in increased production

167 Furthermore, TM significantly increased hepatic LDLR expression and reduced plasma LDL concentra

168 Tgr5 gene in mice alleviated fasting-induced hepatic lipid accumulation.

169 ibition of hepatic mTOR in Am mice increased hepatic lipid deposition and HIRI.

170 l metabolism.HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liv

171 We sought to determine the role of ACOT1 in hepatic lipid metabolism in C57Bl/6J male mice 1 week af

172 etabolic reprogramming, suggesting increased hepatic lipid metabolism prior to overt tumor developmen

173 22-treated mice revealed novel regulators of hepatic lipid metabolism that are responsive to miR-122

174 te transporter involved in nutrient flux and hepatic lipid metabolism.

175 Saturated fat ingestion rapidly increases hepatic lipid storage, energy metabolism, and insulin re

176 Unexpectedly, mice lacking hepatic lipogenesis have a twofold increase in tumour in

177 he constitutive activation of mTORC1 reduced hepatic lipogenic gene expression and produced hypotrigl

178 from WD-induced developmental programming of hepatic lipotoxicity and may help slow the advancing epi

179 ARdelta by agonist L165041 in mice increased hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activi

180 Only polymyxin B could reduce hepatic lymphocytes in WD-fed FXR KO mice.

181 mor-infiltrating lymphocytes (TIL) and intra-hepatic lymphocytes.

182 nifested further with extramedullary tumors, hepatic macrophage infiltration, and metabolic reprogram

183 BTKB66 significantly decreased hepatic markers of sterile inflammation, such as C-X-C m

184 s the functional consequences of rs641738 on hepatic MBOAT7 expression.

185 nd conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor,

186 FXR in regulation of bile acid synthesis and hepatic metabolism has been studied extensively.

187 However, the role of TGR5 in hepatic metabolism has not been explored.

188 ited significant improvement in stability to hepatic metabolism.

189 imaging modality for response assessment of hepatic metastases of breast cancer according to the REC

190 However, hepatic metastasis was present.

191 indings, one patient had colon cancer with a hepatic metastasis, one patient had a hepatic angioma, o

192 12 was rapidly metabolized by hepatic microsomes, which supports its topical use.

193 3D hepatic microtissues, unlike 2D cell cultures, retain ma

194 ients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy express

195 2-year high-fat, high-sucrose diet increased hepatic mIndy expression.

196 Hepatic mitochondria play a central role in the regulati

197 here is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V CS) and p

198 effects are mediated through alterations in hepatic mitochondrial function.

199 utilized primary human peripheral blood and hepatic mononuclear cells, mouse MAIT hybridoma lines, H

200 es with a pivotal function in epithelial and hepatic morphogenesis, differentiation and cell-type ide

201 Inhibition of hepatic mTOR in Am mice increased hepatic lipid depositi

202 Activation of hepatic mTOR in AT mice decreased lipid accumulation att

203 ose anticoagulation therapy, and substantial hepatic or renal impairment.

204 EBP-1 processing in WT mice, while silencing hepatic Osbpl3 reverses the lipogenic phenotype of LRH-1

205 sonance imaging to compare the metabolic and hepatic outcomes of 1-year maintenance of serum ferritin

206 PPARalpha activity, Acot1 knockdown enhanced hepatic oxidative stress and inflammation.

207 fied the relationship between DMGV and early hepatic pathology.

208 Tissue volume and hepatic PDFF accuracy were assessed by means of linear r

209 Tissue volume and hepatic PDFF intra- and interexamination repeatability w

210 Individual reader ICCs for hepatic PDFF measurements across all three imager manufa

211 imager-generated parametric maps to measure hepatic PDFF.

212 report an increase in the expression of the hepatic PEPCK depending on previous metabolic status.

213 Genetic loss of Gcn2 intensified hepatic PERK activation to asparaginase, yet surprisingl

214 choice for the identification of gas in the hepatic portal system in children.

215 fat diet (HFD) by reducing the expression of hepatic PPARgamma and its target gene CIDEA as well as o

216 HNF1alpha, thus relieving the suppression of hepatic PPARgamma expression and promoting tumorigenesis

217 s of the liver reveals global differences in hepatic proteins when comparing diets rich in the two so

218 We propose hepatic PTPR-gamma as a link between obesity-induced inf

219 Analysis of liver function, hepatic regeneration, and comprehensive genomic and meta

220 d cancer-specific survival (CSS) rates after hepatic resection were worse in patients with RLI grade

221 annual volume and inpatient mortality after hepatic resection.

222 associated with high NLR (>5) 3 months after hepatic resection.

223 N2 and ATF4 serve complementary roles in the hepatic response to asparaginase.

224 pproaches that account for the complexity of hepatic responses and their systemic consequences in oth

225 this production resulted in highly elevated hepatic retinoid stores.

226 Next, animals were allocated to hepatic RFA or sham treatment with or without STAT3 (sig

227 ) mice, which have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously de

228 ibrotic liver tissue from mice and patients, hepatic S1P levels increased owing to increased hepatic

229 y-proven NAFLD, this study demonstrates that hepatic scar in NASH is actively remodeled even in advan

230 Fetuin-A is a hepatic secretory protein and a novel risk factor for di

231 f variable sizes, distributed throughout all hepatic segments.

232 S. mansoni eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatoc

233 ne program regulating lipid homeostasis, and hepatic-specific ablation of either component increases

234 liver endothelial cells were grown from core hepatic specimens from swine.

235 atic S1P levels increased owing to increased hepatic sphingosine kinase-1 expression, which contribut

236 host-parasite protein interaction during the hepatic stage of infection by Plasmodium parasites.

