ライフサイエンスコーパス: heretofore

1 f a climate-conflict link than has been seen heretofore.

2 than the recombinant alpha-synuclein studied heretofore.

3 be more important than has been appreciated heretofore.

4 le of B. burgdorferi has not been determined heretofore.

5 ration of veterinary and human medicine than heretofore.

6 evaluation of malaria control programs than heretofore.

7 id tumors and has been largely unappreciated heretofore.

8 such as cyclic voltammetry have been lacking heretofore.

9 e human infections caused by type emm59 GAS, heretofore an exceedingly rare cause of disease, spread

10 We found that many physiological roles heretofore ascribed to intracellular trehalose, includin

11 This spirochete, heretofore associated with LB only in Europe, is widely

12 ted by dietary proteins and not, as has been heretofore assumed, simply triggered by reduced caloric

13 cess to biomedically relevant data and tools heretofore available primarily in the private sector.

14 riation associated with mental disorders has heretofore been based on the search for rare or common v

15 term pharmacosynthetics to describe what has heretofore been called pharmacogenetics or chemicogeneti

16 NAs come from regions of the genome that had heretofore been deemed "junk DNA," yet no one could answ

17 acids, and the primary lipid recipients have heretofore been defined as phosphatidylglycerol (PG) and

18 mising, human Treg cell infusion therapy has heretofore been difficult to implement in the clinic, an

19 sers" of the cytoskeleton and epigenome have heretofore been distinct.

20 antichondrogenic activity of Twist1 has not heretofore been established.

21 These types of reactions have not heretofore been examined in the gas phase.

22 y be used for glutathione synthesis, has not heretofore been identified as active in mammary cells.

23 No genes for Perrault syndrome have heretofore been identified.

24 s important features of the system that have heretofore been ignored (such as highly variable substra

25 s, an important class of substrates that has heretofore been incompatible with the harsh conditions r

26 ge of gas phase carbonyl oxide reactions has heretofore been inferred by indirect means, with derived

27 en problems in biological research that have heretofore been insoluble.

28 This interplay has heretofore been masked by the use of pertussis toxin, a

29 ledge could have great social value that has heretofore been overlooked.

30 with a greater degree of precision than has heretofore been possible.

31 The mechanism by which this occurs has heretofore been unknown.

32 Pyrosequencing has heretofore been used for generating short sequence reads

33 To our knowledge, BiS has not heretofore been well studied as a functional measure of

34 wer >100 that permits separation of numerous heretofore "coeluting" isomers.

35 nting a unifying model that can explain many heretofore confusing aspects of immune regulation, immun

36 Heretofore considered largely restricted to activated T

37 IgM, to that of IgM sufficient C57BL6x129Sv (heretofore, control) mice at different times after intra

38 athology and clinical parkinsonism that have heretofore defined the disease.

39 buted to a reversed crystal growth mechanism heretofore described only in the synthesis of inorganic-

40 Our study brings together heretofore diverse observations on spontaneous cytoskele

41 We sought heretofore elusive evidence that human drug users could

42 mises to enable systematic dissection of the heretofore enigmatic structure/function relationships th

43 cuss new technologies that have allowed this heretofore enigmatic subset of B cells to be identified

44 triazolylidene carbenes) that have not been heretofore examined in vacuo.

45 6-chloropurine, xanthine) that have not been heretofore examined.

46 ve more profound effects on their hosts than heretofore expected.

47 Theories of breathing's neural origins have heretofore focused on intrinsically bursting "pacemaker"

48 T(DC) express genes heretofore found uniquely in T cells or dendritic cells,

49 ide a critical and comprehensive overview of heretofore generated data on renal denervation in experi

50 ith recent theoretical predictions that have heretofore gone unaddressed.

51 inolytic properties of this serpin that have heretofore gone unrecognized.

52 olyketide prymnesins from whole cells, which heretofore has not been reproduced since their original

53 n with other substances, including solvents, heretofore has stymied efforts to develop robust methods

54 tors in addition to mu-opioid receptors that heretofore have been associated with opiate respiratory

55 of modulating T cell-mediated immunity, that heretofore have been studied almost exclusively in the c

56 ancer progression, depending on factors that heretofore have been undefined.

