ライフサイエンスコーパス: heritability

1 ing loss in children, and known to have high heritability.

2 ildhood-onset psychiatric disorder with high heritability.

3 onding to approximately 25% of the estimated heritability.

4 wever, the known genes explain little of the heritability.

5 buting by individual small effect to disease heritability.

6 only account for a small portion of the T2D heritability.

7 ied, they do not completely explain the high heritability.

8 nd found that such variants explained little heritability.

9 h low levels of LD (LLD) have larger per-SNP heritability.

10 methylation might contribute to this missing heritability.

11 ed many genes, which explain only 14% of the heritability.

12 s of which explain only a portion of disease heritability.

13 eterogeneous disorders characterized by high heritability.

14 dentifying specific loci responsible for its heritability.

15 significant amount of pathway-level regional heritability.

16 ke negligible contributions to complex trait heritability.

17 enetic (co)variances, and parameters such as heritability.

18 ty' can be explained by an overestimation of heritability.

19 ity, causal allele frequency divergence, and heritability.

20 l risk of tooth loss as well as estimates of heritability.

21 P regulation and explain part of the missing heritability.

22 vere overfitting in the calculation of trait heritability.

23 onents are used for calculating the unbiased heritability.

24 explained by shared socialization but not by heritability.

25 while other traits revealed negligibly small heritabilities.

26 Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, in

27 EE is a familial trait (heritability = 0.52); therefore, in the current study, w

28 CI, 0.68 to 0.89) and moderately heritable (heritability, 0.40; 95% CI, 0.14 to 0.51), but did not s

29 CARMS category showed moderate heritability (heritability, 0.49; 95% CI, 0.26 to 0.72).

30 tic variances in breeding date (sex-specific heritabilities: 0.07 and 0.02, respectively) and a stron

31 Our estimates of chip heritability (14-27%) support a role for common genetic

32 ariance of AF was 19.9% for genetic factors (heritability), 3.5% for shared environmental factors, an

33 ough major depressive disorder (MDD) has low heritability, a genome-wide association study in humans

34 ed loci that explain a significant amount of heritability across multiple traits.

35 prior assumptions about the distribution of heritability across the genome, but current assumptions

36 The total estimated heritability across three analyses ranged from 37.22% to

37 up of neurodevelopmental disorders with high heritability, although the underlying genetic determinan

38 ted pathway analysis and multilevel regional heritability analyses in a pipeline designed to identify

39 hypotheses through univariate and bivariate heritability analyses in a three-generation pedigree wit

40 Bivariate heritability analyses provided the first evidence for a

41 Finally, polygenic modification score and heritability analyses suggest the existence of additiona

42 sent a linear mixed effects model to conduct heritability analyses that explicitly accounts for intra

43 Heritability analyses were conducted in 1432 twins (426

44 Heritability analyses were conducted using maximum likel

45 e that is not fully captured by conventional heritability analyses.

46 Regional heritability analysis can be used to detect genomic regi

47 Existing heritability analysis methods do not discriminate betwee

48 GWAS heritability analysis suggested that common variants are

49 Genome-wide heritability analysis using case-control genotyped SNPs

50 e used electronic health records, genetic co-heritability analysis, and a two-sample Mendelian Random

51 m 71 crosses involving 72 adults to estimate heritabilities and genetic correlations among vegetative

52 otypes, of which 49 demonstrated significant heritability and 13 showed significant trait-like associ

53 Heritability and association with ADHD symptoms were est

54 Tissue-specific heritability and biological process enrichment analyses

55 re needed to further unravel the unexplained heritability and biology of this disease.

56 Genetic co-heritability and causality via MR was assessed using dat

57 We then used these data to (i) estimate the heritability and familial environmental patterns of 149

58 urity, and plant height predictions had high heritability and gave the highest accuracy for predictio

59 oci explain approximately 28% of the genetic heritability and generate a discriminatory genetic risk

60 Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated us

61 Heritability and genome stability are shaped by meiotic

62 evelopmental disorders with large degrees of heritability and heterogeneity.

