ライフサイエンスコーパス: heterodimer

1 mismatch repair protein MutSbeta (Msh2-Msh3 heterodimer).

2 1 interaction compared with VDRM:TRPV6 bound heterodimer.

3 silico model for the ectodomain of the E1E2 heterodimer.

4 rp9 increases the DNA repair activity of the heterodimer.

5 gnizes DNA in the same manner as the MYC/MAX heterodimer.

6 small subunits form the catalytically active heterodimer.

7 an in silico model of the full-length E1/E2 heterodimer.

8 map to antigenic clusters in E2 or the E1E2 heterodimer.

9 h results in the formation of the protonated heterodimer.

10 dues of the interface surfaces of the D4-A20 heterodimer.

11 ng separation of the alphaIIbbeta3 TM domain heterodimer.

12 nvasion is highly dependent on the HER2/HER3 heterodimer.

13 rved "hinge" in the middle module MED21-MED7 heterodimer.

14 sting this activity is catalysed by a unique heterodimer.

15 either the inactive homodimer or the active heterodimer.

16 formational change in the alpha/beta-tubulin heterodimer.

17 oteolytically at a WGSS cleavage site into a heterodimer.

18 Y12 drives internalization of the PAR4-P2Y12 heterodimer.

19 tanding the pathophysiological roles of mGlu heterodimers.

20 ily and allow the different isoforms to form heterodimers.

21 and beta-tubulin subunits and assembly into heterodimers.

22 AP, which disassemble syntaxin-1 and SNAP-25 heterodimers.

23 alongside a GluK5 homomer or as two GluK2/K5 heterodimers.

24 of binding and stripping for both homo- and heterodimers.

25 olved in the biogenesis of alphabeta-tubulin heterodimers.

26 djuvants, interacting with cell surface TLR2 heterodimers.

27 effects observed for FGFR3 wild-type/mutant heterodimers.

28 the ability to cooperate on DNA elements as heterodimers.

29 ing formation of the EGFR/HER2 and HER2/HER3 heterodimers.

30 rs in vitro, although AtxA1 and AtxA2 formed heterodimers.

31 ion, trafficking, and activity of alpha-beta heterodimers.

32 200 of these peptides are found as homo- or heterodimers.

33 y creating signaling-incompetent Dome:Et/Lat heterodimers.

34 (named for ClpV-interacting protein A and B) heterodimers.

35 ts Lck proximal to the four ITAMs of the CD3 heterodimers.

36 t that are assembled from alpha/beta-tubulin heterodimers.

37 ce homodimers and Pi-regulated low-abundance heterodimers.

38 e maintenance of a pool of alphabeta-tubulin heterodimers.

39 ediate conformations forming a flat dimer of heterodimers.

40 HSPB6 dictates the preferential formation of heterodimers.

41 red enthalpy of binding of the Naph(+*)(Pyr) heterodimer (20.9 kcal/mol) exceeds that of the Naph(+*)

42 Under N starvation, TCP20-NLP6&7 heterodimers accumulate in the nucleus, and this coincid

43 d wing vein patterning but not for Gbb15-Dpp heterodimer activity in cell culture.

44 he intestinal lumen via the sterol-exporting heterodimer adenosine triphosphate binding cassette subf

45 genes, noting the possibility that bursicon heterodimers also lead to up-regulation of these genes c

46 nals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLI

47 Here, we report crystal structures of the Ku heterodimer and Est1 complexed with their key binding pa

48 binding of PER2 to BMAL1 in the BMAL1/CLOCK heterodimer and is an important component in the organiz

49 ecificity of the interaction between the TCR heterodimer and its peptide-MHC ligand derives largely f

50 CYREN acts by binding to the Ku70/80 heterodimer and preferentially inhibits cNHEJ at breaks

51 complex whose formation requires the Ku70/80 heterodimer and the DNA-dependent protein kinase catalyt

52 (DSBs) in DNA are recognized by the Ku70/80 heterodimer and the MRE11-RAD50-NBS1 (MRN) complex and r

53 lytic amplification of KSHV DNA, the Ku70/80 heterodimer and the MRN complex consistently colocalize

54 DNA interactomes of 80 heterodimers and 22 homodimers revealed that 72% of hete

55 2 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-media

56 ethod can be applied across Igs to design Fc heterodimers and bsAbs.

