ライフサイエンスコーパス: hepatocyte nuclear factor

1 ding a chloroplast dimerization co-factor of hepatocyte nuclear factor 1 (DCoH)/pterin-4alpha-carbino

2 GFBP-1 promoter activation was via an intact hepatocyte nuclear factor 1 (HNF-1) site and was depende

3 cells, we have identified a highly conserved hepatocyte nuclear factor 1 (HNF1) binding site residing

4 experimental process was defined by studying hepatocyte nuclear factor 1 (HNF1), which binds DNA as a

5 loss of liver-enriched transcription factors hepatocyte nuclear factor 1 (HNF1alpha) and hepatocyte n

6 ing and for the transcription factor variant hepatocyte nuclear factor 1 (vhnf1) in specification of

7 th factor (Fgf) signals from r4; and variant hepatocyte nuclear factor 1 (vhnf1, also known as tcf2),

8 olamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha), a gene that was rece

9 odenal homeobox-1, BETA2/NeuroD, Nkx6.1, and hepatocyte nuclear factor 1 alpha), beta-cell metabolic

10 ntly down-regulated pathways associated with hepatocyte nuclear factor 1 homeobox A (Hnf1a) and hepat

11 Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are

12 tion cells in human cirrhotic livers express hepatocyte nuclear factor 1 homeobox B (HNF1beta).

13 Heterozygous deletion or mutation in hepatocyte nuclear factor 1 homeobox B/transcription fac

14 lpha1-antitrypsin messenger RNA, albumin and hepatocyte nuclear factor 1 protein were detected in the

15 es for known trans-acting factors, including hepatocyte nuclear factor 1, Forkhead box A1 and CCCTC-b

16 osa lipase/histamine N-methyltransferase and hepatocyte nuclear factor 1, respectively.

17 ent genome-wide association study identified hepatocyte nuclear factor 1-alpha (HNF1A) as a key regul

18 48; 95% CI, 2.83-10.61; P = 4.4 x 10(-7)) in hepatocyte nuclear factor 1-alpha (HNF1A), the gene resp

19 the binding site of the transcription factor hepatocyte nuclear factor-1 (HNF-1) and specifically sup

20 , in LLC-PK cells, but not in HepG2 cells, a hepatocyte nuclear factor-1 (HNF-1) binding site was cri

21 Herein, we investigated the role of a hepatocyte nuclear factor-1 (HNF-1) cis-acting element t

22 arkedly decreases mRNA and protein levels of hepatocyte nuclear factor-1 (HNF-1), a transcription fac

23 Herein, we show that hepatocyte nuclear factor-1 alpha (HNF-1 alpha), GATA-4,

24 zygous mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF1A or TCF1 gene) r

25 mon polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive

26 tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1) through binding the coactiv

27 Region A binds hepatocyte nuclear factor-1, which acts as an accessory

28 subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in be

29 subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in be

30 Hepatocyte nuclear factor-1a (HNF-1alpha) is a transcrip

31 DCoHm (dimerization cofactor of hepatocyte nuclear factor 1alpha ( HNF1alpha) from muscl

32 Variants in HNF1A encoding hepatocyte nuclear factor 1alpha (HNF-1A) are associated

33 nal farnesoid X receptor (FXR) signaling via hepatocyte nuclear factor 1alpha (HNF-1alpha) compared w

34 nts with diabetes caused by mutations in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene have

35 Mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha) lead to ma

36 tus, results most commonly from mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha).

37 The role of hepatocyte nuclear factor 1alpha (HNF1 alpha) in the reg

38 with glucokinase (GCK)-diabetes (MODY2) and hepatocyte nuclear factor 1alpha (HNF1A)-diabetes (MODY3

39 rotumoral interaction of Akt2 signaling with hepatocyte nuclear factor 1alpha (HNF1alpha) and PPARgam

40 ur previous in vitro studies have identified hepatocyte nuclear factor 1alpha (HNF1alpha) as an oblig

41 llular carcinoma development, directly binds hepatocyte nuclear factor 1alpha (HNF1alpha) mRNA, a neg

42 Hepatocyte nuclear factor 1alpha (HNF1alpha)-null mice h

43 ce deficient of a transcriptional activator, hepatocyte nuclear factor 1alpha (HNF1alpha).

