ライフサイエンスコーパス: heritable

1 that disrupt corneal organization are highly heritable.

2 ndicate that serum gd-IgA1 levels are highly heritable.

3 confirmed that observed changes in sex were heritable.

4 The present data suggest that HCC is highly heritable.

5 plex and elusive etiology that is moderately heritable.

6 ers aggregates in families and is moderately heritable.

7 ty, suggesting that marker expression is not heritable.

8 but differences are stable over days and are heritable.

9 d with sudden death and has been shown to be heritable.

10 rge-scale brain networks can be considerably heritable.

11 both exploratory tendency and aggression are heritable.

12 All anxiety measures were moderately heritable (30% to 41%), and non-shared environmental fac

13 Achievement after two years was also highly heritable (35-76%).

14 Both support indices were moderately heritable (55% and 49%, respectively), an interesting fi

15 physical and psychiatric diseases are partly heritable [6].

16 for g This spatial ability factor is highly heritable (69%).

17 RNFL thickness was highly heritable (82%) but there was low phenotypic sharing bet

18 ate that these phenomena do not always model heritable absence epilepsy or post-traumatic epilepsy in

19 DNA cytosine methylation, changes that were heritable across cell divisions even after the compound

20 ic changes are associated with conditionally heritable adaptive phenotypic stress responses.

21 MetS severity seems highly heritable among whites and blacks.

22 CC)n repeat expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to t

23 Androgenetic alopecia (AGA) is a common heritable and androgen-dependent hair loss condition in

24 ifferences in cognitive functions are partly heritable and are associated with important life outcome

25 nal connectivity that are both significantly heritable and associated with ADHD.

26 herosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developin

27 ascular TGF-beta signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover

28 he cellular milieu, centromere positions are heritable and defined by the interactions of a small set

29 bination of 2469 transcripts that are highly heritable and expressed in whole blood in 1748 unrelated

30 cell complex thickness appears to be highly heritable and further genetic analysis may help identify

31 Many aspects of sleep are heritable and genes influencing traits such as timing, E

32 Bipolar disorder (BD) is a highly heritable and heterogeneous mental illness whose manifes

33 white matter integrity in the brain are also heritable and highly sensitive to both normal and pathol

34 ep duration and disruption, these traits are heritable and identification of the genes involved shoul

35 Variation in telomere length is heritable and is currently considered a promising biomar

36 Both heritable and lifestyle risk factors contribute to eleva

37 The findings elucidate heritable and nonheritable pathways to early callous-une

38 ructural and functional connections that are heritable and pertinent to ADHD.

39 ation in many of these brain regions is also heritable and polygenic but whether their genetic archit

40 er group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations.

41 al pathogenic Candida species are capable of heritable and reversible switching between two epigeneti

42 rmore, tooth form is considered to be highly heritable and selectively neutral; thus, teeth are assum

43 nd sex.Carotenoid concentrations were highly heritable and significant [alpha-carotene: heritability

44 gene responsible for their release is highly heritable and that their accumulation is synchronized wi

45 etic studies have shown that obesity risk is heritable and that, of the many common variants now asso

46 in DNA because transcription errors are not heritable and usually result in a very limited number of

47 ty as assessed by a continuous MetS score is heritable and whether this varies by race.

48 These modifications are dynamic, potentially heritable, and can be induced by environmental stimuli o

49 Fate-switch variability is heritable, and comparing mutant strains selectively bred

50 at the level of groups, if this variation is heritable, and if it plays a role in the success or fail

51 icit hyperactivity disorder (ADHD) is highly heritable, and large, rare copy number variants (CNVs) c

52 is a consistent subject-specific measure, is heritable, and shows a significant relationship with cog

53 ect to genetic influences, and thus possibly heritable, and to what degree is it nurtured by families

54 ER may therefore represent an underlying heritable arrhythmia syndrome or risk factor for sudden

55 e right superior longitudinal fasciculus and heritable aspects of the default mode network (phenotypi

56 as fragile X syndrome (FXS), the most common heritable autism disorder.

57 cues, with FMRP loss causing the most common heritable autism spectrum disorder (ASD), fragile X synd

58 Because heritable autosomal dominant mutations of NLRP3, APP, TR

59 There is increasing interest in the heritable bacteria of invertebrate vectors of disease as

60 ve ability (intelligence) is one of the most heritable behavioural traits and most predictive of soci

61 trolled doses of Schistocephalus We observed heritable between-population differences in several immu

62 ing methylation data has proved a useful and heritable biomarker, with acceleration in epigenetic age

63 ognitive functioning, spindles may represent heritable biomarkers of neuropsychiatric disease.

