ライフサイエンスコーパス: hepatotropic

1 when mice were challenged with an unrelated hepatotropic adenovirus as a nonspecific stimulus.

2 In a murine model of intravenous hepatotropic adenovirus infection, liver-primed antivira

3 ntiviral immunity in humanized mice during a hepatotropic adenovirus infection.

4 Hepatotropic adenovirus was introduced intravenously int

5 e evaluated by challenging these mice with a hepatotropic adenovirus.

6 hepatitis C virus (HCV) are considered to be hepatotropic and are a major cause of hepatocellular car

7 mically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to t

8 ed an infectious clone and chimeric virus of hepatotropic and lymphotropic HCV strains derived from a

9 highly neurovirulent MHV-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acut

10 We sought to determine whether HGV was hepatotropic and to determine whether coinfection with H

11 ne and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the b

12 tion, as expression of immunity against this hepatotropic bacterial pathogen is dependent on antigen-

13 se (HE), which is not produced by MHV-A59, a hepatotropic but only mildly neurovirulent strain.

14 infected with murine hepatitis virus A59, a hepatotropic coronavirus, resulted in significant reduct

15 ly being investigated particularly for their hepatotropic effects.

16 es infected with hepatitis C virus (HCV), an hepatotropic flavivirus that frequently causes persisten

17 GB virus B (GBV-B) is a recently discovered hepatotropic flavivirus that is distantly related to hep

18 impanzees, while GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primat

19 fide liver cells and support replication of hepatotropic hepatitis B virus (HBV).

20 rdiotropic coxsackievirus B3 (CVB3), and the hepatotropic hepatitis C virus (HCV) mediate translation

21 Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only

22 protective or pathological responses during hepatotropic infections and autoimmune liver disease.

23 ered in Norway rats can establish high-titer hepatotropic infections in laboratory mice with immunolo

24 nized mouse model for studying HCV and other hepatotropic infections, human immune response and hepat

25 injury, gene regulation, drug toxicity, and hepatotropic infections.

26 Although remaining hepatotropic like AAV2, the AAV2G9 chimera mediates rapi

27 ved from GB virus B (GBV-B), an unclassified hepatotropic member of the family Flaviviridae that is c

28 acivirus (EHCV; nonprimate hepacivirus) is a hepatotropic member of the Flaviviridae family that infe

29 ctional antiviral immune responses against a hepatotropic pathogen in humanized HLA-transgenic mice.

30 the dynamic behavior whereby CD8 TE control hepatotropic pathogens and suggest how liver fibrosis mi

31 Hepatotropic pathogens can take advantage of this niche

32 and HCV infection, and possibly other human hepatotropic pathogens, and prove useful for antiviral d

33 l animal model that accurately recapitulates hepatotropic pathogens, including hepatitis C virus (HCV

34 pathogenesis and vaccine development against hepatotropic pathogens.

35 altered the systemic tropism of AAV9 into a hepatotropic phenotype, characterized by markedly increa

36 tropic JHM strain does not reproduce the A59 hepatotropic phenotype.

37 Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver diseas

38 ere, we show that hepatitis A virus (HAV), a hepatotropic picornavirus, ablates type 1 IFN responses

39 Taking advantage of the hepatotropic properties of adenovirus vectors, gene tran

40 d have reduced liver disease associated with hepatotropic PTV infection.

41 Here, we show that hepatotropic revertant variants may be selected from the

42 Hepatitis C virus (HCV) is a hepatotropic RNA virus frequently associated with chroni

43 bstitution in nsp1 of JHM.WU or A59, another hepatotropic strain, significantly attenuates replicatio

44 NASH complicates hepatotropic viral disease.

45 r Mvarphi uniquely up-regulated SR-AI during hepatotropic viral infection and displayed increased exp

46 +) DCs are highly immunogenic in response to hepatotropic viral infection and serve as a major APC to

47 However, in response to hepatotropic viral infection, the liver's ability to swi

48 insight into the response of the liver to a hepatotropic viral infection.

49 Persistent hepatotropic viral infections are a common etiologic age

50 Antiviral T cell responses in hepatotropic viral infections such as hepatitis B virus

51 Although both are hepatotropic viral infections, there are important diffe

52 8(+) T cells (CD8 TE) play a key role during hepatotropic viral infections.

53 GB virus B (GBV-B) is a hepatotropic virus and close relative of HCV.

54 A previously unrecognized hepatotropic virus has been suspected as a potential eti

55 in the liver during acute infection with the hepatotropic virus murine cytomegalovirus (MCMV) involve

56 Hepatitis B virus (HBV) is a hepatotropic virus that can cause severe liver diseases.

57 Although HCV is primarily a hepatotropic virus, an increasing body of evidence sugge

58 HCV) is a single-stranded positive-sense RNA hepatotropic virus.

59 This study does not support HGV as a primary hepatotropic virus.

60 esponse against viruses may be important for hepatotropic viruses (e.g., hepatitis B and C) to develo

61 ar renal transplant recipients infected with hepatotropic viruses (HBV and HCV) have a high rate of a

62 The impact of infection with hepatotropic viruses (hepatitis B virus [HBV] and hepati

63 a high frequency of coinfections with other hepatotropic viruses and ongoing fibrosis, leading to ci

64 Hepatotropic viruses are important causes of human disea

65 nce, CD8 T-cell antiviral efficiency against hepatotropic viruses has been linked to their capacity t

66 regulated via distinct pathways that involve hepatotropic viruses or cytokines.

67 No known hepatotropic viruses were detected in the tested normal

68 tious complications (including recurrence of hepatotropic viruses), and deliver immunosuppression wit

69 flares may be caused by infection with other hepatotropic viruses, and this situation may inhibit HBV

70 mphocytes (CTLs) or infection with unrelated hepatotropic viruses, including lymphocytic choriomening

71 and screen for combination therapies against hepatotropic viruses.

72 ral infection, with a particular emphasis on hepatotropic viruses.

73 t initial infection with either of these two hepatotropic viruses.

74 linically relevant in chronic persistence of hepatotropic viruses.

75 and may also be useful for studies of other hepatotropic viruses.

76 d patients who become superinfected by other hepatotropic viruses; they suggest that pharmacological