ライフサイエンスコーパス: hepatic ischemia

1 flammation on I/R in a murine model of total hepatic ischemia.

2 rvival was determined using a model of total hepatic ischemia.

3 more vulnerable to necrosis after transient hepatic ischemia.

4 Numerous clinical circumstances lead to hepatic ischemia.

5 attenuate tissue injury after an episode of hepatic ischemia.

6 leotidase may be a potential therapeutic for hepatic ischemia.

7 is rats underwent 60 minutes of partial warm hepatic ischemia.

8 ingly, male rats were subjected to 1 hour of hepatic ischemia (70%) followed by reperfusion; animals

9 ute kidney injury, myocardial, intestinal or hepatic ischemia, acute lung injury, or during organ tra

10 d to 4 groups: 1.Sham; 2.IR: 40 min of lobar hepatic ischemia and 2 hr reperfusion; 3.RIPC+IR: 6 cycl

11 e were subjected to 75 or 120 minutes of 70% hepatic ischemia and 3 hours of reperfusion.

12 C57BL/6 mice underwent 90 minutes of partial hepatic ischemia and 4 hours of reperfusion in the prese

13 Rats were killed after 60 min of partial hepatic ischemia and after 2, 6, 24, and 48 hr of reperf

14 deposited in liver parenchyma, and decreased hepatic ischemia and endothelial injury.

15 rculation, resulting in microscopic areas of hepatic ischemia and explaining the mechanism of IL-2-in

16 These drugs lowered hepatic ischemia and inflammation, whereas pretreatment

17 Cell transplantation-induced hepatic ischemia and recruitment of vasoconstrictors (e.

18 Hepatic ischemia and reperfusion (IR) injury is a major

19 Hepatic ischemia and reperfusion caused increased expres

20 Hepatic ischemia and reperfusion causes neutrophil-depen

21 y leukocyte protease inhibitor (SLPI) during hepatic ischemia and reperfusion in mice.

22 Hepatic ischemia and reperfusion injury (IRI) remains an

23 Hepatic ischemia and reperfusion injury (IRI), an exogen

24 a unique role for Neo1 in the development of hepatic ischemia and reperfusion injury and identified N

25 A model of hepatic ischemia and reperfusion injury in fatty and lea

26 d in a significant reduction of experimental hepatic ischemia and reperfusion injury, involving atten

27 Burn and sepsis are associated with hepatic ischemia and reperfusion injury.

28 ammation, we hypothesized that Neo1 enhances hepatic ischemia and reperfusion injury.

29 lanine, and proinflammatory cytokines during hepatic ischemia and reperfusion injury.

30 RA1, ADORA2A, ADORA2B, or ADORA3) attenuates hepatic ischemia and reperfusion injury.

31 ous SLPI on liver and lung injury induced by hepatic ischemia and reperfusion were evaluated.

32 C57BL/6 mice underwent partial hepatic ischemia and reperfusion with or without intrave

33 Using a murine model of partial hepatic ischemia and reperfusion, we evaluated the role

34 wild-type and IL-10(-/-) mice in response to hepatic ischemia and reperfusion.

35 uired for the full induction of injury after hepatic ischemia and reperfusion.

36 Evidence for total hepatic ischemia and spontaneous shunts was demonstrated

37 cute liver damage and inflammation caused by hepatic ischemia and subsequent reperfusion.

38 ly elevated in vehicle-treated animals after hepatic ischemia and subsequent reperfusion.

39 ) mice were exposed to 90 minutes of partial hepatic ischemia and up to 24 hours of reperfusion.

40 ) mice were exposed to 90 minutes of partial hepatic ischemia and up to 24 hours of reperfusion.

41 ull mice were subjected to 60 min of partial hepatic ischemia, and at various times thereafter, blood

42 This was due to hepatic ischemia, endothelial injury, and activation of

43 Analysis of microcirculatory events included hepatic ischemia, endothelial injury, including with gen

44 Rats were subjected to 60 minutes of partial hepatic ischemia followed by 0, 3, 6, 24, or 48 hours of

45 re subjected to 10 or 30 min of partial warm hepatic ischemia followed by 3 to 24 hr of reperfusion.

46 A mouse model of partial 90-min warm hepatic ischemia followed by 6 hr of reperfusion was use

47 STAT6 knockout mice underwent 90 minutes of hepatic ischemia followed by 8 hours of reperfusion.

48 before subjecting them to 90 minutes of warm hepatic ischemia followed by reperfusion for 6 or 24 hou

49 Warm and cold hepatic ischemia followed by reperfusion leads to necrot

50 C57BL/6 mice underwent 90 minutes of partial hepatic ischemia followed by reperfusion with or without

51 ent mice were subjected to 90 min of partial hepatic ischemia followed by reperfusion.

52 mice were subjected to 90 minutes of partial hepatic ischemia followed by reperfusion.

