ライフサイエンスコーパス: heterogeneity

1 o adapt while maintaining their intratumoral heterogeneity.

2 a bloodstain to account for intrinsic sample heterogeneity.

3 odels, one of them accounting for subsurface heterogeneity.

4 ify what determines local savanna vegetation heterogeneity.

5 cal method, Phantom, to investigate gene set heterogeneity.

6 enes, the 3' boundary displays gene-specific heterogeneity.

7 guide prospective characterization of cancer heterogeneity.

8 ins have not been scrutinized for underlying heterogeneity.

9 erage uptake rather than to the uptake local heterogeneity.

10 studies that included overall abuse revealed heterogeneity.

11 ng therapy resistance caused by intratumoral heterogeneity.

12 solutions used due to their physicochemical heterogeneity.

13 private polymorphisms) likely contribute to heterogeneity.

14 rth, leading to functional and proliferative heterogeneity.

15 hree-repeat-domain Tau(3RD) with an inherent heterogeneity.

16 ent, are not adapted to the analysis of this heterogeneity.

17 istics including connectivity, stability and heterogeneity.

18 rd Ottawa sand, which presented less surface heterogeneity.

19 dynamic CNS damage hypothesis to explain MS heterogeneity.

20 ity, energetic heterogeneity, and functional heterogeneity.

21 hape the expansion and constraint of genomic heterogeneity.

22 results was not possible due to considerable heterogeneity.

23 es unparalleled resolution to study cellular heterogeneity.

24 compared with the visual assessment of tumor heterogeneity.

25 t how zDHHC enzymes contribute to acyl chain heterogeneity.

26 iffness, without disrupting local structural heterogeneity.

27 easurement to overcome challenges of wetland heterogeneity.

28 , which contributes to its observed clinical heterogeneity.

29 sis was 1.43 (95% CI, 1.19-1.67; P-value for heterogeneity =0.76).

30 se (IQ-OR, 1.44; 95% CI, 1.16 to 1.79; P for heterogeneity = .10) versus estrogen receptor-negative d

31 or the novel oral anticoagulant type (P for heterogeneity = .15).

32 to the indication for anticoagulation (P for heterogeneity = .49) or the novel oral anticoagulant typ

33 To examine subtype heterogeneity across known breast cancer risk factors, w

34 Despite this high degree of heterogeneity, AD is still considered a single disease a

35 Method potential) indicate a common dynamic heterogeneity, along with other features of glass-formin

36 tissue restriction, and even identified flux heterogeneity among Drosophila clades.

37 When THEMIS is used to analyze tumor heterogeneity among multiple biopsies from the same pati

38 tive epidemiological approach highlights the heterogeneity among polio transmission determinants.

39 g single-cell RNA-seq, we unearth unexpected heterogeneity among SCs and TACs of hair follicles.

40 There was moderate to high heterogeneity among the included studies.

41 rom which can be used to identify phenotypic heterogeneities and inter-cellular interactions that fur

42 Heterogeneities and oncogenesis essentially result from

43 Additionally, intratumoral heterogeneity and adaptations to therapeutic pressure by

44 of these findings were hindered by potential heterogeneity and by the rarity of the implicated allele

45 ate can arise from host, group and landscape heterogeneity and can result in different patterns of sp

46 ly, these studies have revealed the cellular heterogeneity and complexity of antigen-bearing cells wi

47 This study sheds new light on the heterogeneity and complexity of MDSC during chronic infe

48 may, for example, uncover the immunological heterogeneity and differentiation of Langerhans cells, d

49 s, the TRACERx consortium investigates tumor heterogeneity and evolution in early-stage non-small cel

50 nisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases.

51 ts must take into account this environmental heterogeneity and how its effects on regeneration dynami

52 We show that group size heterogeneity and intergroup interactions affect the str

53 development is challenged by high intratumor heterogeneity and interpatient diversity.

