ライフサイエンスコーパス: hepatic metabolism

1 ion of key transcription factors controlling hepatic metabolism.

2 ited significant improvement in stability to hepatic metabolism.

3 m that plays an important role in regulating hepatic metabolism.

4 ic corticosteroid activity due to first-pass hepatic metabolism.

5 undance and interfere with glucose-regulated hepatic metabolism.

6 duced CRP elevation is related to first-pass hepatic metabolism.

7 hose involving cytochrome P450 isoenzymes in hepatic metabolism.

8 study is focused on the action of leptin on hepatic metabolism.

9 availability as a result of high first-pass hepatic metabolism.

10 ibed as a potent mechanism for orchestrating hepatic metabolism.

11 Hepatic metabolism and biliary transport had an importan

12 define the mechanisms by which leptin alters hepatic metabolism and corrects steatosis.

13 sing in vitro model for long-term studies of hepatic metabolism and cytotoxicity.

14 as examined, compounds with both significant hepatic metabolism and daily dose >50 mg (n = 50) were s

15 en hepatic adverse events and combination of hepatic metabolism and daily dose was examined, compound

16 a study to examine the relationship between hepatic metabolism and DILI of prescription medications.

17 nd conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor,

18 miR-26a targeted several key regulators of hepatic metabolism and insulin signaling.

19 parts clinically relevant sex differences to hepatic metabolism and liver disease susceptibility.

20 f Phd gene knockouts did not further improve hepatic metabolism and only added toxicity.

21 or potential treatments for inborn errors of hepatic metabolism and suggest that cardiac glycosides c

22 This probably results from the zonation of hepatic metabolism and, in some cases, from differences

23 -anhydro-D-mannitol (2,5-AM; an inhibitor of hepatic metabolism) and methyl palmoxirate (MP; an inhib

24 tabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and tran

25 corticosteroid with an extensive first-pass hepatic metabolism appeared promising for the treatment

26 ant dose-dependency and drugs with extensive hepatic metabolism are associated with higher frequency

27 Reactive metabolites generated by hepatic metabolism are thought to play an important role

28 a common weight-loss approach that modifies hepatic metabolism by increasing gluconeogenesis (GNG) a

29 Later, steady-state hepatic metabolism can be assessed using only the arteri

30 Compared with compounds with lesser hepatic metabolism, compounds belonging to the significa

31 These methods were used to analyze the hepatic metabolism considering available data sets obtai

32 The impairment of hepatic metabolism due to liver injury has high systemic

33 have also emerged as players in dysregulated hepatic metabolism due to nutritional overload.

34 metabolites (HO-PCBs) in mice with defective hepatic metabolism due to the liver-specific deletion of

35 r 1alpha (PGC-1alpha), a global regulator of hepatic metabolism during fasting.

36 unction, and inhibition of Foxo1 can improve hepatic metabolism during insulin resistance and the met

37 hese studies also indicate distinct roles in hepatic metabolism for Hif-1alpha, which promotes glycol

38 ed for the development of rigorous models of hepatic metabolism for preclinical screening of drug cle

39 lism, compounds belonging to the significant hepatic metabolism group had significantly higher freque

40 Twelve compounds with no hepatic metabolism had no reports of liver failure, live

41 FXR in regulation of bile acid synthesis and hepatic metabolism has been studied extensively.

42 However, the role of TGR5 in hepatic metabolism has not been explored.

43 are inconsistent with the canonical model of hepatic metabolism in which Akt is an obligate intermedi

44 Instead, enhanced hepatic metabolism, independent of GLP-1 receptor activa

45 ion, hypoxia induced cancer, decreased extra hepatic metabolism, intestinal infarction and lactic aci

46 These data confirm that hepatic metabolism is the major route of CPA elimination

47 Because tipifarnib undergoes extensive hepatic metabolism, MTD is doubled in patients on EIAEDs

48 were characterized as those with significant hepatic metabolism (n = 149).

49 Hepatic metabolism of 22:6,n-3, however, generates 20:5,

50 device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the t

51 Hepatic metabolism of ethanol by cytochrome P450 2E1 (CY

52 However, the patients showed impaired hepatic metabolism of FMZ.

53 est that these effects result from the rapid hepatic metabolism of fructose catalyzed by fructokinase

54 Hepatic metabolism of fructose favors de novo lipogenesi

55 ies, adverse glycemic effects, and increased hepatic metabolism of fructose leading to de novo lipoge

56 Hepatic metabolism of glucose, fatty acids, and lipoprot

57 levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol.

58 clinical samples led us to reinvestigate the hepatic metabolism of mesna and dimesna.

59 This clearance is probably due to hepatic metabolism of the immune complexes.

60 ctivated transcription factor, regulates the hepatic metabolism of therapeutics as well as endobiotic

61 This is used in studies of regulation of hepatic metabolism of, for example, (18)F-FDG and (11)C-

62 provide a means for assessing the impact of hepatic metabolism on amino acid availability to periphe

63 rtnership that mediates endocrine control of hepatic metabolism plays a role in cellular homeostasis

64 modular platform to emulate and investigate hepatic metabolism processes, with particular potential

65 clic groups designed to decrease the rate of hepatic metabolism provided analogues with improved phar

66 However, the effects of CR on hepatic metabolism remain unknown.

67 Hepatic metabolism requires mitochondria to adapt their

68 anges of biological cascades associated with hepatic metabolism, response to hormone stimuli, glucone

69 his is true, then compounds with significant hepatic metabolism should cause more DILI than those wit

70 BCB11 deficiency may cause unique changes in hepatic metabolism that are predictive of liver injury.

71 uses a primary defect in gene expression and hepatic metabolism that leads to the eventual developmen

72 le disorders are a group of inborn errors of hepatic metabolism that result in often life-threatening

73 In addition to reduced hepatic metabolism, there was reduced long chain fatty a

74 fect on the core clock but rather reprograms hepatic metabolism through altered pro-inflammatory resp

75 iabetes, yet its contribution to deregulated hepatic metabolism under diseased states is not well und

76 s nitric oxide synthase inhibitor, undergoes hepatic metabolism via dimethylarginine-dimethylamino-hy

77 Hepatic metabolism was analyzed using in vivo 13C/31P/1H

78 To this end, hepatic metabolism was assessed in wild-type (WT) and PG

79 Local hepatic metabolism was studied in vivo in male Sprague-D

80 ted in vitro in a cellular environment where hepatic metabolism was well maintained.

81 he effect of reduced mitochondrial fusion on hepatic metabolism, we generated mice with a liver-speci

82 Compounds with >50% hepatic metabolism were characterized as those with sign

83 eal key roles for Them2 in the regulation of hepatic metabolism, which are potentially mediated by PC

84 ncentrations, which are determined mainly by hepatic metabolism, which may be increased or decreased

85 f the autonomic control in the regulation of hepatic metabolism, which plays a major role in the deve

86 Mass-balance analysis of hepatic metabolism will be useful in characterizing chan

87 2 have complementary roles in the control of hepatic metabolism, with IRS-1 more closely linked to gl

88 The seminal event in halothane hepatitis is hepatic metabolism, yet the enzyme responsible for oxida