ライフサイエンスコーパス: heterocyclization

1 ide-mediated palladium-catalyzed reductive N-heterocyclization.

2 orresponding 1,5-diketones followed by their heterocyclization.

3 y uncharacterized mode of post-assembly line heterocyclization.

4 is, 1,2-addition of the Normant reagent, and heterocyclization.

5 iocyanates 3 via condensation and subsequent heterocyclization.

6 re crucial for both amide bond formation and heterocyclization.

7 its N-terminal region necessary for peptide heterocyclization.

8 -544) and is the first demonstration of such heterocyclization ability in a nonribosomal peptide synt

9 le for the protein scaffold component of the heterocyclization acceptor substrate.

10 Full heterocyclization activity could be restored by providin

11 s not stimulate synthetase reconstitution or heterocyclization activity in vitro.

12 The swapping of PCP2 of HMWP2 abolished the heterocyclization activity of the Cy2 domain while retai

13 Heterocyclization activity was reconstituted only by com

14 he second site resulted in a decrease in the heterocyclization activity when MBP-McbB was reconstitut

15 in (MBP), and the in vitro reconstitution of heterocyclization activity.

16 s presented, based on Pd-catalyzed oxidative heterocyclization-alkoxycarbonylation of readily availab

17 lds (56-93%) through a sequential 5-endo-dig heterocyclization-alkoxycarbonylation-dehydration proces

18 and leucine zipper motifs and a specialized heterocyclization and condensation domain found in certa

19 c and domain-deletion mutagenesis to map the heterocyclization and primary and secondary amine acylat

20 Mechanistic aspects of the heterocyclization are discussed.

21 that these cascade Pd(II)-mediated oxidative heterocyclizations are of value for various synthetic ap

22 Detection of the heterocyclization capacity of HMWP2 1-1491 implies salic

23 Furthermore, the first radical heterocyclization cascade triggered by reduction of amid

24 s rely on Pd(II)-catalyzed aerobic oxidative heterocyclization chemistry, which was employed to rapid

25 RPS modules, the C domain is replaced by the heterocyclization (Cy) domain, a homologous domain that

26 or 1,3-diketones, followed by dehydration or heterocyclization-dehydration of resulting products, rem

27 protein domains (ArCP, PCP1, PCP2), and two heterocyclization domains (Cy1, Cy2).

28 mechanism for threonyl, seryl, and cysteinyl heterocyclization domains in siderophore and antibiotic

29 We also examined heterocyclization donor substrate specificity at the lev

30 s and for uncoupling of the condensation and heterocyclization functions of Cy1 and Cy2.

31 ized utilizing two subsequent intramolecular heterocyclizations in one pot.

32 Novel three-component heterocyclization involving gem-bromofluorocyclopropanes

33 m of (IMes)Pd(TFA)2(H2O)-catalyzed oxidative heterocyclization of (Z)-4-hexenyltosylamide was investi

34 osphate catalyst promotes the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and f

35 dihydrothiazoles has been devised by [4 + 1] heterocyclization of alpha-(N-hydroxy/aryl)imino-beta-ox

36 sing InCl(3)- and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide

37 alyze deoxygenative N-N bond-forming Cadogan heterocyclization of o-nitrobenzaldimines, o-nitroazoben

38 A one-step heterocyclization of o-nitrobenzylamines to 3-alkoxy-2H-

39 A novel platinum-catalyzed double heterocyclization of propargylic ethers is described.

40 and subsequent base mediated intramolecular heterocyclization of the resulting alpha-hydroxyiminoimi

41 lation by 2,3-dihydrobenzoyl- (DHB-) S-VibB (heterocyclization or Cy domain), heterocyclization to DH

42 amide bond formation) step of the three-step heterocyclization process, while Cy1 is capable of and l

43 enzofused nitrogen heterocycles, and various heterocyclization processes furnish highly substituted a

44 oholic solvent affect the efficiency of this heterocyclization reaction (approximately 40-90%).

45 We used a three-component Biginelli-like heterocyclization reaction for the synthesis of a series

46 ino-2-(trifluoromethyl)-1H-pyrroles from the heterocyclization reaction of 5-bromo-4-methoxy-1,1,1-tr

47 Conversely, the gold-catalyzed heterocyclization reaction of beta-amino-gamma-hydroxyal

48 ished from beta-lactam-linked enynes through heterocyclization reaction taking advantage of the aceto

49 This contrasts sharply with oxidative heterocyclization reactions catalyzed by other nonheme i

50 and regioselectivity in the metal-catalyzed heterocyclization reactions of allenic amino alcohols.

51 ear precursor was fundamental to achieve the heterocyclization step as well as obtain the correct reg

52 t not the methyloxazolinyl thioesters of the heterocyclization step.

53 B-) S-VibB (heterocyclization or Cy domain), heterocyclization to DHP-oxazolinyl- and DHP-thiazolinyl

54 ocarbonyl)urethane as the starting material, heterocyclization to the putative "Dts-urethane" does no

55 NRP heterocyclizations to thiazoles and oxazoles can occur o

56 Radical heterocyclizations triggered by electron transfer to ami

57 mation, thus providing examples of reductive heterocyclizations where hydrogen embedded within an alc

58 eral types of palladium- and copper-assisted heterocyclizations with the participation of the C ident

59 uirement for ATP or GTP in peptide substrate heterocyclization, with GTP one-third as effective as AT