63 at 5% FDR in this study explain 21.2% of CAD heritability and identify 243 loci that implicate pathwa

64 eractivity disorder (ADHD) shows substantial heritability and is two to seven times more common in ma

65 We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysi

66 Heritability and polygenic load associated with Tourette

67 environments, achieving near complete trait heritability and precisely estimating additive (73%), do

68 AF, as well as the relative contributions of heritability and shared and nonshared environmental fact

69 Both the regional heritability and single-SNP associations within this blo

70 th low LLD have significantly larger per-SNP heritability and that roughly half of this effect can be

71 evaluate the impact of imputation method on heritability and the accuracy of genome-wide prediction

72 its/diseases using LD Hub; and estimated SNP heritability and the genetic correlation across the diff

73 Our aims were to estimate ICD heritability and to predict ICD by a candidate genetic m

74 ]-based heritability [h(2)SNP]), partitioned heritability, and genetic correlations (rg) between anor

75 age and sex, which may inflate estimates of heritability; and (iv) we developed a goodness of fit te

76 hat a substantial fraction of the twin-based heritability arises from common genetic variation.

77 onsive BD explained by common variants ('SNP heritability') as 0.25 and 0.29 using two definitions of

78 ntly no clear consensus on the value of SPVL heritability, as multiple studies have reported apparent

79 regulator of transcription state change and heritability at both euchromatin and heterochromatin.

80 BMI is highly polygenic, with 75% of the SNP heritability attributable to loci that each explain <0.0

81 Further we show that the phenotypic heritability attributable to read-mapping anomalies diff

82 Twin studies have indicated that this has a heritability between 6 and 50%.

83 mutation depends on the degree of phenotypic heritability between generations, called phenotypic memo

84 y efficient method, ALBI (accurate LMM-based heritability bootstrap confidence intervals), for estima

85 tion to trust is explained to some extent by heritability but not by shared socialization, the dispos

86 onsequence of prematurity, has a significant heritability, but little is known about predisposing gen

87 ecture of MDD by estimating and partitioning heritability by chromosome, minor allele frequency, and

88 Partitioning heritability by minor allele frequency indicated that th

89 We also demonstrated that the heritability calculated through cross validation is equi

90 Heritability calculation showed that these phenotypes ar

91 ied traits for which the majority of the SNP heritability can be confined to a small percentage of th

92 of core disease-related genes and that most heritability can be explained by effects on genes outsid

93 unately, as we demonstrate, LMM estimates of heritability can be inflated when using a standard model

94 e provide evidence that part of the 'missing heritability' can be explained by an overestimation of h

95 Heritability, defined as the proportion of phenotypic va

96 riation in song tempo but that the degree of heritability depends profoundly on the quality of instru

97 In this study, we demonstrated overfitting heritability due to the inclusion of trait-irrelevant ma

98 iduals, we report a molecular genetics-based heritability estimate (h(2)SNP) for European-American fe

99 Meta-analyses revealed a combined heritability estimate for Adult Treatment Panel-III MetS

100 Despite a significant genetic heritability estimate of treatment non-response trait (h

101 utcome to include SZ spectrum disorders, the heritability estimate was almost similar (73%).

102 did not play a significant role because the heritability estimate was negligible (H(2) = 0; 95% conf

103 onality (for example, worry and guilt) (1) ; heritability estimated from twin studies ranges from 30

104 This study provides updated heritability estimates based on nationwide twin data and

105 Heritability estimates for both endophenotypes were high

106 The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.

107 The majority (52 of 65) of our study's heritability estimates matched earlier reports, and 84 o

108 Nevertheless, heritability estimates of facial traits have often been

109 Heritability estimates of SZ in twin samples have varied

110 Heritability estimates ranged from 20-53% in the six anc

111 however, LT-Fam uses published narrow-sense heritability estimates to avoid the problem of biased he

112 Age-adjusted heritability estimates were derived using standard maxim

113 Heritability estimates were larger for Adult Treatment P

114 the simulated and Ugandan data, narrow-sense heritability estimates were lower using the more general

115 this type of ascertainment can severely bias heritability estimates; we show here that it also impact

116 Typically, heritability estimation under LMMs uses the restricted m

117 Recently, heritability estimation using linear mixed models (LMMs)

118 ity estimates to avoid the problem of biased heritability estimation, enabling correct calibration.

119 d a diagnosis of AF and were included in the heritability estimation.

120 als), for estimating the distribution of the heritability estimator and for constructing accurate con

121 - and 2.5-fold increase in the proportion of heritability explained for the different lipid traits.

