ライフサイエンスコーパス: heroin

1 o a migration to other opioids, particularly heroin.

2 ersion of prescription opioid analgesics and heroin.

3 thway that increases intake of high doses of heroin.

4 ivity did not differ from patients receiving heroin.

5 , with first use on average 2.0 years before heroin.

6 the motivation to take increasing amounts of heroin.

7 e hyporesponsive to the rewarding effects of heroin.

8 ividuals may switch to other opiates such as heroin.

9 dendrocytes in regulating the motivation for heroin.

10 deaths is occurring, many of which are from heroin.

11 ther methamphetamine (0.1 mg/kg/infusion) or heroin (0.1 mg/kg/infusion) for 12 days (6 h/day).

12 mates (A/A) were allowed to self-administer heroin (0.25 mg/kg/unit dose, FR1 with a nose poke respo

13 1) first opioid used (prescription opioid or heroin), (2) sex, (3) race/ethnicity, and (4) age at fir

14 When NOP (-/-) rats were tested for heroin (20 mug/infusion) and ethanol (10% v/v) self-admi

15 16.5 years) whose first opioid of abuse was heroin (80%).

16 terize and identify predictors of periods of heroin abstinence in the natural history of recovery fro

17 tor in striatal disturbances associated with heroin abuse and relevant to genetic mutation of OPRM1.

18 To address whether genetic associations with heroin abuse exist in relation to dopamine and glutamate

19 heroin addiction and the damaging effects of heroin abuse on cognition and the salience network.

20 e allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigat

21 tion on gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls.

22 homogenous European Caucasian population of heroin abusers and control subjects and in an animal mod

23 s of the periamygdaloid cortex (PAC) in both heroin abusers and MDD subjects.

24 evealed ~20% of downregulated genes in human heroin abusers are ELK1 targets.

25 Striatal ELK1 in heroin abusers associated with the polymorphism rs207557

26 A characteristic feature of heroin abusers was decreased expression of MOR and extra

27 Heroin abusers with the C allele had lower measures of G

28 ncy of rs1137070 was significantly higher in heroin abusers.

29 The result is efficient blockade of heroin activity in treated rats, preventing various feat

30 Relative to placebo, heroin acutely reduced the fear-induced modulation of co

31 that had prior suggestive associations with heroin addiction (smallest p = 2.7 x 10(-8) for rs382301

32 iated with an increase in the sensitivity to heroin addiction and the damaging effects of heroin abus

33 hanisms underlying negative reinforcement in heroin addiction and the effects of regular heroin subst

34 Heroin addiction and the rs1137070 variant interactively

35 ral mechanisms that underlie greater risk of heroin addiction in carriers of the A118G SNP.

36 e results in substantially increased risk of heroin addiction in humans; however, the neurobiological

37 eQTL SNPs were significantly associated with heroin addiction in the Urban Health Study (smallest p =

38 it loci (cis-eQTL) SNPs for association with heroin addiction in the Urban Health Study and two repli

39 Heroin addiction is treated successfully with opiate rep

40 ted the interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78

41 l SNP allele rs1799971-A was associated with heroin addiction only in the presence of rs3778150-C (p

42 wever, the association between rs1137070 and heroin addiction remains unclear.

43 y = 16%-19%) being associated with increased heroin addiction risk.

44 The cost and pervasiveness of heroin addiction, including resistance to recovery from

45 ve strategy for the treatment of intractable heroin addiction, particularly in individuals who are re

46 sisted therapies for the treatment of severe heroin addiction.

47 ion of the subthalamic nucleus (STN HFS) for heroin addiction.

48 onsistent associations between rs1799971 and heroin addiction.

49 ron 1 SNPs have replicable associations with heroin addiction.

50 to nominate and then test associations with heroin addiction.

51 t STN HFS may have on relapse in humans with heroin addiction.

52 d that cue-elicited craving among detoxified heroin addicts was substantially attenuated following R-

53 Heroin administration acutely reduced the left amygdala

54 hese same mice following saline (control) or heroin administration in a CPP design.

