ライフサイエンスコーパス: heterochronic

1 variation in tomato (Lycopersicon spp.) via heterochronic allelic variation of fw2.2 expression, rat

2 The changes in timing of gene expression (heterochronic allelic variation), combined with overall

3 additive expression in the hybrid endosperm: heterochronic allelic variation, allelic variation in th

4 ompared, developmental analysis reveals that heterochronic alterations (changes in the relative timin

5 Here we show that heterochronic and heterotopic changes early in limb deve

6 Here we show that heterochronic blood exchange between young and old mice

7 hat, compared with heterochronic parabiosis, heterochronic blood exchange in small animals is less in

8 theories such as psychosocial acceleration, heterochronic brain development, dual-process models, gl

9 uence deletions resulted in a novel class of heterochronic C-function mutants with delayed onset of P

10 Heterochronic cell transplantations demonstrated that Va

11 We report that the heterochronic change in msp130 expression is regulated a

12 Our data indicate that this heterochronic change, an altered timing of developmental

13 hape are the most common focus in studies of heterochronic change.

14 Such heterochronic changes arguably permit great evolutionary

15 providing a mechanism for how species-level heterochronic changes can occur in nature.

16 The goal of this work is to describe heterochronic changes in brain evolution within its basi

17 g trunks of snakes are likely to result from heterochronic changes in Oct4 activity during body axis

18 Heterochronic co-cultures containing older cortex demons

19 A heterochronic coculture system was used to demonstrate t

20 n early stage of embryogenesis, we have used heterochronic cocultures to investigate whether noradren

21 Using heterochronic cocultures, we have found that striated mu

22 Heterochronic cultures indicate that it is the age of th

23 In P6-P12 heterochronic cultures, the P12 axons failed to cross th

24 matergic events in both purely embryonic and heterochronic cultures.

25 both mutants lacked ta-siRNAs and displayed heterochronic defects in which vegetative phase change w

26 er met1-1 allele caused late flowering and a heterochronic delay in the juvenile-to-adult rosette lea

27 ecifically, the Lep phenotype results from a heterochronic delay in the retraction and fusion of the

28 We show that mutations of genes in the heterochronic developmental timing pathway, including li

29 t permits the combination of heterotypic and heterochronic epithelial and mesenchymal cells.

30 n this study, we find that expression of the heterochronic factor Lin28b decreases in common myeloid

31 mong these are four new alleles of lin-42, a heterochronic gene for which a single allele had been de

32 c development of Caenorhabditis elegans, the heterochronic gene lin-14 controls the timing of develop

33 The Caenorhabditis elegans heterochronic gene lin-14 generates a temporal gradient

34 The Caenorhabditis elegans heterochronic gene lin-14 specifies the temporal sequenc

35 l of zig gene expression is conferred by the heterochronic gene lin-14, a nuclear factor previously i

36 We show that the heterochronic gene lin-14, which controls the timing of

37 by the 22-nt RNA lin-4 and positively by the heterochronic gene lin-14.

38 bles seven such elements in the 3'UTR of the heterochronic gene lin-14.

39 ted the mammalian homologs of the C. elegans heterochronic gene lin-28 in regulating cellular differe

40 The heterochronic gene lin-28 is a regulator of developmenta

41 Mutations in the heterochronic gene lin-28 of C. elegans cause precocious

42 The heterochronic gene lin-28 of the nematode Caenorhabditis

43 Vulva formation requires the heterochronic gene lin-29, which triggers hypodermal cel

44 Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of

45 Inactivation of the heterochronic gene lin-42 causes hypodermal terminal dif

46 The heterochronic gene lin-42 is the C. elegans homolog of D

47 We find that inactivation of the heterochronic gene lin-42a, which is related to the core

48 lin-28, affecting both the regulation of the heterochronic gene pathway and execution of stage-specif

49 The C. elegans heterochronic gene pathway consists of a cascade of regu

50 ntified lin-57 as a member of the C. elegans heterochronic gene pathway, which ensures that postembry

51 col-19 promoter, a downstream target of the heterochronic gene pathway.

52 type animals and temporally regulated by the heterochronic gene pathway.

53 ntiation and thus define a new member of the heterochronic gene pathway.

54 nd mammals, is another core component of the heterochronic gene pathway.

55 rance in the hypodermis is controlled by the heterochronic gene pathway: LIN-29 accumulates in the hy

56 A network of heterochronic gene products including Lin28a, let-7, IMP

57 We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans.

58 We identified a new heterochronic gene, lin-46, from mutations that suppress

59 Here, we identify a new heterochronic gene, mab-10, and show that mab-10 encodes

60 Here, we describe dre-1, a heterochronic gene, whose mutant phenotypes include prec

61 n vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G

62 ogen resistance by let-7 involves downstream heterochronic genes and the p38 MAPK pathway.

