ライフサイエンスコーパス: heterocycle

1 by reversing the amide bond and changing the heterocycle.

2 ne after rearrangements of the central P2 N2 heterocycle.

3 sfully addresses this problem for the indole heterocycle.

4 aromatization sequence to afford the desired heterocycle.

5 without harming the sensitive four-membered heterocycle.

6 ODIPY fragment in conjugation with an indole heterocycle.

7 positions of olefinic substituents of the N-heterocycle.

8 ented herein contains a chiral center at the heterocycle.

9 ity as well as the aromatic character of the heterocycle.

10 on the position of the sulfate group in the heterocycle.

11 nthesis and study of a previously unexplored heterocycle.

12 mide group rather than a suitably positioned heterocycle.

13 tion) has been extended to oxygen and sulfur heterocycles.

14 ient construction of various carbocycles and heterocycles.

15 including aryls, vinyls, heteroaromatics and heterocycles.

16 e ligand into the N-H bond of the aromatic N-heterocycles.

17 facile access to these unsaturated strained heterocycles.

18 kov hydrosilylation of vinylarenes and vinyl heterocycles.

19 sy access for the synthesis of bis-vinylated heterocycles.

20 structures of benzoxa- and benzothiadiazole heterocycles.

21 NI3K affinity for a variety of hinge binding heterocycles.

22 rmaceutical compound library that is rich in heterocycles.

23 rticularly in functionalization of bioactive heterocycles.

24 zothiadiazine-1,1-dioxides, hitherto unknown heterocycles.

25 access to the anti-Minisci product of basic heterocycles.

26 Pyrroles are structurally important heterocycles.

27 egorized by the number of built-in carbo- or heterocycles.

28 f enantioenriched benzo-fused seven-membered heterocycles.

29 harmaceutical molecules and other classes of heterocycles.

30 ion into a variety of biologically important heterocycles.

31 he synthesis of P-substituted and P-centered heterocycles.

32 sis of a wide number of different carbo- and heterocycles.

33 ogenation of alkenes, imines, carbonyls, and heterocycles.

34 nd their application for the construction of heterocycles.

35 readily extended to the synthesis of fused N-heterocycles.

36 aring strongly coordinating substituents and heterocycles.

37 s were obtained for the fused bicyclic 3-aza-heterocycles.

38 ise difficult-to-obtain medium-ring nitrogen heterocycles.

39 ther cyclization reactions to give pi-rich P-heterocycles.

40 nd-forming steps that establish the flanking heterocycles.

41 o the nature of bioisosterism and to profile heterocycles.

42 bered rings, other carbocycles and, finally, heterocycles.

43 reliable selectivity with five-membered-ring heterocycles.

44 transform electron-deficient substrates and heterocycles.

45 y in oxidative dehydrogenations of several N-heterocycles.

46 access to a series of 11 new tellurium-boron heterocycles.

47 pentanes, indanes, and six-membered N- and O-heterocycles.

48 rray of medicinally relevant derivatives and heterocycles.

49 omene acetals to deliver alpha-chiral oxygen heterocycles.

50 widespread use with simple aryls and robust heterocycles.

51 rings to various aromatic systems, including heterocycles.

52 e natural products bearing azole and azoline heterocycles.

53 as thiols, organic di- and polysulfides, or heterocycles.

54 lting in a double functionalization of the N-heterocycles.

55 groups, including aliphatic amines and basic heterocycles.

56 monounsaturated six-membered carbocycles and heterocycles.

57 nding and aromaticity are common features of heterocycles.

58 ldehydes, ketones, esters, free phenols, and heterocycles.

59 is to deliver enantioenriched sulfur-bearing heterocycles.

60 ge of valuable saturated nitrogen and oxygen heterocycles.

61 thin the oligonucleotide backbone, sugar and heterocycles.

62 rings in fused ring systems built upon boron heterocycles.

63 ective construction of highly functionalized heterocycles.

64 thiated and rearranged, followed by Fc and N-heterocycles.

65 ines that bear various functional groups and heterocycles.

66 catalytic synthesis of highly functionalized heterocycles.

67 de moiety by five- and six-membered aromatic heterocycles.