44 IRT1 regulates the expression of FXR through hepatocyte nuclear factor 1alpha (HNF1alpha).

45 Transcription factor 1 (Tcf1; hepatocyte nuclear factor 1alpha [HNF1alpha]) is critica

46 f hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1alpha [HNF1alpha], -1beta, -3

47 adenomas combined with genetic analysis for hepatocyte nuclear factor 1alpha and beta-catenin mutati

48 Hepatocyte nuclear factor 1alpha, a transcription factor

49 ritical regulator of pregnane X receptor and hepatocyte nuclear factor 1alpha, and inactivation of th

50 rs, CCAAT/enhancer-binding protein alpha and Hepatocyte nuclear factor 1alpha, which are known to be

51 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1alpha (encoded by TCF1).

52 GATA-4, -5, and -6 zinc finger and hepatocyte nuclear factor-1alpha (HNF-1alpha) homeodomai

53 tion domain of the transcriptional activator hepatocyte nuclear factor-1alpha (HNF-1alpha) is essenti

54 Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations

55 the cells with expression cassettes encoding hepatocyte nuclear factor-1alpha (HNF-1alpha) or HNF-4.

56 c syndrome most commonly due to mutations in hepatocyte nuclear factor-1alpha (HNF-1alpha).

57 Hepatocyte nuclear factor-1alpha (HNF1alpha) is a transc

58 mutations in the transcriptional activator, hepatocyte nuclear factor-1alpha (HNF1alpha).

59 total HNF1A transcript levels, but residual hepatocyte nuclear factor-1alpha protein activity in G31

60 tations in hepatocyte nuclear factor-4alpha, hepatocyte nuclear factor-1alpha, insulin promoter facto

61 Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcr

62 The transcription factor hepatocyte nuclear factor 1beta (HNF1beta) is ubiquitous

63 Hepatocyte nuclear factor 1beta (HNF1beta)-associated di

64 er biliary cytokeratins or nuclear levels of hepatocyte nuclear factor 1beta.

65 Here, we evaluated the potential role of hepatocyte nuclear factor-1beta (HNF-1beta) in regulatin

66 Hepatocyte nuclear factor-1beta (HNF-1beta) is a homeodo

67 Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1,

68 Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1,

69 Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcr

70 The transcription factor hepatocyte nuclear factor-1beta (HNF-1beta) is essential

71 The transcription factor hepatocyte nuclear factor-1beta (HNF-1beta) regulates ti

72 E4C is regulated by the transcription factor hepatocyte nuclear factor-1beta (HNF-1beta), mutations o

73 factor-1alpha, insulin promoter factor-1 and hepatocyte nuclear factor-1beta, respectively, cause MOD

74 ation of epithelial markers, E-cadherin, and hepatocyte nuclear factor-1beta.

75 onal repression of PKD genes Pkd1, Pkd2, and hepatocyte nuclear factor-1beta.

76 The hepatocyte nuclear factor 3 (HNF-3) proteins are members

77 ing motifs for transcription factors such as hepatocyte nuclear factor 3 (HNF-3) that are involved in

78 main that includes binding sites for NKX2.1, hepatocyte nuclear factor 3 (HNF-3), or cAMP response el

79 The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) fami

80 elements that included GATA (-110/-105) and hepatocyte nuclear factor 3 (HNF3) (-96/-88) motifs.

81 Mutation of the area II hepatocyte nuclear factor 3 (HNF3) binding element in th

82 Hepatocyte nuclear factor 3 (HNF3) inhibits nuclear horm

83 or-dependent HBV replication is inhibited by hepatocyte nuclear factor 3 (HNF3).

84 ng Sp1, Sp3, thyroid transcription factor 1, hepatocyte nuclear factor 3 and activating transcription

85 In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone

86 ated that PHx could induce the expression of hepatocyte nuclear factor 3 gamma (HNF3gamma) when viral

87 The data suggest that hepatocyte nuclear factor 3 may be important for basal I

88 (CCAAT/enhancer binding protein)/HNF-3beta (hepatocyte nuclear factor 3) and AP-1(activator protein

89 overexpression of the transcription factors hepatocyte nuclear factor 3, octamer-binding protein 1,

90 a (FKHR), a recently described member of the hepatocyte nuclear factor 3/forkhead homeotic gene famil

91 Hepatocyte nuclear factors 3 alpha, beta, and gamma (Fox

92 ownstream targets of the winged helix factor hepatocyte nuclear factor-3 homologue 1 (HFH-1).