64 idermolysis bullosa (EB), a group of complex heritable blistering diseases, is the topic of triennial

65 rmolysis bullosa is a heterogeneous group of heritable blistering disorders with considerable morbidi

66 proposed to underlie CNS pathophysiology in heritable brain disorders and age-related neurodegenerat

67 TS is highly heritable, but its underlying genetic causes are still e

68 demonstrate that skin pigmentation is highly heritable, but known pigmentation loci explain only a sm

69 Postmortem genetic testing for heritable cardiovascular (CV) disorders is often lacking

70 ic cardiomyopathy, one of the most prevalent heritable cardiovascular disorders.

71 tion.SIGNIFICANCE STATEMENT FXS is a leading heritable cause of intellectual disability and autism sp

72 in fragile X syndrome (FXS), the most common heritable cause of intellectual disability.

73 ational epigenetics in plants, which entails heritable changes in DNA methylation.

74 environmental or developmental stimuli with heritable changes in gene expression that are associated

75 ted with domestication may first manifest as heritable changes to global patterns of gene expression.

76 genomic instability can thus associate with heritable changes.

77 Height is a highly heritable, classic polygenic trait with approximately 70

78 Additionally, we estimate the heritable component of dementia with Lewy bodies to be a

79 plex traits, including the proportion of the heritable component of each blood trait explained by the

80 disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wid

81 uctive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the under

82 Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk

83 ith osteogenesis imperfecta (Col1a2(oim)), a heritable connective tissue disorder caused by abnormali

84 Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations

85 uch positional shifts are stochastic and not heritable, consistent with prior findings that centromer

86 udies to begin to decipher the nature of the heritable contribution to traits and disease.

87 our FFPET cases with a clinical phenotype of heritable CV disorder were analyzed.

88 to develop and evaluate the use of FFPET for heritable CV disorders via next-generation sequencing.

89 e response identified progressively acquired heritable de novo methylation programs that restrict T c

90 y relevant: PTSD has been shown to be highly heritable despite being definitionally linked to specifi

91 leiotropy are complex traits, with extensive heritable differences arising from naturally occurring v

92 s and Peromyscus maniculatus, have large and heritable differences in parental behaviour.

93 d in our study can inform sex differences in heritable disease prevalence, we integrated our data wit

94 Crohn's disease (CD) is a highly heritable disease that is particularly common in the Ash

95 ome, and the majority of these are linked to heritable disease.

96 OAG), the most common optic neuropathy, is a heritable disease.

97 ically expanded our understanding of complex heritable diseases.

98 Bipolar disorder is a heritable disorder characterized by mood dysregulation a

99 ardiomyopathy (DCM) has been recognized as a heritable disorder for over 25 years, yet clinical genet

100 ty disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime o

101 Hypomyelinating leukodystrophies are heritable disorders defined by lack of development of br

102 sorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burde

103 These findings suggest that heritable DNA methylation plays a role in regulating BP

104 We compare genome-wide assessments of heritable DNA methylation variation and its phenotypic i

105 Pseudoxanthoma elasticum, a heritable ectopic mineralization disorder, is caused by

106 Heritable ectopic mineralization disorders represent a p

107 eudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused in

108 Pseudoxanthoma elasticum is a prototype of heritable ectopic mineralization disorders, with phenoty

109 ontext of climate change and may demonstrate heritable effects.

110 The analyses identified two heritable endophenotypes related to Tourette syndrome th

111 twin cohort and assessed the contribution of heritable, environmental and longitudinal effects on the

112 Transgenerationally heritable epialleles are defined by the stable propagati

113 mutation describes a process that results in heritable epigenetic changes of gene regulation and tran

114 These mechanisms that specify heritable epigenetic information represent genetic syste

115 tiation of transcription to long-lasting and heritable epigenetic marks such as DNA methylation.

116 riants with distinct IGS features may induce heritable epigenetic reprogramming of the partner rDNA a

117 iator of long-term cellular reprogramming is heritable (epigenetic) regulation of transcription, exem

118 develop a computational approach to nominate heritable facilitators of somatic genomic events in the

119 hemic stroke has a strong genetic basis, but heritable factors also contribute to the extent of damag

120 Environmental pollutants as non-heritable factors are now recognized as triggers for mul

121 ss.Environmental factors often outweigh host heritable factors in structuring host-associated microbi

122 An important role for familial/heritable factors in the etiology of a broad range of ps

123 molecular trait in mouse, and that some top heritable features coincide with expression quantitative

124 These analyses indicate that GWAS of single heritable features of genetically complex disorders foll

125 The genetic variation underlying many heritable forms of cardiovascular disease is incompletel

126 Rarely, heritable forms of RCM have been reported, and mutations

127 cases, subregions within each network showed heritable functional connectivity with the rest of that

128 us is required to initiate small-RNA-induced heritable gene silencing.

