ライフサイエンスコーパス: heterochronic

1 etic lineage tracing with sequential injury, heterochronic adoptive transfer, and parabiosis, we foun

2 variation in tomato (Lycopersicon spp.) via heterochronic allelic variation of fw2.2 expression, rat

3 The changes in timing of gene expression (heterochronic allelic variation), combined with overall

4 additive expression in the hybrid endosperm: heterochronic allelic variation, allelic variation in th

5 ompared, developmental analysis reveals that heterochronic alterations (changes in the relative timin

6 Here we show that heterochronic and heterotopic changes early in limb deve

7 Second, we observe heterochronic and heterotopic shifts in ossification tha

8 reased across most regions, PCr changes were heterochronic and regional: hippocampal increases were m

9 Here we show that heterochronic blood exchange between young and old mice

10 hat, compared with heterochronic parabiosis, heterochronic blood exchange in small animals is less in

11 theories such as psychosocial acceleration, heterochronic brain development, dual-process models, gl

12 uence deletions resulted in a novel class of heterochronic C-function mutants with delayed onset of P

13 Heterochronic cell transplantations demonstrated that Va

14 We report that the heterochronic change in msp130 expression is regulated a

15 Our data indicate that this heterochronic change, an altered timing of developmental

16 hape are the most common focus in studies of heterochronic change.

17 Such heterochronic changes arguably permit great evolutionary

18 providing a mechanism for how species-level heterochronic changes can occur in nature.

19 The goal of this work is to describe heterochronic changes in brain evolution within its basi

20 onobos both in vitro and in vivo, suggesting heterochronic changes in human neurons.

21 g trunks of snakes are likely to result from heterochronic changes in Oct4 activity during body axis

22 patterns of evolutionary integration due to heterochronic changes under ratchet-like evolution.

23 Heterochronic co-cultures containing older cortex demons

24 of the functional impact of stromal aging in heterochronic co-implantation models revealed that revit

25 A heterochronic coculture system was used to demonstrate t

26 n early stage of embryogenesis, we have used heterochronic cocultures to investigate whether noradren

27 Using heterochronic cocultures, we have found that striated mu

28 Heterochronic cultures indicate that it is the age of th

29 In P6-P12 heterochronic cultures, the P12 axons failed to cross th

30 matergic events in both purely embryonic and heterochronic cultures.

31 both mutants lacked ta-siRNAs and displayed heterochronic defects in which vegetative phase change w

32 er met1-1 allele caused late flowering and a heterochronic delay in the juvenile-to-adult rosette lea

33 ecifically, the Lep phenotype results from a heterochronic delay in the retraction and fusion of the

34 rt that diapause-inducing pheromones correct heterochronic developmental cell lineage defects caused

35 We show that mutations of genes in the heterochronic developmental timing pathway, including li

36 ify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway.

37 Our findings identify heterochronic dynamics of a gene network that, while est

38 Thus, heterochronic enhancer elements, and their associated tr

39 t permits the combination of heterotypic and heterochronic epithelial and mesenchymal cells.

40 Through heterotypic and heterochronic epithelial-mesenchymal recombination exper

41 n this study, we find that expression of the heterochronic factor Lin28b decreases in common myeloid

42 deleted the spacer DNA to induce a potential heterochronic gain of function of Hoxb13 at physiologica

43 mong these are four new alleles of lin-42, a heterochronic gene for which a single allele had been de

44 We also show that the dre-1/F box heterochronic gene functions early in development to con

45 c development of Caenorhabditis elegans, the heterochronic gene lin-14 controls the timing of develop

46 The Caenorhabditis elegans heterochronic gene lin-14 generates a temporal gradient

47 The Caenorhabditis elegans heterochronic gene lin-14 specifies the temporal sequenc

48 l of zig gene expression is conferred by the heterochronic gene lin-14, a nuclear factor previously i

49 We show that the heterochronic gene lin-14, which controls the timing of

50 by the 22-nt RNA lin-4 and positively by the heterochronic gene lin-14.

51 bles seven such elements in the 3'UTR of the heterochronic gene lin-14.