93 e method to identify a previously unreported hepatocyte nuclear factor-3 site created in intron 8 of

94 roteins, such as histone 5 and the family of hepatocyte nuclear factor-3 winged-helix-turn-helix tran

95 istone H2A co-occupies, along with the FoxA (hepatocyte nuclear factor-3) transcription factor, DNA f

96 oic acid receptor, retinoic acid X receptor, hepatocyte nuclear factor-3, glucocorticoid receptor, nu

97 positive- and negative-acting members of the hepatocyte nuclear factor-3/forkhead family of transcrip

98 Hepatocyte nuclear factors-3 (Foxa-1-3) are winged forkh

99 The winged helix transcription factors, hepatocyte nuclear factors 3alpha, -beta, and -gamma (HN

100 er-specific transcription factors, including hepatocyte nuclear factor 3beta (HNF-3beta), HNF-6alpha,

101 transcription factor homologous to mammalian hepatocyte nuclear factor 3beta (HNF-3beta), the secreto

102 This study led to the identification of hepatocyte nuclear factor 3beta (HNF3 beta), a transcrip

103 these, the winged helix transcription factor hepatocyte nuclear factor 3beta (HNF3beta or Foxa2) is e

104 The forkhead transcription factor hepatocyte nuclear factor 3beta (HNF3beta) is essential

105 B virus (HBV) transgenic mice expressing rat hepatocyte nuclear factor 3beta (HNF3beta) were generate

106 forkhead/winged helix transcription factor, Hepatocyte Nuclear Factor 3beta (HNF3beta).

107 of forkhead box A2 (FoxA2, previously called hepatocyte nuclear factor 3beta [HNF-3beta]), which caus

108 tion factor Foxa2 (Forkhead box a2, formerly Hepatocyte nuclear factor 3beta) in pancreatic beta cell

109 or the tissue-specific transcription factors hepatocyte nuclear factor 3beta, hepatocyte nuclear fact

110 in which increased hepatic expression of the hepatocyte nuclear factor-3beta (HNF-3beta) protein was

111 tiated into epithelioid cells that expressed hepatocyte nuclear factor-3beta (HNF-3beta), GATA4, cyto

112 The winged helix transcription factor, hepatocyte nuclear factor-3beta (HNF-3beta), mediates th

113 ker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3gamma (HNF-3gamma), making it

114 In this study, we cloned the cowpea bruchid hepatocyte nuclear factor 4 (CmHNF-4) and demonstrated i

115 The orphan nuclear receptor hepatocyte nuclear factor 4 (HNF-4) regulates the expres

116 l HBV promoters by decreasing the binding of hepatocyte nuclear factor 4 (HNF-4), HNF-3, and fetoprot

117 enes repressed by beta-catenin bind Tcf-4 on hepatocyte nuclear factor 4 (Hnf-4)-responsive elements.

118 ctor COUP-TF, pregnane X receptor (PXR), and hepatocyte nuclear factor 4 (HNF-4).

119 The nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and retinoid X recept

120 The nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X al

121 expression of the nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X re

122 Hepatocyte nuclear factor 4 (HNF4) is the most ancient f

123 reatly altering the efficiency of binding of hepatocyte nuclear factor 4 (HNF4) to this recognition s

124 We present a model of hepatocyte nuclear factor 4 (Hnf4)-induced lipotoxicity

125 hepatocyte nuclear factor 1 (HNF1alpha) and hepatocyte nuclear factor 4 (HNF4).

126 enhances CYP2D6 promoter transactivation by hepatocyte nuclear factor 4 (HNF4alpha), a known transcr

127 major isoforms of the transcription factor, hepatocyte nuclear factor 4 alpha (HNF-4 alpha), in live

128 lls give rise to both hepatocytes [marked by hepatocyte nuclear factor 4 alpha (HNF-4alpha) expressio

129 Finally, we show that hepatocyte nuclear factor 4 alpha (HNF-4alpha) plays a k

130 Hes6 subsequently represses hepatocyte nuclear factor 4 alpha (HNF-4alpha)-activated

131 rol of some genes is critically dependent on hepatocyte nuclear factor 4 alpha (HNF-4alpha; NR2A1), w