129 Our results reveal strong heritable genetic contributions to interindividual varia

130 d in the human superior frontal cortex, that heritable genetic factors influence SERPING1 gene expres

131 y due to poorly controlled hypertension, and heritable genetic variants.

132 d failures to remove mutagenic lesions cause heritable genome changes.

133 an efficient protocol for the generation of heritable germline mutations in the parasitoid jewel was

134 ene cinnabar, generating several independent heritable germline mutations in this gene.

135 Notably, heritable germline silencing directs somatic epigenetic

136 The replicated methylation sites are heritable (h(2) > 30%) and independent of known BP genet

137 tance misuse, and violent crime) were highly heritable (h(2)=53-71%).

138 and genomic context in propagation of a cis-heritable H3K9me-dependent silenced state.

139 , 0.78; 95% CI, 0.68 to 0.89) and moderately heritable (heritability, 0.40; 95% CI, 0.14 to 0.51), bu

140 e results suggest that tiredness is a partly heritable, heterogeneous and complex phenomenon that is

141 Endometriosis is a heritable hormone-dependent gynecological disorder, asso

142 Eating disorders are lethal and heritable; however, the underlying genetic factors are u

143 or the inbred WAG/Rij strain (a rat model of heritable human absence epilepsy) could exercise volunta

144 It is one of the most common heritable human diseases with eventual development of re

145 related to the genetic risk for this highly heritable illness.

146 The EPSPS gene amplification was heritable in common waterhemp and can be transferred via

147 fertility, fecundity, and fecundability, is heritable in humans, but identifying and functionally ch

148 vestigated whether gating measures were more heritable in multiply affected families with a positive

149 single locus, suggesting vitamin D status is heritable in this population.

150 g time, maturation, and growth rate that are heritable independent of MSH1.

151 76% of these traits show a predominantly heritable influence, whereas 24% are mostly influenced b

152 Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD

153 The leading cause of heritable intellectual disability (ID) and autism spectr

154 gene promoter and is the most common form of heritable intellectual disability and autism.

155 ria for the metabolic syndrome (MetS) appear heritable, it is not known whether MetS severity as asse

156 Heritable L1 insertions may therefore arise in germ cell

157 Additionally, our data suggest that many heritable L1 insertions originate from individuals with

158 We traced heritable L1 insertions to pluripotent embryonic cells a

159 ighlight the rate and evolutionary impact of heritable L1 retrotransposition and reveal retrotranspos

160 gene expression levels and reducing risks of heritable loss of transgene expression.

161 Niemann-Pick disease, type C1 (NPC1) is a heritable lysosomal storage disease characterized by a p

162 alized manganese efflux transporter, cause a heritable manganese metabolism disorder resulting in ele

163 6mA regulates gene expression as a potential heritable mark.

164 tial neurobiological correlates and specific heritable markers of suicide vulnerability.

165 rstand the epigenetic mechanisms that enable heritable memory of temporary stimuli.

166 ast infections and as an armour of potential heritable memory.

167 To determine the frequency of the known heritable meningioma- or schwannoma-predisposing mutatio

168 (BPD) are frequently co-occurring and highly heritable mental health conditions.

169 Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by

170 Heritable microbes represent an important component of t

171 This mitotically heritable mode of regulation is recently evolved; in a d

172 at miRNA and mRNA expression can be a highly heritable molecular trait in mouse, and that some top he

173 gence (general cognitive ability) are highly heritable, molecular genetic analyses to date have had l

174 Prostate cancer is a highly heritable molecularly and clinically heterogeneous disea

175 Heritable mutations in ABCC6 underlie the incurable calc

176 s potential to be used for the correction of heritable mutations in human embryos by complementing pr

177 uals with potentially clinically significant heritable mutations over the predicted yield of targeted

178 ted leucine-rich repeat subfamily XII genes, heritable mutations were recovered in 15 of the 54 genes

179 Up to 15% of cases are attributable to heritable mutations, which, if identified, provide criti

180 Many heritable mutualisms, in which beneficial symbionts are

181 Huntington's disease (HD) is a heritable neurodegenerative disorder caused by expansion

182 n-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder that shows clinica

183 k, course, or treatment response in complex, heritable neuropsychiatric illnesses.