54 Disease heterogeneity and poor understanding of pathogenic mecha

55 ver, a detailed understanding of the spatial heterogeneity and potential temporal variability of thes

56 h to target LSCs, with their well-documented heterogeneity and readily evident intra- and interpatien

57 uidance in clinical decision making owing to heterogeneity and scarcity.

58 based techniques, begins to elucidate the FH heterogeneity and the mutation spectrum in the Iranian p

59 a critical functional link between ribosome heterogeneity and the post-transcriptional circuitry of

60 , including its sensitivity to environmental heterogeneity and to choice of currency.

61 xt for the use of this system to examine how heterogeneity and transitions between disease and non-di

62 lonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

63 contributes to cancer evolution, intratumor heterogeneity, and drug resistance.

64 ncluding structural heterogeneity, energetic heterogeneity, and functional heterogeneity.

65 Study quality, heterogeneity, and inconsistency were evaluated.

66 al data to characterize disease progression, heterogeneity, and severity in patients with severe or d

67 herapeutic drug delivery correlated with TAM heterogeneity, and successful response to CSF-1R blockad

68 ependency, signalling plasticity, and tumour heterogeneity, and we offer a perspective on emerging ne

69 is heterogeneous in 70% of strains, and this heterogeneity arises from sequence exchange between stra

70 re poorly predicted suggesting that chemical heterogeneities as a function of size or chemically dist

71 We treat heterogeneity as a latent class allocation problem and p

72 Clinical and genetic heterogeneity associated with retinal diseases makes ste

73 n of an integrated approach to elucidate how heterogeneity at the transcriptional level manifests in

74 classical prognostic factors and there is no heterogeneity between cohorts.

75 We find evidence of genetic heterogeneity between the sub-phenotypes of NSOFC and am

76 There was no significant heterogeneity between the subgroups in relation to Weste

77 there was no strong statistical evidence for heterogeneity between them (all bootstrap P > 0.003, equ

78 , in the setting of significant intratumoral heterogeneity, biopsies may not be representative of the

79 ich were sensitive to the presence of uptake heterogeneity but did not distinguish between hyper- and

80 e utility of FES imaging for assessing tumor heterogeneity by localizing immunohistochemically ER-pos

81 clusive events with tranexamic acid, with no heterogeneity by site of bleeding (p=0.5956).

82 There was some evidence of heterogeneity by tumor grade ( P = .02), with an increas

83 resent study suggests that organic molecular heterogeneities can withstand diagenesis and be recogniz

84 results show that quantifying CTC phenotypic heterogeneity can help inform the choice between ARSI an

85 e of the major problems in cancer targeting: heterogeneity, change in phenotype during disease progre

86 Locus heterogeneity characterizes a variety of skeletal dyspla

87 This heterogeneity complicates the identification of conserva

88 This heterogeneity could be due to tau aggregates forming dis

89 Mathematical models accounting for this heterogeneity demonstrate that while a patchy distributi

90 tudy aimed to determine whether quantitative heterogeneity derived from various texture features on d

91 This 3' UTR heterogeneity directs distinct temporal patterns of tran

92 te the balance of Wnt signaling and cellular heterogeneity during tumor progression.

93 ment-protein complexes, including structural heterogeneity, energetic heterogeneity, and functional h

94 e follow-up of changing PD-L1 expression and heterogeneity evaluation of PD-L1 expression across tumo

95 ficant intratumoral and intertumoral genomic heterogeneity evolves during tumorigenesis.

96 the HSCT decisions revealed the anticipated heterogeneity, favoring an ongoing prospective matched-p

97 We observed widespread intratumor heterogeneity for both somatic copy-number alterations a

98 Subtype heterogeneity for breast cancer risk factors has been su

99 tation of our analysis is the high degree of heterogeneity for effects on most behaviours, possibly d

100 the diagnostic test accuracy and sources of heterogeneity for the discriminative potential of diffus

101 ontrary to the view that non-allelic genetic heterogeneity hampers gene discovery, this study demonst

102 3',5'-linkages, and overcoming this backbone heterogeneity has long been considered a major limitatio

103 The existence of fine-grain climate heterogeneity has prompted suggestions that species may

104 We identified considerable heterogeneity (I(2) of >75%) between estimates for almos

105 ed to be caused by large-scale compositional heterogeneity (i.e., thermochemical piles).