57 To our knowledge, these five species heretofore have not been reported to cause mycotic infec

58 assess postnatal behavioral outcomes, which heretofore have not typically been pursued with ovine mo

59 Heretofore, HumAb mice have been generated by disrupting

60 Here, we investigate an alternative, heretofore hypothetical, mode of sex determination: mult

61 lants; however, no specific protein has been heretofore identified as activated by cAMP in a manner a

62 mote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a mutagenic outc

63 ncy to integrate niche complementarity and a heretofore-ignored mechanism of diminishing marginal pro

64 involved in interpreting space and time than heretofore imagined.

65 nfected or -activated CD14(+) cells may be a heretofore important but under recognized reservoir part

66 y motoneurons and not secondary motoneurons, heretofore impossible with conventional transgenic appro

67 ch has the highest coordination number known heretofore in chemistry.

68 IL24, which has not been recognized heretofore in MCs, was also tested for its effect on ker

69 Heretofore, in all examples of cotransmission, each rele

70 has not been determined, largely due to the heretofore inability to inactivate bosR in low-passage,

71 beta-disubstituted enones, which have been a heretofore inaccessible substrate class.

72 light has enabled observation of PCET events heretofore inaccessible, revealing active site chemistry

73 of a heterochromatin function that have been heretofore inaccessible.

74 1p at its translation site could explain the heretofore-inexplicable phenomenon of cis preference-the

75 Heretofore, information on host factor requirements for

76 dreds-of-picosecond Auger recombination, but heretofore lack FRET characterizations.

77 However, optical imaging technology has heretofore lacked the combination of spatial resolution

78 ligands that affect the activity of proteins heretofore lacking chemical probes.

79 ce argues that these brain stress systems, a heretofore largely neglected component of dependence and

80 introductions from a single source (MISS), a heretofore largely unexplored model.

81 ing the early blastula stages, a period when heretofore largely unknown events transmit LR patterning

82 nd harmonic generation spectroscopy has been heretofore limited to isotropic materials.

83 Weak complexing agents which have received heretofore little attention may play a key role in the b

84 ied inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as impo

85 were over-represented significantly in this heretofore LQTS cohort (13.2%) compared with exome aggre

86 complementation group 1 (XPF-ERCC1) has been heretofore misplaced.

87 Our results uncover a heretofore missing link in the Hpo signaling pathway and

88 om II Pd23 kernel in 1 provides an essential heretofore "missing" geometrical link as an intermediate

89 Heretofore, models for actin assembly in cells generally

90 Heretofore, most genetic humanizations have involved dis

91 th biophysical and cell-based assays and are heretofore named ZMC2 (NSC319725) and ZMC3 (NSC328784).

92 ptive protein evolution, suggesting that the heretofore neglected dimensions of sequence space may ch

93 events have declined in recent decades, but heretofore no study has examined if there has been a tem

94 Heretofore, no evidence suggested that transfer RNAs (tR

95 to originate via the initial formation of a heretofore non-isolated central Pd23 kernel composed of

96 owledge, a complete ligand-binding event has heretofore not been described in full atomic detail in u

97 tic regional and directional variations have heretofore not been investigated.

98 and organismal development in a way that has heretofore not been possible.

99 ocytosis, the involvement of 26 of which has heretofore not been recognized.

100 noninfectious stimuli in modulating GVHD has heretofore not been recognized.

101 lation status of an entire genome, which has heretofore not been reported.

102 enome-wide association study confirms a gene heretofore not implicated in cardiac pathophysiology as

103 nds to the metal can help explain reactivity heretofore not yet understood in the halogenase SyrB2.