122 Despite its high heritability, few risk genes have been identified for at

123 ty measures in 3666 twins and estimate their heritability, finding novel evidence for strong genetic

124 The heritabilities for BDI and BDII were estimated at 57% (9

125 We determined heritabilities for both carotenoids and examined their g

126 iants might explain a portion of the missing heritability for ADHD.

127 We establish a polygenic heritability for all biomarkers, confirm associations of

128 The heritability for BDI and BDII and the genetic correlatio

129 Here we estimate heritability for body mass index (BMI) in 172,000 siblin

130 ions in GRHL3 that might explain the missing heritability for CPO, we sequenced GRHL3 in cases of CPO

131 e genetic architecture and degree of missing heritability for gene expression in peripheral blood.

132 The twin model revealed a heritability for HCC of 72%.

133 pite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and ad

134 ility loci have been identified, much of the heritability for lung cancer remains unexplained.

135 In univariate analyses, we found significant heritability for measures of fasting insulin sensitivity

136 loci collectively account for 10.94% of the heritability for NSCLP in Chinese population.

137 Although the heritability for schizophrenia approaches 80% only a sma

138 -tutored birds exhibited unexpectedly strong heritability for song tempo and comparatively weak influ

139 The estimated polygenic heritability for susceptibility to bTB was 0.26, 0.37 an

140 The single-nucleotide polymorphism heritability for the extreme IQ trait was 0.33 (0.02), w

141 Few methods are available for calculating heritability for traits derived from high-throughput seq

142 g of the HLA region could narrow the missing heritability gap.

143 translated into 3.8% of the total estimated heritability (h(2) = 0.24).

144 y heritable and significant [alpha-carotene: heritability (h(2)) = 0.81, P = 6.7 x 10(-11); beta-caro

145 , 10,580 (66%) had an estimated narrow-sense heritability (h(2)) greater than zero with a mean (media

146 (single-nucleotide polymorphism [SNP]-based heritability [h(2)SNP]), partitioned heritability, and g

147 n to AF risk (single-nucleotide polymorphism heritability, h(2)g ) using data from 120 286 unrelated

148 ritable, ranging from total additive genetic heritability (h2) = 0.69 (SE, 0.13; P = .0000002) for ra

149 IOP heritability has been estimated to up to 67%, and to dat

150 , the maternal additive genetic variance and heritability has been found exist for this trait, thus,

151 The CARMS category showed moderate heritability (heritability, 0.49; 95% CI, 0.26 to 0.72).

152 r, these loci only explain around 14% of CRC heritability, highlighting the dire need of identifying

153 Further, heritability in CS depth was altered as a function of ac

154 mechanisms is key to a full appreciation of heritability in health and disease.

155 and 29% of the variance in MDD risk, and the heritability in MDD explained by each chromosome was pro

156 tlas of single-nucleotide polymorphism (SNP) heritability in PrCa.

157 ri-allelic genotype' can account for missing heritability in some hypomorphic OCA1 albinism phenotype

158 variants explained approximately 10% of the heritability in the 2 subgroups.

159 P50 gating displayed substantially increased heritability in the 97 multiply affected families (47% a

160 Most parameters showed significant heritability, indicating that genetic factors are import

161 nd viral effects, we estimate a total of 30% heritability, indicating that most of the host effects a

162 We further partitioned this heritability into both lineage and locus effects, and qu

163 complex traits and diseases, partition this heritability into functional categories, and estimate th

164 Incorporating transgenerational epigenetic heritability into risk assessment procedures has been pr

165 The estimated SNP heritability is 43% (95% CI: 34-52%) for TBLH-BMD, and 3

166 Over half of the heritability is explained by two major loci, thus AMD is

167 Heritability is high, and the incidence is significantly

168 en associated with CAD thus far, most of the heritability is unexplained, indicating that additional

169 n traits a substantial part of the estimated heritability is unexplained.

170 Despite evidence for heritability, it is not currently possible to predict wh

171 Despite high heritability, little success was achieved in mapping gen

172 Haplotype-block-based regional heritability mapping (HRHM) estimates the localized gene

173 sing genome-wide association (GWA), regional heritability mapping (RHM) and chromosome association ap

174 The recently developed regional heritability mapping (RHM) method can potentially identi

175 gh curvature measurements, yielding accurate heritability maps of the human face (www.heritabilitymap

176 Missing heritability may be partly due to ignored gene-gene (G-G

177 and control relevant experiential variables, heritability may similarly be contingent on the specific

178 Such 'missing heritability' may be partly due to gene x environment in

179 and different methods to compute and test a heritability measure for such data based on linear and g

180 79% of SNP heritability; using our improved heritability model, their estimated contribution is only

181 herosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide assoc

182 Heritabilities of the genomic regions ranged between 0.0

183 Genomic heritabilities of these traits were estimated to be in t

184 of the theoretical maximum achievable with a heritability of 0.041.