106 gy can be used to evaluate, quantify and map heterogeneities in diffusional properties within complex

107 tinguish between the presence and absence of heterogeneities in lipid-packing order.

108 Dynamic heterogeneities in packing order were detected in mixed-

109 od to investigate the role of noise on tumor heterogeneity in a 38-dimensional network model for pros

110 lation FBA) successfully described metabolic heterogeneity in a population of independent Escherichia

111 ld survival in Africa, there was substantial heterogeneity in absolute levels of under-5 and neonatal

112 meta-analysis across a range of scenarios of heterogeneity in allelic effects between ethnic groups.

113 iation than fixed-effects meta-analysis when heterogeneity in allelic effects is correlated with ance

114 oscopy and AFM-IR imaging to characterize OM heterogeneity in an artificially matured series of New A

115 expression data is commonly used to identify heterogeneity in biologic samples.

116 These data reveal heterogeneity in cancer cell phenotypes, including angio

117 We show how myocardial region-specific heterogeneity in cell function emerges during early deve

118 We examined heterogeneity in colorectal cancer incidence in intermed

119 rmed an unbiased analysis of transcriptional heterogeneity in colorectal tumors and their microenviro

120 reveal distinct local- and continental-scale heterogeneity in community excretion rates.

121 stipation per Rome III criteria, significant heterogeneity in CTT, PAC-SYM, and PAC-QOL exists among

122 odds ratio (MOR) was calculated to quantify heterogeneity in delayed fixation between hospitals.

123 e results show evidence for the role of prey heterogeneity in driving functional complementarity amon

124 ound to in part account for the intratumoral heterogeneity in EGFR activity observed.

125 INTERPRETATION: Despite significant heterogeneity in exposure and outcome measures, clear ev

126 l RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populatio

127 Noise-induced heterogeneity in gene expression is an inherent reality

128 Heterogeneity in gene expression responses among cells a

129 entical cells frequently display substantial heterogeneity in gene expression, cellular morphology an

130 Heterogeneity in genetic architecture underlying complex

131 tudies have unveiled the complexity of tumor heterogeneity in glioblastoma and provide new insights i

132 redator interactions and the consequences of heterogeneity in herbivore body size and diet breadth (i

133 and single-cell RNA sequencing to reveal the heterogeneity in IL-4-induced I transcription.

134 Heterogeneity in LEP expression and secretion may influe

135 To reduce the geographic heterogeneity in liver transplant allocation, the United

136 Here, we take advantage of a region-specific heterogeneity in luminal progenitors to interrogate the

137 s can be ascribed, to a great extent, to the heterogeneity in macrophage activation.

138 ria antibody responses can help characterise heterogeneity in malaria transmission.

139 By revealing heterogeneity in MCII's effectiveness, this research adv

140 We demonstrate spatial genomic heterogeneity in more than 75% of patients, including in

141 ion of novel therapies, there is significant heterogeneity in patient outcome and a need for rational

142 erall and across sociodemographic groups but heterogeneity in patterns of use across clinical conditi

143 ave important implications for water isotope heterogeneity in plants and for our understanding of how

144 tested whether species traits accounted for heterogeneity in range shifts.

145 nted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to det

146 The heterogeneity in resource allocation did not seem to mat

147 Spatial heterogeneity in soil moisture and conspecific density w

148 Heterogeneity in study design prevented meta-analysis.

149 find a high degree of mixed selectivity and heterogeneity in superficial entorhinal neurons.

150 We find significant geographic heterogeneity in survival that can be partially explaine

151 nd accounted for 30% of the between-province heterogeneity in survival.

152 association with these features of clinical heterogeneity in synucleinopathies.