104 vina et al report the most extensive catalog heretofore of HLA-restricted immunogenic peptides derive

105 community-wide ivermectin distribution in a heretofore "off limits" health district in Cameroon and

106 exhibit long-wavelength absorption yet have heretofore only been available via semisynthesis from na

107 lack Sea suggests MTB play an important, but heretofore overlooked role in euxinic marine system iron

108 We propose that twitches represent a heretofore-overlooked form of motor exploration that hel

109 istic magnetizations was established for the heretofore poorly age-constrained Los Colorados Formatio

110 rst reverse genetic analysis of a "novel" or heretofore poorly understood gene implicated in an excee

111 Our study deciphers the fundamentals of the heretofore poorly understood molecular mechanism by whic

112 afficked across membrane barriers, a concept heretofore poorly understood.

113 r protein model to a greater degree than was heretofore possible.

114 However, technical limitations have heretofore precluded examination of the relationship bet

115 cribed, presumed physiological barriers have heretofore precluded investigation of systemic gene deli

116 pmental relation seems more symmetrical than heretofore presumed, suggesting that MDD is not necessar

117 about variation in the TP of bats that have heretofore proven elusive.

118 nt amplitudes greatly exceeding those of all heretofore published ChR variants.

119 Heretofore, radionuclide myocardial perfusion imaging ha

120 s of the world has focused attention on this heretofore rare disease.

121 to self motion are both more widespread than heretofore recognized and also more complex because they

122 vity of neutrophils from healthy adults than heretofore recognized; their model predicts that this co

123 tions within the ATP-binding motifs of PTEN (heretofore referred to as PTEN ATP-binding mutations) ha

124 ew member of this signaling cascade, an LTTR heretofore renamed QseD (quorum-sensing E. coli regulato

125 tructured material synthesis and a survey of heretofore reported materials systems.

126 e measurements of cell-generated forces have heretofore required that cells be cultured on two-dimens

127 series of beta-lactamase inhibitors that had heretofore resisted optimization for in vivo activity.

128 ole of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammator

129 een an OH donor and a covalent F acceptor, a heretofore somewhat ill-defined if not controversial int

130 Heretofore the evidence for this was limited to develope

131 everal LOX crystal structures are available, heretofore the rapid oxygenation of bound substrate has

132 Heretofore, the visualization of large biomolecular syst

133 Heretofore, these measurements have been interpreted in

134 Heretofore, thiol-specific fluorogenic reagents require

135 Heretofore, this variance has been determined in a non-p

136 ty mass from undesirable to desirable states Heretofore, two external control approaches have been ta

137 cceptor poly-arylene chromophores which have heretofore unachieved pi-extension and substantial twist

138 show that ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism,

139 ptor affinity profiling system also revealed heretofore unappreciated complexities underlying CD4/CCR

140 constant levels throughout life and define a heretofore unappreciated developmental heterogeneity wit

141 These results reveal a heretofore unappreciated dynamism of gene content.

142 We propose a heretofore unappreciated effect of chronic HFD on beta-c

143 n Markov model (HMM)-based filter to exploit heretofore unappreciated information inherent in all tra

144 This additionally suggests a heretofore unappreciated ligand-independent role for PRL

145 LT of HIV-1-infected individuals may have a heretofore unappreciated role as a mediator of immune su

146 We found a heretofore unappreciated role for caspase-8 as a major p

147 These findings identify a heretofore unappreciated role for CXCR7 in vascular dysf

148 ial in higher plants and chlorophytes with a heretofore unappreciated role in diatoms.

149 sults further suggest that muscle may play a heretofore unappreciated role in regulating food intake.

150 n dehydrated mice, the latter highlighting a heretofore unappreciated role of GABAergic MnPO neurons

151 These findings suggest a heretofore unappreciated TAM receptor hierarchy in advan

152 Thus, substantial gastric toxicity is a heretofore unappreciated tamoxifen side effect.

153 Our data illustrate a heretofore unappreciated topological complexity in mTORC

154 hic but potentially has a dynamic complexity heretofore unappreciated.

155 present with glucose intolerance, which was heretofore unappreciated.