132 Among 14 alleles, hepatocyte nuclear factor 4 alpha (HNF4A) AA (rs2144908,

133 , extracellular signal-related kinase (ERK), hepatocyte nuclear factor 4 alpha (HNF4A) and tumor necr

134 sion is enhanced by the transcription factor hepatocyte nuclear factor 4 alpha (HNF4A) through increa

135 ndependent microarray studies identified the hepatocyte nuclear factor 4 alpha (HNF4A), a transcripti

136 Elevated HGF induced hepatocyte nuclear factor 4 alpha (Hnf4a), which compete

137 enriched OATP2B1 variant promoter identified hepatocyte nuclear factor 4 alpha (HNF4alpha) as a novel

138 Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a trans

139 owed that over 83% of cells were albumin and hepatocyte nuclear factor 4 alpha (HNF4alpha) positive,

140 Hepatocyte nuclear factor 4 alpha (HNF4alpha), a member

141 Hepatocyte nuclear factor 4 alpha (HNF4alpha), the maste

142 ess maintained functional gene regulation by hepatocyte nuclear factor 4 alpha (HNF4alpha), whereas f

143 scan the human genome for sites that bind to hepatocyte nuclear factor 4 alpha (HNF4alpha).

144 Fs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five

145 we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor alph

146 ucture of the ligand binding domain of human hepatocyte nuclear factor 4 gamma (HNF4gamma).

147 d potential 20q candidates, including HNF4A (hepatocyte nuclear factor 4, alpha), TOMM34 (translocase

148 ion factors hepatocyte nuclear factor 3beta, hepatocyte nuclear factor 4, and CAAT enhancer-binding p

149 Hepatocyte nuclear factor 4-alpha (HNF4A) is a transcrip

150 otassium channel subunit Kir6.2 (KCNJ11) and hepatocyte nuclear factor 4-alpha (HNF4A) SNPs (0.01 < P

151 (n = 188), glucokinase (GCK)-MODY (n = 118), hepatocyte nuclear factor 4-alpha (HNF4A)-MODY (n = 40),

152 Hepatocyte nuclear factor 4-alpha (HNF4alpha) is a well

153 (A6 and EpCam) and hepatocyte-specific (i.e. hepatocyte nuclear factor 4-alpha) antibodies.

154 Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched

155 physically and functionally interacted with hepatocyte nuclear factor-4 alpha (HNF-4 alpha), a nucle

156 e response element-binding protein (ChREBP), hepatocyte nuclear factor-4 alpha (HNF-4alpha) and perox

157 Variants in hepatocyte nuclear factor-4 alpha (HNF4 alpha), a transc

158 ream of the primary beta-cell promoter P2 of hepatocyte nuclear factor-4 alpha (HNF4A).

159 cyte nuclear factor 1 homeobox A (Hnf1a) and hepatocyte nuclear factor 4A (Hnf4a), known modifiers of

160 e network, which was down-regulated in mouse hepatocyte nuclear factor 4A knockout mice; were early-s

161 ass represented 29% of all HCCs; expressed a hepatocyte nuclear factor 4A-driven gene network, which

162 They also expressed alpha-fetoprotein, hepatocyte nuclear factor-4a, and a metabolic marker, cy

163 Two nuclear receptors, hepatocyte nuclear factor 4alpha (HNF-4alpha) and alpha(

164 Hepatocyte nuclear factor 4alpha (HNF-4alpha) is a liver

165 ired for binding of the transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha) to the pro

166 The hepatocyte nuclear factor 4alpha (HNF-4alpha; also known

167 of upstream transcription factors, including hepatocyte nuclear factor 4alpha (Hnf4a) and Hnf1a, as w

168 Common and rare variants of the hepatocyte nuclear factor 4alpha (HNF4A) gene have been

169 ry regions bound by the transcription factor hepatocyte nuclear factor 4alpha (HNF4A) was reduced dur

170 Hepatocyte nuclear factor 4alpha (HNF4alpha) (NR2A1), an

171 Hepatocyte nuclear factor 4alpha (HNF4alpha) activated t

172 Both hepatocyte nuclear factor 4alpha (HNF4alpha) and CES1 we

173 er, PGC-1alpha is induced and interacts with hepatocyte nuclear factor 4alpha (HNF4alpha) and other t