57 rowth factor receptor 2 (HER2) and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism

58 We functionally characterized the heterodimers and found that all combinations form outwar

59 These include heterodimers and higher complex adducts, distal fragment

60 ng domain can associate with soluble tubulin heterodimers and promote assembly of oligomeric ring-lik

61 ational activation of the PPARgamma/RXRalpha heterodimer, and focal amplification/overexpression of P

62 ion in affected kidneys, mostly as a p50/p65 heterodimer, and increased renal expression of NF-kappaB

63 ov1 Stl C-terminal domain, formed DutNM1-Stl heterodimers, and caused the release of the Pstr promote

64 utant TUBB4B is able to fold, form alphabeta-heterodimers, and co-assemble into the endogenous MT lat

65 nds to both ternary SNARE complexes, t-SNARE heterodimers, and monomeric SNAREs, competing with synap

66 TKs are believed to form both homodimers and heterodimers, and the different dimers are believed to p

67 They form homo- and heterodimers, and then collaboratively regulate their ex

68 oth the formation and activity of Split GAL4 heterodimers, and we show how this added layer of contro

69 E2 (HC33.4, HC84.26, and AR3B) and the E1E2 heterodimer (AR4A and AR5A).

70 Soluble alphabeta-tubulin heterodimers are maintained at high concentration inside

71 Cells lacking Mst1, in which Mst1/Mst2 heterodimers are not possible, are resistant to H-ras-me

72 Both OCP1 and OCP2 heterodimers are photoactive, undergoing light-driven he

73 urrent technologies for the generation of Hc heterodimers are suboptimal and often suffer from contam

74 n, indicating that the canonical STAT1-STAT2 heterodimers are the primary signaling transducers of ty

75 raprotofilament interactions between tubulin heterodimers are thought to be lost, while lateral conta

76 w tubes built from alphabeta-tubulin protein heterodimers, are thought to be present only in eukaryot

77 of which can alter the distribution of Ft-Ds heterodimers around the cell periphery.

78 They are comprised of alphabeta-tubulin heterodimers arranged into linear protofilaments and ass

79 e liver X receptor (LXR)/retinoid X receptor heterodimer, as an important event in WD pathogenesis.

80 microtubules both between alphabeta-tubulin heterodimers, as seen for other organisms, and within tu

81 Two Tor-Lst8 heterodimers assemble further into a dyad-symmetry dimer

82 to predict a full-length model of the E1/E2 heterodimer based on the partial crystal structures of t

83 ional analysis disfavored the HIF2alpha:ARNT heterodimer-based PAS-B model, most mutants derived from

84 mostly observed as monomer, with ClC-3-ClC-4 heterodimers being more stable than ClC-4 homodimers.

85 mical evidence that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essential role i

86 erins Fat (Ft) and Dachsous (Ds), which form heterodimers between adjacent cells; and the Golgi kinas

87 ing (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by recruitment of

88 Using EMSA, we demonstrate that the AHR-ARNT heterodimer binds to a specific DRE that overlaps bindin

89 ex is composed of four protomers and one IHF heterodimer bound at the cos site.

90 retinoic X receptor alpha (RARbeta-RXRalpha) heterodimer bound to DNA, ligands and coactivator peptid

91 retinoic X receptor alpha (RARbeta-RXRalpha) heterodimer bound to DNA, ligands and coactivator peptid

92 5alpha increases the amount of p110alpha-p85 heterodimers bound to active receptors, augmenting PI3K

93 /p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-

94 Ralpha) binds to DNA either as homodimers or heterodimers, but it also forms homotetramers whose func

95 nding receptor that recycles through SNX-BAR heterodimers, but not via the retromer trimer, in a liga

96 structural component (the alpha/beta-tubulin heterodimer) can give rise to severe, sporadic neurodeve

97 ts can be interpreted by the intermediacy of heterodimer cation radicals formed between the stannane

98 bunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteas

99 Integrin alphabeta heterodimer cell surface receptors mediate adhesive inte

100 al-amplification strategy based on AuNP-AgNP heterodimers combined through antigen-antibody reactions

101 ch are connected by a flexible linker in the heterodimer, communicate in such a way that when DNA bin

102 in particular the CD11b/CD18 beta2 integrin heterodimer complement receptor type 3/Mac-1.

103 GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation

104 on process of the EphA2-SHIP2 SAM-SAM domain heterodimer complex using unrestrained all-atom molecula

105 onic acid to PGH2 PGHS-2 is a conformational heterodimer composed of allosteric (Eallo) and catalytic

106 Soluble guanylate cyclase (sGC) is a heterodimer composed of alpha and beta subunits.

107 The pre-TCR is a disulfide-linked heterodimer composed of an invariant pre-TCR alpha (pTal

108 inds to the TSLP receptor (TSLPR) complex, a heterodimer composed of TSLPR and IL-7 receptor alpha (C

109 y the pharmacological properties of rat mGlu heterodimers composed of mGlu2 and 4 subunits.