68 ble enantiopure molecules, including various heterocycles.

69 of isonitriles with 1, planar five-membered heterocycles (3) with biradical character are formed by

70 The rigid diferrocene backbone in heterocycles 4-SnP and 4-BP creates an unprecedented chi

71 d 2 to the rare 5/6/6/7/5- and 5/6/5/8-fused heterocycles 5 and 7, respectively.

72 In this study, we show four other amine heterocycles: 6-methyl, 5-oxo-2,3,4,5-tetrahydropyridine

73 Instead of the predicted seven-membered heterocycle, a symmetrical serratamolide analogue is pro

74 how structural variations in the five-member heterocycle affect photophysical and electronic properti

75 Saturated nitrogen-containing heterocycles (alicyclic amines) feature prominently in p

76 The fused bicyclic thiazolo[5,4-d]thiazole heterocycle allows the alkylated pyridinium groups to re

77 tion processes, formation of both carbo- and heterocycles, alpha- and beta-functionalization of carbo

78 , arylalkynes, and electron-rich alkynylated heterocycles amenable to trans-hydrometalation which are

79 own to be compatible with substrates bearing heterocycle and halide substituents.

80 eties (Amt-Nea,Nea) or with one azaquinolone heterocycle and one neamine (Amt-Nea,Azq) as well as its

81 Treatment of 2 with various nitrogen heterocycles and electron-rich arenes provided a series

82 esis of azafluorenone related fused nitrogen heterocycles and fluorenones.

83 A range of heterocycles and functional groups are tolerated under t

84 ssible to implement using saturated nitrogen heterocycles and highlights some of the advantages of be

85 direct C-H functionalization in a number of heterocycles and identify general trends observed across

86 tial for synthesis of five- and six-membered heterocycles and may serve as potentially useful ligands

87 Characteristic nitrogen-containing heterocycles and neighboring thioamides allow these comp

88 or the introduction of the heme-coordinating heterocycles and, among them, the 4-imidazolyl moiety is

89 examples of their application in carbocycle, heterocycle, and natural product syntheses.

90 of nucleophiles including olefins, alkynes, heterocycles, and epoxides are competent traps in the br

91 iverse functional groups, including alkenes, heterocycles, and other heteroatom-containing groups.

92 Five-membered aromatic heterocycles are a ubiquitous skeleton of pi-conjugated

93 These N-heterocycles are also incorporated as chiral auxiliaries

94 Azonia aromatic heterocycles are an important subclass of aza-heterocyle

95 Additionally, these fluorescent heterocycles are easily functionalized using electrophil

96 Nitrogen heterocycles are found in a majority of approved small-m

97 Saturated aza-heterocycles are highly privileged building blocks that

98 N-Alkyl 2-pyridones and other enolizable heterocycles are important synthetic constructs, due to

99 The resulting heterocycles are novel prototypical structures for the d

100 pproaches for accessing fluorinated nitrogen heterocycles are of great significance.

101 Polynitrogen heterocycles are often subject to Dimroth rearrangement

102 n patterns, sensitive functional groups, and heterocycles are tolerated in this reaction, which signi

103 In addition, triazole heterocycles are well employed as a strategy to modify n

104 The use of the succinimide heterocycle as a directing group is also demonstrated in

105 ophile; through the choice of an appropriate heterocycle as the nucleophilic partner, this new method

106 iels-Alder reactions employing 1,2-azaborine heterocycles as 1,3-dienes are reported.

107 Alternatively, the use of aromatic nitrogen heterocycles as synthetic precursors can attenuate the r

108 We show how the selection of appropriate heterocycles, as extending units, allows for tuning of t

109 alogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceuti

110 the polar 3-sulfonamide group and grafting a heterocycle at the 4 position of the phenyl ring, potent

111 and base-free dehydrogenative coupling of N-heterocycles at mild conditions.

112 e benzyl O-protective groups from oxyarene N-heterocycles at positions capable for 2-/4-O-pyridine-2-

113 r CHIR-73911) emerged from an exploration of heterocycles at the C-5 position, phenyl groups at C-4,

114 Solid-state NMR spectra of new P-Se heterocycles based on peri-substituted naphthalene motif

115 A variety of sulfur-containing heterocycles bearing moieties suitable for subsequent fu

116 romaticity ordering in the six five-membered heterocycles becomes thiophene > thiazole > pyrrole > im

117 , and pyrimidine, as well as through the N-S heterocycle benzothiazole.