153 To characterize drivers of state-level heterogeneity in TB epidemiology in the four U.S. states

154 The data suggested a role for Env glycoform heterogeneity in the activation of the lineage germline

155 There was a considerable degree of heterogeneity in the associations across cohorts, includ

156 tion to model force generation and to reveal heterogeneity in the cell population studied.

157 To model this heterogeneity in the data, we introduce a novel, supervi

158 tion, individual neurons displayed extensive heterogeneity in the dynamics of responses to pulses.

159 ays that are related to morphology-dependent heterogeneity in the electrochemical and chemical stabil

160 Our simulations show that the impact of heterogeneity in the host structure is maximal in the bi

161 There is significant heterogeneity in the performance of RNA-Seq workflows to

162 These conditions introduce multiple types of heterogeneity in the pigment-protein complexes, includin

163 A contributor to heterogeneity in the reported literature is the source o

164 The results showed heterogeneity in the responses of individual KSHV episom

165 SNV mutational profiles reflect the expected heterogeneity in this disease.

166 to selectively manipulate owing to cellular heterogeneity in this region.

167 Phenotypic heterogeneity in Tourette syndrome is partly due to comp

168 of significant value for dissecting cellular heterogeneity in tumors and analyzing single circulating

169 ents, propagation of aneuploidy, and genetic heterogeneity in xenograft models likely through modulat

170 Metrics of heterogeneity, including median odds ratio (MOR), were c

171 The conformity index (CI), heterogeneity index (HI), and parameters of critical str

172 the need to account for sparsity due to the heterogeneity intrinsic in multi-group studies.

173 strate this using recent work accounting for heterogeneity involving the pathogen.

174 The results indicate that metabolic heterogeneity is a distinct property of activated beige/

175 Cell-to-cell heterogeneity is a major driver of cancer evolution, pro

176 This heterogeneity is caused by quality issues affecting stud

177 Whether this pathologic heterogeneity is due to a cell of origin of bipotent liv

178 rocesses operate, obfuscate how this spatial heterogeneity is generated.

179 of the most pronounced realisations of this heterogeneity is seen in the case of vector-borne pathog

180 Our work shows that growth rate heterogeneity is the primary shape determinant in Marcha

181 This heterogeneity is the result of increased sensitivity to

182 Stromal-derived intratumoural heterogeneity (ITH) has been shown to undermine molecula

183 chromosome 6q14.1 was the most significant (heterogeneity logarithm of odds score = 3.38).

184 f LCIS and invasive ductal carcinomas (P for heterogeneity < 0.01).

185 and human pancreata reveal a number of novel heterogeneity markers in mammalian beta cells.

186 ach serotype, suggesting that genotype-level heterogeneity may be limited in older children.

187 letely lesioned in stroke survivors and this heterogeneity may have prevented its identification in l

188 anges in C. jejuni morphology due to genetic heterogeneity may promote C. jejuni survival.

189 rease oncogene copy number and intratumoural heterogeneity more effectively than chromosomal amplific

190 gram analysis combining central tendency and heterogeneity mpMRI features is promising for non-invasi

191 as three-dimensional (3D) architecture, cell heterogeneity, nutrient gradients and the interaction be

192 investigations into understanding the signal heterogeneities observed with SMSERS.

193 red with unvaccinated populations, with some heterogeneity observed by country.

194 ue-specific levels of aneuploidy and genetic heterogeneity observed in primary tumors.

195 Spatiotemporal heterogeneities of eco-exergy and specific eco-exergy se

196 tes that although the clinical and etiologic heterogeneity of AN is universally recognized, further c

197 zation of immunoassays is complicated by the heterogeneity of antibodies used and the absence of phys

198 le AP states might increase the local/global heterogeneity of AP repolarisations in the ventricle.

199 demiologists work together to understand the heterogeneity of asthma.

200 tigated the in vivo molecular and functional heterogeneity of astrocytes inter-regionally from adult

201 cycle that reveals surprising conformational heterogeneity of ATP-bound BiP that distinguishes BiP fr

202 itulate key features regarding the intrinsic heterogeneity of cancer tissues.