55 Although acute heroin administration was found to reduce anxiety, cravi

56 r abstinence in rats with extended access to heroin, an animal model of compulsive heroin taking.

57 ed activity in these models, suggesting that heroin and 6-acetylmorphine are critical players in hero

58 a by pioglitazone reduces the motivation for heroin and attenuates its rewarding properties.

59 ved by other drugs of abuse and metabolites (heroin and cannabis abuse).

60 r clonidine blocks stress-induced seeking of heroin and cocaine.

61 kers, excreted following human metabolism of heroin and codeine.

62 hemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleu

63 mic" vaccine that creates antibodies against heroin and its psychoactive metabolites by presenting mu

64 Cue-induced heroin and nicotine relapse increased MMP activity, and

65 The 1 vaccine-induced antibodies bound to heroin and other abused opioids, including hydrocodone,

66 y analysis showed significantly lower use of heroin and other illicit opioids in the extended-release

67 ine drug tests, and number of days of use of heroin and other illicit opioids.

68 ne in maintaining short-term abstinence from heroin and other illicit substances and should be consid

69 hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified

70 u-opioid receptors (MOPRs) are the target of heroin and other prescription opioids, which are current

71 dified, but remarkably, motivation to obtain heroin and palatable food was enhanced in operant self-a

72 s to opiates, including motivation to obtain heroin and palatable food.

73 al of Psychiatry in Basel were studied after heroin and placebo administration, while 17 healthy cont

74 d the interrelationship between their use of heroin and their use of prescription opioids.

75 of context-induced reinstatement of cocaine, heroin, and alcohol seeking.

76 lying conditioned reinforcement and cocaine, heroin, and alcohol seeking.

77 -) rats to study the motivation for cocaine, heroin, and alcohol self-administration in the absence o

78 recreational drug, often in combination with heroin, and can result in lethality during overdose.

79 Opioids such as heroin are considered very rewarding and reinforcing, bu

80 Yet male rats that self-administer heroin as adolescents show attenuated drug-seeking after

81 cated in an open-ended format why they chose heroin as their primary drug and the interrelationship b

82 ry pain reduced motivation for a low dose of heroin, as measured by responding under a PR schedule of

83 ts, probably reflecting the effectiveness of heroin-assisted therapies for the treatment of severe he

84 has shown that a single maintenance dose of heroin attenuates psychophysiological stress responses i

85 accumbens core altered the initial intake of heroin but not the rate of escalation, while local injec

86 at self-administered oxycodone, fentanyl, or heroin, but not buprenorphine had similar profiles of es

87 of TLR4 in the development of incubation of heroin, but not methamphetamine, craving.

88 adults self-administered similar amounts of heroin, but subsequent heroin-seeking was attenuated in

89 Here we show that cocaine and heroin can induce long-lasting deficits in the ability t

90 induced hyperlocomotion following a 50 mg/kg heroin challenge.

91 lowing repeated subcutaneous and intravenous heroin challenges in mice and rats.

92 Following a series of heroin challenges over six months in vaccinated monkeys,

93 ntribute to context-induced reinstatement of heroin, cocaine, and alcohol seeking, but not yet for me

94 circuits in context-induced reinstatement of heroin, cocaine, and alcohol seeking.

95 d, including mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC) and thei

96 tabolites of mephedrone, methadone, cocaine, heroin, codeine, and tetrahydrocannabinol (THC).

97 otherapy options for opioid use disorders, a heroin conjugate vaccine was developed through comprehen

98 oin self-administration showed incubation of heroin craving after forced but not voluntary abstinence

99 nce prevented the emergence of incubation of heroin craving in both sexes.

100 nt of cocaine and heroin seeking in rats and heroin craving in humans.

101 Heroin craving was significantly reduced under active ib

102 ions implicated in incubation of cocaine and heroin craving, in incubation of methamphetamine craving

103 raction) on momentary ratings of cocaine and heroin craving.