184 Plastid depletion of MSH1 causes heritable, non-genetic changes in development and DNA me

185 The most heritable oral bacteria were not associated with caries

186 determined by environmental factors, highly heritable oral taxa were identified.

187 We hypothesized that 16alphaOHE promotes heritable PAH (HPAH) via microRNA-29 (miR-29) family upr

188 well-phenotyped patients with idiopathic or heritable PAH (n=365) from healthy control subjects (n=1

189 ndred sixty-four patients with idiopathic or heritable PAH and 16 with pulmonary veno-occlusive disea

190 Heritable PAH and idiopathic PAH BOECs recapitulated the

191 med on DNA from patients with idiopathic and heritable PAH and with pulmonary veno-occlusive disease/

192 tored normal proliferation and glycolysis in heritable PAH BOECs, corrected the dysregulation of glyc

193 endothelial cells (BOECs) from patients with heritable PAH caused by mutations in the bone morphogene

194 with idiopathic, drug- and toxin-induced, or heritable PAH enrolled in the French pulmonary hypertens

195 assified clinically as having idiopathic and heritable PAH.

196 This study expands the spectrum of heritable pain disorders linked to gain-of-function muta

197 been identified in three families with rare heritable pain disorders, and in patients with painful s

198 imate the genetic correlation between highly heritable pairs and identify transcription factor contro

199 CS surface area and depth were significantly heritable, particularly in the superior regions, but les

200 The results provide a specific heritable pathway to callous-unemotional behaviors and c

201 s, but little research has examined specific heritable pathways to early callous-unemotional behavior

202 Heritable patterns of functional connectivity were detec

203 ging the primary base sequence, to establish heritable patterns of gene expression.

204 h disease type 1A (CMT1A) is the most common heritable peripheral neuropathy and results from a dupli

205 Anorexia nervosa is a complex heritable phenotype for which this study has uncovered t

206 siologic mechanism for ADHD, and identifying heritable phenotypes within these connections could prov

207 To test for thermal local adaptation and heritable phenotypic plasticity in Pacific salmon embryo

208 f genetic variation that are responsible for heritable phenotypic variability.

209 Disruption of certain genes alters the heritable phenotypic variation among individuals.

210 wledge of the genetic and molecular basis of heritable phenotypic variation.

211 c interactions result in ephemeral, but also heritable, phenotypic variations that are important for

212 sting conditions, as well as family-specific heritable plasticity that could facilitate adaptive chan

213 in and among temperature regimes, indicating heritable plasticity.

214 Heritable platelet function disorders (PFDs) are genetic

215 Schizophrenia is a highly heritable, polygenic condition characterized by a relati

216 Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants cont

217 inoblastoma is curable, but survivors with a heritable predisposition are at high risk for second mal

218 the characteristics that are the most highly heritable, preferential attention to eye and mouth regio

219 f PrPs carrying mutations analogous to human heritable prion diseases, support that mutations might p

220 eral prions that are transmitted as altered, heritable protein conformations.

221 loid fibrils and their ability to induce the heritable [PSI(+)] prion phenotype.

222 olar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlappin

223 polar disorder (BD) is a common, complex and heritable psychiatric disorder characterized by episodes

224 The persistence of common, heritable psychiatric disorders that reduce reproductive

225 ein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH).

226 utation has been identified in a family with heritable pulmonary arterial hypertension (PAH).

227 utation has been identified in a family with heritable pulmonary arterial hypertension (PAH).

228 protein receptor type 2 mutation-associated heritable pulmonary arterial hypertension (PAH).

229 n identified in some patients suffering from heritable pulmonary arterial hypertension (PAH).

230 lial cells from patients with idiopathic and heritable pulmonary arterial hypertension compared with

231 Idiopathic and heritable pulmonary arterial hypertension form a rare bu

232 udy, we enrolled patients with idiopathic or heritable pulmonary arterial hypertension from London (U

233 validated in 93 patients with idiopathic or heritable pulmonary arterial hypertension in cohort 4, w

234 RATIONALE: Idiopathic or heritable pulmonary arterial hypertension is characteriz

235 with survival in patients with idiopathic or heritable pulmonary arterial hypertension to improve ris

236 143 consecutive patients with idiopathic or heritable pulmonary arterial hypertension with 2 years'

237 ls from the same patients with idiopathic or heritable pulmonary arterial hypertension, to determine

238 s and the corpus callosum were significantly heritable, ranging from total additive genetic heritabil

239 The age at presentation and presence of a heritable RB1 mutation significantly correlated with an

240 Long recognized to be heritable, recent advances have started to unravel the g

241 ate twin modeling confirmed both traits were heritable (refractive error 85%, intelligence 47%) and t

242 lently modify histones, which contributes to heritable repression.