156 f neo-substrates for kinases could provide a heretofore-unappreciated modality for regulating kinase

157 these results demonstrate that ICP27 plays a heretofore-unappreciated role in modulating the efficien

158 Findings offer heretofore unavailable comparison points for health syst

159 phogenesis of nodes of Ranvier all require a heretofore uncharacterized alternatively spliced giant e

160 dant isoform present before stimulation is a heretofore uncharacterized intracellular form of the IL-

161 Such changes could result in heretofore uncharacterized pathogenesis, potentially imp

162 horin3D (Sema3D), that genetically delineate heretofore uncharacterized proepicardial subcompartments

163 We show that Tempura forms a heretofore uncharacterized RabGGT complex that geranylge

164 argets a restricted subset of DCs, which are heretofore uncharacterized.

165 It is linked to the protein by the heretofore uncommon axial ligand set, His32 and Tyr75.

166 These results indicate a heretofore unconsidered impact of CO2 anaesthesia on sub

167 ials by approximately 100 mV and, thus, is a heretofore unconsidered means of tuning the potential.

168 inciple yields a quantitative account of the heretofore undefined, but theoretically crucial, concept

169 que desosamine-anchoring functionality via a heretofore under-explored "substrate engineering" strate

170 Toxic waste sites are a major, and heretofore underrecognized, global health problem.

171 Surprisingly, using the same approach, a heretofore undescribed filamentous network within the lu

172 tosis [MH]), we identified an unexpected and heretofore undescribed frequent occurrence of myeloid ne

173 Taken together, these data identify a heretofore undescribed myocardin/BMP10 signaling pathway

174 on, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself.

175 ze the potential for switching between these heretofore undetectable, differentiated pneumococcal sub

176 Li-(13) C and (6) Li-(15) N couplings reveal heretofore undetected transannular contacts (laddering)

177 e viruses themselves cause an enteropathy by heretofore undetermined mechanisms.

178 pressure syntheses to allow for inroads into heretofore-undiscovered intermetallic systems for which

179 In addition, this heretofore undocumented POM-MOF interaction results in a

180 circadian system to the brink of explaining heretofore unexplainable biochemical characteristics of

181 en de novo gene variants, we control for the heretofore unexplored confounding bias in coding-sequenc

182 inhibition, suggesting the involvement of a heretofore unexplored part of the protein in the transpo

183 In this study, we examine the heretofore unexplored role of Pin1 in CPCs.

184 agnetic resonance and mass spectroscopy as a heretofore unidentified alpha,beta-unsaturated lactone d

185 Data suggest that heretofore unidentified risk factors for HZ also are cha

186 studies, however, suggest the existence of a heretofore-unidentified receptor for IL-1.

187 oviding the ability to answer questions with heretofore unimaginable speed.

188 Surprisingly, a heretofore universal transition state interaction with t

189 The insight gained from the heretofore unknown ability of NAD(+) to function as a re

190 Implications of the heretofore unknown and anomalous self-limiting behavior

191 Overall, our data identify heretofore unknown biological responses to VPA in buddin

192 mulated by IFNalpha; these genes represent a heretofore unknown class of non-IFN-stimulated gene IEGs

193 ether, these findings directly demonstrate a heretofore unknown contribution of the cranial neural cr

194 ther, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose I

195 ered MSN excitability in HD may be caused by heretofore unknown disturbances of astrocyte-mediated K(

196 Heretofore unknown effects of torcetrapib were revealed

197 r steps of the initiation process, revealing heretofore unknown features, including reversible format

198 e regarding gene functions of both known and heretofore unknown genes, as shown by the identification

199 In this paper, we demonstrate access to heretofore unknown heterotricyclic structures by leverag

200 cement in the hippocampus and demonstrates a heretofore unknown hypersensitivity of the CA3/CA4 to is

201 the efficacy of chemotherapy by blocking its heretofore unknown impact on PAF-R activation.