237 The hepatic stage of the malaria parasite Plasmodium is acco

238 mice were protected against fasting-induced hepatic steatosis (a model of enhanced exogenous FA deli

239 hing efavirenz (EFV) to raltegravir (RAL) on hepatic steatosis among HIV-infected patients with nonal

240 demonstrates that cellular senescence drives hepatic steatosis and elimination of senescent cells may

241 s an attractive target for the management of hepatic steatosis and insulin resistance.

242 nd liver injury with significantly increased hepatic steatosis and serum AST level as well as hepatic

243 On chow, JAK2L mice had hepatic steatosis and severe whole-body and hepatic insu

244 ion protects mice from high-fat diet-induced hepatic steatosis and that mutation of the SLC13A5 ortho

245 Changes in hepatic steatosis at 48 weeks of follow-up over baseline

246 & AIMS: Effective treatments are needed for hepatic steatosis characterized by accumulation of trigl

247 de novo ceramide synthesis reduced PLIN2 and hepatic steatosis in alcohol-fed mice, but only de novo

248 SLC7A11 was associated with reduced risk of hepatic steatosis in participants (odds ratio, 0.69; 95%

249 inal HIF-2alpha could be a viable target for hepatic steatosis therapy.

250 ggesting a possible specific contribution of hepatic steatosis to subclinical vascular impairment.

251 echanisms of inhalation exposure to PM2.5 on hepatic steatosis, a precursor or manifestation of metab

252 ubsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin re

253 t2 knockout mice are leaner and resistant to hepatic steatosis, obesity and insulin resistance under

254 o completed liver ultrasound examination for hepatic steatosis.

255 lop glucose intolerance and high fat-induced hepatic steatosis.

256 asatinib and quercetin (D+Q) reduces overall hepatic steatosis.

257 tissue, decreased gluconeogenesis, and less hepatic steatosis.

258 HIV patients develop hepatic steatosis.

259 ssion was also independently associated with hepatic steatosis.

260 Mechanistically, PTX3 mediated the hepatic stellate cell wound-healing response.

261 r are principally regulated by activation of hepatic stellate cells (HSC).

262 Hepatic stellate cells (HSCs) are key players in the dev

263 tyrosine kinase receptor, is up-regulated in hepatic stellate cells (HSCs) during chronic liver injur

264 Effects of LPS on fibrogenic hepatic stellate cells (HSCs) from WT and TLR4-KO mice w

265 Activation of hepatic stellate cells (HSCs) in response to injury is a

266 A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secr

267 Addition of hepatic stellate cells allowed generation of myeloid-der

268 inhibition of miR-200b in cholangiocytes and hepatic stellate cells in vitro, we evaluated angiogenes

269 The TRAIL pathway can mediate apoptosis of hepatic stellate cells to promote the resolution of live

270 However, the molecular mechanisms for hepatic stellate-cell activation by HCV-infected hepatoc

271 2D MRE can estimate hepatic stiffness in children with NAFLD.

272 sonance (MR) elastography for measurement of hepatic stiffness in pediatric and young adult patients

273 olated using a monoclonal antibody against a hepatic surface protein, leucine amino peptidase (LAP).

274 acids (Omega3FA) on fatty and lean liver in hepatic surgery.

275 This set-up was evaluated during open hepatic surgery.

276 ral steps of bile acid metabolism, including hepatic synthesis and reabsorption.

277 nal tubule cell synthesis of C3, rather than hepatic synthesis of C3, as the primary source of C3 dri

278 To investigate hepatic T-cell subsets upon hypercholesterolemia.

279 eraceae, which were accompanied by increased hepatic taurine-conjugated cholic acid and beta-murichol

280 x weeks of repeated LPS stimulation in vivo, hepatic TNF-alpha and PCNA responses subsided in Nox4-de

281 RMs involved in regulatory activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our mo

282 how, to identify HFD-mediated changes to the hepatic transcriptional program that may persist after w

283 scription factor 4 (ATF4) in controlling the hepatic transcriptome and mediating GCN2-mTORC1 signalin

284 Both PXR activation and deficiency promote hepatic triglyceride accumulation, a hallmark feature of

285 or various covariates, a 10-fold increase in hepatic triglyceride content was associated with an incr

286 atively large population-based cohort study, hepatic triglyceride content was associated with aortic

287 a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis.

288 of primary tumor, age at radioembolization, hepatic tumor burden, presence of extrahepatic disease,

289 in humans and mice reveal that Akt2 controls hepatic tumorigenesis through crosstalk between HNF1alph

290 ignaling pathways can explain the absence of hepatic tumors in AAV-NT mice.

291 we formed a global coalition, the Children's Hepatic tumors International Collaboration (CHIC), with

292 and frequent decrease in GRB14 expression in hepatic tumors when compared to adjacent nontumoral pare

293 ctin proteins, correlated with modulation of hepatic ultrastructure.

294 (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids.

295 ameters were measured 15-20 mm caudal to the hepatic vein junction and recorded by bidimensional imag

296 isease (M), macrovascular involvement of all hepatic veins (V) or portal bifurcation (P), contiguous

297 Low L-Ficolin was associated with hepatic veno-occlusive disease (P = .0053, AUC = 0.80).

298 treatment with rifaximin did not reduce the hepatic venous pressure gradient or improve systemic hem

299 glucose tolerance test (FSIGT), we estimated hepatic versus extrahepatic insulin clearance in 29 EA a

300 Zip14(-/-) (KO) mice, which exhibit impaired hepatic zinc uptake.