118 philic and conformationally rigid amines and heterocycles by decarboxylation of adamantane-oxazolidin

119 for the formation of five-membered saturated heterocycles by intramolecular C(sp(3))-H functionalizat

120 facile access to complex nitrogen-containing heterocycles by simply mixing three common starting mate

121 This heterocycle can serve as a carbostyril mimic, with appli

122 n herein is that polyfunctionalized nitrogen heterocycles can be easily prepared by a visible-light-m

123 he (anti)aromatic character of pi-conjugated heterocycles can be used to fine-tune their hydrogen (H-

124 used for the cyclization toward medium-sized heterocycles cannot be applied.

125 yridine, thereby contributing to the lack of heterocycle catalyst poisoning.

126 and identify general trends observed across heterocycle classes.

127 le solution debenzylates a variety of aryl N-heterocycles cleanly and selectively.

128 sed on a study examining how the presence of heterocycles commonly used in drug development affects t

129 eneral feature of ortho-styryl-substituted N-heterocycles comprising one and two nitrogen atoms.

130 the magnetic (anti)aromatic character of the heterocycles considered.

131 a single metal catalyst-based approach for N-heterocycle construction by tandem C-H functionalization

132 This is particularly true of heterocycles containing a high proportion of sp(3)-carbo

133 ructurally complex pharmaceutically relevant heterocycle-containing molecules.

134 dicted (13)C and/or (1)H chemical shift of a heterocycle correlates qualitatively with the regiochemi

135 luoroamines, and fluoromethylated oxygenated heterocycles could be prepared in very good yields throu

136 ocol is that a wide variety of pi-conjugated heterocycles could be readily accessed by an appropriate

137 It provides rapid access to novel heterocycles, cyclohexadieno-oxazolidino-quinolinols, as

138 he first report showing that the nature of a heterocycle directly connected to a zinc binding group (

139 ation of C-H functionalization in late-stage heterocycle drug discovery.

140 rrent approaches to prepare SF5 -substituted heterocycles during the synthesis of targeted heterocycl

141 rosilanes and various electron-rich aromatic heterocycles enables the synthesis of valuable silylated

142 one, cinnamic acid, various fused carbo- and heterocycles, etc.

143 ls in the C-H functionalization of bioactive heterocycles exemplified by the methylation of the antif

144 d perylene diimide (PDI) dimers bridged with heterocycles exhibit superior photovoltaic performance c

145 tic strategy for construction of the desired heterocycles featuring alpha-amino ynone generation foll

146 some recent advances in the construction of heterocycles, focusing on catalytic methodology.

147 formed through silyl radical addition to the heterocycle followed by subsequent beta-hydrogen scissio

148 hallmark macrolactamidine ring and thiazole heterocycle for which divergent members of the YcaO supe

149 These design stratagems include fused heterocycles for facilitating pi-electron flowing along

150 tive and selective transformations accessing heterocycles for use in organic synthesis.

151 he assembly line timing events of colibactin heterocycle formation.

152 Post-heterocycle-formation olefin isomerization was employed

153 The reaction produces electron-rich heterocycles (four lone pairs) and features homoatomic s

154 tioselective synthesis of substituted oxygen heterocycles from lactol acetates and enolsilanes has be

155 nd streamlined new approach to this class of heterocycles from readily accessible starting materials.

156 is method delivers a range of functionalized heterocycles from readily available starting materials.

