ライフサイエンスコーパス: hepatitis delta

1 gulated in CD8(+) T cells from patients with hepatitis delta.

2 died of fulminant recurrent hepatitis B and hepatitis delta.

3 tion for fulminant recurrent hepatitis B and hepatitis delta.

4 valid surrogate endpoint in the treatment of hepatitis delta.

5 of chronic delta hepatitis, disappearance of hepatitis delta and B virus markers, and improvement in

6 The self-cleaving hairpin, hammerhead, hepatitis delta and Neurospora VS RNAs each adopt unique

7 relapses may occur after PEG-IFNa therapy of hepatitis delta and thus the term sustained virological

8 ve for HBV serologic markers were tested for hepatitis delta antibody (HDAb) at 2 time periods: 1988-

9 titis delta virus (HDV) encodes one protein, hepatitis delta antigen (deltaAg), a 195-amino-acid RNA

10 anched rod structure that is associated with hepatitis delta antigen (HDAg) in cells replicating HDV.

11 e used this method to examine the effects of hepatitis delta antigen (HDAg) on the ribozyme activitie

12 by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) perform essential roles i

13 unbranched rodlike structure of HDV RNA and hepatitis delta antigen (HDAg), a basic, disordered, oli

14 of an elongation factor, in the presence of hepatitis delta antigen (HDAg), and in the presence of t

15 ly distinct forms of the sole viral protein, hepatitis delta antigen (HDAg), from the same open readi

16 roles of the two forms of the viral protein, hepatitis delta antigen (HDAg), in HDV RNA replication a

17 iated with the sole virally encoded protein, hepatitis delta antigen (HDAg), in infected cells; howev

18 rs a single coding region whose product, the hepatitis delta antigen (HDAg), is expressed in two isof

19 HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), whi

20 ws two essential forms of the viral protein, hepatitis delta antigen (HDAg), to be synthesized from a

21 s, whereas HDV RNA encodes a single protein, hepatitis delta antigen (HDAg), which is required for vi

22 However, in the presence of hepatitis delta antigen (HDAg), which is the only protei

23 o essential forms of the sole viral protein, hepatitis delta antigen (HDAg).

24 s a 0.8-kb, polyadenylated mRNA encoding the hepatitis delta antigen (HDAg).

25 two isoforms of its principal gene product, hepatitis delta antigen (HDAg).

26 iral genome that altered the sequence of the hepatitis delta antigen (HDAg).

27 circular RNA which encodes a single protein, hepatitis delta antigen (HDAg).

28 The large hepatitis delta antigen (HDAg-L) mediates hepatitis delt

29 The small hepatitis delta antigen (HDAg-S) is expressed throughout

30 d when expressed in the absence of the small hepatitis delta antigen (HDAg-S).

31 The large form of hepatitis delta antigen (L-HDAg), which is responsible f

32 d by the intracellular accumulation of large hepatitis delta antigen (L-HDAg).

33 wn antiparallel coiled-coils (those from the hepatitis delta antigen (PDB ID code 1A92) and the bovin

34 ring requirement for the de novo-synthesized hepatitis delta antigen and temperature dependence, we f

35 required for production of the viral protein hepatitis delta antigen long form (HDAg-L), which is nec

36 ion, combined with our previous finding that hepatitis delta antigen mRNA synthesis is likely perform

37 Two forms of the sole HDV protein, hepatitis delta antigen, are derived from a single open

38 raction with and incorporation of free large hepatitis delta antigen, it was partially defective in h

39 ctor SL1 could be precipitated together with hepatitis delta antigen, suggesting the association of H

40 ch as glutamate receptor (GluR) subunits and hepatitis delta antigen.

41 itis delta virus (HDV) contains two types of hepatitis delta antigens (HDAg) in the virion.

42 ), which encode the small and large forms of hepatitis delta antigens (S- and L-HDAg), respectively.

43 s (simian virus 40), as well as those of the hepatitis delta enveloped virus large form antigen, with

44 to analyze the clinical long-term outcome of hepatitis delta in relation to different antiviral treat

45 Hepatitis delta is associated with a high rate of death

46 ual posttreatment rate of clinical events in hepatitis delta patients eligible for PEG-IFNa therapy i

47 gth HCV cDNA plasmid containing a cis-acting hepatitis Delta ribozyme to control 3' cleavage, and inf

48 of lHDAg is required for the assembly of the hepatitis delta viral particle, these results suggest th

49 012 (amber/W site) in the antigenomic RNA of hepatitis delta virus (HDV) allows two essential forms o