53 Mice were subjected to partial hepatic ischemia followed by reperfusion.

54 mice were subjected to 90 minutes of partial hepatic ischemia followed by up to 8 hours of reperfusio

55 mice were subjected to 90 minutes of partial hepatic ischemia followed by up to 96 hours of reperfusi

56 T4 and steroid 48 hr before 15 min of total hepatic ischemia, followed by 24 hr of reperfusion.

57 mice were subjected to 90 minutes of partial hepatic ischemia, followed by up to 8 hours of reperfusi

58 Hepatic ischemia for 90 minutes and reperfusion for up t

59 serotype O55:B5 (EC) and 90 min of secondary hepatic ischemia in EC + I/R and saline-infused (normal

60 onditioning as a protective strategy against hepatic ischemia in humans.

61 ttent clamping (IC) using a model of partial hepatic ischemia in mice aged 20 to 24 months.

62 ificantly improved after 75 minutes of total hepatic ischemia in P-selectin deficient mice when compa

63 f ischemia were further studied in models of hepatic ischemia in rats.

64 A model of total hepatic ischemia is currently not available in mice.

65 Furthermore, the potential role of hepatic ischemia, Kupffer cells, and cytokine release in

66 , improved cell engraftment independently of hepatic ischemia or inflammation, without improving live

67 Systemic administration of DAR decreases hepatic ischemia-related events and thus indirectly impr

68 mediator of inflammation and organ damage in hepatic ischemia reperfusion (I/R) injury.

69 Hepatic ischemia reperfusion injury (IRI) is a major cli

70 The findings suggest that hepatic ischemia reperfusion injury may play a critical

71 tate aminotransferase, a surrogate marker of hepatic ischemia reperfusion injury, was the only consis

72 m and xenon have additionally been tested in hepatic ischemia reperfusion injury, whereas neon was on

73 sulfide (H2S) production and protection from hepatic ischemia reperfusion injury.

74 ble from wild-type mice in their response to hepatic ischemia reperfusion.

75 Octreotide exerts a protective effect in hepatic ischemia-reperfusion (HIR) injury.

76 ment NO. bioavailability and protect against hepatic ischemia-reperfusion (I-R) injury in type 2 diab

77 CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the m

78 Hepatic ischemia-reperfusion (I/R) injury continues to b

79 oprotection, we subjected CS-eNOS-Tg mice to hepatic ischemia-reperfusion (I/R) injury.

80 Hepatic ischemia-reperfusion (IR) injury is a common cli

81 Hepatic ischemia-reperfusion (IR) injury is frequently f

82 Hepatic ischemia-reperfusion (IR) results in Kupffer cel

83 L/6 mice were subjected to 60-minute partial hepatic ischemia-reperfusion and posttreated with sirtui

84 n of sirtuin 1 attenuates liver injury after hepatic ischemia-reperfusion by restoring mitochondrial

85 Hepatic ischemia-reperfusion can be associated with acut

86 Hepatic ischemia-reperfusion injury (I/R) occurs in the

87 Hepatic ischemia-reperfusion injury (IRI), an innate imm

88 play an essential role in the early phase of hepatic ischemia-reperfusion injury and determine the ex

89 ose tissue-derived mesenchymal stem cells in hepatic ischemia-reperfusion injury and the underlying m

90 Hepatic ischemia-reperfusion injury can result in organ

91 Hepatic ischemia-reperfusion injury is a disease pattern

92 Hepatic ischemia-reperfusion injury or sham operation.

93 ematopoietic Plexin C1 in the development of hepatic ischemia-reperfusion injury, and suggest that Pl

94 antibody and a Semaphorin 7A peptide reduced hepatic ischemia-reperfusion injury, as measured by the

95 Moreover, in animal models of peritonitis, hepatic ischemia-reperfusion injury, Salmonella infectio

96 role of Plexin C1 in a mouse model of early hepatic ischemia-reperfusion injury.

97 nt (PLXNC1) mice also demonstrated decreased hepatic ischemia-reperfusion injury.

98 ockout is crucial for reducing the extent of hepatic ischemia-reperfusion injury.

99 activation of sirtuin 1 is protective after hepatic ischemia-reperfusion injury.

100 e context of acetaminophen hepatotoxicity or hepatic ischemia-reperfusion injury.

101 e stress, and apoptosis in a rodent model of hepatic ischemia-reperfusion injury.

102 Hepatic ischemia-reperfusion is a major clinical problem

103 The pathophysiology of hepatic ischemia-reperfusion is characterized by mitocho

104 zed that pulmonary injury is associated with hepatic ischemia-reperfusion resulting from descending t

105 hts into possible mechanisms responsible for hepatic ischemia-reperfusion-related acute lung injury a

106 rotects against inflammation and damage from hepatic ischemia/reperfusion (I/R) and other insults.

107 that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not comple

108 Hepatic ischemia/reperfusion (I/R) injury associated wit

109 nflammatory responses play critical roles in hepatic ischemia/reperfusion (I/R) injury associating wi

110 Hepatic ischemia/reperfusion (I/R) injury is associated

111 catalysis of heme, in the protection against hepatic ischemia/reperfusion (I/R) injury needs to be es

112 he liver to examine their role in total warm hepatic ischemia/reperfusion (I/R) injury with bowel con

113 Using an in vivo model of hepatic ischemia/reperfusion (I/R) injury, we show that

114 critical mediator of leukocyte migration in hepatic ischemia/reperfusion (I/R) injury.