157 nd cost-effective routes for the assembly of heterocycles from simple inputs is important for many sc

158 ally relevant hydantoin (imidazolidinedione) heterocycle functions as a weakly coordinating directing

159 iodic pi-conjugated polymers of the group 16 heterocycles (furan, thiophene, and selenophene) were sy

160 ads to two different products; a tricyclic N-heterocycle-fused beta-lactone and a bicyclic enamine de

161 A series of bi- and tricyclic, N-heterocycle-fused, beta-lactones were first synthesized

162 astereo- and enantioselective synthesis of N-heterocycle-fused-beta-lactones from N-linked ketoacids

163 on of a second heteroatom in a five-membered heterocycle has a detrimental effect on its aromaticity,

164 substances in which the 1,3,4-thiadiazoline heterocycle has been found as the active pharmacophore,

165 n of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyze

166 The stereochemistry of these N-heterocycles has been confirmed by several X-ray diffrac

167 The ubiquitous use of pi-rich five-membered heterocycles has driven the development of new methods f

168 The intramolecular reactions of olefinic N-heterocycles have been studied.

169 An oxidative alkenylation of N-heterocycles having C-sp(3) carbon (2-methylaza-arenes)

170 native coupling (CDC) of benzylamines with N-heterocycles having sp(2) or sp(3) carbon resulted in th

171 the synthesis of various benzimidazole-fused heterocycles in a concise manner has been reported.

172 structurally complex, biologically relevant heterocycles in a one-pot operation.

173 common occurrence of five-membered nitrogen heterocycles in bioactive molecules, the discovery of me

174 d carbodiimides afford four-membered anionic heterocycles in formal [2+2] cycloaddition reactions.

175 o-alkynyl aldehydes into medicinally useful heterocycles in good to excellent yields under mild and

176 d smoothly affording the desired sulfur-rich heterocycles in good to excellent yields, exhibiting gra

177 ded access to bicyclic beta-lactone-fused, N-heterocycles in moderate to good yields (up to 80%) with

178 ntermolecular sense to generate polycyclic N-heterocycles in one pot, with the formation up to three

179 vatives bearing saturated oxygen or nitrogen heterocycles in the N-9 substituent has revealed a remar

180 lities such as carboxyl groups, alcohols, or heterocycles in the vicinity of the C horizontal lineC b

181 eaction products are converted into valuable heterocycles in two steps.

182 thod allowing rapid entry to spirocyclic bis-heterocycles, in which inexpensive iron(III) catalysts m

183 egioselective late-stage silylation of small heterocycles, including drugs and drug derivatives, with

184 Heterocycles, including indole, thiophene, and indazole,

185 ows the derivatization of a diverse range of heterocycles, including pyrroles, indoles, imidazoles, b

186 Various chiral oxygen heterocycles, including tetrahydrofurans, tetrahydropyra

187 Simple benzo-fused nitrogen heterocycles (indolines, tetrahydroquinolines, and their

188 ing studies supported a strong direct cation-heterocycle interaction between the Lys-155 side chain o

189 Among the various heterocycles investigated, compound 23, carrying an imid

190 H bond, isomerization is averted because the heterocycle is deprotonated in situ.

191 epines, in which the seven-membered nitrogen heterocycle is replaced by a 9-12-membered ring, were ma

192 The resulting amine or heterocycle is then protonated/metalated by the catalyst

193 The synthesis of heterocycles is arguably one of the oldest and at the sa

194 The former class of heterocycles is characterized by a strong absorption aro

195 ophiles in the preparation of SF5-containing heterocycles is demonstrated.

196 nt iodination reaction of electron-deficient heterocycles is described.

197 azole-containing 5,5- and 5,6-fused bicyclic heterocycles is described.

198 ein, a facile synthesis of intricate fused N-heterocycles is disclosed by employing C-H activation an

199 enhancement or disruption of aromaticity of heterocycles is experimentally revealed by comparing hom

200 The coordination chemistry of the new heterocycles is explored.

201 , the wealth of synthetic methodology toward heterocycles is overwhelming, and catalysis, in particul

202 arylation of nitrogen-containing halogenated heterocycles is possible without protection of the N-H g

203 oxaline and quinoxalinone family of nitrogen heterocycles is present in molecules of therapeutic rele

204 bromination and iodination of electron-rich heterocycles is reported.

205 synthesis of sulfur- and sulfone-containing heterocycles is reported.

206 es for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply a

207 ide with a variety of five- and six-membered heterocycles led to the identification of 6-(1-ethyl-3-(

208 ategies that quickly generate complex indole heterocycle libraries that contain novel cyclohepta- and

209 s pharmacophore comprises a 6 + 5 fused ring heterocycle linked to an aliphatic substituent via a ure

210 trosobenzene produced highly enantioenriched heterocycle-linked trialkylamine.