185 e resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive

186 ance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%).

187 An overall heritability of 31% (CI 15%-43%) is consistent with othe

188 It has an estimated heritability of 37%, but published genome-wide associati

189 The estimated DeltaVO2 max heritability of 47% suggests that genomic-based predicto

190 iotic inflammatory disease with an estimated heritability of 50%.

191 ldwide for the severe forms and an estimated heritability of 50%.

192 With a heritability of 64%, positive affect is substantially in

193 Heritability of a phenotypic or molecular trait measures

194 loci only explain a small proportion of the heritability of AAA.

195 ignals, these explain only a fraction of the heritability of ADHD.

196 genic Linkage Analysis Routines) to evaluate heritability of Adult Treatment Panel-III MetS and a sex

197 Through structural equation modeling, the heritability of all phenotypes was calculated.

198 To investigate the heritability of and factors associated with GCC thicknes

199 ate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk vari

200 The heritability of atrial fibrillation (AF), the contributi

201 The heritability of autism is high and multiple genes have b

202 The heritability of autosomal recombination rate was low but

203 stencies and account for some of the missing heritability of blood pressure and are generally relevan

204 We also find that heritability of breast cancer due to all single-nucleoti

205 Using germline genotypes, the heritability of breast cancer subtypes (basal vs nonbasa

206 ar features and survival and to estimate the heritability of breast cancer subtypes.

207 Studies demonstrate high heritability of callous-unemotional traits, but little r

208 Heritability of cancer overall was 33% (95% CI, 30%-37%)

209 ic scheme, which exploits trans-generational heritability of Cas9 activity in heterozygous loss-of-fu

210 coding and noncoding) to fill in the missing heritability of complex disorders.

211 mmary-level results data to estimate the SNP heritability of complex traits and diseases, partition t

212 ographic (MEG) recordings from a subset, the heritability of connectivity among 39 cortical regions w

213 disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01)

214 In 2843 subjects, we estimated that the heritability of diabetic kidney disease was 35% (P=6.4x1

215 Despite evidence for a substantial heritability of diabetic kidney disease, efforts to iden

216 There are also issues regarding the missing heritability of disease that cannot be entirely explaine

217 Heritability of early-onset inflammatory bowel disease i

218 Studies of the heritability of gut microbiotas reveal a subset of micro

219 e present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and ge

220 ictions suggest that approximately 5% of the heritability of height is due to the positive covariance

221 ould substantially contribute to the missing heritability of height.

222 r can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that

223 not appear to be hiding much of the missing heritability of intelligence.

224 We hypothesized that some of the missing heritability of IQ might lie hidden in the human leukocy

225 We estimated the chip heritability of loneliness and examined coheritability b

226 Previous studies have estimated the heritability of loneliness between 37 and 55% using twin

227 ntrol genotyped SNPs suggested that the mean heritability of LSLs attributable to common variants is

228 Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there h

229 The SNP-based heritability of major depressive disorder was 0.21 (SE =

230 We hypothesized that heritability of MR exists across different MR subtypes i

231 We also estimated heritability of MR in 539 FHS pedigrees (7580 individual

232 parental and sibling data in FHS pedigrees, heritability of MR was estimated at 0.15 (95% CI, 0.07-0

233 The heritability of nicotine intake was estimated to be 0.54

234 as estimated at 44% (95% CI=35%-52%) and the heritability of nonperinatal depression at 32% (95% CI=2

235 To estimate heritability of parameters of human retinal electrophysi

236 In the sibling design, the heritability of perinatal depression was estimated at 44

237 ces of partner resemblance on prevalence and heritability of psychiatric traits in the offspring gene

238 Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlyi

239 This study explored heritability of retinal electrophysiologic parameters an

240 genetic variation, which emphasized the low heritability of RN and its plasticity toward relatively

