ライフサイエンスコーパス: hepatic cell

1 ity to HCV when ectopically expressed in non-hepatic cells.

2 can be utilized to regulate adhesion between hepatic cells.

3 many of which are expressed specifically in hepatic cells.

4 he question of how HCV is able to persist in hepatic cells.

5 hepatitis C virus (HCV) replication in human hepatic cells.

6 .1 or I.4 in breast, ovarian, placental, and hepatic cells.

7 ls, which may account for HCV persistence in hepatic cells.

8 ent inhibitor of IFN-alpha expression by the hepatic cells.

9 dogenous interferon-alpha (IFN-alpha) in the hepatic cells.

10 -HCV ability of recombinant IFN-alpha in the hepatic cells.

11 play a major role in targeting Ad vectors to hepatic cells.

12 tates the interaction between sporozoite and hepatic cells.

13 d abuse, on HCV replicon expression in human hepatic cells.

14 iapoptotic and mitogenic actions of IL-22 in hepatic cells.

15 ng to negatively regulate GATA-4 function in hepatic cells.

16 3beta DNA binding complexes were enriched in hepatic cells.

17 trated that AMPK was inhibited by ethanol in hepatic cells.

18 neural tubules, gut, pulmonary bronchi, and hepatic cells.

19 serpin allele that fails to be activated in hepatic cells.

20 CV RNA expression in the replicon containing hepatic cells.

21 of genes that are specifically expressed in hepatic cells.

22 sions of transplanted, lentivirus-transduced hepatic cells.

23 ting apical protein trafficking in polarized hepatic cells.

24 n liver cells, but had minimal effect in non-hepatic cells.

25 rol-sensitive signal transduction pathway in hepatic cells.

26 the uptake and ultimate expression of DNA in hepatic cells.

27 greatly reducing reporter gene expression in hepatic cells.

28 upregulated by type I and II interferons in hepatic cells.

29 nd Co-induced signaling and EPO induction in hepatic cells.

30 -induced gamma-fibrinogen gene expression in hepatic cells.

31 of acute-phase plasma protein (APP) genes in hepatic cells.

32 een described in neutrophils, monocytes, and hepatic cells.

33 or major PC biosynthetic pathway in all non-hepatic cells.

34 tercellular adhesion molecule-1 (ICAM-1), on hepatic cells.

35 r set of acute phase plasma protein genes in hepatic cells.

36 by interleukin (IL)-6 and glucocorticoids in hepatic cells.

37 sferase reporter gene in both nonhepatic and hepatic cells.

38 ich pRb modulates the apoptotic threshold in hepatic cells.

39 induce rapid growth arrest and apoptosis in hepatic cells.

40 e of the LDLR and attenuated LDL uptake into hepatic cells.

41 miRNAs) that regulate LDLR activity in human hepatic cells.

42 icking but did block hyperphosphorylation in hepatic cells.

43 ities displayed negligible toxicity on human hepatic cells.

44 to differentiate to phenotypically distinct hepatic cells.

45 uciferase reporter assays in mouse and human hepatic cells.

46 le saturated fatty acid exhibits toxicity in hepatic cells.

47 expression of primary and mature miR-122 in hepatic cells.

48 the functional maturation of cocultured KDR- hepatic cells.

49 onal activation of PCK1 and G6PC in cultured hepatic cells.

50 assay for HBV-receptor expression screens in hepatic cells.

51 iR-33* reduces fatty acid oxidation in human hepatic cells.

52 , generate KDR+ hepatic progenitors and KDR- hepatic cells.

53 es on ApoB degradation were then observed in hepatic cells.

54 examined in HIV-1- and HCV-coinfected human hepatic cells.

55 a large increase in the number of apoptotic hepatic cells.

56 amino acid dampening of insulin signaling in hepatic cells.

57 in 1) coregulator via NF-kappaB signaling in hepatic cells.

58 fibroblasts, but not in lymphoid, myeloid or hepatic cells.

59 bled the linkage of CTGF to FN and activated hepatic cells.

60 r enzymes, and the presence of few apoptotic hepatic cells.

61 FGF21 was upregulated and released from the hepatic cells and adipocytes into the circulation and in

62 immunopathogenesis of HCV in both immune and hepatic cells and are relevant to the development of hos

63 ility of gene transfer to diseased liver and hepatic cells and demonstrate the potential of a novel t

64 tivation of gluconeogenic gene expression in hepatic cells and in mouse liver by PGC-1alpha.

65 excess lipid accumulation, both in cultured hepatic cells and in mouse livers.