50 Hepatitis delta virus (HDV) and cytoplasmic polyadenylat

51 little information on the early kinetics of hepatitis delta virus (HDV) and hepatitis B surface anti

52 The small, 195-amino-acid form of the hepatitis delta virus (HDV) antigen (deltaAg-S) is essen

53 RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W si

54 Hepatitis delta virus (HDV) assembly also uses the envel

55 ge hepatitis delta antigen (HDAg-L) mediates hepatitis delta virus (HDV) assembly and inhibits HDV RN

56 Hepatitis delta virus (HDV) can dramatically worsen live

57 679-nt genomic and antigenomic RNAs of human hepatitis delta virus (HDV) can fold into a rod-like str

58 The circular RNA genome of hepatitis delta virus (HDV) can fold into an unbranched

59 The antigenomic RNA of hepatitis delta virus (HDV) can form a short duplex, P2a

60 Hepatitis delta virus (HDV) causes both acute and chroni

61 Hepatitis delta virus (HDV) causes the most severe form

62 The two ribozymes of hepatitis delta virus (HDV) cleave faster in divalent me

63 Hepatitis delta virus (HDV) contains a circular RNA whic

64 Hepatitis delta virus (HDV) contains a viroid-like circu

65 Hepatitis delta virus (HDV) contains a viroid-like circu

66 Hepatitis delta virus (HDV) contains two RNA species (HD

67 Hepatitis delta virus (HDV) contains two types of hepati

68 n (deltaAg-S and deltaAg-L, respectively) of hepatitis delta virus (HDV) differ only in the 19-aa C-t

69 The human pathogenic hepatitis delta virus (HDV) employs a unique self-cleavi

70 Hepatitis delta virus (HDV) encodes one protein, hepatit

71 Hepatitis delta virus (HDV) encodes two isoforms of its

72 Hepatitis delta virus (HDV) expresses two essential prot

73 dates utilize self-cleaving ribozymes of the hepatitis delta virus (HDV) family for processing their

74 The circular genome and antigenome RNAs of hepatitis delta virus (HDV) form characteristic unbranch

75 As early as 5 days after DNA copies of the hepatitis delta virus (HDV) genome or even in vitro-tran

76 Hepatitis delta virus (HDV) genome replication requires

77 transfected with a cDNA expressing a mutated hepatitis delta virus (HDV) genome that could only repli

78 elf-cleaving sequences or ribozymes from the hepatitis delta virus (HDV) genomic RNA and its compleme

79 The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving cata

80 Hepatitis delta virus (HDV) has a circular RNA genome th

81 The ribozymes of hepatitis delta virus (HDV) have so far been studied pri

82 Assembly of hepatitis delta virus (HDV) in infected human hepatocyte

83 Hepatitis delta virus (HDV) infection and spread in vivo

84 Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory

85 vere form of chronic liver disease caused by hepatitis delta virus (HDV) infection superimposed on ch

86 The sera of 46 Italian patients with chronic hepatitis delta virus (HDV) infection were analyzed for

87 titis B virus (HBV) genotypes A to I support hepatitis delta virus (HDV) infectivity.

88 A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by tran

89 ed that the replication of the RNA genome of hepatitis delta virus (HDV) involves redirection of RNA