202 lglycerol-PO4 moiety, a substitution that is heretofore unknown in the bacterial polysaccharide liter

203 the asymptomatic phase is exemplified by the heretofore unknown length of time from initial infection

204 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly of a FN

205 nto the bacterial cytoplasm, thus defining a heretofore unknown mechanism of intracytoplasmic membran

206 of Ly6C(low) monocytes in tumors unveiled a heretofore unknown mechanism of resistance to anti-VEGF

207 g cancer cells is significant in revealing a heretofore unknown mechanism of tumorigenesis and metast

208 The data identify a heretofore unknown metabolic function of Notch and sugge

209 We also identify a heretofore unknown modification-an N-terminally bound gl

210 We report the identification of a heretofore unknown multispecies true-moss-cyanobacteria

211 occur by a radical chain mechanism involving heretofore unknown NHC-boryl radicals.

212 latory strategies and may help conceptualize heretofore unknown ones.

213 surement by fluorescence anisotropy reveal a heretofore unknown preference for binding single-strande

214 results were made possible by exploiting the heretofore unknown propensity of a hydrogen-bonding OH-a

215 everal actinomycete genomes, we identified a heretofore unknown RIF resistance gene, RIF phosphotrans

216 acid ligand as the catalytic nucleophile, a heretofore unknown role for the alphaCys(113)-OH sulfeni

217 Our data suggest that SLC11A1 has a heretofore unknown role in activation of a large subset

218 e results demonstrate an important role of a heretofore unknown signal in the cytoplasmic tail of CD1

219 nal anatomical data to identify coherent but heretofore unknown subgroups.

220 e describe protein S-nitrosylation in yeast (heretofore unknown) that is mediated by S-nitroso-CoA (S

221 The presence of a heretofore unknown, yet related, protein could explain t

222 l such large RNP granules first assemble was heretofore unknown.

223 r genes responsible for these syndromes were heretofore unknown.

224 pose tissue, skeletal muscle, and liver, was heretofore unknown.

225 retion, and its biological significance were heretofore unknown.

226 The molecular basis for this disorder is heretofore unknown.

227 The cellular receptor for these viruses was heretofore unknown.

228 o-fused sultams via complementary pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine buil

229 f insulin receptor signaling, highlighting a heretofore-unknown link between insulin sensitivity and

230 In summary, we report a heretofore-unknown role for trace amine systems in cloza

231 ndidates led to the discovery of three genes heretofore unlinked to malignant breast cancer that were

232 data for the phylum Cyanobacteria reveals a heretofore unobserved diversity in cyanobacterial CP12 p

233 ation of a NusB-NusE-dsRNA complex reveals a heretofore unobserved dsRNA binding site contiguous with

234 )-Galbeta1-4GlcNAc also coordinate Ca(2+), a heretofore unobserved mode of galactose binding in a C-t

235 The meteorite also contains heretofore unobserved phases of iron-nickel and iron sul

236 lex in the presence of ADP and Mg(2+); and a heretofore unobserved RbsBC complex in the absence of co

237 The initial photochemical step is the heretofore unobserved reductive quenching of the low-ene

238 bocyclic substrate led to the discovery of a heretofore-unobserved mechanistic pathway, providing bic

239 Patients with NVAMD enjoy heretofore unprecedented vision gains when managed with

240 herwise photochromic benzo-/naphthopyrans is heretofore unprecedented.

241 Our results indicate that one heretofore unquantified human health effect associated w

242 ted into a scientific database and provide a heretofore unrealized depth of sequence data based on mu

243 We conclude that the heretofore unrecognized activation of RyR2 channels and

244 myofilament Ca2+ sensitization represents a heretofore unrecognized arrhythmia mechanism.

245 yofilament Ca(2+) sensitization represents a heretofore unrecognized arrhythmia mechanism.

246 We found that ERK5, heretofore unrecognized as mediating TLR2 activation in

247 ally and antigenically similar organism as a heretofore unrecognized cause of acute febrile illness i

248 Finally, we identify a heretofore unrecognized class of piRNAs processed from c

249 and activation of GSTP1 by EGFR as a novel, heretofore unrecognized component of the EGFR signaling

250 biased, forward genetic approach has found a heretofore unrecognized critical step in fasting energy

251 ons by influencing who survives gestation, a heretofore unrecognized effect of climate on humanity.