174 on was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxis

175 Hepatocyte nuclear factor 4alpha (HNF4alpha) and retinoi

176 nal link between the orphan nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) and transcr

177 tional knockout mice have shown that loss of hepatocyte nuclear factor 4alpha (HNF4alpha) blocks the

178 ure assays were employed to demonstrate that hepatocyte nuclear factor 4alpha (HNF4alpha) bound to th

179 Hepatocyte nuclear factor 4alpha (HNF4alpha) controls th

180 We show here that Hepatocyte Nuclear Factor 4alpha (HNF4alpha) directly in

181 o decreased by 45% in the setting of reduced hepatocyte nuclear factor 4alpha (HNF4alpha) expression.

182 Hepatocyte nuclear factor 4alpha (HNF4alpha) has an impo

183 The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) has just re

184 enesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cel

185 Loss of the nuclear hormone receptor hepatocyte nuclear factor 4alpha (HNF4alpha) in hepatocy

186 Hepatocyte nuclear factor 4alpha (HNF4alpha) is a novel

187 We show that the transcription factor hepatocyte nuclear factor 4alpha (HNF4alpha) is a target

188 Here we report that hepatocyte nuclear factor 4alpha (Hnf4alpha) is essentia

189 Hepatocyte nuclear factor 4alpha (HNF4alpha) is essentia

190 The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4alpha) is tumor su

191 We previously reported that hepatocyte nuclear factor 4alpha (HNF4alpha) participate

192 Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates g

193 Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates t

194 Hepatocyte nuclear factor 4alpha (HNF4alpha) strongly ac

195 Here we show that hepatocyte nuclear factor 4alpha (HNF4alpha), a liver-en

196 zation of tumor suppressor proteins Rb, p53, hepatocyte nuclear factor 4alpha (HNF4alpha), and CCAAT/

197 ), LXRalpha, liver receptor homolog (LRH-1), hepatocyte nuclear factor 4alpha (HNF4alpha), and short

198 oters including the glucocorticoid receptor, hepatocyte nuclear factor 4alpha (HNF4alpha), and the pe

199 /arginine-rich splicing factor 3 (Srsf3) and hepatocyte nuclear factor 4alpha (Hnf4alpha), and was cr

200 ion of a known positive regulator of CYP2D6, hepatocyte nuclear factor 4alpha (HNF4alpha), did not ch

201 Multiple nuclear receptors, including hepatocyte nuclear factor 4alpha (HNF4alpha), retinoid X

202 mouse liver genome, and are co-recruited by hepatocyte nuclear factor 4alpha (HNF4alpha).

203 ession by inhibiting DNA-binding activity of hepatocyte nuclear factor 4alpha (HNF4alpha).

204 ing the activity of the transcription factor hepatocyte nuclear factor 4alpha (HNF4alpha).

205 r data show that PGC-1alpha interaction with hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1) dire

206 ing protein-1c (SREBP-1c) strongly inhibited hepatocyte nuclear factor 4alpha and peroxisome prolifer

207 We identified hepatocyte nuclear factor 4alpha as a regulatory factor

208 ntrol on the hepatocyte transcription factor hepatocyte nuclear factor 4alpha by modulating its activ

209 matrigel, suggesting that down-regulation of hepatocyte nuclear factor 4alpha expression is involved

210 These findings support a role of hepatocyte nuclear factor 4alpha in controlling claudin-

211 TNFalpha inhibited the induction of hepatocyte nuclear factor 4alpha induced by OSM and matr

212 R-specific agonist and adenovirus expressing hepatocyte nuclear factor 4alpha or constitutively activ

213 X-Gal staining showed Adamts7 expression in hepatocyte nuclear factor 4alpha(+) hepatocytes and desm

214 ICD) mice is accompanied by re-expression of hepatocyte nuclear factor 4alpha(HNF4alpha), possibly in

215 HNF4alpha (hepatocyte nuclear factor 4alpha) plays an essential rol

216 damage, increase in expression of HNF4alpha (hepatocyte nuclear factor 4alpha), a key driver associat

217 The tumor cells coexpressed hepatocyte (hepatocyte nuclear factor 4alpha), progenitor/biliary (k

218 were found in the perigenic regions: HNF4A (hepatocyte nuclear factor 4alpha), SLC12A5 (potassium-ch

219 the presence of the liver-specific markers, hepatocyte nuclear factor 4alpha, albumin, cytokeratin 1

220 way linking FXR to changes in hepatic p-JNK, hepatocyte nuclear factor 4alpha, and finally SR-BI.