90 The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) s

91 Hepatitis delta virus (HDV) is a cause of acute and chro

92 Hepatitis delta virus (HDV) is a circular pathogenic RNA

93 Hepatitis delta virus (HDV) is a highly pathogenic human

94 The hepatitis delta virus (HDV) is a human pathogen and sate

95 Human hepatitis delta virus (HDV) is a natural subviral agent

96 Hepatitis delta virus (HDV) is a natural subviral agent

97 Hepatitis delta virus (HDV) is a pathogenic human virus

98 Hepatitis delta virus (HDV) is a satellite virus of hepa

99 Hepatitis delta virus (HDV) is a small single-stranded R

100 Hepatitis delta virus (HDV) is a small, defective RNA vi

101 Hepatitis delta virus (HDV) is a subviral human pathogen

102 Hepatitis delta virus (HDV) is a subviral human pathogen

103 Hepatitis delta virus (HDV) is a subviral pathogen that

104 Hepatitis delta virus (HDV) is known to express a protei

105 In a natural setting, hepatitis delta virus (HDV) is only found in patients th

106 Hepatitis delta virus (HDV) is responsible for the most

107 Intrinsic to the life cycle of hepatitis delta virus (HDV) is the fact that its RNAs un

108 Hepatitis delta virus (HDV) is the most severe form of v

109 The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA kn

110 Hepatitis delta virus (HDV) is unique relative to all kn

111 haracterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused princi

112 Most hepatitis delta virus (HDV) prevalence estimates from th

113 Hepatitis delta virus (HDV) produces two essential forms

114 The large form of the hepatitis delta virus (HDV) protein (L) can be isoprenyl

115 Hepatitis delta virus (HDV) replicates by a double rolli

116 Hepatitis delta virus (HDV) replicates by RNA-dependent

117 Hepatitis delta virus (HDV) replicates its circular RNA

118 Hepatitis delta virus (HDV) replication and packaging re

119 Hepatitis delta virus (HDV) replication involves process

120 Moderation of hepatitis delta virus (HDV) replication is a likely prer

121 f the genomic and antigenomic ribozymes from hepatitis delta virus (HDV) requires divalent cation for

122 Hepatitis delta virus (HDV) requires host RNA editing at

123 Replication of the genome of hepatitis delta virus (HDV) requires RNA-directed RNA sy

124 The hepatitis delta virus (HDV) ribozyme and HDV-like ribozy

125 mogeneous RNA transcripts: one encodes a 3'- hepatitis delta virus (HDV) ribozyme and the other, used

126 f RNA-bound magnesium hydrate in crystals of hepatitis delta virus (HDV) ribozyme and to follow the e

127 While the hepatitis delta virus (HDV) ribozyme can undergo self-cl

128 The hepatitis delta virus (HDV) ribozyme catalyzes a self-cl

129 The hepatitis delta virus (HDV) ribozyme is a self-cleaving

130 The hepatitis delta virus (HDV) ribozyme is a self-cleaving

131 A small ribozyme related in structure to the hepatitis delta virus (HDV) ribozyme occurs in a number

132 erous group II intron domain 5-domain 6, and hepatitis delta virus (HDV) ribozyme RNA constructs.

133 The Hepatitis Delta Virus (HDV) ribozyme self-cleaving activ

134 nd product forms of the cis-cleaving genomic hepatitis delta virus (HDV) ribozyme show a divalent met

135 The hepatitis delta virus (HDV) ribozyme uses a cytosine to

136 The hepatitis delta virus (HDV) ribozyme uses the nucleobase

137 The Hepatitis Delta Virus (HDV) ribozyme was the first RNA e

138 Well-ordered crystals of a genomic hepatitis delta virus (HDV) ribozyme, a large, globular

139 In the hepatitis delta virus (HDV) ribozyme, site-specific self

140 In the case of the hepatitis delta virus (HDV) ribozyme, there are three hi

141 pseudoknot structure similar to that of the hepatitis delta virus (HDV) ribozyme.

142 The hepatitis delta virus (HDV) ribozymes are self-cleaving

143 ndary structures proposed for the cis-acting hepatitis delta virus (HDV) ribozymes contain four duple

144 Hepatitis delta virus (HDV) ribozymes employ multiple ca

145 rally and biochemically related to the human hepatitis delta virus (HDV) ribozymes.

146 Hepatitis delta virus (HDV) RNA forms an unbranched rod

147 m of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unk

148 cleavage site in the antigenomic sequence of hepatitis delta virus (HDV) RNA is 33-nt downstream of t

149 Hepatitis delta virus (HDV) RNA replicates in the nuclei

150 When the hepatitis delta virus (HDV) RNA was released by treatmen

151 pendent RNA replication and transcription of hepatitis delta virus (HDV) RNA, generating a full-lengt

152 In models of the replication of human hepatitis delta virus (HDV) RNA, it is generally assumed

153 ion of the 1,679-nucleotide (nt) unit-length hepatitis delta virus (HDV) RNAs in the livers of two HD

154 Hepatitis B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope prote

155 with DNA-directed mRNA constructs containing hepatitis delta virus (HDV) target sequences.

156 A host-mediated RNA-editing event allows hepatitis delta virus (HDV) to express two essential pro

157 Hepatitis delta virus (HDV) uses a host-encoded RNA-edit

158 Hepatitis delta virus (HDV) uses genomic and antigenomic

159 We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during teno

160 Efficient assembly of hepatitis delta virus (HDV) was achieved by cotransfecti

161 ecific drugs are currently available against hepatitis delta virus (HDV), a defective virus leading t

162 Infection by the hepatitis delta virus (HDV), a satellite of the hepatiti

163 on of replication of the RNA genome of human hepatitis delta virus (HDV), a series of linear RNAs con

164 Hepatitis delta virus (HDV), a single-stranded RNA virus

165 ction of primary human hepatocytes either by hepatitis delta virus (HDV), a subviral agent that uses