241 GCTA analyses found a significant SNP-based heritability of self-reported alcohol consumption of 13%

242 Using the classic twin model, we found the heritability of serum gd-IgA1 and IgA levels to be 80% (

243 ds and the United Kingdom) and estimated the heritability of set-point viral load at 31% (CI 15%-43%)

244 f the viral population, we must quantify the heritability of set-point viral load, which is the fract

245 We draw three (i) The high heritability of spatial ability makes it a good target f

246 The heritability of SPVL quantifies how much of the variatio

247 The familial nature and significant heritability of stone disease is known, and recent genet

248 The estimated 79% heritability of SZ is congruent with previous reports an

249 We estimated the heritability of SZ to be 79%.

250 Quantitative genetic approaches suggest heritability of task performance, and population genetic

251 o estimate probandwise concordance rates and heritability of the diagnoses of SZ and SZ spectrum diso

252 SNP-based heritability of the HLA variants was small and not signi

253 e difference by race narrowed when assessing heritability of the MetS severity score (JHS 0.52 [95% C

254 h knock-outs and knock-ins, and demonstrated heritability of the modifications, a crucial advance in

255 regate, these explain only a fraction of the heritability of this disease.

256 assessments, particularly when comparing the heritability of traits that exhibit different levels of

257 nged from 0.40 to 0.70, correlating with the heritability of traits.

258 roved model leads to estimates of common SNP heritability on average 43% (s.d. 3%) higher than those

259 Despite moderate heritability, only one study has identified genome-wide

260 s tend to have lower LLD and to explain more heritability (P = 2.38 x 10(-104)); the youngest 20% of

261 tion were modeled for disorders with varying heritabilities, population prevalence (lifetime risk), a

262 Scotopic responses tended to show lower heritability (possibly relating to greater rod system su

263 fic environmental condition, and analyze the heritability, predictability, and genetic basis of this

264 al given a twin's development of cancer) and heritability (proportion of variance in cancer risk due

265 es ranges from 30 to 50% (2) , and SNP-based heritability ranges from 6 to 15% (3-6) .

266 ar germ cell tumors (TGCTs), but much of the heritability remains unexplained.

267 lity loci for colorectal cancer, but much of heritability remains unexplained.

268 Second, we observed co-heritability (rg = 0.191, P = 0.03) between serum calciu

269 t than CP-fit for estimating and testing the heritability scores, while NB-fit is the most computatio

270 used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based

271 Many phenotypes have imperfect heritability, so that a measurement of the phenotype for

272 dentified, and a large proportion of missing heritability still needs to be accounted for.

273 igated by family studies and recently by SNP-heritability studies, the possibility that genetic effec

274 We present here a large-scale heritability study of face geometry that aims to address

275 serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to va

276 st 20% of common SNPs explain 3.9 times more heritability than the oldest 20%, consistent with the ac

277 SNP heritability, the proportion of phenotypic variance expl

278 ghlight the value of analyzing components of heritability to clarify genetic architecture.

279 ross 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk w

280 For high heritability traits, genomic data remain the most effici

281 ty sites were reported to explain 79% of SNP heritability; using our improved heritability model, the

282 e a model that more accurately describes how heritability varies with minor allele frequency (MAF), l

283 However, current estimates of heritability vary widely, from 6% to 59%.

284 , respectively, with accumulated explanatory heritability varying from 43.06% to 48.36%; additive by

285 SNP-heritability was 32% for MDD, 38% and 43% for subtypes w

286 AD heritability was enriched within the PU.1 cistrome, impl

287 ICD heritability was estimated by restricted maximum likelih

288 h closely and distantly related individuals, heritability was estimated for all expression traits.

289 We then tested whether heritability was fixed and independent of experience by

290 The CP-fit approach for assessing heritability was implemented for the first time to our k

291 Specifically, heritability was measured using models of character evol

292 However, no evidence for heritability was observed for either measure in the 96 s

293 Pathway-level regional heritability was significant in this pathway in one subs

294 To investigate this missing heritability, we recruited 21 families with at least one

295 For both samples the regional heritabilities were further localized to the gene and su

296 Age-adjusted estimates of heritability were significant for all parameters (except

297 egression on genome-wide markers (or genomic heritability) when wild/domestic status is considered th

298 r, there is a high level of reported missing heritability, where only a single heterozygous mutation

299 S/F and O/DM had the highest genomic heritability, whereas F/B and O/P had the lowest.

300 Elucidating the genetic basis of this heritability will be important in understanding the path