ライフサイエンスコーパス: hepaticus

1 tal infection with the pathogen Helicobacter hepaticus.

2 cillus paracasei and then challenged with H. hepaticus.

3 iously described granulating cytotoxin in H. hepaticus.

4 manner following infection with Helicobacter hepaticus.

5 ter experimental infection with Helicobacter hepaticus.

6 genic enterohepatic Helicobacter species, H. hepaticus.

7 op colitis after infection with Helicobacter hepaticus.

8 ing intragastric infection with Helicobacter hepaticus.

9 us is genetically most closely related to H. hepaticus.

10 A gene and is biochemically distinct from H. hepaticus.

11 hat harbored or did not harbor endogenous H. hepaticus.

12 ion, or T-cell activation with or without H. hepaticus.

13 this cytotoxic activity were cloned from H. hepaticus.

14 totoxic activities seen with sonicates of H. hepaticus.

15 s, suggesting transplacental infection of H. hepaticus.

16 Cr mice naturally infected with Helicobacter hepaticus.

17 o serum immunoglobulin G response against H. hepaticus.

18 d microbial flora that included Helicobacter hepaticus.

19 Helicobacter species and named Helicobacter hepaticus.

20 the presence of a single murine pathogen, H. hepaticus.

21 nd carcinogenesis in livers infected with H. hepaticus.

22 adication and reintroduction of Helicobacter hepaticus.

23 infection by disrupting the putA gene in H. hepaticus.

24 nd failed to mount IgG1 responses against H. hepaticus.

25 ild-type macrophages after challenge with H. hepaticus.

26 ng the p50/p105 subunit of NF-kappaB with H. hepaticus.

27 challenge with either mutant or wild-type H. hepaticus.

28 In situ hybridization for H. hepaticus 16S rRNA showed that the bacteria was found th

29 Helicobacter hepaticus, a causative agent of chronic hepatitis and he

30 experimental colitis induced by Helicobacter hepaticus, a commensal bacterium with pathogenic potenti

31 s and colon cancer triggered by Helicobacter hepaticus, a widespread murine enterohepatic pathogen.

32 We here show that H. hepaticus Ag (SHelAg)-specific CD4+ Th1 clones transfer

33 s (59%) were most commonly colonized with H. hepaticus alone or in combination with other Helicobacte

34 Coinfection with H. hepaticus also suppressed H. pylori-induced elevation of

35 oculated by gastric gavage with Helicobacter hepaticus, an enteric bacterial pathogen of mice.

36 Helicobacter hepaticus, an enterohepatic helicobacter in mice, is kno

37 -deficient mice inoculated with Helicobacter hepaticus, an opportunistic pathogenic bacterium, develo

38 re experimentally infected with wild-type H. hepaticus and a CDT-deficient isogenic mutant.

39 FlgR from Helicobacter hepaticus and Campylobacter jejuni, which are closely re

40 presence of immunoglobulin G antibody to H. hepaticus and changes in the liver enzyme alanine aminot

41 genase activity was detected in Helicobacter hepaticus and compared to the activity in Helicobacter p

42 sible pathogenicity island from Helicobacter hepaticus and components of a potential type IV secretio

43 Infections with H. hepaticus and H. bilis have been associated with hepatit

44 aises the possibility that H. canis, like H. hepaticus and H. bilis in mice, can cause inflammation o

45 estriction enzyme analyses indicated that H. hepaticus and H. bilis infections are widespread in labo

46 However, mice infected with H. hepaticus and H. pylori (HhHp mice) developed more sever

47 onius was found to be less prevalent than H. hepaticus and H. rodentium but as prevalent as H. bilis.

48 bacter bilis or coinfected with Helicobacter hepaticus and Helicobacter rodentium and fed a lithogeni

49 y responded when stimulated in vitro with H. hepaticus and Helicobacter typhlonius Ag, but not when c

50 e we investigate the interactions between H. hepaticus and host immune cells that may promote mutuali

51 The discovery of Helicobacter hepaticus and its role in hepatitis, hepatocellular carc

52 ase gene cluster and to UreI of Helicobacter hepaticus and Streptococcus salivarius.

53 odulatory role that allows persistence of H. hepaticus and that in IL-10-/- mice this alteration of t

54 h natural infection of SCID/NCr mice with H. hepaticus and that lesions are progressive with age.

