ライフサイエンスコーパス: herpetic

1 medical subject headings (MESH) "Keratitis, Herpetic/" AND "Acyclovir/" limiting by the key words "t

2 lar pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), owing to either herpes s

3 ained unchanged after exclusion of eyes with herpetic anterior uveitis.

4 Seventy-three herpetic AU patients were included.

5 Patients with herpetic AU presenting themselves between 2001 and 2013

6 econdary glaucoma are major complications in herpetic AU.

7 in the local trigeminal ganglion and reduced herpetic blepharitis and corneal scarring.

8 In the current study, a rabbit herpetic corneal endotheliitis model was made of induced

9 as a reduction in the incidence of recurrent herpetic corneal epithelial disease and stromal disease

10 completely protected from local or systemic herpetic disease after intravaginal challenge with wild-

11 glia, the majority never develop a recurrent herpetic disease and remain asymptomatic (ASYMP).

12 ptomatic" antigens (ID-S-Ags) may exacerbate herpetic disease and therefore must be excluded from any

13 ng what differentiates humans with recurrent herpetic disease from the vast majority of asymptomatic

14 olved in protection against recurrent ocular herpetic disease in therapeutically vaccinated animals a

15 luation in both primary and recurrent ocular herpetic disease models.

16 Fifty subjects without signs of ocular herpetic disease participated.

17 a history of numerous episodes of recurrent herpetic disease) and asymptomatic (ASYMP) individuals (

18 s (individuals who have never had a clinical herpetic disease) has not been elucidated.

19 infected but never experienced any recurrent herpetic disease).

20 ory of numerous episodes of recurrent ocular herpetic disease).

21 sitive for HSV-1 but never had any recurrent herpetic disease, while there were frequent less-differe

22 ches to reducing susceptibility to recurrent herpetic disease.

23 ent likely to reduce long-term scarring from herpetic disease.

24 ding in tears that trigger recurrent corneal herpetic disease.

25 to the clinical findings and the history of herpetic disease.

26 ersely, HIV-1 is associated with more-severe herpetic disease.

27 in both virus shedding and recurrent corneal herpetic disease.

28 SV-1 reactivation from latency and recurrent herpetic disease.

29 c potential to reduce or eliminate recurrent herpetic disease.

30 cause potentially blinding recurrent corneal herpetic disease.

31 uals (individuals who have frequent clinical herpetic diseases) using determination of a combination

32 hosphonoformic acid, a specific inhibitor of herpetic DNA polymerase.

33 action of the acyclic alpha-CNPs against the herpetic DNA polymerases differs from the nature of the

34 ft of approximately 100-fold in favor of the herpetic DNA polymerases when compared to selectivity fo

35 to 100-fold) inhibits HIV-1 RT compared with herpetic DNA polymerases.

36 Acyclovir (ACV), a highly specific anti-herpetic drug, acts as a DNA chain terminator for severa

37 ster prodrug of acyclovir, an effective anti-herpetic drug.

38 f new safe and effective broad spectrum anti-herpetic drugs that fill an unmet need.

39 , heightened susceptibility of muK/O mice to herpetic encephalitis as well as to herpetic stromal ker

40 The morbidity from recurrent herpetic episodes is high, and the resultant corneal sca

41 ate for improving antiviral efficacy against herpetic epithelial and stromal keratitis.

42 rus (HSV) from neuron to epithelial cells in herpetic epithelial keratitis.

43 Herpetic eye disease (due to herpes simplex and herpes z

44 results could help support the diagnosis of herpetic eye disease in these patients.

45 RELEVANCE The association between atopy and herpetic eye disease may be explained by various factors

46 The Herpetic Eye Disease Study (HEDS) I showed a significant

47 Between 1993 and 1997, the Herpetic Eye Disease Study (HEDS) randomized 703 partici

48 episodes of HSV have been verified by early Herpetic Eye Disease Study (HEDS) trials.

49 ata from 308 participants in the multicenter Herpetic Eye Disease Study between 1992 and 1998 (48% fe

50 an HSCT patient who suffered from recurrent herpetic gingivostomatitis and was treated alternatively

51 rt an important role in host defense against herpetic infection for several polymorphic genes implica

52 stem contributes to protection during ocular herpetic infection.

53 not seem to influence the clinical course of herpetic infection.

