ライフサイエンスコーパス: hepatic bile

1 Hepatic bile acid and lipid content was elevated in WT m

2 acid synthetic enzymes but exhibited higher hepatic bile acid and serum bilirubin levels, suggesting

3 rate-limiting step in the classic pathway of hepatic bile acid biosynthesis from cholesterol.

4 ion of the side chain of C27 steroids in the hepatic bile acid biosynthesis pathway, which begins wit

5 testine-specific deletion of SIRT1 increased hepatic bile acid biosynthesis, reduced hepatic accumula

6 isrupts the classical homeostatic control of hepatic bile acid biosynthesis.

7 ted the effect of the C-36 serpin peptide on hepatic bile acid biosynthesis.

8 In addition, hepatic bile acid export in humans is more dependent on

9 cid intraduodenally for 24 hours so that the hepatic bile acid flux reached prefistula levels.

10 IRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1alpha/FXR

11 ter gene expression, including the principal hepatic bile acid importer, the Na(+)/taurocholate co-tr

12 rifampicin, a ligand for human PXR, reduces hepatic bile acid levels in cholestasis patients.

13 aminotransferase, alkaline phosphatase, and hepatic bile acid levels in WT mice.

14 These observations suggest that hepatic bile acid levels or therapeutic agents targeting

15 alysis detected a 4.6-fold increase in total hepatic bile acid levels, despite the coordinated repres

16 cid synthetic pathways, thereby reducing the hepatic bile acid pool and blood levels of bile acids.

17 stomorphology, serum liver enzyme, serum and hepatic bile acid profiles, and hepatic bile acid synthe

18 tein that controls the rate-limiting step in hepatic bile acid secretion.

19 Furthermore, Pon3KO mice exhibited decreased hepatic bile acid synthesis and decreased bile acid leve

20 of the dual FXR and TGR5 agonist INT-767 on hepatic bile acid synthesis and intestinal secretion of

21 e, serum and hepatic bile acid profiles, and hepatic bile acid synthesis and transportation gene expr

22 culation to induce FGF15/19, which modulates hepatic bile acid synthesis and uptake.

23 Hepatic bile acid synthesis is controlled, in part, by a

24 rm complex in the SHP-mediated inhibition of hepatic bile acid synthesis via coordinated chromatin mo

25 On ursodiol therapy, hepatic bile acid synthesis was enhanced 2-fold compared

26 dy is to investigate the role of TGFbeta1 in hepatic bile acid synthesis.

27 rthermore, FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner, su

28 The mechanism for abnormal hepatic bile acid transport was investigated in an 18-mo

29 for pathologic alterations in intestinal and hepatic bile acid transporter expression.

30 on, correlating with suppression of critical hepatic bile acid transporter gene expression, including

31 ion of bile salt export pump (BSEP), a major hepatic bile acid transporter.

32 The molecular regulation of hepatic bile acid transporters during cholestasis is lar

33 hydroxylase, sterol-12alpha-hydroxylase, and hepatic bile acid transporters on both sinusoidal and ca

34 ic adenosine monophosphate (cAMP) stimulates hepatic bile acid uptake by translocating sodium-tauroch

35 Hepatic bile acid uptake kinetics were determined in wil

36 Interestingly, the major human hepatic bile acid uptake transporter NTCP, but not rat N

37 OB2) regulates metabolic pathways, including hepatic bile acid, lipid, and glucose homeostasis.

38 ted in aberrant gene expression profiles for hepatic bile acid-responsive genes consistent with chole

39 chromatography/mass spectroscopy analysis of hepatic bile acids indicated no difference in levels of

40 In response to increased hepatic bile acids, SHP gene expression is induced and t

41 -derived-fat-promoted taurine conjugation of hepatic bile acids, which increases the availability of

42 etion of bile acids, leading to elevation of hepatic bile acids.

43 gulating the expression of genes involved in hepatic bile and fatty acid synthesis, glucose metabolis

44 The radiolabeled hepatic bile area within the gallbladder lumen was trace

45 subcutaneous implants alters partitioning of hepatic bile between gallbladder and small intestine and

46 at many dividing pre-cystic renal tubule and hepatic bile duct cells from Tsc1, Tsc2 and Pkd1 heteroz

47 Following common bile duct ligation or left hepatic bile duct ligation, the expression of p53, c-Myc

48 ng and dilatation of the intra- and/or extra-hepatic bile ducts.

49 lized polycystin to renal tubular epithelia, hepatic bile ductules, and pancreatic ducts, all sites o

50 In the basal state, more of the hepatic bile entered the gallbladder (67%) than the smal

51 Hepatic bile entered the gallbladder continuously during

52 Radiolabeled hepatic bile entered the gallbladder first along its cen

53 Hepatic bile enters the gallbladder continuously during

54 The aim of the project was to study hepatic bile entry into and the transit pattern within t

55 technique of bile collection gives access to hepatic bile from donors and recipients for bile analysi

56 netic resonance analysis has been applied to hepatic bile from selected liver grafts to evaluate its

57 The results showed that the hepatic bile from steatotic grafts collected before tran

58 s received 111-185 MBq 99mTc-mebrofenin as a hepatic bile marker.

59 Radiolabeled CE was increased 3-fold in hepatic bile of Cel(-/-) mice, and the mass of CE in gal

60 Significantly less hepatic bile partitioned into the gallbladder in progest

61 Hepatic bile partitioning and gallbladder emptying were

62 lt lampreys tolerate cholestasis by altering hepatic bile salt composition, while maintaining normal

63 Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP).

64 cytes and may act as a gatekeeper to prevent hepatic bile salt overload.

65 Hepatic bile salt secretion and bile formation are essen

66 acid, which results in toxic accumulation of hepatic bile salts, ER stress and liver injury.

67 sis occurred in the absence of any defect in hepatic bile secretion.

68 The hepatic bile transit rate was calculated (as mm2/min) an

69 ides is transported in a rat model measuring hepatic bile transport.

70 Hepatic bile was collected from eight liver donors (four

71 Total radiolabeled transport from plasma to hepatic bile was more rapid in Cel(-/-) mice.

72 he 6-hour recovery of [(14) C]cholesterol in hepatic bile was significantly lower in both groups of k