110 Within the native IL-12 heterodimer, composed of IL-12alpha and IL-12beta, IL-12

111 ns to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits.

112 ned in the longitudinally adjacent alphabeta-heterodimer, consistent with a role in maintaining MT st

113 FSH is a heterodimer consisting of an alpha subunit, also present

114 a, whereas Ls's activity is caused by Bin, a heterodimer consisting of BinA, the toxin, and BinB, a m

115 Ricin toxin is a heterodimer consisting of RTA, a ribosome-inactivating p

116 e-strand DNA breaks that likely occur due to heterodimers consisting of both an N-terminal truncated

117 s with mutations located within the spectrin heterodimer contact site exhibited severe and progressiv

118 F65) and small (U2AF35) subunits of the U2AF heterodimer contact the polypyrimidine tract (Py-tract)

119 is a glycoprotein consisting of a trimer of heterodimers containing gp120 and gp41 subunits that med

120 binding domain (LBD), enabling the homodimer-heterodimer conversion.

121 Of note, one VHH heterodimer could reduce Shigella hemolytic activity by

122 Finally, TREK1/TRAAK heterodimers differ in function from TRAAK homodimers in

123 ules are less tapered and that these tubulin heterodimers display lower curvatures.

124 m of disulfide bond reduction and alpha/beta heterodimer dissociation in the cytosol.

125 ers are photoactive, undergoing light-driven heterodimer dissociation, but differ in their ability to

126 the interaction between the nuclear receptor heterodimer EcR:RXR and MfR.

127 However, certain covalent homo- or heterodimers eliminated twitching motility, suggesting t

128 The heterodimer enables the DNA polymerase to efficiently sy

129 Using ERAP1 and ERAP2 heterodimers (ERAP1/2), and N-terminally extended model

130 crotubules are polymers of alphabeta-tubulin heterodimers essential for all eukaryotes.

131 Our results show that all possible FGFR heterodimers form, suggesting that the biological roles

132 Co-expression of Nodal and Vg1 results in heterodimer formation and mesendoderm induction.

133 repeat is important for alpha/beta spectrin heterodimer formation and/or alphaII spectrin function.

134 Heterodimer formation between the catalyst and sulfur do

135 capable of sensing H2O2 Similarly, disulfide heterodimer formation was abolished in H9C2 cells expres

136 re of three bZIP proteins in pairs showed no heterodimer formation whereas A-ZIP53 interacted and for

137 ciated the DBD-LBD interaction, allowing CAR heterodimer formation with RXRalpha.

138 nuate SOD1 maturation prevented the SOD1-CCS heterodimer formation.

139 y hydrophobic intermolecular interface; this heterodimer formed a higher order complex with a second

140 The heterodimer formed by glycoproteins E1 and E2 within the

141 jawed vertebrates (B- and T-cell receptors), heterodimers formed by pairs of Ig domains.

142 m the same organism, we show that an NTD-CTD heterodimer forms when the domains are expressed as sepa

143 tween HR and NHEJ via displacement of the Ku heterodimer from DSBs to allow HR.

144 ction of at least four functionally distinct heterodimers from only five subunits.

145 ), which results from activation of D2/TAAR1 heterodimers, fully reproduced the inhibitory effects of

146 -T cell receptor (pre-TCR) is a pTalpha-beta heterodimer functioning in early alphabeta T cell develo

147 Two SAV1-MST2 heterodimers further dimerize through SAV1 WW domains to

148 The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols

149 more pyridine molecules to the Naph(+*)(Pyr) heterodimer gives 10-11 kcal/mol increments in binding e

150 ation in the heterodimer interface gives the heterodimer greater conformational plasticity, allowing

151 different storage conditions, the bispecific heterodimer, guided by the knob-into-hole assembly, prov

152 olled synthesis of ribonucleosidic homo- and heterodimers has been achieved from inexpensive d-xylose

153 ns and is favored over homodimers, and these heterodimers have much-reduced protein kinase activity c

154 To our knowledge, CH4-based heterodimers have not been previously reported.

155 The IL-12p35 subunit is shared by 2 heterodimers: IL-12 and IL-35.

156 crystal structure of the mammalian AHR-ARNT heterodimer in complex with the DRE, in which ARNT curls

157 scaffolded by a specific SMC protein dimer (heterodimer in eukaryotes) held together via their hinge

158 SOD1 and CCS formed a highly stable heterodimer in human spinal cord homogenates that was re

159 lar FRET efficiencies for FT-FD and AcMFT-FD heterodimer in nucleus were observed.