54 V-2 in patients presenting for evaluation of herpetic infections.

55 is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geog

56 L-null mice showed significantly more severe herpetic keratitis (PI day 8, SLE score, mean +/- SEM: 3

57 ere examined daily for 49 days for recurrent herpetic keratitis and for recurrent infectious HSV-1 sh

58 ased number of eyes exhibited recurrences of herpetic keratitis compared with recurrences in adjuvant

59 Herpetic keratitis developed in all rabbits.

60 Liu et al. confirm prior literature that herpetic keratitis has higher recurrence rate in childre

61 latently infected rabbits with a history of herpetic keratitis to determine whether the viral DNA re

62 which the Boston KPro has been used include herpetic keratitis, aniridia, autoimmune ocular disorder

63 ror, corneal ectatic disorders, a history of herpetic keratitis, Avellino corneal dystrophy, signific

64 th regards to the way in which they manifest herpetic keratitis, making rapid diagnosis and treatment

65 neurotrophic keratitis, exposure keratitis, herpetic keratitis, ocular motor cranial neuropathies, a

66 To evaluate the severity of herpetic keratitis, slit lamp examinations (SLE) were pe

67 al presentation, diagnosis, and treatment of herpetic keratitis, with specific attention to pediatric

68 une responses, including graft rejection and herpetic keratitis.

69 in the eye including allograft rejection and herpetic keratitis.

70 as of patients and animals with a history of herpetic keratitis.

71 ely due to the initial misdiagnosis of AK as herpetic keratitis.

72 is, an essential step in the pathogenesis of herpetic keratitis.

73 :0.16-0.32, p<0.001) but not the presence of herpetic lesions (beta = -0.10, 95%CI:-0.28-0.08, p = 0.

74 SV-2 seronegative women to 94% in women with herpetic lesions (geometric means 1634 vs 3339 copies/ml

75 Although virus strains isolated from herpetic lesions cause limited cell fusion in cell cultu

76 t also reduced the frequency and severity of herpetic lesions following intravaginal HSV challenge.

77 unodeficiency virus (HIV) infection, genital herpetic lesions may be extensive and tend to persist fo

78 ment the role of DCs in vitro and perhaps in herpetic lesions or draining lymph nodes.

79 imited cell fusion in cell culture, clinical herpetic lesions typically contain large syncytia, under

80 wise healthy African elephants with external herpetic lesions yielded herpesvirus sequences identical

81 ngal nail infection, fungal dermatitis, oral herpetic lesions, and bronchiolitis obliterans organizin

82 NK cells infiltrate human herpetic lesions, but their role has been underexplored.

83 V shedding with HIV plasma viral load (PVL), herpetic lesions, HSV shedding and other factors were ex

84 oxic responses were present at all stages of herpetic lesions, including biopsies early in the diseas

85 ted in early onset and delayed resolution of herpetic lesions, reduced viral clearance at the site of

86 .73 of HSV DNA are frequently recovered from herpetic lesions.

87 contributing to acquisition of HIV-1 through herpetic lesions.

88 rminants of genital HIV than the presence of herpetic lesions.

89 in the dermal infiltrate of human recurrent herpetic lesions.

90 0 clinic visits who were never observed with herpetic lesions; (4) 18 HSV-2 seronegative women at 45

91 ercent) subsequently reported having typical herpetic lesions; the duration of their recurrences in t

92 keratoconus in its final stages, 3 had post-herpetic leukoma, and 5 had corneal scars.

93 Post-herpetic neuralgia (PHN) is the most significant complic

94 n and has serious consequences, notably post-herpetic neuralgia (PHN).

95 mechanisms involved in the genesis of acute herpetic neuralgia and open new avenues for its control.

96 he pathophysiological mechanisms involved in herpetic neuralgia are not totally elucidated.

97 TNF, via TNFR1, mediates herpetic neuralgia development through downregulation of

98 for its control.SIGNIFICANCE STATEMENT Acute herpetic neuralgia is the most important symptom of herp

99 Herpetic neuralgia is the most important symptom of herp

100 to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the cen

101 F, which in turn mediates the development of herpetic neuralgia through downregulation of the inwardl

102 sory ganglia that account for the genesis of herpetic neuralgia using a murine model of Herpes Simple

103 9, 23); CNS infections, 12 (CI: 5, 13); post-herpetic neuralgia, 11 (CI: 6, 17); and major neurologic

104 in clinical trials for the treatment of post-herpetic neuralgia, diabetic peripheral neuropathy, gene

105 cted DRGs and account for the development of herpetic neuralgia.