66 stress increased cholesterol accumulation in hepatic cells and in the livers of apolipoprotein E knoc

67 nol on lipin-1 were investigated in cultured hepatic cells and in the livers of chronic ethanol-fed m

68 lase (ACC), and SREBP-1 were assessed in rat hepatic cells and in the livers of ethanol-fed mice.

69 The FHIT gene is expressed in normal hepatic cells and is not expressed or is abnormally expr

70 pid content and stimulates beta-oxidation in hepatic cells and liver by an autophagy-lysosomal pathwa

71 -mediated knockdown of PPARdelta in cultured hepatic cells and liver tissue reduced LPCAT3 mRNA level

72 sitive regulator of HCV replication in human hepatic cells and may compromise IFN-alpha therapy.

73 ptional activation of PCK1 and G6PC in human hepatic cells and mouse liver was FoxO1-dependent and fu

74 lesteryl ester hydrolysis in transformed rat hepatic cells and primary rat hepatocytes.

75 ed specific HBV receptor/ligand complexes on hepatic cells and quantified the turnover kinetics.

76 tetracycline, and cyclosporin A) in cultured hepatic cells and the livers of different animal models

77 h to instruct their own differentiation into hepatic cells and to non-cell-autonomously support the f

78 e whether HA or HA fragments induced iNOS in hepatic cells, and to characterize the signaling pathway

79 We measured nucleosome occupancy in human hepatic cells before and after treatment with transformi

80 the SCF/c-kit signal transduction systems in hepatic cell biology.

81 and SMADs in mediating TGF-beta functions in hepatic cells, but it is not clear how STATs are activat

82 that PE inhibits IL-6 activation of STAT3 in hepatic cells by a p42/44 mitogen-activated protein kina

83 Here we report that infection of hepatic cells by HCV stimulates nuclear factor kappa B (

84 se latter findings suggest that infection of hepatic cells by L. monocytogenes in vivo does not requi

85 that opioid abuse favors HCV persistence in hepatic cells by suppressing IFN-alpha-mediated intracel

86 We suggest virally infected hepatic cells can process potent CD1d-presented liver Ag

87 in expression of a murine CYP2D5 homolog in hepatic cells, confirming the selective ability of C/EBP

88 irectional, condition-dependent regulator of hepatic cell Cp expression.

89 il (CRF-V, normal-V) using liver homogenate, hepatic cell culture for 8 h, and in vitro liver perfusi

90 hough preparations of PHH contain up to 100% hepatic cells, cultures of differentiated HepaRG cells a

91 ded in TPEF images, such as inflammatory and hepatic cell damage, equally important as collagen depos

92 Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered ne

93 Its role in hepatic cell death and hepatic diseases is not clear.

94 Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation.

95 d accumulation, necroinflammation, and focal hepatic cell death in mice than rats.

96 erimental models of hepatitis, we found that hepatic cell death in vivo was dramatically reduced in T

97 ed by eosinophils in response to large-scale hepatic cell death.

98 tosis, indicating that TRAIL may not mediate hepatic cell death.

99 he functional maturation and preservation of hepatic cells derived from human induced pluripotent ste

100 und that pigtail macaque (Macaca nemestrina) hepatic cells derived from induced pluripotent stem cell

101 highlight how tight quantitative control of hepatic cell differentiation is exerted through specific

102 at gp130 signaling for APP gene induction in hepatic cells differs qualitatively from that controllin

103 n of the acute-phase plasma protein genes in hepatic cells during infection and injury.

104 Hepatic cells expressing the non-phosphorylatable C/EBPb

105 genetic inactivation of Fgf10 also result in hepatic cell fate conversion.

106 whether Notch signaling also underlies adult hepatic cell fate decisions is largely unknown.

107 ide a functional link between IDH mutations, hepatic cell fate, and IHCC pathogenesis, and present a

108 d growth and commitment of the endoderm to a hepatic cell fate.

109 Culture of hepatic cells for 8 h was associated with an increase in

110 e specifically modified human chromosomes to hepatic cells for functional tests.

111 eration of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs).

112 the mechanisms by which TGF-beta influences hepatic cell functions remain incompletely defined.

113 to induction of p450 expression and that in hepatic cells genes are also induced to block apoptosis,

114 resent an important mechanism for control of hepatic cell growth and hepatocarcinogenesis.

115 tional cytokine pivotal in the regulation of hepatic cell growth, differentiation, migration, extrace

116 smembrane domain (TMD) proteins in polarized hepatic cells has been inferred but never directly demon

117 availability of the HCV replicon containing hepatic cells has provided a unique opportunity to inves

118 ing that holoHC is transported into cultured hepatic cells (HepG2) via the asialoglycoprotein recepto

119 of the RSK1-DN mutant in L6 myocytes and FAO hepatic cells improved insulin action on glucose uptake

120 onsequences of N-myc up-regulation in rodent hepatic cells in culture.