203 in the dysfunctional state and highlight the heterogeneity of CD8(+) T-cell phenotypes present in chr

204 ing neurological diseases do not address the heterogeneity of cell types from one CNS region to anoth

205 Both heterogeneity of classical MPNs and prognosis are determ

206 immune system with donor cells, although the heterogeneity of clinical manifestations suggests that p

207 attention has been given to potential sexual heterogeneity of confounder associations with outcomes.

208 croscopy and flow cytometry to highlight the heterogeneity of drug activity within tumor cells locate

209 y analysis can provide new insights into the heterogeneity of drug treatment effects.

210 tep meta-analysis did not reveal evidence of heterogeneity of effect (I(2)=0.0, p=0.56).

211 ctive material for future studies in spatial heterogeneity of electrocatalytic surfaces.

212 Small-scale heterogeneity of element distributions recently has rece

213 In particular, the heterogeneity of farming practices between continents wa

214 e the presumably high molecular and cellular heterogeneity of ILD, common protein regulations are obs

215 ion and activation processes, as well as the heterogeneity of immune cell types.

216 he purpose was to determine whether size and heterogeneity of LGE predict appropriate implantable car

217 The spatial heterogeneity of malaria suggests that interventions may

218 dings highlight the molecular and anatomical heterogeneity of midbrain dopaminergic neurons and contr

219 We analyzed the spatial heterogeneity of multiregional biopsies from 35 patients

220 There is significant heterogeneity of outcomes in studies examining the effec

221 However, a small increase in the heterogeneity of packing velocities was observed in the

222 pproaches are needed to overcome the genetic heterogeneity of pancreatic cancer predisposition.

223 An improved understanding of the heterogeneity of presenting symptoms among patients with

224 this study characterized the plasticity and heterogeneity of prostate cancer cells with regard to an

225 vely little is known about the compositional heterogeneity of protein complexes, mostly due to techni

226 Heterogeneity of protein glycosylation poses great chall

227 Participants with T2DM exhibited greater heterogeneity of repolarization during hypoglycemia as d

228 ns arose independently, leading to subclonal heterogeneity of resistant disease.

229 velopment projects, especially regarding the heterogeneity of sediment element composition and its ec

230 eneralization of the data was limited by the heterogeneity of study populations, methods, and outcome

231 In hydrological sciences, the heterogeneity of subsurface properties, such as hydrauli

232 The functional heterogeneity of T cell responses to diverse antigens ex

233 f the total T cell response, underlining the heterogeneity of T cell responses to HDM allergens.

234 bservations highlight the serotype-dependent heterogeneity of the capsid assembly process and challen

235 could not be performed because of the large heterogeneity of the included studies.

236 au constructs and characterized the size and heterogeneity of the tau-tubulin complexes formed under

237 spite significant progress, the high genetic heterogeneity of these disorders often requires large sa

238 The heterogeneity of these novel strains hampers a single sp

239 transformed T cells further highlighted the heterogeneity of this disease.

240 The continued observation of heterogeneity of treatment response by baseline lipids s

241 in PDX mice and also exhibited in vivo-like heterogeneity of tumor responses.

242 We observed inter- and intratumoral heterogeneity of uptake, and (89)Zr-bevacizumab uptake w

243 change by indicating a spatial and temporal heterogeneity of vegetation change at the EOT in both he

244 ymmetry and exploring structure dynamics and heterogeneity of viral assemblies have revealed importan

245 Our data shows that the heterogeneity of VTD responses reflects distinct subpopu

246 or quantifying the structural complexity and heterogeneity of weighted complex networks.

247 effects of age, sex, genetics, and cellular heterogeneity on the interindividual variability of immu

248 Unobserved heterogeneity only explains a small fraction of the vari

249 h primary magmatic processes, such as mantle heterogeneity or change in depth of melt formation withi

250 ng accelerated cancer progression, etiologic heterogeneity, or risk factor exposure in PLWH.