63 Mutations in heterochronic genes cause temporal transformations in ce

64 In Caenorhabditis elegans, heterochronic genes constitute a developmental timer tha

65 C. elegans heterochronic genes constitute a regulatory cascade that

66 The Caenorhabditis elegans heterochronic genes control the relative timing and sequ

67 Heterochronic genes control the relative timing of event

68 Heterochronic genes control the timing of vulval develop

69 In the roundworm Caenorhabditis elegans, the heterochronic genes encode components of a molecular dev

70 rhabditis elegans, a well-defined pathway of heterochronic genes ensures the proper timing of stage-s

71 Characterization of the heterochronic genes has provided a strong foundation for

72 Investigation of the heterochronic genes has revealed a mechanism composed of

73 Our observations reveal a role of heterochronic genes in non-dividing cells, and provide a

74 e nervous system and, furthermore, implicate heterochronic genes in postmitotic neural patterning eve

75 accumulation is dependent upon the upstream heterochronic genes in some, but not all, of these non-h

76 ocious phenotypes caused by mutations in the heterochronic genes lin-14 and lin-28.

77 ements in the 3' untranslated regions of the heterochronic genes lin-14, lin-28, lin-41, lin-42 and d

78 f the L2-to-L3 transition in parallel to the heterochronic genes lin-28 and lin-46.

79 The heterochronic genes lin-28, let-7 and lin-41 regulate fu

80 The heterochronic genes lin-4, lin-14, lin-28, and lin-29 sp

81 s that human homologs of multiple C. elegans heterochronic genes might act in an evolutionarily conse

82 Homologs of certain heterochronic genes of vertebrates show temporally regul

83 The C. elegans heterochronic genes program stage-specific temporal iden

84 We propose daf-12 and other heterochronic genes provide cellular memories of chronol

85 We speculate that these heterochronic genes regulate let-7 expression through it

86 Heterochronic genes that involve hormonal signaling have

87 of let-7 microRNAs, evolutionarily conserved heterochronic genes that reduce HMGA2 expression.

88 , we propose that Mkrns, together with other heterochronic genes, constitute an evolutionarily ancien

89 th let-7 family microRNAs and let-7-targeted heterochronic genes, hbl-1, lin-41 and lin-42.

90 cell fate determination is controlled by the heterochronic genes, including let-7 microRNAs.

91 s elegans is regulated by a set of so-called heterochronic genes, including lin-28 that specifies sec

92 The heterochronic genes, including the microRNA lin-4 and it

93 long-term self-renewal of ES cells including heterochronic genes, microRNAs, genes involved in telome

94 ecific developmental events is controlled by heterochronic genes, which include those encoding a set

95 of developmental events is controlled by the heterochronic genes, whose products include microRNAs (m

96 s in the C. elegans larva is governed by the heterochronic genes.

97 through repressing the expression of certain heterochronic genes.

98 onad morphogenesis is unique among the known heterochronic genes: inactivation of lin-42 causes the e

99 vision patterns is shared by the majority of heterochronic genes; their mutation temporally alters st

100 screen and shown that it functions with the heterochronic genetic pathway that regulates development

101 of the flank after primordium migration and heterochronic grafting experiments suggest that extracel

102 ecification of these two populations using a heterochronic grafting strategy, in ovo.

103 tail bud mesoderm are disadvantaged in such heterochronic grafts from incorporating into the axis an

104 ests an important level of regulation in the heterochronic hierarchy.

105 rythroid tissues a downstream element of the heterochronic let-7 miRNA pathway, the insulin-like grow

106 lation of the GCP gene is independent of the heterochronic lin-14 control mechanism of postembryonic

107 e GCP at both mRNA and protein levels in the heterochronic lin-4 (lf) and lin-14 (gf) mutants compare

108 The Caenorhabditis elegans heterochronic loci are global regulators of larval tempo

109 Genetic interactions with other heterochronic loci place dre-1 in the larval-to-adult sw

110 c A. talpoideum populations with theories of heterochronic mechanisms and life history evolution, we

111 ycle exit, indicating that its function as a heterochronic microRNA is conserved.

112 Expression of the heterochronic microRNA let-7 is tightly correlated with

113 which is due to the targeting of Imp by the heterochronic microRNA let-7.

114 demonstrate that lin-42 negatively regulates heterochronic miRNA transcription.

115 Thus, these heterochronic miRNAs, originally identified in C. elegan

116 In contrast, heterochronic misexpression of Toll in the musculature l

117 re, using complementary in vivo and in vitro heterochronic models, we show that age-associated change

118 itive, ABA-hypersensitive, ABA-deficient, or heterochronic mutants indicates that ABI4 expression is

119 type of let-7 mutants similar to other known heterochronic mutants.

120 Genetic analyses of heterochronic mutations in the nematode Caenorhabditis e

121 Surprisingly, heterochronic mutations that enhance LIT-1 activity in s

122 which correlate with reduced neurogenesis in heterochronic parabionts and aged mice, and the levels o

123 Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems o

124 ithin the hippocampus of aged mice and young heterochronic parabionts.

125 asticity improved in the hippocampus of aged heterochronic parabionts.