52 ted the mammalian homologs of the C. elegans heterochronic gene lin-28 in regulating cellular differe

53 The heterochronic gene lin-28 is a regulator of developmenta

54 Mutations in the heterochronic gene lin-28 of C. elegans cause precocious

55 The heterochronic gene lin-28 of the nematode Caenorhabditis

56 Vulva formation requires the heterochronic gene lin-29, which triggers hypodermal cel

57 Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of

58 Inactivation of the heterochronic gene lin-42 causes hypodermal terminal dif

59 The heterochronic gene lin-42 is the C. elegans homolog of D

60 We find that inactivation of the heterochronic gene lin-42a, which is related to the core

61 lin-28, affecting both the regulation of the heterochronic gene pathway and execution of stage-specif

62 The C. elegans heterochronic gene pathway consists of a cascade of regu

63 ntified lin-57 as a member of the C. elegans heterochronic gene pathway, which ensures that postembry

64 col-19 promoter, a downstream target of the heterochronic gene pathway.

65 type animals and temporally regulated by the heterochronic gene pathway.

66 ntiation and thus define a new member of the heterochronic gene pathway.

67 nd mammals, is another core component of the heterochronic gene pathway.

68 rance in the hypodermis is controlled by the heterochronic gene pathway: LIN-29 accumulates in the hy

69 A network of heterochronic gene products including Lin28a, let-7, IMP

70 edback loop unites the molting timer and the heterochronic gene regulatory network, possibly by funct

71 We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans.

72 We identified a new heterochronic gene, lin-46, from mutations that suppress

73 Here, we identify a new heterochronic gene, mab-10, and show that mab-10 encodes

74 Here, we describe dre-1, a heterochronic gene, whose mutant phenotypes include prec

75 n vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G

76 ogen resistance by let-7 involves downstream heterochronic genes and the p38 MAPK pathway.

77 We propose that heterochronic genes are components in the UNC-6/Netrin p

78 This screen identified heterochronic genes as major regulators of DA neuron pre

79 Mutations in heterochronic genes cause temporal transformations in ce

80 In Caenorhabditis elegans, heterochronic genes constitute a developmental timer tha

81 C. elegans heterochronic genes constitute a regulatory cascade that

82 The Caenorhabditis elegans heterochronic genes control the relative timing and sequ

83 Heterochronic genes control the relative timing of event

84 Heterochronic genes control the timing of vulval develop

85 C. elegans heterochronic genes determine the timing of expression o

86 In the roundworm Caenorhabditis elegans, the heterochronic genes encode components of a molecular dev

87 rhabditis elegans, a well-defined pathway of heterochronic genes ensures the proper timing of stage-s

88 Characterization of the heterochronic genes has provided a strong foundation for

89 Investigation of the heterochronic genes has revealed a mechanism composed of

90 Our observations reveal a role of heterochronic genes in non-dividing cells, and provide a

91 e nervous system and, furthermore, implicate heterochronic genes in postmitotic neural patterning eve

92 These findings highlight the role of heterochronic genes in postmitotic neuronal patterning e

93 accumulation is dependent upon the upstream heterochronic genes in some, but not all, of these non-h

94 ocious phenotypes caused by mutations in the heterochronic genes lin-14 and lin-28.

95 ements in the 3' untranslated regions of the heterochronic genes lin-14, lin-28, lin-41, lin-42 and d

96 f the L2-to-L3 transition in parallel to the heterochronic genes lin-28 and lin-46.

97 The heterochronic genes lin-28, let-7 and lin-41 regulate fu

98 The heterochronic genes lin-4, lin-14, lin-28, and lin-29 sp

99 While the heterochronic genes lin28 and let-7 are well-established

100 The heterochronic genes Lin28a/b and let-7 regulate inverteb

101 s that human homologs of multiple C. elegans heterochronic genes might act in an evolutionarily conse

102 Homologs of certain heterochronic genes of vertebrates show temporally regul

103 The C. elegans heterochronic genes program stage-specific temporal iden

104 We propose daf-12 and other heterochronic genes provide cellular memories of chronol

105 We speculate that these heterochronic genes regulate let-7 expression through it

106 Heterochronic genes that involve hormonal signaling have

107 of let-7 microRNAs, evolutionarily conserved heterochronic genes that reduce HMGA2 expression.