211 Groundbreaking principles to form heterocycles, mainly by condensation reactions, were rec

212 l halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural pr

213 Here we show that two plausible prebiotic heterocycles, melamine and barbituric acid, form glycosi

214 Diarylethenes with different heterocycle moieties (thiophene, benzo[b]thiophene, fura

215 ould be obtained by selective 1,2,3-triazole heterocycle N(2) arylation in 1-beta-d-ribofuranosyl-2H-

216 A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with this new met

217 zole, as well as other related five-membered heterocycles, namely, 1,3,4-oxadiazol(thio)ones, 1,3,4-t

218 Benzoylation of N-heterocycles occurs via (NH4)2S2O8 catalyzed benzoyl rad

219 under mild conditions to form the oxadiazine heterocycle of 1.

220 Both heterocycles of carinatine A, a rare naturally occurring

221 Substituted pyridines are prevalent heterocycles of fundamental importance.

222 lity as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups,

223 , derived from a hydantoin core, with unique heterocycles on the side chains were synthesized as pote

224 zoles and benzpyrazoles by the addition of N-heterocycles onto functionalized terminal and internal a

225 een utilized for the preparation of numerous heterocycles, opportunities to extend its power remain.

226 C-H functionalization of saturated nitrogen heterocycles, particularly at sites remote to nitrogen,

227 The heterocycles prepared through the hydrogen bond donor ca

228 ond formation to increase the yield of the N-heterocycle product.

229 onality in RN-18 (IC50 = 6 muM) by isosteric heterocycles resulted in the discovery of a 1,2,3-trizol

230 depend on the nature and number of different heterocycle(s) present in place of pyrrole ring(s).

231 n of N-allyl ynamides to form fused nitrogen-heterocycle scaffolds.

232 e copolymers were fine-tuned by altering the heterocycle sequence, and atomic force microscopy reveal

233 witches containing an indazole five-membered heterocycle shows photochemical isomerization with high

234 ide is ultrafast and quantitative, while the heterocycle specifically influences the energy transfer

235 Modification of the N-spiroimidate heterocycle substituent led to (1S,2R,4S)-N-isoquinolin-

236 Purines and related heterocycles substituted at C-2 with 4'-sulfamoylanilino

237 Heterocycle substitutions at C24 were well-tolerated and

238 ding the poisoning effect of a wide range of heterocycle substrates.

239 f the alcohol nucleophile and is tolerant of heterocycles, substrates with epimerizable stereocenters

240 tertiary amino ozonides with cycloalkyl and heterocycle substructures were superior to their acyclic

241 r two pyrrole rings with other five-membered heterocycles such as furan, thiophene, selenophene, tell

242 substitution pattern of nitrogen-containing heterocycles such as indoles, quinolones, pyrazoles, and

243 Benzoannulated nitrogen-containing heterocycles such as indolines, tetrahydroquinolines, an

244 the synthesis of highly substituted nitrogen heterocycles such as pyrazines and imidazoles starting f

245 ynthetic interest because they can lead to N heterocycles such as pyrroles and pyridines.

246 ped for the asymmetric synthesis of nitrogen-heterocycles such as pyrrolidines and indolizidines.

247 d five- and six-membered nitrogen and oxygen heterocycles such as thieno[3,2-b]pyrroles, thieno[3,2-b

248 and secondary aliphatic and aromatic amines, heterocycles, such as indoles, pyrazole, and carbazole,

249 irect arylation of the C3-position of oxygen heterocycles, such as tetrahydrofuran and 1,4-benzodioxa

250 amides is proposed as a crucial step in many heterocycle syntheses.

251 n are highly amenable for fast and efficient heterocycle synthesis as well as compound scale-ups.

252 tural products is a six-membered nitrogenous heterocycle that is assembled via a formal [4+2] cycload

253 ed a new route for the production of complex heterocycles that are inaccessible by typical synthetic

254 dation catalysis: (1) The reaction tolerates heterocycles that commonly poison Pd catalysts.