104 hine hydrochloride (the active ingredient in heroin), delivered under supervision, is effective for t

105 International Consortium on the Genetics of Heroin Dependence [ICGHD]).

106 Aggregate heroin dependence risk associated with 2 SNPs, rs877138

107 terventions is the best treatment option for heroin dependence, there is limited research focusing sp

108 pharmacological target for the treatment of heroin dependence.

109 6Met gene variants, but by the length of the heroin dependency.

110 ere negatively correlated with the length of heroin dependency.

111 At baseline, this study recruited 503 heroin dependent patients discharged from Shanghai compu

112 actors influence recovery consequences among heroin dependent patients have shown mixed results.

113 gative recovery consequences by gender among heroin dependent patients in Shanghai, China.

114 Our findings indicate that female heroin dependent patients tend to have less negative rec

115 double-blind, vehicle-controlled design, 22 heroin-dependent and heroin-maintained outpatients from

116 Among 471 heroin-dependent males, 387 (82.2%) reported 932 abstine

117 plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were

118 a prognostic tool to assess stress levels in heroin-dependent patients and to quantify the efficacy o

119 ce processing after the placebo treatment in heroin-dependent patients transiently normalizes after a

120 In heroin-dependent patients, plasma BDNF levels were negat

121 ates psychophysiological stress responses in heroin-dependent patients, probably reflecting the effec

122 n, saline and heroin were administered to 22 heroin-dependent patients, whereas 17 healthy control su

123 NF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients.

124 he acute dopaminergic effects of cocaine and heroin determined by in vivo microdialysis, on the reinf

125 inforcement, an effect dissociable from high heroin dose PR responding.

126 While we did not find heroin dose-related changes in mRNA expression levels in

127 Half of the mice then continued in a heroin dose-response study, while extinction from heroin

128 increased for high, but attenuated for low, heroin doses with concomitant alterations in mesolimbic

129 trong preference for the palatable food over heroin during the choice-based voluntary abstinence.

130 lts show a direct relation between the acute heroin effects on stress-related emotions, stress reacti

131 the reinforcing and motivating properties of heroin, even in subjects with a history of dependence.

132 ive rats, but did not differ between the two heroin-experienced groups.

133 creased in the nucleus accumbens core in all heroin-exposed rats, but selectively increased in the nu

134 In contrast, heroin exposure (15 and 25 mg/L) evoked a hyperlocomotor

135 sizes a direct relationship between repeated heroin exposure and ELK1 dysregulation.

136 stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including coc

137 f mainstream media reports that the abuse of heroin has migrated from low-income urban areas with lar

138 Opioid addiction, including addiction to heroin, has markedly increased in the past decade.

139 and CpG oligodeoxynucleotide (ODN) generated heroin "immunoantagonism", reducing heroin potency by >1

140 take between commonly prescribed opioids and heroin in animal models have not yet been performed.

141 antagonist, on the reinforcing properties of heroin in rats on short (1 h: ShA) or long (12 h: LgA) a

142 Respondents who began using heroin in the 1960s were predominantly young men (82.8%;

143 estration of brain-permeable constituents of heroin in the bloodstream following vaccination.

144 on of dopamine levels produced by cocaine or heroin in the nucleus accumbens shell.

145 verdose deaths from prescription opioids and heroin in the United States over the past 20 years is be

146 effective in reducing self-administration of heroin in wild-type but not D3R knockout mice.

147 In this age group, poisonings from heroin increased from 0.96 (95% CI, 0.75-1.18) to 2.51 (

148 bolite, morphine, is insufficient to prevent heroin-induced activity in these models, suggesting that

149 induced high anti-1 IgG levels that reduced heroin-induced antinociception and locomotive behavioral

150 st the functional role of Sox10 in mediating heroin-induced behavioral plasticity, we selectively ove

151 omotor effects of heroin were abolished, and heroin-induced catalepsy was increased.