121 fferential in-gel electrophoresis to analyze hepatic cells in early response to virosome-induced memb

122 Promoter 2, 5' to exon II, is active only in hepatic cells in promoter assays in vitro.

123 Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) an

124 y generate significant numbers of functional hepatic cells in this noninjury large animal model and t

125 in determining adenovirus infectivity toward hepatic cells in vivo.

126 uciferase reporter genes in transduced mouse hepatic cells in vivo.

127 (iii) internalization of L. monocytogenes by hepatic cells in vivo.

128 We demonstrated that silencing of SAMHD1 in hepatic cells increased HBV replication, while overexpre

129 , we found that HFE increases TfR2 levels in hepatic cells independent of holo-Tf.

130 r-derived cells and minimal or modest in non-hepatic cells, indicating that a liver-specific factor i

131 Overexpression of miR-33b in human hepatic cells inhibits PCK1 and G6PC expression, leading

132 These cytokines regulate hepatic cell interaction and crosstalk of the various in

133 d modulating the cellular phenotype to alter hepatic cell interactions.

134 hat Pdx1-VP16 is able to selectively convert hepatic cells into pancreatic endocrine precursor cells.

135 strated that oncogenic regulation by Gab2 in hepatic cells involved multiple signaling molecules, inc

136 The data suggest that OB-RL action in hepatic cells is equivalent to that of IL-6 receptor.

137 Our results imply that hepatic cells lack trans-Golgi network (TGN)-based machi

138 (+) and ATP are not efficiently sustained in hepatic cells, largely because of transcriptional repres

139 ic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan failure.

140 in RA-induced signaling in a non-transformed hepatic cell line AML 12.

141 chromatin, and depletion of C/EBPalpha in a hepatic cell line decreased hDBP expression.

142 atterns in zebrafish models and in the human hepatic cell line HepaRG shared many similarities, while

143 INDO activity is not induced in the hepatic cell line HepG2.

144 in the HEK293-RXFP1 cAMP assay and the human hepatic cell line LX-2.

145 cytes and in the bile transporter-expressing hepatic cell line McNtcp.24, leading to a significant in

146 study, we generated a stably transfected rat hepatic cell line named WB-1 that expresses an active fo

147 Studies in a human hepatic cell line revealed that BCO2 is expressed as an

148 a simple system, by using a non-transformed hepatic cell line that is able to express sufficient amo

149 a simple system, by using a non-transformed hepatic cell line that is able to express sufficient amo

150 ammatory hormones and iron was examined in a hepatic cell line that secretes plasma proteins.

151 In the human hepatic cell line, HepG2, apolipoprotein B100 (apoB100)

152 E exists as endoproteolyzed fragments in the hepatic cell line, HepG2.

153 mplex with Cdk2 in the NS5A-expressing human hepatic cell line.

154 how that human primary hepatocytes and human hepatic cell lines (Huh7 and HepG2) spontaneously produc

155 HCV-pp efficiently infected tamarin hepatic cell lines and primary marmoset hepatocyte cultu

156 demonstrate that TMPRSS6 is up-regulated in hepatic cell lines by hypoxia and by other activators of

157 n liver during the APR and can be induced in hepatic cell lines by interleukin-6 (IL-6), an acute-pha

158 s animal models, or in transformed malignant hepatic cell lines in which thyroid hormone receptor (TR

159 pic expression of CLDN1 rendered several non-hepatic cell lines permissive to HCV infection.

160 ilin, in cardiovascular disease, and because hepatic cell lines that stably express wild-type or muta

161 ffects of ethanol on primary hepatocytes and hepatic cell lines were also studied in vitro.

162 Transient transfection of hepatic cell lines with NHERF1 or NHERF2 caused a signif

163 these two tight junction proteins in various hepatic cell lines, indicating that E-cadherin plays an

164 eases paracellular permeability in polarized hepatic cell lines, supporting the hypothesis that parac

165 Using human hepatic cell lines, we determined that TRAP80 selectivel

166 atty acid oxidation and insulin signaling in hepatic cell lines, whereas inhibition of endogenous miR

167 tion using a panel of well characterized rat hepatic cell lines.

168 ts increased LPCAT3 mRNA levels in all three hepatic cell lines.

169 at reduced secreted ApoC-III levels in human hepatic cell lines.