243 eserving treatments on long-term survival in heritable retinoblastoma, and the genetic background of

244 treated at the national reference center for heritable retinoblastoma.

245 Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwi

246 Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma an

247 QT interval prolongation is a heritable risk factor for ventricular arrhythmias and ca

248 finding that positive reinforcement buffered heritable risk for callous-unemotional behaviors has imp

249 However, much of the heritable risk is unknown.

250 oci have been reported; however, much of the heritable risk remains unidentified.

251 ed for the inheritance of small RNAs and for heritable RNAi in worms, which typically persist for a f

252 Equally significant is the stable and heritable silencing of master regulators that would spec

253 Dystrophic epidermolysis bullosa is a heritable skin disease manifesting with sub-lamina densa

254 nce through amplification and maintenance of heritable small RNAs, and those that limit the persisten

255 continued transposition is a source of both heritable structural variation as well as somatic mutati

256 In this review, we examine how heritable symbiont-host interactions may alter host ther

257 ed for antagonism-to-mutualism transition in heritable symbioses.

258 Eukaryotes commonly host communities of heritable symbiotic bacteria, many of which are not esse

259 Heritable temperament traits have been linked to several

260 Though heritable, the specific genes influencing risk of dental

261 Heritable thoracic aortic aneurysms and dissections (TAA

262 udes 15 centers worldwide that specialize in heritable thoracic aortic diseases, was used to gather d

263 ation independent of DNA sequence, which are heritable through cell division.

264 of lean body mass.Lean body mass is a highly heritable trait and is associated with various health co

265 Binge eating is a highly heritable trait associated with eating disorders that is

266 is that socially acquired nicotine IVSA is a heritable trait by using female rats of six inbred strai

267 attern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, pro

268 Resting heart rate is a heritable trait correlated with life span.

269 Obesity is a heritable trait that contributes to substantial global m

270 Glucose-aversion is a heritable trait that evolved in a number of German cockr

271 ess, as defined in this study, is a modestly heritable trait that has a highly polygenic genetic arch

272 uring non-rapid eye movement sleep, a highly heritable trait with fingerprint reproducibility, is cor

273 ces the likelihood of quitting smoking, is a heritable trait with firmly established associations wit

274 Resting heart rate is a heritable trait, and an increase in heart rate is associ

275 genomic selection was observed for the lowly heritable traits DPR, PL, and SCS.

276 iously mapped genomic regions for two highly heritable traits, chaff color, and leaf cuticular wax.

277 dant examples of natural selection acting on heritable traits, conclusive evidence for contemporary a

278 g of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pa

279 e mineral density and lean skeletal mass are heritable traits.

280 its and from threefold to fourfold for lowly heritable traits.

281 me (ORF; approximately 5,300 ORFs) to induce heritable traits.

282 contributing to the formation of stable and heritable transcriptional patterns.

283 ansgene design parameters as means to reduce heritable transgene silencing.

284 ure to environmental contaminants can induce heritable "transgenerational" modifications to organisms

285 ion of infectious particles that can lead to heritable transposition events.

286 s and are probably mediated via other partly heritable variables, including cognitive ability, person

287 p to 9% at age 16, accounting for 15% of the heritable variance.

288 ning REC8 and RNF212B explained 26.2% of the heritable variation in recombination rate in both sexes.

289 sults show that stickleback recently evolved heritable variation in their capacity to suppress helmin

290 foraging in Caenorhabditis elegans, and that heritable variation in this behaviour generates alternat

291 clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, wi

292 In females, 46.7% of the heritable variation was explained by a subtelomeric regi

293 loci do not explain substantial fractions of heritable variation, leaving an open question of whether

294 As both are heritable, we set out to examine whether there is a gene

295 ted and were more likely to be significantly heritable when compared with DNAm sites in regions of hi

296 r mean DNAm level and were more likely to be heritable when compared with DNAm sites in the transcrip

297 ithin the superior portion are significantly heritable, whereas central and inferior portions of the

298 These two newly defined phenotypes are heritable with no measurable pleiotropic effects.

299 Developmental language disorders are highly heritable with substantial societal impact.

300 Age-adjusted GCC thickness was highly heritable, with additive genetic effects explaining 81%