106 ia that account for the development of acute herpetic neuralgia.

107 nglia play a critical role in the genesis of herpetic neuralgia.

108 zed mice, and were completely protected from herpetic ocular disease following corneal challenge with

109 is represents a useful adjunct to therapy of herpetic ocular disease, an important cause of human bli

110 mechanisms involved in the genesis of acute herpetic pain and open new avenues for its control.SIGNI

111 ty was consistently affected in both eyes of herpetic patients.

112 r experimental ultraviolet radiation-induced herpetic recurrences.

113 uced reactivation in the rabbit eye model of herpetic recurrent disease.

114 se patients with newly diagnosed or incident herpetic retinitis and choroiditis (rates = 21.7 deaths/

115 Eyes with newly diagnosed herpetic retinitis appeared to have a poor visual progno

116 5% confidence intervals [CI]) of these were: herpetic retinitis, 0.007/100 person-years (PY) (95% CI

117 In the murine model of herpetic retinitis, the same methods were used to compar

118 stic infections were diagnosed: 16 patients, herpetic retinitis; 11 patients, toxoplasmic retinitis;

119 Unilaterality was also more common in herpetic scleritis (80%) than in idiopathic disease (56.

120 We present the observed clinical features of herpetic scleritis and describe the clinical differences

121 Most patients with herpetic scleritis presented with acute (85.7%) and unil

122 itis was more commonly seen in patients with herpetic scleritis versus patients with idiopathic disea

123 We found that herpetic skin lesions consistently demonstrated oligoclo

124 7-fold reduction on the incidence of primary herpetic skin lesions in immunized animals.

125 Herpetic stromal keratitis (HSK) is a CD4+ T cell-contro

126 Herpetic stromal keratitis (HSK) is an important vision-

127 Herpetic stromal keratitis (HSK) is an inflammatory dise

128 Herpetic stromal keratitis (HSK) is characterized by an

129 An immunoinflammatory blinding lesion called herpetic stromal keratitis (HSK) that follows ocular inf

130 mice to herpetic encephalitis as well as to herpetic stromal keratitis (HSK) was observed.

131 n immunopathologic disease of the eye termed herpetic stromal keratitis (HSK), in which the principal

132 Herpetic stromal keratitis (HSK), resulting from corneal

133 blinding immunoinflammatory lesion known as herpetic stromal keratitis (HSK).

134 ment of an immunopathological lesion, termed herpetic stromal keratitis (HSK).

135 valuated in a mouse model of human recurrent herpetic stromal keratitis (HSK).

136 induces an immunopathologic response termed herpetic stromal keratitis (HSK).

137 c inflammatory response in the stroma termed herpetic stromal keratitis (HSK).

138 arked reduction in the development of severe herpetic stromal keratitis (HSK).

139 tors in the cornea during the development of herpetic stromal keratitis as a means to alleviate furth

140 to determine whether established lesions of herpetic stromal keratitis could be controlled by topica

141 atitis and also indicate that the therapy of herpetic stromal keratitis could benefit by procedures t

142 We could show in three separate models of herpetic stromal keratitis that adoptive transfers of in

143 HSV-1 infections may lead to herpetic stromal keratitis that may advance to corneal b

144 -induced angiogenesis in the pathogenesis of herpetic stromal keratitis were experiments showing that

145 gies from HSV include the blindness-inducing herpetic stromal keratitis, highly debilitating and leth

146 This immunopathologic disease, called herpetic stromal keratitis, is an important cause of imp

147 epresent a vital step in the pathogenesis of herpetic stromal keratitis, these results indicate that

148 ition should prove useful for the therapy of herpetic stromal keratitis.

149 unoinflammatory lesion of the cornea, termed herpetic stromal keratitis.

150 Vision loss was significantly greater in herpetic than idiopathic scleritis (34.3% vs 11.5%; P<0.

151 among HIV-1-seropositive participants with a herpetic ulcer.

152 were 295 HIV-1-positive participants with a herpetic ulcer.

153 ave long been recognized as being present in herpetic ulcerations, their role in subclinical reactiva

154 is commonly detected in the affected eyes of herpetic uveitis patients, suggesting the role of cross-