115 ed mitochondrial function that is evident in hepatic ischemia/reperfusion (I/R) injury.

116 Hepatic ischemia/reperfusion (I/R) is a major adverse re

117 Hepatic ischemia/reperfusion (I/R) leads to liver injury

118 Hepatic ischemia/reperfusion (I/R) results in a neutroph

119 In a model of mouse hepatic ischemia/reperfusion (I/R), recombinant adenovir

120 Platelets play a critical role during hepatic ischemia/reperfusion (I/R).

121 regeneration of functional liver mass after hepatic ischemia/reperfusion (I/R).

122 iverse roles in the acute injury response to hepatic ischemia/reperfusion (I/R).

123 g with HMGB1 results in protection following hepatic ischemia/reperfusion (I/R).

124 ese Zucker rats are susceptible to increased hepatic ischemia/reperfusion (I/RP) injury.

125 ever, their in vivo functional importance in hepatic ischemia/reperfusion (IR) injury is perplexing.

126 Hepatic ischemia/reperfusion (IRI) injury remains a majo

127 In addition, hepatic ischemia/reperfusion caused significant increase

128 Therefore, we investigated the response to hepatic ischemia/reperfusion in STAT4-deficient mice.

129 Hepatic ischemia/reperfusion in wild-type and STAT6 knoc

130 Hepatic ischemia/reperfusion increased expression of TNF

131 (ALT) levels and histological improvement of hepatic ischemia/reperfusion injuries.

132 However, in swine that survived hepatic ischemia/reperfusion injury (45 minutes of ische

133 stic target of rapamycin (mTOR) signaling in hepatic ischemia/reperfusion injury (HIRI) in normal and

134 NK cells in dictating outcomes after partial hepatic ischemia/reperfusion injury (IRI).

135 Amelioration of hepatic ischemia/reperfusion injury after inhibition of

136 ate that SLPI has protective effects against hepatic ischemia/reperfusion injury and suggest that end

137 The data suggest that IL-10 protects against hepatic ischemia/reperfusion injury by suppressing NFkap

138 sought to determine the role of PPARgamma in hepatic ischemia/reperfusion injury in mice.

139 er the LPS signaling pathway is activated by hepatic ischemia/reperfusion injury in the transplant se

140 Hepatic ischemia/reperfusion injury involves a complex i

141 Hepatic ischemia/reperfusion injury is caused primarily

142 Hepatic ischemia/reperfusion injury is initiated by the

143 We observed that hepatic ischemia/reperfusion injury leads to: (1) a coin

144 ies with isolated cells and a mouse model of hepatic ischemia/reperfusion injury revealed that NOX2 f

145 have previously employed an animal model of hepatic ischemia/reperfusion injury, and have shown that

146 Furthermore, P5779 can protect mice against hepatic ischemia/reperfusion injury, chemical toxicity,

147 R1, and IL-6 levels, are increased following hepatic ischemia/reperfusion injury, implying that TACE

148 Rgamma activation is hepatoprotective during hepatic ischemia/reperfusion injury, mice were treated w

149 In an in vivo model of mouse hepatic ischemia/reperfusion injury, recombinant adenovi

150 rtant therapeutic intervention strategies in hepatic ischemia/reperfusion injury.

151 (IL-12) in the induction and development of hepatic ischemia/reperfusion injury.

152 he roles of MIP-2 and KC in the induction of hepatic ischemia/reperfusion injury.

153 rovide sensitive and quantitative markers of hepatic ischemia/reperfusion injury.

154 ctions, which contribute to the pathology of hepatic ischemia/reperfusion injury.

155 ns but also protection from tissue injury in hepatic ischemia/reperfusion injury.

156 tical role in the inflammatory cascade after hepatic ischemia/reperfusion injury.

157 mplying that TACE plays an important role in hepatic ischemia/reperfusion injury.

158 Liver injury induced by hepatic ischemia/reperfusion is characterized by activat

159 pathways that are activated by the stress of hepatic ischemia/reperfusion remain unknown.

160 as to determine whether IL-10 could suppress hepatic ischemia/reperfusion-induced NFkappaB activation

161 us regulator of the inflammatory response to hepatic ischemia/reperfusion.

162 hil-dependent hepatic injury associated with hepatic ischemia/reperfusion.

163 bjected to 70% hepatectomy and 30 minutes of hepatic ischemia showed significantly reduced regenerati

164 t) following 30, 45, and 90 minutes of acute hepatic ischemia, the systemic release of eight differen

165 R4 knockout (KO) mice were subjected to warm hepatic ischemia, there was significant protection in th

166 vival was observed after 75 minutes of total hepatic ischemia using both protective protocols, wherea

167 Seventy percent hepatic ischemia was induced in male adult rats by placi

168 ncapsulated clodronate 48 h before 35 min of hepatic ischemia with bowel congestion, followed by 6 or