221 indicated that viral replication mediated by hepatocyte nuclear factor 4alpha, retinoid X receptor al

222 acid receptor, the retinoid X receptor, the hepatocyte nuclear factor 4alpha, the chicken ovalbumin

223 l cell adhesion molecule-negative (EpCAM(-)) hepatocyte nuclear factor 4alpha-positive (HNF4alpha(+))

224 rent feedforward loop between miR-337-3p and hepatocyte nuclear factor 4alpha.

225 y genes, including nuclear factor kappaB and hepatocyte nuclear factor 4alpha.

226 It has been shown previously that hepatocyte nuclear factor-4alpha (HNF-4) and the alpha(1

227 ich was accompanied by restoring activity of hepatocyte nuclear factor-4alpha (HNF-4alpha) and peroxi

228 Mutations in the gene encoding hepatocyte nuclear factor-4alpha (HNF-4alpha) result in

229 eneration was associated with an increase in hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-e

230 Hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-e

231 s-regulatory element transcription factor as hepatocyte nuclear factor-4alpha (HNF-4alpha), and confi

232 is dependent on the orphan nuclear receptor hepatocyte nuclear factor-4alpha (HNF-4alpha), the gene

233 d the CAR-dependent inhibition was linked to hepatocyte nuclear factor-4alpha (HNF4alpha)-mediated tr

234 ere we show that the orphan nuclear receptor hepatocyte nuclear factor-4alpha (HNF4alpha; HNF4A) is c

235 Down-regulation of hepatocyte nuclear factor-4alpha expression and defectiv

236 Reduced hepatocyte nuclear factor-4alpha was associated with act

237 ivated receptor gamma coactivator 1alpha and hepatocyte nuclear factor-4alpha were increased in IUGR

238 rs showed membranous EpCAM(+)/HNF-4alpha(+) (hepatocyte nuclear factor-4alpha) staining and were cont

239 or PGC-1alpha partners, including PPARalpha, hepatocyte nuclear factor-4alpha, and estrogen receptor

240 Mutations in hepatocyte nuclear factor-4alpha, hepatocyte nuclear fac

241 ryl hydrocarbon receptor, but not of CYP3A4, hepatocyte nuclear factor-4alpha, or pregnane X receptor

242 epatocyte transcriptional factors, including hepatocyte nuclear factor-4alpha, that is early down-reg

243 nctions in synergy with the nuclear receptor hepatocyte nuclear factor-4alpha.

244 rs: CCAAT-enhancer binding protein-alpha and hepatocyte nuclear factor-4alpha.

245 tein but no change in expression of GAPDH or hepatocyte nuclear factor-4alpha.

246 Our previous work demonstrated that hepatocyte nuclear factor 4alpha1 (HNF4alpha1, NR2A1) in

247 Hepatocyte nuclear factor 6 (HNF-6) belongs to the famil

248 Hepatocyte nuclear factor 6 (HNF-6) is a member of the o

249 The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein i

250 complexes between the DNA-binding domains of hepatocyte nuclear factor 6 (HNF6) and forkhead box a2 (

251 lexes between the DNA binding domains of the hepatocyte nuclear factor 6 (HNF6) and Forkhead Box a2 (

252 xplore the requirement for downregulation of hepatocyte nuclear factor 6 (HNF6) expression in the ass

253 Hepatocyte nuclear factor 6 (HNF6) is required for liver

254 Here, we report that hepatocyte nuclear factor 6 (HNF6), a liver-enriched tra

255 regulated transcriptional activators (STAT5, hepatocyte nuclear factor 6 [HNF6], FOXA1, and FOXA2) an

256 ts was positively correlated (p < 0.05) with hepatocyte nuclear factor 6 and estrogen receptor-alpha

257 ntin, and the transcription factors SOX9 and hepatocyte nuclear factor 6.