160 trict monoubiquitination to the FANCD2:FANCI heterodimer in only a DNA-bound form.

161 ts highlight the importance of the RAP1-TRF2 heterodimer in protecting telomeres from inappropriate p

162 during DNA replication, binds a single H3-H4 heterodimer in solution.

163 We also show that sNxf1 forms heterodimers in conjunction with the full-length Nxf1 an

164 gene loci, indicating a requirement for CBF heterodimers in EBNA3 recruitment during target-gene reg

165 romoter activity in the context of RXRA/PPAR heterodimers in human bladder cancer cells.

166 strong evidence for the existence of mGlu2-4 heterodimers in native cells.

167 2 receptors can form functionally asymmetric heterodimers in vitro and in vivo that must be considere

168 D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs)

169 ding evidence that physical formation of the heterodimer indeed mediates enhanced function.

170 llosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding.

171 nity of parental (homodimer) and bispecific (heterodimer) interactions within the CH3 domain, further

172 We show that frustration in the heterodimer interface gives the heterodimer greater conf

173 rtion of the N-terminal alpha-helix into the heterodimer interface, leading to enzyme activation.

174 modest reorientation in the lateral tubulin heterodimer interface.

175 gree of S-acylation was highest for SOD1-CCS heterodimers, intermediate for CCS monomers, and lowest

176 We now report that PAR4 and P2Y12 heterodimer internalization is required for beta-arresti

177 uence the incorporation of mutant-containing heterodimers into microtubule polymers.

178 ed through shape transformation from Pd/Ni-P heterodimers into Pd-Ni-P nanoparticles and tuning the N

179 module, our data suggest that the Munc13-RIM heterodimer is an active component of the vesicle dockin

180 ination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that i

181 hat the structural architecture of the P1-P2 heterodimer is critical for binding RTA.

182 contrast, AF2 of VDR within VDRM:BGLAP bound heterodimer is more vulnerable for large stabilization u

183 Thus, internalization of the PAR4-P2Y12 heterodimer is necessary for beta-arrestin recruitment t

184 e (NHC)-cyclic (alkyl)(amino) carbene (CAAC) heterodimers is presented.

185 lapping DNA binding domains in the ERCC1-XPF heterodimer jointly bind to an ssDNA/dsDNA substrate and

186 dults with recombinant bursicon (r-bursicon) heterodimer led to cuticle tanning in both species.

187 -HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C proto

188 It is composed of a membrane-spanning heterodimer, MalF-MalG; a homodimeric ATPase, MalK2; and

189 rmore, the highly stable S-acylated SOD1-CCS heterodimer may serve as a long-lived maturation interme

190 suggesting that the biological roles of FGFR heterodimers may be as significant as the homodimer role

191 quired in vivo for Gbb-Decapentaplegic (Dpp) heterodimer-mediated wing vein patterning but not for Gb

192 P53 inhibited three bZIPs and their putative heterodimers-mediated transactivation of GUS reporter ge

193 We show that the Dtx3L/Parp9 heterodimer mediates NAD(+)-dependent mono-ADP-ribosylat

194 The P1-P2 heterodimer missing a CTD on P2 was able to bind RTA.

195 In contrast, the P1-P2 heterodimer missing the CTD of P1 protein displayed almo

196 Eukaryotic MutLalpha (mammalian MLH1-PMS2 heterodimer; MLH1-PMS1 in yeast) functions in early step

197 termolecular communication within the KIF3AC heterodimer modulates entry into the processive run rega

198 specific for TLR4, and Pam3Cys, specific for heterodimer molecule TLR1/TLR2.

199 imers and 22 homodimers revealed that 72% of heterodimer motifs correspond to conjoined half-sites pr

200 ependent DNA binding ability of the AhR:ARNT heterodimer mutants was evaluated.

201 for essential Pol I/III subunits that form a heterodimer necessary for Pol I/III assembly, and many T

202 fold or become assembled into the alpha/beta-heterodimer, nor did it influence the incorporation of m

203 ross section in helium for the Naph(+*)(Pyr) heterodimer of 84.9 +/- 2.5 A(2) at 302 K agrees well wi

204 aspergamide B, and waikialoid A, which is a heterodimer of avrainvillamide and aspergamide B.