55 Both wild-type H. hepaticus and the CDT-deficient mutant successfully colo

56 o whole Helicobacter bacteria (H. pylori, H. hepaticus, and H. felis) was mediated not by TLR4 but ra

57 rs with Helicobacter muridarum, Helicobacter hepaticus, and Helicobacter sp. MIT 94-022.

58 relates with recent findings of Helicobacter hepaticus- and Helicobacter bilis-related hepatic diseas

59 esenteric lymph node cells with a soluble H. hepaticus antigen (Ag) preparation.

60 production by IL-10 KO CD4(+) cells in an H. hepaticus antigen-specific manner.

61 responses by splenic mononuclear cells to H. hepaticus antigens.

62 tudy, suggesting that the urease genes of H. hepaticus are stable.

63 resulting from the relative dominance of H. hepaticus as a member of the community.

64 tact mice were persistently infected with H. hepaticus as identified by culture and PCR, in both the

65 ice with a membrane digest preparation of H. hepaticus as the antigen.

66 develop a significant immune response to H. hepaticus associated with prominent multifocal mononucle

67 ription factors during the development of H. hepaticus-associated liver tumors and may have relevance

68 netic background were monoassociated with H. hepaticus ATCC 51448 by oral feeding and rectal enemas.

69 Infection with WT H. hepaticus, but not HhcdtBm7, at 8 wpi was associated wit

70 16 (37%) had mice infected with Helicobacter hepaticus; but monoinfection with H. bilis, H. mastomyri

71 e; all were confirmed to be infected with H. hepaticus by culture and PCR.

72 Sera from mice positive for H. hepaticus by PCR or histologic examination (n = 88), pos

73 ytes has shown that UreI of H. pylori and H. hepaticus can transport urea only at acidic pH, whereas

74 Infection with Helicobacter hepaticus causes chronic active hepatitis in certain str

75 H. hepaticus causes chronic active hepatitis, with progress

76 Helicobacter hepaticus causes disease in the liver and lower intestin

77 Helicobacter hepaticus causes hepatitis in selected strains of mice a

78 Helicobacter hepaticus causes hepatitis in susceptible strains of mic

79 Helicobacter hepaticus causes hepatitis, hepatic adenomas, and hepato

80 These lines of evidence indicate that (i) H. hepaticus CDT plays a crucial role in the persistent col

81 be for this assay were generated from the H. hepaticus cdtB gene (encoding subunit B of the H. hepati

82 In this study we have demonstrated that H. hepaticus challenge of macrophages induces ERK activatio

83 acilli reduced intestinal inflammation in H. hepaticus-challenged IL-10-deficient mice despite simila

84 In this H. hepaticus-challenged IL-10-deficient murine colitis mode

85 s assay, the sensitivity for detection of H. hepaticus chromosomal DNA prepared from pure culture was

86 arbouring B. fragilis not expressing PSA, H. hepaticus colonization leads to disease and pro-inflamma

87 after inoculation by culture and PCR for H. hepaticus colonization of the liver and cecum, and micro

88 (ii) SW female mice are more resistant to H. hepaticus colonization than male mice; (iii) there was p

89 paticus in the ileum of female mice; (iv) H. hepaticus colonization was associated with down-regulati

90 Two days after infection, H. hepaticus comprised a minor component of the mucosa-asso

91 r, but when reintroduced into a Helicobacter hepaticus-containing specific pathogen-free room, these

92 The results of H. hepaticus culture and H. hepaticus-specific PCR concurre

93 ared to 14 of 44 of the mice (32%) having H. hepaticus cultured from their frozen liver tumors.

94 icus cdtB gene (encoding subunit B of the H. hepaticus cytolethal distending toxin).

95 accelerates development of colitis while H. hepaticus delays disease.

96 -10 KO) mice reconstituted with Helicobacter hepaticus develop severe colitis associated with a Th1-t

97 Mice infected with H. hepaticus developed progressively severe perivascular, p

98 Animals infected with wild-type H. hepaticus developed serum immunoglobulin G1 (IgG1) and I

99 Only animals infected with wild-type type H. hepaticus developed significant typhlocolitis.

100 Mice were gavaged with H. hepaticus; DFO feeding was continued; and mice were sacr

101 lower sensitivity (10(6)-fold) than from H. hepaticus DNA.