108 , we propose that Mkrns, together with other heterochronic genes, constitute an evolutionarily ancien

109 th let-7 family microRNAs and let-7-targeted heterochronic genes, hbl-1, lin-41 and lin-42.

110 cell fate determination is controlled by the heterochronic genes, including let-7 microRNAs.

111 s elegans is regulated by a set of so-called heterochronic genes, including lin-28 that specifies sec

112 The heterochronic genes, including the microRNA lin-4 and it

113 This rewiring includes engagement of certain heterochronic genes, lin-46, lin-4, and nhl-2, that are

114 long-term self-renewal of ES cells including heterochronic genes, microRNAs, genes involved in telome

115 ecific developmental events is controlled by heterochronic genes, which include those encoding a set

116 of developmental events is controlled by the heterochronic genes, whose products include microRNAs (m

117 s in the C. elegans larva is governed by the heterochronic genes.

118 through repressing the expression of certain heterochronic genes.

119 onad morphogenesis is unique among the known heterochronic genes: inactivation of lin-42 causes the e

120 vision patterns is shared by the majority of heterochronic genes; their mutation temporally alters st

121 screen and shown that it functions with the heterochronic genetic pathway that regulates development

122 eviously undescribed cell state within which heterochronic grafted cells are stalled.

123 of the flank after primordium migration and heterochronic grafting experiments suggest that extracel

124 ecification of these two populations using a heterochronic grafting strategy, in ovo.

125 g varied sizes of tissue, we find that small heterochronic grafts disperse more readily and contribut

126 tail bud mesoderm are disadvantaged in such heterochronic grafts from incorporating into the axis an

127 Heterochronic grafts from older to younger embryos have

128 ormed single-cell transcriptomic analysis on heterochronic grafts of somite progenitors in the chicke

129 ests an important level of regulation in the heterochronic hierarchy.

130 sis, and resistant wall formation, which are heterochronic in some conjugate algae, became standardiz

131 rythroid tissues a downstream element of the heterochronic let-7 miRNA pathway, the insulin-like grow

132 lation of the GCP gene is independent of the heterochronic lin-14 control mechanism of postembryonic

133 e GCP at both mRNA and protein levels in the heterochronic lin-4 (lf) and lin-14 (gf) mutants compare

134 The Caenorhabditis elegans heterochronic loci are global regulators of larval tempo

135 Genetic interactions with other heterochronic loci place dre-1 in the larval-to-adult sw

136 c A. talpoideum populations with theories of heterochronic mechanisms and life history evolution, we

137 ycle exit, indicating that its function as a heterochronic microRNA is conserved.

138 Expression of the heterochronic microRNA let-7 is tightly correlated with

139 which is due to the targeting of Imp by the heterochronic microRNA let-7.

140 developmental upregulation of the conserved heterochronic microRNA LIN-4 and the subsequent promotio

141 ter stages, and that a mutation in the let-7 heterochronic miRNA gene causes dendritic misplacement o

142 demonstrate that lin-42 negatively regulates heterochronic miRNA transcription.

143 Thus, these heterochronic miRNAs, originally identified in C. elegan

144 In contrast, heterochronic misexpression of Toll in the musculature l

145 ost-constrained connectional homophily and a heterochronic model of ontogenetically phased cortical m

146 re, using complementary in vivo and in vitro heterochronic models, we show that age-associated change

147 itive, ABA-hypersensitive, ABA-deficient, or heterochronic mutants indicates that ABI4 expression is

148 In many heterochronic mutants, presynapses of this cholinergic m

149 type of let-7 mutants similar to other known heterochronic mutants.

150 Genetic analyses of heterochronic mutations in the nematode Caenorhabditis e

151 Surprisingly, heterochronic mutations that enhance LIT-1 activity in s

152 we provide a disease-relevant framework for heterochronic orientation of stem cell ontogeny along th

153 which correlate with reduced neurogenesis in heterochronic parabionts and aged mice, and the levels o

154 Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems o

155 ithin the hippocampus of aged mice and young heterochronic parabionts.