205 nduction of the AP-1 transcription factor, a heterodimer of c-FOS and c-JUN.

206 These results imply that an ATP/ADP heterodimer of cytosolic Hsp90 is the predominant active

207 The p65p50 heterodimer of NFkappaB is the strongest DNA binder, and

208 Calprotectin, a heterodimer of S100A8 and S100A9, is an abundant neutrop

209 at converges on the Rag GTPases, an obligate heterodimer of two related GTPases.

210 yotic and archaeal replication, primase is a heterodimer of two subunits, PriS and PriL.

211 thermodynamic stabilities of homodimers and heterodimers of kainate and AMPA receptors using fluores

212 In this study, we demonstrate that heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5,

213 that in epidermal keratinocytes, unliganded heterodimers of vitamin D receptor (VDR)/RXR-alpha and r

214 s by packing structurally flexible synthetic heterodimers on single-walled carbon nanotubes, and ther

215 guarantees the cell surface targeting of the heterodimer only.

216 e formatted either as conventional alphabeta heterodimers, or as single-chain fragments variable cons

217 the mechanism for preferential formation of heterodimers over homodimers for some members of the TGF

218 ression of Farnesoid X receptor (FXR), small heterodimer partner (SHP) and bile salt export pump (BSE

219 ceptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bi

220 Here, we show that Small Heterodimer Partner (SHP) mediates postprandial epigenet

221 An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regu

222 e acetonide (TA) and a fragment of the small heterodimer partner (SHP).

223 e, together with modulation of hepatic small heterodimer partner and cholesterol-7alpha-hydroxylase m

224 Farnesoid X receptor; Small Heterodimer Partner double knockout mice, a model for bi

225 ylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool s

226 Interestingly, stimulation of the PAR4-P2Y12 heterodimer promotes beta-arrestin and Akt co-localizati

227 These data indicate that the U2AF heterodimer promotes spliceosome assembly by a dynamic p

228 e nucleation site of the alpha/beta spectrin heterodimer region.

229 inase 14 (MAP3K14), the NFkappaB DNA binding heterodimer RelB/NFkappaB2, and proteins involved in NFk

230 However, RTK heterodimers remain poorly characterized, as compared wi

231 tibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug

232 These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of

233 ure HIV-1 reverse transcriptase (RT) p66/p51 heterodimer requires subunit-specific processing of the

234 lation and identification of DQ8 and DQ2-DQ8 heterodimer-restricted, proinsulin-reactive CD4(+) T cel

235 It seems paradoxical that the heterodimer should bind more strongly than either of the

236 TREK1-TREK2 heterodimers show low levels of activity at physiologica

237 esence of the large Fc tag, Fc-d E1E2 formed heterodimers similar to those formed by GNA-purified wil

238 in-tagged E1E2 antigen that forms functional heterodimers similar to those with native E1E2.

239 f IkappaBalpha appears to twist the NFkappaB heterodimer so that the DNA can no longer bind.

240 We used either a heterodimer-specific conformational LRET-based biosensor

241 luteinizing hormone (LH), both of which are heterodimers specified by unique beta subunits (FSHbeta/

242 but both show a general pattern of increased heterodimer stability as compared to the homodimers of t

243 lydisperse oligomer array composed solely of heterodimers, suggesting preferential association that i

244 read out, we designed an obligate pair of H3 heterodimers, termed H3X and H3Y, which we extensively v

245 l elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex

246 elterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates

247 e unique among other interleukins in forming heterodimers that arise from extensive subunit sharing w

248 Here, we purify and characterize tubulin heterodimers that have human beta-tubulin isotype III (T

249 essfully built several new CH3- or CH4-based heterodimers that may prove useful for designing new bsA

250 glycoprotein (Env) is a trimer of gp120/gp41 heterodimers that mediates viral entry.

251 eta/IL-4Ralpha or IL-4Ralpha/IFNAR2 receptor heterodimers, that do not occur naturally, triggering si

252 he cytosol occurs on the oxidized alpha/beta heterodimer, the precise mechanism of how the toxin cros

253 our study reveals that, in vivo within their heterodimers, the RXR and RAR isotypes are not functiona

254 Medicinal targeting of heterodimer thermodynamics represents a plausible strate

255 ater conformational plasticity, allowing the heterodimer to better accommodate the DNA.