102 We conclude that H. hepaticus does not induce or potentiate disease in our I

103 d in sequential isolates of one strain of H. hepaticus during an 18 month in vivo colonization study,

104 The H. hepaticus enzyme coupled H(2) oxidation to reduction of

105 The putA mutant strain of H. hepaticus exhibited increased proline levels and resista

106 Animals infected with wild-type H. hepaticus exhibited severe typhlocolitis at 8 months aft

107 Helicobacter hepaticus expresses a member of the cytolethal distendin

108 that IL-10(-/-) mice monoassociated with H. hepaticus for up to 16 weeks showed almost no histologic

109 Genomic DNAs from 11 isolates of H. hepaticus from the United States, Germany, France, and T

110 ivalent to approximately 14 copies of the H. hepaticus genome based on an estimated genome size of ap

111 The aim of this study was to examine the H. hepaticus genome by pulsed-field gel electrophoresis (PF

112 rtion of the urease structural genes from H. hepaticus genomic DNA.

113 d was able to detect as little as 5 pg of H. hepaticus, H. bilis, or H. muridarum DNA.

114 H. hepaticus had a strong affinity for molecular H(2) (appa

115 l bioassays conducted with B6C3F(1) mice, H. hepaticus has been regarded as a confounding factor beca

116 Helicobacter hepaticus has been reported to induce colitis, hepatitis

117 These findings indicate that H. hepaticus has urease structural genes which are homologo

118 Monoinfections with H hepaticus , Helicobacter cinaedi , and H rodentium gave

119 have recently been identified: Helicobacter hepaticus, Helicobacter muridarum, and Helicobacter bili

120 C57BL/6 mice were inoculated per os with H. hepaticus, Helicobacter muridarum, or H. bilis.

121 In the absence of IL-10, Helicobacter hepaticus (Hh) induces colitis.

122 and then orally inoculated with Helicobacter hepaticus (Hh) or sterile media at 8 weeks of age.

123 nt (p50(-/-); p65(+/-)) mice to Helicobacter hepaticus (Hh)-induced colitis.

124 embrane segment urea channel of Helicobacter hepaticus (HhUreI), homologous to the essential UreI of

125 he need to include diagnostic testing for H. hepaticus in a murine health monitoring program.

126 ) there was persistent colonization of WT H. hepaticus in cecum, colon, and jejunum but only transien

127 icient mice despite similar quantities of H. hepaticus in cocolonized animals.

128 h sensitivity and specificity to quantify H. hepaticus in experimentally infected mouse models as wel

129 approaches for assessing the presence of H. hepaticus in livers lacking characteristic lesions.

130 udy confirms the widespread prevalence of H. hepaticus in mice, its potential to confound experimenta

131 ay was developed to quantitatively detect H. hepaticus in mouse ceca and feces using the ABI Prism 77

132 complicated by the presence of Helicobacter hepaticus in selected silver-stained liver sections whic

133 al role in the persistent colonization of H. hepaticus in SW mice; (ii) SW female mice are more resis

134 6 wpi; however, colonization levels of WT H. hepaticus in the cecum and colon of male mice were appro

135 ejunum but only transient colonization of H. hepaticus in the ileum of female mice; (iv) H. hepaticus

136 ce of a single murine pathogen, Helicobacter hepaticus, in combination with the abnormal immunologica

137 invasive adenocarcinoma, possibly because H. hepaticus, in delaying the development of colitis, allow

138 course of acute DSS and chronic Helicobacter hepaticus induced colitis in dectin-1 deficient mice.

139 ct in the regulation of IL-12 expression, H. hepaticus induced markedly higher levels of IL-12 p40 in

140 c interval Hiccs that regulates Helicobacter hepaticus-induced colitis and associated cancer suscepti

141 nocyte populations are unable to suppress H. hepaticus-induced colitis in p50(-/-)p65(+/-)Rag-2(-/-)

142 H. hepaticus-induced colitis is associated with elevated le

143 mmation in IL-10 KO mice with established H. hepaticus-induced colitis.

144 40 from p50(-/-)p65(+/-) mice ameliorates H. hepaticus-induced disease.

145 To identify gene expression specific to H. hepaticus-induced hepatitis and progression to hepatocel

146 /JCr mice are particularly susceptible to H. hepaticus-induced hepatitis and subsequent development o

147 orms of androgen interruption can inhibit H. hepaticus-induced hepatitis in young male mice, whereas

148 ible and C57BL/6NCr mice are resistant to H. hepaticus-induced hepatitis.

