ライフサイエンスコーパス: hereditary prostate cancer

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1 iated with a significantly increased risk of hereditary prostate cancer.

2 A total of 74 North American families with hereditary prostate cancer.

3 The hereditary prostate cancer 1 (HPC1) allele maps to the R

4 a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) allele.

5 chromosome 1q24-q31 interval, including the hereditary prostate cancer 1 (HPC1) locus.

6 The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a si

7 ncer families that show linkage to the HPC1 (hereditary prostate cancer 1) region at 1q24-25.

8 ified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for spor

9 e 1q24-25 region in 772 families affected by hereditary prostate cancer and ascertained by the member

10 NKX3.1 may play a role in susceptibility to hereditary prostate cancer and underscore a role for NKX

11 r study shows that a significant fraction of hereditary prostate cancers are diagnosed in advanced st

12 ine mapping linkage analysis at 8p among 206 hereditary prostate cancer families also provided eviden

13 sequenced the NKX3.1 gene in 159 probands of hereditary prostate cancer families recruited at Johns H

14 amilies, which represent a stratification of hereditary prostate cancer families with potentially inc

15 ases and 222 controls) and family-based (159 hereditary prostate cancer families) association study w

16 y genome-wide scans, encompassing some 1,500 hereditary prostate cancer families, indicate that prost

17 A recent study of hereditary prostate cancer has provided evidence for a p

18 d with prostate cancer risk in families with hereditary prostate cancer (HPC) and in patients with no

19 reviously performed a genome-wide search for hereditary prostate cancer (HPC) genes, finding evidence

20 The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging

21 Multiple genome-wide scans for hereditary prostate cancer (HPC) have identified suscept

22 nd linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this re

23 nd prostate cancer susceptibility in several hereditary prostate cancer (HPC) populations, we hypothe

24 nkage analyses, in 159 pedigrees affected by hereditary prostate cancer (HPC), using 24 markers on th

25 recently identified as a candidate gene for hereditary prostate cancer (HPC).

26 C2/ELAC2 gene at 17p11 in 159 pedigrees with hereditary prostate cancer (HPC); (2) a mutation-screeni

27 ecently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene.

28 A 10-cM genomewide scan of 94 families with hereditary prostate cancer, including 432 affected men,

29 Recent studies suggest that hereditary prostate cancer is a complex disease involvin

30 small proportion of all families affected by hereditary prostate cancer, it appears to play a more pr

31 ided by the identification of other putative hereditary prostate cancer loci on Xq27-28, 1q42-43, and

32 on human chromosome 1q24, near the putative hereditary prostate cancer locus (HPC1).

33 dentify the susceptibility genes involved in hereditary prostate cancer (OMIM 176807) and hyperparath

34 recently identified as a candidate gene for hereditary prostate cancer (PC).

35 Recent studies suggest that hereditary prostate cancer (PRCA) is a complex disease,

36 NPs were further genotyped in a total of 159 hereditary prostate cancer probands, 245 sporadic prosta

37 Most importantly, the subset of hereditary prostate cancer probands, whose families prov

38 We have recently mapped a locus for hereditary prostate cancer (termed HPCX) to the long arm

39 mine if these loci were also associated with hereditary prostate cancer, we genotyped them in a famil

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