152 have previously shown strain differences in heroin-induced conditioned place preference (CPP) betwee

153 th a marked and selective reduction of acute heroin-induced elevation of extracellular dopamine (DA)

154 Vaccinated mice had reduced heroin-induced hyperlocomotion following a 50 mg/kg hero

155 ts are associated with a marked reduction of heroin-induced increase in phosphorylation of DARPP-32 p

156 Heroin-induced increases in striatal dopamine levels are

157 vivo microdialysis was used to measure acute heroin-induced increases of striatal dopamine in the GG

158 Heroin-induced neuronal activation was modified at both

159 possibly because of the greater increases of heroin-induced striatal dopamine in the GG mice.

160 0 or BRG1 decreased the motivation to obtain heroin infusions in a progressive ratio test without alt

161 did not differ from those of patients after heroin injection.

162 STN HFS prevented the re-escalation of heroin intake after abstinence in rats with extended acc

163 lf-administration, rats showed escalation of heroin intake over several weeks.

164 ns shell selectively suppressed increases in heroin intake over time without altering initial intake.

165 time, whereas LgA leads to an escalation of heroin intake thought to model important dependence-rela

166 ghts that show that inflammatory pain alters heroin intake through a desensitization of MORs located

167 In the presence of inflammatory pain, heroin intake under an FR schedule was increased for hig

168 Heroin is a highly abused opioid and incurs a significan

169 As heroin is converted to morphine in man, selective revers

170 ory studies to date, craving for cocaine and heroin is greater with the combination of drug cues and

171 uced drug craving and stress-induced initial heroin lapse.

172 e-controlled design, 22 heroin-dependent and heroin-maintained outpatients from the Centre of Substan

173 patients transiently normalizes after acute heroin maintenance treatment.

174 proportion of urinalyses positive for street heroin markers (margin, 10% of the observed rate in the

175 h 95% CI, -0.04 to 0.2; P < .001) and use of heroin (mean difference, -3.2 with 95% CI, -4.9 to -1.5;

176 administration and the motivation to consume heroin, measured using a progressive-ratio schedule, in

177 low nanomolar antiserum affinity for the key heroin metabolite, 6-acetylmorphine (6AM), with minimal

178 abuse consisting of a prescription opioid or heroin (N = 10,784) at entry to 1 of 150 drug treatment

179 areas both in ShA and LgA rats compared with heroin-naive rats, but did not differ between the two he

180 cannabis, club drug, cocaine, hallucinogen, heroin, nonheroin opioid, sedative/tranquilizer, and/or

181 alleled by reduced motivation to respond for heroin on a progressive-ratio schedule of reinforcement,

182 nds, Delta(9)-tetrahydrocannabinol (THC) and heroin, on adult zebrafish behavior in the novel tank te

183 Participants who had injected heroin or been in prison were more likely to choose to t

184 Participants who reported injecting heroin or being in prison during the 3 months before ope

185 and methamphetamine addictions, but not for heroin or cocaine addiction.

186 riment 2, we trained rats to self-administer heroin or sucrose for 12 hours per day (extended access)

187 OR] 1.8, 95% CI 1.4-2.2; p<0.0001), injected heroin (OR 1.5, 1.1-2.1; p=0.007), or had been in prison

188 isit than those who did not report injecting heroin (OR 3.0, 95 % CI 1.3-7.3; p=0.01) or being in pri

189 9971, have been conclusively associated with heroin/other opioid addiction, despite their biological

190 e by ethanol may be a contributory factor in heroin overdose deaths.

191 l is a considerable risk factor for death in heroin overdose.

192 ) are correlated with changes in the rate of heroin overdoses (HOD).

193 both dependence on alcohol and dependence on heroin (P=0.0005 and OR=1.22 (1.09, 1.37) for rs211014).

194 ring antibodies caused marked attenuation of heroin potency (>4-fold) in a schedule-controlled respon

195 enerated heroin "immunoantagonism", reducing heroin potency by >15-fold.

196 In contrast, passive exposure to heroin produced increases in TacR1 expression in the pre

197 entions may simply lead to a shift in use to heroin rather minimizing the reduction in harm.

198 hat pharmacological NK1R blockade attenuates heroin reinforcement.