149 These results suggest that inhibition of H. hepaticus-induced IL-12 p40 expression by NF-kappaB subu

150 g-deficient hosts significantly inhibited H. hepaticus-induced inflammation and development of cancer

151 In this study, we show using Helicobacter hepaticus-induced intestinal inflammation that IL-17A(Cr

152 In contrast, anti-IL-17F had no effect on H. hepaticus-induced intestinal pathology.

153 sion profile of A/JCr mice with Helicobacter hepaticus-induced typhlitis at month 1 of infection, pri

154 the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response

155 These results suggest that H. hepaticus induces ERK activation by a pathway dependent

156 with a single bacterial agent, Helicobacter hepaticus, induces chronic colitis in SPF-reared IL-10(-

157 nalysis of the gene expression in ceca of H. hepaticus infected mice revealed 25 up-regulated and 3 d

158 te proliferation, a longitudinal study of H. hepaticus-infected A/JCr mice was undertaken.

159 report profiling cecal gene expression in H. hepaticus-infected A/JCr mice.

160 n females (P < 0.016 and 0.031 between WT H. hepaticus-infected and sham-dosed females, respectively)

161 f colonic, but not cecal, inflammation in H. hepaticus-infected anti-IL-10R-treated mice, demonstrati

162 H. hepaticus-infected BALB-RagMin mice developed moderate h

163 However, H. hepaticus-infected BALB-RagMin mice had a significant in

164 hat the cotransfer of CD4(+) T cells from H. hepaticus-infected but not uninfected WT mice prevents t

165 tic liver lesions were observed in 69% of H. hepaticus-infected F1 male mice and H. hepaticus was iso

166 ce, were divided equally into control and H. hepaticus-infected groups and euthanized at 18 months po

167 t reduction of intestinal inflammation in H. hepaticus-infected IL-10(-/-) mice, suggesting an import

168 H. hepaticus-infected mice seroconverted by 2 weeks and mai

169 s present in feces and cecal samples from H. hepaticus-infected mice was readily quantified.

170 The H. hepaticus-infected mouse will provide an ideal model to

171 tocellular carcinoma was diagnosed in one H. hepaticus-infected mouse.

172 enteric lymph node (MLN) cells alone from H. hepaticus-infected mutant mice.

173 H. hepaticus-infected parental strains including A/J and C5

174 Helicobacter hepaticus-infected Rag2(-/-) mice emulate many aspects o

175 Helicobacter hepaticus-infected Rag2(-/-) mice emulate many aspects o

176 H. hepaticus-infected Rag2-/-, but not sham-dosed Rag2-/- m

177 cific CD4+ Th1 clones transfer disease to H. hepaticus-infected T cell-deficient RAG KO hosts.

178 H. hepaticus-infected wild-type mice did not develop inflam

179 The combination of H. hepaticus infection and CD45RB(high) CD4+ T-cell reconst

180 omoting model combining chronic Helicobacter hepaticus infection and the carcinogen azoxymethane, we

181 s conducted to determine the incidence of H. hepaticus infection and to evaluate different diagnostic

182 In this study, we determined if H. hepaticus infection could prevent H. bilis-induced colit

183 r mice with naturally occurring Helicobacter hepaticus infection develop a progressive chronic active

184 H. hepaticus infection elicited both T cell-mediated and T

185 h regulatory cells at 4 or 12 weeks after H. hepaticus infection had reduced severity of inflammatory

186 Helicobacter hepaticus infection in A/JCr mice results in chronic act

187 Helicobacter hepaticus infection in mice is being used as an animal m

188 orbent assay (ELISA) for serodiagnosis of H. hepaticus infection in mice with a membrane digest prepa

189 ive and specific for the serodiagnosis of H. hepaticus infection in mice.

190 ed colitis development despite persistent H. hepaticus infection in recipient mice.

191 of a cell-mediated Th1 immune response to H. hepaticus infection in the A/JCr mouse should prove valu

192 we demonstrate that persistent Helicobacter hepaticus infection modulates host responses to diarrhea

193 In contrast, H. hepaticus infection of mdr1a-/- mice did not accelerate

194 Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombinatio

195 e human viral hepatitis, murine Helicobacter hepaticus infection produces inflammation and HCC with a

196 gether, our data support the concept that H. hepaticus infection results in the induction in WT mice

197 quipped to mount a successful response to H. hepaticus infection, increasing colon cancer risk.

198 for the development of colitis following H. hepaticus infection.

199 40 show no intestinal pathology following H. hepaticus infection.

200 and the immune response of A/JCr mice to H. hepaticus infection.

201 ave histological features compatible with H. hepaticus infection.

202 tained liver sections is used to diagnose H. hepaticus infection.