166 a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produ

167 The hepatitis delta virus (HDV), an infectious human pathoge

168 The hepatitis delta virus (HDV), an infectious human pathoge

169 As for hepatitis delta virus (HDV), another cause of liver dise

170 iral agent of human hepatitis B virus (HBV), hepatitis delta virus (HDV), requires only the envelope

171 mic and antigenomic RNA strands of the human hepatitis delta virus (HDV), where they serve a crucial

172 No specific therapy exists for hepatitis delta virus (HDV), which can cause severe live

173 Lacking an RNA-dependent RNA polymerase, hepatitis delta virus (HDV), which contains a circular R

174 Such difficulties can be circumvented with hepatitis delta virus (HDV), which needs the HBV large e

175 s were similar to those observed for HBV and hepatitis delta virus (HDV), which shares the same L, M,

176 We show that large hepatitis delta virus (HDV)-like ribozymes are activated

177 Patients transplanted for hepatitis delta virus (HDV)-related cirrhosis are report

178 feron alpha is the only treatment option for hepatitis delta virus (HDV).

179 auliflower mosaic virus 35S promoter and the hepatitis delta virus antigenomic ribozyme with a downst

180 In the hepatitis delta virus antigenomic ribozyme, imidazole bu

181 In the ribozyme of hepatitis delta virus antigenomic RNA, two short duplexe

182 The RNA enzyme (ribozyme) from hepatitis delta virus catalyzes self-cleavage of a phosp

183 ulture model enabling functional genomics of hepatitis delta virus entry and infection.

184 Hepatitis delta virus expresses two essential proteins,

185 ive secondary structure, based on a modified hepatitis delta virus genome.

186 Ribozymes of hepatitis delta virus have been proposed to use an activ

187 Activity of the two ribozymes from hepatitis delta virus in monovalent salts was examined a

188 The hepatitis delta virus large antigen (lHDAg) is a virally

189 The two forms of the hepatitis delta virus ribozyme are derived from the geno

190 ons (minus sense) of the NS gene joined to a hepatitis delta virus ribozyme at its 3' end.

191 l II polymerase promoter at the 5' end and a hepatitis delta virus ribozyme at the 3' end.

192 The hepatitis delta virus ribozyme catalyzes an RNA cleavage

193 of the T7 promoter and upstream of the human hepatitis delta virus ribozyme domain, we inserted a com

194 formed molecular dynamics simulations on the hepatitis delta virus ribozyme in the product form and a

195 The hepatitis delta virus ribozyme is a small, self-cleaving

196 NA polymerase promoter and the autocatalytic hepatitis delta virus ribozyme of a transcription plasmi

197 gth HCV cDNA plasmid containing a cis-acting hepatitis delta virus ribozyme to control 3' cleavage.

198 ectivity of the plasmid, a cDNA encoding the hepatitis delta virus ribozyme was added to the 3' end o

199 btilis RNaseP and an artificial trans-acting hepatitis delta virus ribozyme were expressed as the exo

200 solated from the antigenomic sequence of the hepatitis delta virus ribozyme with the P2 and P3 stems

201 catalytic RNAs, the hairpin ribozyme and the hepatitis delta virus ribozyme, and that the shifts are

202 eet western yellows virus pseudoknot and the hepatitis delta virus ribozyme, despite distinct structu

203 For the hepatitis delta virus ribozyme, we predict several nonna

204 ription by T7 RNA polymerase and cleavage by hepatitis delta virus ribozyme.

205 Hepatitis delta virus ribozymes have been proposed to pe

206 rsistently normal; after several years, both hepatitis delta virus RNA and serum HBsAg became undetec

207 The two ribozymes found in hepatitis delta virus RNA form related but non-identical

208 The unusual structure of hepatitis delta virus RNA has previously been shown to e

209 s of hepatitis B surface antigen (HBsAg) and hepatitis delta virus RNA.

210 RNA-protein complexes (RNPs) formed by the hepatitis delta virus RNAs and protein, HDAg, perform cr

211 delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.

212 ame envelope proteins, hepatitis B virus and hepatitis delta virus use the sodium/taurocholate cotran

213 Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infect

214 titis C virus, human immunodeficiency virus, hepatitis delta virus, and alanine aminotransferase leve

215 Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a fam

216 self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro-selected lead-depend

217 ween a variety of catalysts that include the hepatitis delta virus, hammerhead, X motif and Tetrahyme

218 cyte-specific entry of hepatitis B virus and hepatitis delta virus.

219 cDNA encoding a self-cleaving ribozyme from hepatitis delta virus.

220 IFNalpha-based antiviral therapy of hepatitis delta was independently associated with a lowe