255 ineO)-R, R2NH, or R3C-Br) silicon-containing heterocycles that contain Si-MOP, Si-DMOP, or Si-TMOP mo

256 On the one hand, it protonates the N-heterocycles that reduces their reduction potentials not

257 le with functionalities, such as Lewis-basic heterocycles, that are often found in pharmaceutical sub

258 Despite the weakly acidic nature of N-heterocycles, the reactions proceed with good efficiency

259 d amines from their readily available parent heterocycles, this approach has largely been limited to

260 d for the construction of highly substituted heterocycles through a facile Lewis-acid-catalyzed oxeta

261 e a range of different substituents into the heterocycles through a judicial choice of Lewis acid and

262 ork, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted po

263 olycyclic aromatic hydrocarbons (PAHs) and N-heterocycles to surface waters.

264 nthesis of biologically interesting arylated heterocycles under mild conditions.

265 eta-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.

266 A number of heterocycles undergo N-arylation which is followed by ru

267 yclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator.

268 a method for the synthesis of seven-membered heterocycles via a Pictet-Spengler condensation reaction

269 ve synthesis of several important classes of heterocycles via controlled cyclizations of easily acces

270 on and (ii) synthesis of nitrogen-containing heterocycles via polarity reversal of the amide bond.

271 catalyzed cyclization step gave the required heterocycles, via an intramolecular Friedel-Crafts react

272 Two classes of heterocycles viz.　4,5-disubstituted 1,2,4-triazole-3-t

273 The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only eight steps startin

274 zation of mono- and bis-styryl-substituted N-heterocycles was investigated.

275 The synthetic utility of these heterocycles was studied using 5-bis(organoselanyl)-3,6-

276 ns for the synthesis of various thieno-fused heterocycles were cinnamyl bromide, 2-bromobenzyl chlori

277 , it was reported that C-H bonds in aromatic heterocycles were converted to C-Si bonds by reaction wi

278 thermore, three separate nitrogen-containing heterocycles were prepared from the N-acylguanidines syn

279 ed aldehydes and the indazole-7-carbaldehyde heterocycles were studied in order to broaden the scope

280 enzo ring (Cl, NO2, NH2, CF3, ureido, amido, heterocycles), were synthesized, and several of them sho

281 razin-1-yl)methanones derived from tricyclic heterocycles which were screened for effects on tumor ce

282 s reaction offers access to an underexplored heterocycle, which opens up the study of the fundamental

283 converting to the pyrazolo[1,5-a]-pyrimidine heterocycle, while potency, metabolic, and physicochemic

284 alkynes for the synthesis of functionalized heterocycles, while further expanding the scope of the d

285 l activity is investigated in comparisons of heterocycles with 4n + 2 and 4n pi-electrons, in cyclic

286 paring homodimer H-bond energies of aromatic heterocycles with analogs that have the same H-bonding m

287 dation at the phenyl ring of 2-phenylimidazo heterocycles with aryl isocyanates has been achieved via

288 catalyses the direct silylation of aromatic heterocycles with hydrosilanes, furnishing heteroarylsil

289 and atom-efficient assembly of six-membered heterocycles with multiple chirality centres.

290 transition metals to catalyze alkylation of heterocycles with olefins via a C-H activation, migrator

291 hly selective access to valuable halogenated heterocycles with regiochemistry complementary to those

292 ic azides to generate a range of saturated N-heterocycles with the highest turnover number (TON) (1 m

293 tudy has compared the properties of these BN heterocycles with their carbon-based analogues.

294 omaticity and bonding in these five-membered heterocycles with two heteroatoms.

295 The mechanism of arylation of N-heterocycles with unsymmetric diaryliodonium salts is el

296 ts (organophosphorus ligands, diamides and N-heterocycles), with a focus on the separation of actinid

297 first syntheses of privileged [5,6]-bicyclic heterocycles, with ring-junction nitrogen atoms, by tran

298 ood to excellent yields of the aforesaid aza-heterocycles within short time spans (20-40 min).

299 of an array of ortho-amidated phenylimidazo heterocycles without prior activation of C(sp(2))-H.

300 dure, provides a simplified method to access heterocycles without workup and purification after each