203 ic gene expression profile in response to H. hepaticus infection.

204 recently discovered bacterium, Helicobacter hepaticus, infects the intrahepatic bile canaliculi of m

205 istal intestinal infection with Helicobacter hepaticus, influence small intestinal transit time.

206 Helicobacter hepaticus is a gram-negative, spiral-shaped microaerophi

207 Helicobacter hepaticus is a member of the mouse intestinal microbiota

208 g human foodborne pathogen, and Helicobacter hepaticus is a mouse pathogen; both species are associat

209 Helicobacter hepaticus is a naturally occurring pathogen of mice and

210 Helicobacter hepaticus is a new bacterial species that is homologous

211 Helicobacter hepaticus is a newly recognized bacterium associated wit

212 Helicobacter hepaticus is an enterohepatic Helicobacter species that

213 By PFGE, the genomic size of H. hepaticus is estimated to be roughly 1.3 Mb, which compa

214 se, the murine liver carcinogen Helicobacter hepaticus is most pathogenic in male mice infected befor

215 completed in our laboratory indicate that H. hepaticus is widespread in academic and commercial mouse

216 A cdtB-deficient H. hepaticus isogenic mutant (HhcdtBm7) was generated and c

217 Diversity among H. hepaticus isolates was evaluated by means of a restricti

218 Like H. hepaticus, it is a spiral bacterium with bipolar sheathe

219 ersistent murine infection with Helicobacter hepaticus leads to chronic gastrointestinal inflammation

220 nfection of Rag2(-/-) mice with Helicobacter hepaticus led to accumulation of macrophages and neutrop

221 ct mice became persistently infected with H. hepaticus, lesions were less severe and the levels of se

222 Concurrent infection with H. hepaticus may confound studies that have been attributed

223 en SMAD3-/- mice are exposed to Helicobacter hepaticus, mild colitis is observed 4 weeks postinfectio

224 d mice that were either monoinfected with H. hepaticus, monoinfected with seven other Helicobacter sp

225 However, a CDT-negative H. hepaticus mutant had a significantly diminished capacity

226 /6 interleukin 10(-/-) mice with isogenic H. hepaticus mutants revealed that CDT expression is not re

227 on exist, and to analyze the influence of H. hepaticus on hepatocyte proliferation, a longitudinal st

228 nterohepatic bacterial pathogen Helicobacter hepaticus on liver and intestine tumorigenesis in BALB-R

229 C57BL/6 mice were infected with Helicobacter hepaticus or Helicobacter muridarum, followed by H. pylo

230 both female and male mice colonized by WT H. hepaticus or in males transiently colonized through 8 wp

231 Male A/JCr mice were infected with H. hepaticus or vehicle at 4 weeks and randomized into surg

232 ing A/JCr mice (n = 67) were gavaged with H. hepaticus or vehicle.

233 teric mouse bacterial pathogen, Helicobacter hepaticus, or sham-dosed with media only.

234 eukin-4 (IL-4) or IL-5 when cultured with H. hepaticus outer membrane proteins.

235 ggesting a role for proline metabolism in H. hepaticus pathogenicity in vivo.

236 table in IL-10-/- mice, whereas wild-type H. hepaticus persisted for the 8-month duration of the expe

237 To analyze whether H. hepaticus persists in specified ecological niches, to de

238 in C57BL/6 mice inoculated with Helicobacter hepaticus plus anti-IL-10 receptor (IL-10R) monoclonal a

239 helicobacters, H. pylori and H. mustelae, H. hepaticus possesses a high level of urease activity.

240 H. hepaticus present in feces and cecal samples from H. hep

241 e on the flagellar hook protein (FlgE) of H. hepaticus presented by I-Ab.

242 Nongastric H. hepaticus produces urease similar to that of H. pylori.

243 Here, we characterize PutA from Helicobacter hepaticus (PutA(Hh)) and Helicobacter pylori (PutA(Hp))

244 Strong H. hepaticus-reactive antibody responses as measured by Ag-

245 rying the cloned cdtABC gene cluster from H. hepaticus reproduced the cytotoxic activities seen with

246 olic PutA flavoenzymes from H. pylori and H. hepaticus revealed that Helicobacter PutA generates reac

247 The level of H. hepaticus serum antibody was highest in experimentally i

248 fected mice also developed sustained anti-H. hepaticus serum immunoglobulin G antibody responses and

249 that hepatitis of male mice infected with H. hepaticus show significant increases in the oxidatively