156 asticity improved in the hippocampus of aged heterochronic parabionts.

157 culatory system) between young and old mice (heterochronic parabioses), exposing old mice to factors

158 ged tissues/organs and their rejuvenation in heterochronic parabiosis (HP), a classical model to stud

159 The negative effects of B2M and heterochronic parabiosis are, in part, mitigated in the

160 Studies of heterochronic parabiosis demonstrated that with age, the

161 Heterochronic parabiosis has been used as a model to stu

162 Furthermore, heterochronic parabiosis increased aged hepatocyte proli

163 oped for aging research as an alternative to heterochronic parabiosis or plasma injections.

164 levels, which normally decline with age, by heterochronic parabiosis or systemic delivery of recombi

165 Exposure to a youthful circulation through heterochronic parabiosis or systemic reconstitution with

166 Heterochronic parabiosis rejuvenates the performance of

167 Notably, heterochronic parabiosis restored the activation of Notc

168 how that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repa

169 Here, using heterochronic parabiosis we show that blood-borne factor

170 d the influence of circulating factors using heterochronic parabiosis, a surgical technique in which

171 ystemic and lifestyle interventions, such as heterochronic parabiosis, administration of 'young blood

172 We conclude that, compared with heterochronic parabiosis, heterochronic blood exchange i

173 Experiments using heterochronic parabiosis, in which the circulatory syste

174 In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most promin

175 tabolic manipulation, partial reprogramming, heterochronic parabiosis, pharmaceutical administration

176 pression of p16/INK4A mRNA did not change in heterochronic parabiosis, suggesting the involvement of

177 Using heterochronic parabiosis, we observe that young circulat

178 pecific responses to young and aged blood in heterochronic parabiosis.

179 microglial aging that also emerge following heterochronic parabiosis.

180 espan and in the experimental aging model of heterochronic parabiosis.

181 muscle stem cells, Alzheimer's disease, and heterochronic parabiosis.

182 w days, and leads to different outcomes than heterochronic parabiosis.

183 xposed to a youthful systemic milieu through heterochronic parabiosis.

184 ic factors in old regenerating muscle of the heterochronic parabiotic partners.

185 Treating these heterochronic parameters as phenotypes, a univariate map

186 ) in terms of their role in influencing four heterochronic parameters: the timing of the inflection p

187 e molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes

188 e L4-to-adult molt, but ruled out a relevant heterochronic pathway as a cue for DTC elaboration.

189 In Caenorhabditis elegans, the heterochronic pathway controls a timely juvenile-to-adul

190 In Caenorhabditis elegans, the heterochronic pathway controls the timing of development

191 wn temporal regulator in Drosophila with the heterochronic pathway defined in C. elegans.

192 on between steroid hormone signaling and the heterochronic pathway in insects.

193 Like lin-28 and other heterochronic pathway members, vertebrate Mkrns are invo

194 e report that murine Hedgehog signaling is a heterochronic pathway that determines the timing of prog

195 re, we find that the lin-28-let-7 axis (the 'heterochronic pathway') determines the timing of these e

196 hythm proteins, functions as a member of the heterochronic pathway, regulating temporal cell identiti

197 rsectionally through the lin-28/let-7/lin-41 heterochronic pathway, sex chromosome configuration and

198 Consistent with its role in the heterochronic pathway, we find that lin-41 governs the t

199 is regulated by the evolutionarily conserved heterochronic pathway, whereas cell division asymmetry i

200 ing, upstream of or in parallel to the let-7 heterochronic pathway.

201 adult fates through the let-7 branch of the heterochronic pathway.

202 daf-12 between lin-14 and lin-28 within the heterochronic pathway.

203 and downstream transcription factors in the heterochronic pathway.

204 ing a broad role for Hedgehog signaling as a heterochronic pathway.

205 rst identified in the Caenorhabditis elegans heterochronic pathway.