258 Notch signaling and hepatocyte nuclear factor-6 (HNF-6) are two genetic fact

259 Mutations in Pdx1 or upstream hepatocyte nuclear factors cause autosomal forms of earl

260 Our results indicate that binding sites for hepatocyte nuclear factors (especially HNF-1 and HNF-4)

261 er genes, including the proximally expressed hepatocyte nuclear factor/forkhead homologue 4 (Hfh4) an

262 e mouse Oatp4 putative response elements for hepatocyte nuclear factor (HNF) 1, CAAT/enhancer binding

263 homeodomain-containing transcription factor, hepatocyte nuclear factor (HNF) 1, plays a central role

264 s activated 15-40-fold by the liver-enriched hepatocyte nuclear factor (HNF) 3 alpha, HNF3 beta, and

265 n activity was obtained by cotransfection of hepatocyte nuclear factor (HNF) 3gamma or HNF4alpha.

266 In addition, a hepatocyte nuclear factor (HNF) 3gamma-containing comple

267 Our recent DNA microarrays have identified hepatocyte nuclear factor (HNF) 4alpha and insulin-like

268 Hepatocyte nuclear factor (HNF) 4alpha regulates the exp

269 le canaliculi, probably through an effect on hepatocyte nuclear factor (HNF) 4alpha.

270 of cytochrome P450 2D6 (CYP2D6) promoter by hepatocyte nuclear factor (HNF) 4alpha.

271 Hepatocyte nuclear factor (HNF) 6 (also known as OC-1) i

272 ice), combined (or not) with inactivation of hepatocyte nuclear factor (HNF) 6 (Foxa3-Cre/Dicer(loxP/

273 ified miR-122 as a direct target of the LETF hepatocyte nuclear factor (HNF) 6.

274 The hepatocyte nuclear factor (HNF) family regulates complex

275 pancreatic transcription factors, including hepatocyte nuclear factor (HNF)-1 and HNF-3, form a tigh

276 estine-specific Cdx homeodomain proteins and hepatocyte nuclear factor (HNF)-1, which are conserved i

277 Mutations in hepatocyte nuclear factor (HNF)-1alpha (MODY3) account f

278 ygous mutations in the transcription factors hepatocyte nuclear factor (HNF)-1alpha and -1beta result

279 ansporters; and 4) nuclear protein levels of hepatocyte nuclear factor (HNF)-1alpha and retinoid X re

280 ucokinase (GCK) and the transcription factor hepatocyte nuclear factor (HNF)-1alpha are the most comm

281 Diabetes in subjects with hepatocyte nuclear factor (HNF)-1alpha gene mutations (m

282 ysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insu

283 were subclassified into 14 inflammatory, 20 hepatocyte nuclear factor (HNF)-1alpha-mutated, one beta

284 The hepatocyte nuclear factor (HNF)-3 homologous DNA binding

285 ion of the apo A-I promoter, which binds the hepatocyte nuclear factor (HNF)-3beta.

286 e of suppression of its key transactivators, hepatocyte nuclear factor (HNF)-4alpha and HNF6.

287 tations in the human HNF4A gene encoding the hepatocyte nuclear factor (HNF)-4alpha are known to caus

288 Subjects with the Q268X mutation in the hepatocyte nuclear factor (HNF)-4alpha gene (RW pedigree

289 Hepatocyte nuclear factor (HNF)-4alpha is a transcriptio

290 Hepatocyte nuclear factor (HNF)-4alpha is part of a tran

291 some proliferator-activated receptor (PPAR), hepatocyte nuclear factor (HNF)-4alpha, and liver X rece

292 Overexpression of hepatocyte nuclear factor (HNF)-4alpha, which binds to t

293 and -99, and this sequence was shown to bind hepatocyte nuclear factor (HNF)-6.

294 x1 strongly and specifically interacted with hepatocyte nuclear factor (HNF)4alpha, an important tran

295 enes such as glucagon, forkhead homeobox A2, hepatocyte nuclear factor (HNF)4alpha, and HNF1alpha.

296 lap three nuclear receptor binding sites for hepatocyte nuclear factor (HNF-4), liver X receptor (LXR

297 Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulat

298 that bind the gAF1, gAF2, and gAF3 elements (hepatocyte nuclear factor [HNF]4/chicken ovalbumin upstr

299 Hepatocyte nuclear factors (HNFs) -1alpha, -3beta, -4alp

300 The hepatic promoter depends on a cluster of hepatocyte nuclear factor sites 123-155 bp upstream of t

301 including C/EBP, nuclear factor-kappaB, and hepatocyte nuclear factor were found in the region upstr