250 thermore, prior exposure of donor mice to H. hepaticus significantly enhances antitumor potency of th

251 intestinal bacterial pathogen, Helicobacter hepaticus, significantly promotes mammary carcinoma in f

252 ated by real-time PCR quantitation of the H. hepaticus-specific cytolethal distending toxin gene and

253 e without characteristic hepatic lesions, H. hepaticus-specific DNA was amplified from the livers of

254 ic oxide synthase (iNOS) mRNA levels, and H. hepaticus-specific IFN-gamma secretion by mesenteric lym

255 The results of H. hepaticus culture and H. hepaticus-specific PCR concurred (i.e., both positive an

256 inhibit TNF-alpha secretion by Helicobacter hepaticus-stimulated macrophages.

257 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity

258 The wild-type and putA mutant H. hepaticus strains displayed similar levels of infection

259 The urease genes among H. hepaticus strains were also well conserved, showing 98.8

260 y is a potential virulence determinant of H. hepaticus that may play a role in the pathogenesis of He

261 , derived from A/J and C57BL/6 mice, with H. hepaticus to determine the genetic basis of resistance t

262 e have shown that although the ability of H. hepaticus to induce colitis in Rag-2(-/-) mice is inhibi

263 icantly impaired the ability of Helicobacter hepaticus to induce colitis upon infection of RAG-2-defi

264 ritical role in inhibiting the ability of H. hepaticus to induce IL-12 p40.

265 The introduction of Helicobacter hepaticus to the gut of nonsusceptible mice was sufficie

266 An H. hepaticus transposon mutant with a disrupted cdtABC codi

267 te the role of CDT in the pathogenesis of H. hepaticus, transposon mutagenesis was used to generate a

268 otes innate immune pathology in Helicobacter hepaticus-triggered intestinal inflammation by augmentin

269 of Th1-like ex-Th17 cells, the degree of H. hepaticus-triggered intestinal inflammation in mice in w

270 2 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involv

271 Our results show that H. hepaticus triggers early IL-10 induction in intestinal m

272 d A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complet

273 educed amino acid sequence of the partial H. hepaticus ureA gene product was found to exhibit 60% ide

274 The H. hepaticus urease cluster contains a homolog of each gene

275 The H. hepaticus urease gene cluster was expressed in Escherich

276 However, the H. hepaticus urease structural gene sequences have not been

277 btain enzymatic activity from recombinant H. hepaticus urease; special conditions including NiCl2 sup

278 deduced amino acid sequence of a partial H. hepaticus ureB gene product exhibited 75% identity and 8

279 Colonization of the mucosa by H. hepaticus was associated with a decrease in the overall

280 ed animals throughout the 18-month study, H. hepaticus was consistently isolated from the lower bowel

281 H. hepaticus was cultured from fetal viscera of 2 of 11 pup

282 Wild-type (WT) H. hepaticus was detected in the corresponding intestinal r

283 of H. hepaticus-infected F1 male mice and H. hepaticus was isolated from hepatic tissues of all F1 mi

284 However, H. hepaticus was not considered a complicating factor, beca

285 H. hepaticus was orally inoculated into 30 axenic, outbred

286 properties of the CdtB of H. pullorum and H. hepaticus were assessed on human intestinal and hepatic

287 Hydrogenase activities in H. hepaticus were constitutive and not dependent on the inc

288 oassays, and the quantities of intestinal H. hepaticus were evaluated by real-time PCR.

289 onicates of the murine pathogen Helicobacter hepaticus were found to cause progressive cell distensio

290 tumors, argyrophilic bacteria resembling H. hepaticus were observed in liver sections, associated wi

291 y) responses in the mice infected with WT H. hepaticus when compared to HhcdtBm7 at 16 wpi.

292 in subsequent epidemiological studies of H. hepaticus when the source and method of spread of this m

293 H. hepaticus, which forms a spreading film on selective aga

294 Helicobacter hepaticus, which induces chronic hepatitis and typhlocol

295 The data suggest that H. hepaticus, which is present in many research colonies, p

296 H. hepaticus, which persists in the lower bowels and livers

297 ther enterohepatic microaerobe, Helicobacter hepaticus, which, like C. jejuni, produces CDT.

298 lin G1 (IgG1) and IgG2c responses against H. hepaticus, while animals challenged with the CDT-deficie

299 The aim of this study was to determine if H. hepaticus will cause colitis in monoassociated mice lack

300 whether infection with either H. bilis or H. hepaticus would accelerate the development of inflammato