256 ns that disrupt binding of the Fus2p/Rvs161p heterodimer to membranes affect Cdc42p ZCF localization.

257 RXRalpha, as well as the PPARgamma:RXRalpha heterodimer to more than 300 target DNA sites and varian

258 re telomere-specific proteins that bind as a heterodimer to single-stranded telomere DNA to prevent i

259 d bHLH51 act sequentially as either homo- or heterodimers to choreograph tapetal development.

260 several floral MADS domain protein homo- and heterodimers to measure their DNA binding specificities.

261 vitamin D receptor/retinoid X receptor-alpha heterodimer (VDRRXRalpha) regulates bone mineralization

262 vitamin D receptor/retinoid X receptor-alpha heterodimer (VDRRXRalpha) regulates bone mineralization.

263 higher order complex with a second K1-K10-2B heterodimer via a Cys401(K10) disulfide link, although t

264 ell known that Ascl1 binds DNA as a homo- or heterodimer via its basic helix-loop-helix (bHLH) motif,

265 its synthesis in six steps from a butenolide heterodimer via its likely biosynthetic precursor, 3,6-d

266 An unexpected acidanion heterodimer was discovered with weaker picric acid, whic

267 olated hearts exposed to H2O2 This disulfide heterodimer was sensitive to reduction by mercaptoethano

268 The structure and RNA binding of the heterodimer was unaffected by cancer-linked myelodysplas

269 by U2AF65 and the role of U2AF35 in the U2AF heterodimer, we have combined single-pair FRET and NMR e

270 xpressed in Nicotiana benthamiana leaves and heterodimers when coexpressed with AtARAD1 The expressio

271 port that 5-HT2 receptors can form homo- and heterodimers when expressed alone or co-expressed in tra

272 nd biologically active as a disulfide-bonded heterodimer, whereas it forms inactive disulfide-bonded

273 QD surfaces transforms individual HNCs into heterodimers, whereas the interparticle fusion drives as

274 study evidences the flexibility of MDM2/MDM4 heterodimer, which allows the development of a positive

275 tion leading to formation of NFATc3 and FosB heterodimer, which binds and activates the TF promoter.

276 loops are initiated by CLOCK-CYCLE (CLK-CYC) heterodimers, which activate transcription of genes enco

277 simultaneously by inducing HER2-IL13Ralpha2 heterodimers, which promoted superadditive T cell activa

278 RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including t

279 It demonstrates a parallel, coiled-coil heterodimer with a predominantly hydrophobic intermolecu

280 The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which

281 of the GluN1/2A agonist binding domain (ABD) heterodimer with bound ACEPC antagonists reveal a bindin

282 hes, we found that CXCR4 can form an induced heterodimer with cannabinoid receptor 2 (CB2) in human b

283 a was activated and formed a disulfide-bound heterodimer with MAP2K3 (MKK3) in rat cardiomyocytes and

284 hymotrypsin-like serine protease is a 28-kDa heterodimer with optimum activity at venom's pH of 6.0.

285 wn type, we propose that MAG2 forms a stable heterodimer with PGLa.

286 nteraction also prevented CAR from forming a heterodimer with RXRalpha.

287 modifies gene expression by binding DNA as a heterodimer with the Retinoid X receptor (RXR).

288 whereas A-ZIP53 interacted and formed stable heterodimers with bZIP53, bZIP10, and bZIP25.

289 Ascl2 also forms heterodimers with classical E-proteins to sequester thei

290 found to constitutively form homodimers and heterodimers with CXCR2, a main neutrophil chemotactic r

291 s study, we show that RcsB in addition forms heterodimers with MatA (also known as EcpR) and with Dct

292 beta-tubulin isotype III (TUBB3), as well as heterodimers with one of two beta-tubulin mutations (D41

293 HER2 forms homodimers as well as heterodimers with other HER family members and we now sh

294 onversion from inactive homodimers to active heterodimers with retinoid X receptor alpha (RXRalpha),

295 hosphorylated IRAK4 kinase domain then forms heterodimers with the IRAK1 kinase domain within the Myd

296 Additionally, the IRAK1 kinase domain forms heterodimers with the phosphorylated, but not unphosphor

297 scriptional activities and abilities to form heterodimers with wild-type EBF3.

298 nformation-dependent, interaction within the heterodimer, with beta2AR activation rapidly uncoupling

299 ach of these mutations stabilize most of the heterodimers, with the largest effects observed for FGFR

300 Because KSR and B-Raf exist as heterodimers within the cell, this binding also brings B