206 ductive development and a pervasive role for heterochronic pathways in shaping C. hirsuta natural var

207 e E75A mutant second instar larvae display a heterochronic phenotype in which they induce genes speci

208 This heterochronic phenotype indicates that miRNAs are key re

209 mutations in puf-9 enhance the lethality and heterochronic phenotypes caused by mutations in the let-

210 et-7 microRNA (miRNA), while suppressing the heterochronic phenotypes of lin-41, a let-7 target and h

211 o homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 muta

212 let-7 mutations cause similar reiterated heterochronic phenotypes that are suppressed by lin-41 m

213 and ring finger RBX homologs yielded similar heterochronic phenotypes.

214 l and palaeontological data to show that the heterochronic process of paedomorphosis, by which descen

215 ly emerged as a non-functional by-product of heterochronic processes driven by selection towards larg

216 ll populations, by performing isochronic and heterochronic quail-to-chick grafts.

217 ypes, a univariate mapping model detected 19 heterochronic quantitative trait loci (hQTLs), of which

218 n be further explored through heterotopic or heterochronic recombination.

219 Here we show that overexpression of the heterochronic regulator Lin28 during kidney development

220 Here, we show that loss of lin-28, a central heterochronic regulator of hypodermal development, cause

221 were discovered in Caenorhabditis elegans as heterochronic regulators of larval and vulval developmen

222 TRA-1 binds to sites adjacent to a number of heterochronic regulatory genes, some of which drive male

223 cells, which are programmed by genes in the heterochronic regulatory network.

224 standing whether microRNAs and the resulting heterochronic regulatory pathway have the potential to a

225 As triggers transitions in the complement of heterochronic regulatory proteins to coordinate developm

226 terotopic (relative changes in position) and heterochronic (relative changes in timing) shifts in gen

227 This heterochronic role of let-7 is likely just one of the wa

228 ult aligns with evidence for a developmental heterochronic shift in human prefrontal growth [7, 8], s

229 Additionally, a heterochronic shift in Oct4 expression may underlie the

230 This major heterochronic shift in the anteroposterior developmental

231 This novel heterochronic shift in the development of axillary meris

232 the lack of JH and its receptor Met causes a heterochronic shift in the development of the visual sys

233 ssion of apical dominance, homeotic changes, heterochronic shift toward juvenility, flower defects, a

234 importance of both novel gene expression and heterochronic shifts in developmental evolution, as well

235 n inflorescence architecture is modulated by heterochronic shifts in the acquisition of floral fate.

236 in holometabolan insects can be explained by heterochronic shifts in timing factor expression plus ex

237 uring the reproductive transition, driven by heterochronic shifts of dynamic genes, including transcr

238 nce, including numerous evolutionary losses, heterochronic shifts, and expansions or contractions of

239 g the dinosaur-bird transition; however, the heterochronic signal is not uniform across time and neur

240 fied a quantitative trait locus (QTL) in the heterochronic SPL9 transcription factor as a determinant

241 Heterochronic studies revealed that the loss of repellan

242 we highlight the RBP Lin28B, which acts as a heterochronic switch between fetal and adult lymphopoies

243 In Arabidopsis, we can induce a heterochronic switch from flower to shoot development, a

244 Here we show that let-7 is a heterochronic switch gene.

245 , noncoding regulatory RNAs that function as heterochronic switch genes in the nematode C. elegans.

246 Paedomorphosis is a heterochronic syndrome in which adult individuals displa

247 iches after parabiont separation, nor direct heterochronic transplantation had any observable rejuven

248 and parvalbumin-expressing interneurons upon heterochronic transplantation in the postnatal mouse cor

249 their respective neuronal progeny following heterochronic transplantation into younger embryos.

250 Heterochronic transplantation of GABAergic interneuron p

251 Here, we used heterochronic transplantation of leukemia driven by MLL/

252 In a heterochronic transplantation setting, we further show t

253 of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gast

254 Heterochronic transplantations demonstrated that the not

255 nnosaurini probably evolved due to divergent heterochronic trends-paedomorphosis versus peramorphosis

256 Such heterochronic variation has been noted across phylogeny,

257 r, this is not true for all species; indeed, heterochronic variation in the timing of vegetative phas