251 However, whether this heterogeneity originates from neuronal identity and/or n

252 It also remains unclear how translational heterogeneity originates.

253 the smaller sample size and sample-to-sample heterogeneity, our prediction models were not able to di

254 ract disease were larger for men than women (heterogeneity P<0.001), but RRs for serious liver compli

255 iver complications appeared higher in women (heterogeneity P<0.001).

256 Such biochemical wall heterogeneities precede wall bending.

257 Heterogeneity precluded meta-analysis.

258 Clinical heterogeneity precluded primary outcome meta-analysis fo

259 y fashion, not accounting for the structural heterogeneity present in disordered regions.

260 es to the phenomenon of intratumoral genetic heterogeneity, provides the genetic diversity required f

261 barriers, salinity, depth, and environmental heterogeneity relate to the evolution of biota.

262 al relevance of the observed tonic signaling heterogeneity remain open questions today.

263 s, ontogeny, transcriptional regulation, and heterogeneity remains largely unknown, hampering their c

264 imensional TAM composition, tumour-to-tumour heterogeneity, response to colony-stimulating factor 1 r

265 pathology in our model that recapitulate the heterogeneity seen in these human diseases.

266 Accordingly, we suggest spatial heterogeneity should be a major focus for maintaining th

267 thromboembolism; the increase in model clot heterogeneity shows that S. epidermidis can rupture a fi

268 ous approaches may yield insights into tumor heterogeneity; single cell analysis may provide a key fo

269 - cell state can promote intra-tumor genetic heterogeneity, spur tumor evolution and increase tumor f

270 An important source of disease heterogeneity stemmed from variation in each patient's p

271 Furthermore, substantial heterogeneity supports the need for more robust studies

272 Interestingly, we found genetic heterogeneity (that is, different sets of loci associate

273 ed changes suggest compositional or physical heterogeneity, their scale has not resulted in substanti

274 y, conceivably because, due to spatial tumor heterogeneity, they were restricted to clones that were

275 ial to improve our understanding of cellular heterogeneity through discovering novel quality attribut

276 nd utilization rates would reduce geographic heterogeneity to 4.9% in the 8-region model and 4.6% in

277 onstrates how to exploit this inherent tumor heterogeneity to discover therapeutic vulnerabilities.

278 prehend genetic, biological, and symptomatic heterogeneity underlying Alzheimer's disease (AD) requir

279 and additionally uncover static and dynamic heterogeneity usually masked in molecular ensembles.

280 ere conducted with random effect models, and heterogeneity was addressed with I(2) index, controlling

281 impact of p53 loss on 5-methylcytosine (5mC) heterogeneity was also evident in human ESCs and mouse e

282 Heterogeneity was assessed by the Cochran Q statistic an

283 Heterogeneity was driven by neuropathologic subtype and

284 Heterogeneity was explored using stratification and rand

285 cation bias was not evident (Egger P = .51); heterogeneity was high (I(2) = 92%, P < .001).

286 cation bias was not evident (Egger P = .28); heterogeneity was high (I(2) = 98%, P < .001).

287 Significant center-level heterogeneity was noted in BMI of accepted donors; the M

288 Moderate-to-substantial statistical heterogeneity was noted.

289 Overall, high heterogeneity was observed for comparisons involving xan

290 Considerable between-study heterogeneity was observed for most outcomes.Isolated so

291 Heterogeneity was quantified on the basis of the diversi

292 ug resistance is rooted mainly in tumor cell heterogeneity, we examined the drug effect in different

293 To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA inter

294 Risk of bias and heterogeneity were assessed.

295 uronal growth cones, and uncover a molecular heterogeneity whereby different filopodia display marked

296 heterogeneous, suggesting that environmental heterogeneity will affect large-scale Wolbachia transfor

297 a hiPSC-based panel spanning the mutational heterogeneity within a single disease and establishes a

298 Heterogeneity within pathogen species can have important

299 It further reveals that expression heterogeneity within single-cell populations is regulate

300 -cell gene expression analysis to define the heterogeneity within the LSC population in chronic phase