199 ng co-abused substances but do little to the heroin relapse rate.

200 Reporting significant increases in heroin-related deaths since 2014, the New England region

201 Overall, our data suggest that heroin-related histone H3 hyperacetylation contributes t

202 nigra and ventral tegmental area (SN/VTA) to heroin reward by measuring mRNA levels of 7 of the most

203 eventing various features of drugs of abuse: heroin reward, drug-induced reinstatement of drug seekin

204 c structures to the immune system that match heroin's metabolism.

205 and 6-acetylmorphine are critical players in heroin's psychoactivity.

206 first studies to examine the acquisition of heroin SA in this mouse model.

207 n dose-response study, while extinction from heroin SA was studied in the other half.

208 ke) than A/A mice, in the initial 10 days of heroin SA, and in the subsequent dose-response study.

209 edure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans.

210 tests had no effect on incubated cue-induced heroin seeking.

211 s the reinstatement of cocaine, alcohol, and heroin seeking.

212 s of forced abstinence, rats were tested for heroin-seeking over 1 h by measuring the number of lever

213 the prelimbic or infralimbic mPFC during the heroin-seeking test, whereas the adult-onset heroin self

214 ed similar amounts of heroin, but subsequent heroin-seeking was attenuated in the younger rats.

215 al prefrontal cortex (mPFC) in age-dependent heroin-seeking.

216 impairments were detected in the striatum of heroin self-administering rats.

217 This study examined heroin self-administration (SA) behavior in A112G (G/G)

218 rmore, G/G male mice escalated the amount of heroin self-administration across 10 extended-access ses

219 ional readout of acetylated lysines, reduced heroin self-administration and cue-induced drug-seeking

220 L822429 reduced heroin self-administration and the motivation to consume

221 ole for HCRT-R2 signaling in compulsive-like heroin self-administration associated with extended acce

222 drug seeking, and reescalation of compulsive heroin self-administration following abstinence in depen

223 heroin-seeking test, whereas the adult-onset heroin self-administration group showed two to six times

224 istered NBI-80713 dose-dependently decreased heroin self-administration in LgA, but not in ShA, anima

225 fects of a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed short- (1 h;

226 A rat heroin self-administration model was used to obtain tran

227 e compared effects of cocaine, morphine, and heroin self-administration on two forms of extinction le

228 We also found no sex differences in heroin self-administration or the strong preference for

229 ShA produces heroin self-administration rates that are stable over ti

230 is that inflammatory pain leads to increased heroin self-administration resulting from altered mu opi

231 ever, male and female rats with a history of heroin self-administration showed incubation of heroin c

232 imbic DA transmission and on rat intravenous heroin self-administration under fixed ratio (FR) and pr

233 Consistent with the reduction in low dose FR heroin self-administration, inflammatory pain reduced mo

234 Using a 12 h long-access model of heroin self-administration, rats showed escalation of he

235 ) or long- (12 h; LgA) access to intravenous heroin self-administration.

236 kg) had no effect on ongoing extended access heroin self-administration.

237 a key role in some age-dependent effects of heroin self-administration.

238 d control subjects and in an animal model of heroin self-administration.

239 A) or long (12 h: LgA) access to intravenous heroin self-administration.

240 t altering the acquisition or maintenance of heroin self-administration.

241 d (2) male and female rats with a history of heroin self-administration.

242 yte differentiation and maturation following heroin self-administration.

243 Male and female G/G mice responded for heroin significantly more (and thus had greater intake)

244 heroin addiction and the effects of regular heroin substitution.

245 in taking and compulsive-like responding for heroin, suggesting that KOR antagonists may be promising

246 An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported.

247 mbens mediates the increasing motivation for heroin taking and compulsive-like responding for heroin,

248 e into the RMTg but not into the VTA reduced heroin taking.

249 ess to heroin, an animal model of compulsive heroin taking.