126 culatory system) between young and old mice (heterochronic parabioses), exposing old mice to factors

127 The negative effects of B2M and heterochronic parabiosis are, in part, mitigated in the

128 Studies of heterochronic parabiosis demonstrated that with age, the

129 Furthermore, heterochronic parabiosis increased aged hepatocyte proli

130 levels, which normally decline with age, by heterochronic parabiosis or systemic delivery of recombi

131 Heterochronic parabiosis rejuvenates the performance of

132 Notably, heterochronic parabiosis restored the activation of Notc

133 how that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repa

134 Here, using heterochronic parabiosis we show that blood-borne factor

135 d the influence of circulating factors using heterochronic parabiosis, a surgical technique in which

136 We conclude that, compared with heterochronic parabiosis, heterochronic blood exchange i

137 Experiments using heterochronic parabiosis, in which the circulatory syste

138 pression of p16/INK4A mRNA did not change in heterochronic parabiosis, suggesting the involvement of

139 Using heterochronic parabiosis, we observe that young circulat

140 xposed to a youthful systemic milieu through heterochronic parabiosis.

141 w days, and leads to different outcomes than heterochronic parabiosis.

142 ic factors in old regenerating muscle of the heterochronic parabiotic partners.

143 Treating these heterochronic parameters as phenotypes, a univariate map

144 ) in terms of their role in influencing four heterochronic parameters: the timing of the inflection p

145 e molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes

146 In Caenorhabditis elegans, the heterochronic pathway controls the timing of development

147 wn temporal regulator in Drosophila with the heterochronic pathway defined in C. elegans.

148 on between steroid hormone signaling and the heterochronic pathway in insects.

149 Like lin-28 and other heterochronic pathway members, vertebrate Mkrns are invo

150 hythm proteins, functions as a member of the heterochronic pathway, regulating temporal cell identiti

151 Consistent with its role in the heterochronic pathway, we find that lin-41 governs the t

152 is regulated by the evolutionarily conserved heterochronic pathway, whereas cell division asymmetry i

153 adult fates through the let-7 branch of the heterochronic pathway.

154 daf-12 between lin-14 and lin-28 within the heterochronic pathway.

155 rst identified in the Caenorhabditis elegans heterochronic pathway.

156 ing, upstream of or in parallel to the let-7 heterochronic pathway.

157 e E75A mutant second instar larvae display a heterochronic phenotype in which they induce genes speci

158 This heterochronic phenotype indicates that miRNAs are key re

159 mutations in puf-9 enhance the lethality and heterochronic phenotypes caused by mutations in the let-

160 et-7 microRNA (miRNA), while suppressing the heterochronic phenotypes of lin-41, a let-7 target and h

161 o homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 muta

162 let-7 mutations cause similar reiterated heterochronic phenotypes that are suppressed by lin-41 m

163 and ring finger RBX homologs yielded similar heterochronic phenotypes.

164 l and palaeontological data to show that the heterochronic process of paedomorphosis, by which descen

165 ll populations, by performing isochronic and heterochronic quail-to-chick grafts.

166 ypes, a univariate mapping model detected 19 heterochronic quantitative trait loci (hQTLs), of which

167 Here we show that overexpression of the heterochronic regulator Lin28 during kidney development

168 were discovered in Caenorhabditis elegans as heterochronic regulators of larval and vulval developmen

169 TRA-1 binds to sites adjacent to a number of heterochronic regulatory genes, some of which drive male

170 cells, which are programmed by genes in the heterochronic regulatory network.

171 standing whether microRNAs and the resulting heterochronic regulatory pathway have the potential to a

172 As triggers transitions in the complement of heterochronic regulatory proteins to coordinate developm

173 terotopic (relative changes in position) and heterochronic (relative changes in timing) shifts in gen

174 This heterochronic role of let-7 is likely just one of the wa

175 ult aligns with evidence for a developmental heterochronic shift in human prefrontal growth [7, 8], s

176 Additionally, a heterochronic shift in Oct4 expression may underlie the

177 This novel heterochronic shift in the development of axillary meris

178 the lack of JH and its receptor Met causes a heterochronic shift in the development of the visual sys

179 ssion of apical dominance, homeotic changes, heterochronic shift toward juvenility, flower defects, a

180 n inflorescence architecture is modulated by heterochronic shifts in the acquisition of floral fate.

181 uring the reproductive transition, driven by heterochronic shifts of dynamic genes, including transcr

182 nce, including numerous evolutionary losses, heterochronic shifts, and expansions or contractions of

183 Heterochronic studies revealed that the loss of repellan

184 we highlight the RBP Lin28B, which acts as a heterochronic switch between fetal and adult lymphopoies

185 In Arabidopsis, we can induce a heterochronic switch from flower to shoot development, a

186 Here we show that let-7 is a heterochronic switch gene.

187 , noncoding regulatory RNAs that function as heterochronic switch genes in the nematode C. elegans.

188 In a heterochronic transplantation setting, we further show t

189 of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gast

190 Heterochronic transplantations demonstrated that the not

191 Such heterochronic variation has been noted across phylogeny,