252 face patch system, moving faces recruited a heretofore unrecognized face patch.

253 Recent research suggests that other, heretofore unrecognized factors, such as the osteocyte-s

254 of the apoptotic phosphoproteome, revealing heretofore unrecognized forms of functional crosstalk be

255 This finding demonstrates a heretofore unrecognized function of the ventromedial pre

256 These data suggest that a heretofore unrecognized graft-infiltrating, short-lived

257 and neck squamous cell cancer cells express heretofore unrecognized L-selectin ligand(s) that mediat

258 gest that the ZAL2/ZAL2(m) polymorphism is a heretofore unrecognized model for the early stages of se

259 tes and link functional diversification to a heretofore unrecognized neuronal gradient of the CAZ ult

260 i (Cretaceous, North America), we detected a heretofore unrecognized ontogenetic series, sexual dimor

261 These studies identify KLF15 as part of a heretofore unrecognized pathway regulating the cardiac r

262 This constitutes a heretofore unrecognized process associated with loss of

263 We propose that Rap1p represents a heretofore unrecognized regulator of TBP.

264 of oxidized methionine in proteins may be a heretofore unrecognized regulatory event underlying immu

265 These studies also suggest a heretofore unrecognized role for angiostatic basement me

266 Elucidation of this heretofore unrecognized role for KLF15 now implicates th

267 Together, our data unveil a heretofore unrecognized role for PAFR in modulating acti

268 To our knowledge, our data unveil a heretofore unrecognized role for the GPCR BLT1 in contro

269 seascape configuration played a critical but heretofore unrecognized role in determining connectivity

270 These data demonstrate a heretofore unrecognized role of microbial metabolites an

271 These findings raise a heretofore unrecognized role of Sun1 in the selective ge

272 These experiments reveal a heretofore unrecognized role of the schistosome tegument

273 Heretofore unrecognized roles for which oxytocin may hav

274 for antiviral responses, plays a variety of heretofore unrecognized roles in antibacterial responses

275 Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thromb

276 Our data reveal a heretofore unrecognized strategy by which a pathogenic m

277 These findings reveal a heretofore unrecognized subterranean methane sink and co

278 after a high-dose regimen of METH produces a heretofore unrecognized toxicity to GABAergic cells, as

279 m Rhodobacter sphaeroides has demonstrated a heretofore unrecognized ultrastructural complexity withi

280 In summary, we describe the heretofore unrecognized up-regulation of a small calcium

281 Our results identify a heretofore unrecognized, homeostatic negative feedback m

282 These results describe a heretofore unrecognized, yet potentially general propert

283 These experiments identify a heretofore-unrecognized but functionally important subpo

284 V) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-ind

285 Thus, we elucidate a heretofore-unrecognized human amyloid-depolymerase syste

286 A heretofore-unrecognized multigene family encoding divers

287 ken together our findings identify Rab5 as a heretofore-unrecognized regulator of compound exocytosis

288 dramatic decrease in sepsis-induced PUMA, a heretofore unreported effect of IL-7.

289 This study represents a heretofore unreported mechanism for the c-Myc-dependent

290 Collectively, our findings suggest a heretofore-unreported function for mitoStat3 as a potent

291 form a highly extended stalk-like structure heretofore unseen in prokaryotic or eukaryotic protein s

292 It includes a heretofore unseen interaction motif between W77 of S3, t

293 Thus, these studies unveil heretofore unseen mechanisms by which inducible sensor d

294 Thus, these data reveal a heretofore unseen restructuring of an enzyme active site

295 to consider multiple DCs at each position, a heretofore unsolved problem, while adhering to a constra

296 N production in the liver, and they reveal a heretofore unsuspected aspect of the innate host respons

297 tion that Dip3 in photoreceptors activates a heretofore unsuspected diffusible ligand that may work i

298 In this study, we provide evidence for a heretofore unsuspected role for Isc1p in mediating this

299 This pool of sphingolipids may play a heretofore unsuspected role in myocardial pathology or p

300 ssions from numerous lanthanide dopants that heretofore would have been quenched in a more convention