250 Immunization of mice with an optimized heroin-tetanus toxoid (TT) conjugate formulated with adj

251 e and female G/G mice self-administered more heroin than did A/A mice over a 10-day period, possibly

252 For heroin, the mean was not significantly greater than 0, b

253 cal therapies and devices, and growth in the heroin trade, as well as population mixing during armed

254 nced rats or rats trained to self-administer heroin under extended access conditions exhibited normal

255 y outcomes were self-reported days of street heroin use (primary), days of any street-acquired opioid

256 ow-up was observed for injection cocaine and heroin use among HCV seroconverters but not among HCV-se

257 Lifetime heroin use and DSM-IV heroin use disorder.

258 The prevalence of heroin use and heroin use disorder increased significant

259 eatment in populations at increased risk for heroin use and heroin use disorder.

260 ational campaigns regarding harms related to heroin use and the need to expand access to treatment in

261 ce, patterns, and associated demographics of heroin use and use disorder from 2001-2002 to 2012-2013

262 the proportion of respondents meeting DSM-IV heroin use disorder criteria (63.35% [SE, 4.79%] in 2001

263 The prevalence of heroin use and heroin use disorder increased significantly, with greate

264 ttle is know about the course of heroin use, heroin use disorder, and associated factors.

265 lations at increased risk for heroin use and heroin use disorder.

266 idate for targeted clinical interventions in heroin use disorder.

267 Lifetime heroin use and DSM-IV heroin use disorder.

268 has shifted over the last 50 years such that heroin use has changed from an inner-city, minority-cent

269 istone H3, showing dynamic correlations with heroin use history and acute opiate toxicology.

270 between the prescription opioid epidemic and heroin use in this population.

271 se of prescription opioids before initiating heroin use increased across time among white individuals

272 edical use of prescription opioids preceding heroin use increased among white individuals, supporting

273 Heroin use is an urgent concern in the United States.

274 is (-1.44; 90% CI, -3.22 to 0.27) for street heroin use, although the margin of 4 days was not exclud

275 er and correlated with documented history of heroin use, an effect reproduced in an animal model that

276 attributed to wound contamination related to heroin use, and the source of 5 cases was unknown.

277 Little is know about the course of heroin use, heroin use disorder, and associated factors.

278 y target in the physiopathology of long-term heroin use.

279 who received a primary (DSM-IV) diagnosis of heroin use/dependence (n = 2797) and (2) data from unstr

280 overdoses and a secondary analysis assuming heroin users are a net cost to society.

281 e that plasma BDNF concentration in habitual heroin users are not affected by BDNF Val66Met gene vari

282 ata show that the demographic composition of heroin users entering treatment has shifted over the las

283 homogeneous European Caucasian population of heroin users for transcriptional and epigenetic profilin

284 al drug-related expenditures were applied to heroin users, the ICER was $2429.

285 e rats acquired lever-pressing maintained by heroin using a fixed ratio one reinforcement schedule (0

286 Because the heroin vaccine does not target opioid receptors or commo

287 d potential clinical utility of an effective heroin vaccine in treating opioid use disorders.

288 Although the "high" produced by heroin was described as a significant factor in its sele

289 Place preference to heroin was not modified, but remarkably, motivation to o

290 fungibility between prescription opiates and heroin was supported by these analyses.

291 In contrast, locomotor effects of heroin were abolished, and heroin-induced catalepsy was

292 , crossover, double-blind design, saline and heroin were administered to 22 heroin-dependent patients

293 ged 15 to 19 years, poisonings attributed to heroin were also identified.

294 SI-MS, as the signals of methamphetamine and heroin were completely suppressed by matrix and substrat

295 observation that animals with ShA and LgA to heroin were similarly affected by L822429 indicates that

296 nistration of these prescription opioids and heroin, which has been previously established to induce

297 nted arrays of cocaine, methamphetamine, and heroin with a deposited-mass ranging nominally from 10 p

298 yed increased work effort to self-administer heroin, with enhanced stereotyped behaviors during the p

299 ystemic nor-BNI also significantly decreased heroin withdrawal-associated anxiety-like behavior.

300 eotyped behaviors during the period of acute heroin withdrawal.