170 In cultured hepatic cells, lipid availability dictates the rate of a

171 AM and AFP to reveal HCC subtypes similar to hepatic cell maturation lineages, which may enable progn

172 g field in which the epigenomic microRNAs of hepatic cells may be manipulated with potential therapeu

173 issue-specific function was demonstrated for hepatic cells micropatterned alone and in coculture with

174 expression of paracellular junction genes in hepatic cells of rat and human origin.

175 down-regulation of ApoH expression in either hepatic cells or mouse livers by RNA interference result

176 itors carry a high risk for toxic effects to hepatic cells or show moderate improvement.

177 miRNA in the liver, appears to maintain the hepatic cell phenotype, and its inhibition decreases tot

178 a membrane (PM) proteins in three classes of hepatic cells: polarized and differentiated WIF-B cells,

179 ith enhanced IFNgamma production within some hepatic cell populations but also with decreased numbers

180 an and mouse liver samples and primary mouse hepatic cell populations were used for Western blot anal

181 he liver, the role of TLRs in the individual hepatic cell populations, and the implication of TLR sig

182 In normal hepatic cells, preproET-1 messenger RNA (mRNA) was detec

183 nificantly different in phenotype from other hepatic cells previously reported as candidates for live

184 Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells,

185 apy slightly impaired liver regeneration and hepatic cell proliferation compared with control.

186 suppression of SDF-1 resulted in decrease of hepatic cell proliferation, implying the repair process

187 with multiplicity of infection (MOI, vector:hepatic cell ratio).

188 7.5 times more nanomaterial interaction with hepatic cells relative to peripheral cells.

189 that Plasmodium berghei parasites infecting hepatic cells rely on the PVM transmembrane protein UIS3

190 ors effecting entry of L. monocytogenes into hepatic cells remain to be determined.

191 licular and basolateral domains of polarized hepatic cells, respectively.

192 iated gene transfer of murine TGF-beta1 into hepatic cells results in the expression of biologically

193 These results show for the first time that hepatic cells secrete ferritin, that this ferritin secre

194 In hepatic cells, Smad and SnoN proteins converge with p53

195 Hepatic cell-specific expression of the human apolipopro

196 Hepatic cell-specific expression of the human apolipopro

197 been observed in specific subpopulations of hepatic cells that express some of the known cholangiocy

198 riptional features in myeloid, lymphoid, and hepatic cells that indicate the presence of multiple pro

199 ssion of acute phase plasma protein genes in hepatic cells through the action of gp130, the signal-tr

200 apolipoprotein B (apoB) mRNA is regulated in hepatic cells to achieve a steady state proportion of ed

201 stigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic an

202 alpha1-ACT localizes to the nuclei of hepatic cells to control chromatin condensation and prol

203 s the signal that enables target cardiac and hepatic cells to learn to desensitize their responses.

204 potent negative regulator of the response of hepatic cells to pro-inflammatory cytokines, particularl

205 e proliferation of terminally differentiated hepatic cells to regenerate the original size of the adu

206 ature miR-181b were augmented on exposure of hepatic cells to TGFbeta and were significantly reduced

207 mia type I and a stringent in vivo model for hepatic cell transplantation.

208 sis likely involves actions of the different hepatic cell types and multiple extrahepatic signals.

209 n, proliferation, and morphogenesis of other hepatic cell types during liver development and regenera

210 Death of hepatocytes and other hepatic cell types is a characteristic feature of liver

211 tudy of the biology of ductal and periductal hepatic cell types, including progenitors.

212 mmation, and fibrosis by targeting different hepatic cell types.

213 on of nitric oxide (NO) by several different hepatic cell types.

214 inding of this preparation to cultured human hepatic cells was both dose dependent and saturable.

215 on polymorphonuclear neutrophils (PMNs) and hepatic cells was increased more than twofold.

216 The gene expression pattern of rat hepatic cells was studied during their differentiation i

217 To get more insight into COP1 in hepatic cells, we examined the impact of COP1 on insulin

218 pical plasma membrane protein trafficking in hepatic cells, we found that specific inhibition of Vps3

219 Twenty-two hours after the injection of LPS, hepatic cells were isolated by collagenase and pronase d

220 these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived.

221 use liver metabolism and on normal and tumor hepatic cells were studied.

222 atient-derived induced pluripotent stem cell-hepatic cells with a JNK inhibitor reduced accumulation

223 Although stimulation of hepatic cells with interleukin-6 induces the expression

224 IL-1Ra is produced by hepatic cells with the characteristics of an acute phase

225 s induce hepatic genes and stabilize nascent hepatic cells within the endodermal epithelium.