ライフサイエンスコーパス: heterokaryon

1 thin the common cytoplasm of a multinucleate heterokaryon.

2 het locus (11 in N. crassa) to form a stable heterokaryon.

3 on in normal matings and in the self-fertile heterokaryon.

4 self-fertile strain, which was shown to be a heterokaryon.

5 fusion with a different individual to form a heterokaryon.

6 n endothelial cells in stable, non-dividing, heterokaryons.

7 ons, while those of the same VCG form viable heterokaryons.

8 oration within the somatic partner nuclei in heterokaryons.

9 nucleus and shuttle between nuclei in yeast heterokaryons.

10 al fusion with different individuals to form heterokaryons.

11 ramming of somatic cells in experimental ESC-heterokaryons.

12 uman and mouse transcripts in these chimeric heterokaryons.

13 ith ~0.4% of Purkinje cells being binucleate heterokaryons.

14 FTR channels, in control NHBEs and hMSC/NHBE heterokaryons.

15 BEs) and observed the formation of hMSC/NHBE heterokaryons.

16 s a role in the formation of Purkinje neuron heterokaryons.

17 ns resulting in the formation of binucleated heterokaryons.

18 r cells after fusion in stable multinucleate heterokaryons.

19 ls to initiate somatic cell reprogramming in heterokaryons.

20 assembly in human cells and in human-simian heterokaryons.

21 elic expression of selected Xi-genes by many heterokaryons (30-50%).

22 omorphs (a and A), resulting in self-fertile heterokaryons (a type of sexual reproduction termed pseu

23 t for heterokaryon), they cannot form stable heterokaryons after vegetative fusion.

24 Neuroblast:glioma heterokaryon analyses revealed that loss of neurovirulen

25 Nucleocytoplasmic shutting was determined by heterokaryon analyses.

26 Both ATP depletion studies and heterokaryon analysis demonstrated that TRbeta rapidly s

27 Neuron-glioma heterokaryon analysis implicates neuronal trans-dominant

28 Heterokaryon analysis indicates that Cca1p is a nucleus/

29 Combining heterokaryon analysis with fluorescence in situ hybridiz

30 Using a modified heterokaryon analysis, we have localized the Vpr nuclear

31 tly reprogram lymphocytes and fibroblasts in heterokaryon and hybrid assays.

32 Heterokaryon and in situ hybridization experiments revea

33 Heterokaryon and transformation tests showed that nonsel

34 t the fact that matings can produce unstable heterokaryons and disrupt the pseudohomothallic life cyc

35 uman keratinocytes and mouse muscle cells in heterokaryons, and extensive changes are observed within

36 lasmic shuttling activity in an interspecies heterokaryon assay and for the ability to associate with

37 Examination of Mta localization in a heterokaryon assay provided evidence that Mta shuttles b

38 aller than 42 kDa shuttle efficiently in the heterokaryon assay via a crm-1-independent mechanism.

39 not demonstrate detectable shuttling in the heterokaryon assay yet still coactivates EBNA2 similarly

40 Using a series of SENP2 mutants and a heterokaryon assay, we demonstrate that SENP2 shuttles b

41 Furthermore, using an interspecies heterokaryon assay, we found that QKI-5, but not another

42 uclear shuttling of v-Rel in an interspecies heterokaryon assay.

43 ttled between the nucleus and cytoplasm in a heterokaryon assay.

44 her confirmed the functionality of NES2 by a heterokaryon assay.

45 Heterokaryon assays confirmed directly that ACF shuttles

46 However, heterokaryon assays demonstrated that ZBP-89 retained p5

47 We carried out heterokaryon assays using cells that endogenously produc

48 RM1-specific inhibitor leptomycin B (LMB) in heterokaryon assays, suggesting a role for an export rec

49 0 is unable to shuttle out of the nucleus in heterokaryon assays, suggesting the existence of specifi

50 -1 was cloned by a novel procedure employing heterokaryon-assisted transformation and ligation-mediat

51 In addition, heterokaryons at the MAT locus were observed in field is

52 Analysis of heterokaryons between CsA-dependent HeLa-P4 cells and Cs

53 Interestingly, heterokaryons between primary monocytes and a human embr

54 y macrophages and macrophage-epithelial cell heterokaryons, but not epithelial cell lines.

55 s round 1 genomic exclusion, resulted in two heterokaryon clones of different mating types which have

56 These rad51 null heterokaryons complete all of the early and middle stage

57 erozygous loci to homozygosity, resulting in heterokaryons containing highly diverse populations of d

58 In heterokaryons containing Mdm2 and p19(ARF), the longer t

59 afficking was analyzed by using interspecies heterokaryons containing nuclei from infected and uninfe

60 The heterokaryons created ectopic ventricular pacemaker acti

61 nalysis of LPS-induced NF-kappaB activity in heterokaryons derived from polyethylene glycol-fused cel

62 These heterokaryons display a T-cell-like phenotype with respe

63 ed somatic cells were poorly reprogrammed in heterokaryons, due in part to defective DNA replication.

64 leocytoplasmic shuttling was demonstrated by heterokaryon experiments and energy-dependent blockade o

65 ion maintenance 1 (CRM1) overexpression, and heterokaryon experiments indicate that Bright actively s

66 Heterokaryon experiments revealed that v-ErbA did not un

67 Using a heterokaryon export assay in transfected cultured cells,

68 As assayed in heterokaryons, export of SLBP from the nucleus is depend

69 The heterokaryons expressed several proteins characteristic

70 Heterokaryons expressed the alpha- and gamma-ENaC subuni

71 man Jurkat T leukemia cells and formation of heterokaryons failed to result in a complementation of t

72 compatibility, minimizing the possibility of heterokaryon formation and mitotic recombination.

73 Within 4 h of heterokaryon formation and with protein synthesis inhibi

74 , het genes play crucial roles by regulating heterokaryon formation between different individuals.

75 However, viable heterokaryon formation between individuals of the same V

76 The observation that heterokaryon formation in the cerebellum occurs as part

77 e, we have explored Purkinje cell fusion and heterokaryon formation in the human brain and the influe

78 1 does not greatly affect vegetative growth, heterokaryon formation or male fertility in either matin

79 We have shown that heterokaryon formation takes place in control subjects,

80 ween nucleus and cytoplasm was also shown by heterokaryon formation upon cell fusion.

81 Purkinje cells were analysed for heterokaryon formation using immunohistochemistry techni

82 o tightly linked genes in barrage formation, heterokaryon formation, and asymmetric, gene-specific in

83 related increase in Purkinje cell fusion and heterokaryon formation.

84 ransplanted BMDCs predominantly derives from heterokaryon formation.

85 BMDC-Purkinje heterokaryons formation may reflect an endogeneous neuro

86 activity of influenza A viral polymerases in heterokaryons formed between avian (DF1) and human (293T

87 ivo experiments examining lysosome fusion in heterokaryons formed between cells containing fluorescen

88 Heterokaryons formed by the fusion of anergic murine T c

89 in reprogramming, we generated interspecies heterokaryons (fused mouse embryonic stem (ES) cells and

90 uttle between the nucleus and cytoplasm in a heterokaryon fusion assay, suggesting the presence of nu

91 ttles from the nucleus to the cytoplasm in a heterokaryon fusion assay.

92 tep gene replacement and by a new procedure, heterokaryon gene replacement.

93 e transcription products, and is dominant in heterokaryons generated by fusion of permissive and nonp

94 fungal individuals are unable to form viable heterokaryons if they differ in allelic specificity at a

95 In mitotic heterokaryons, INCENP was detected in association with s

96 Heterokaryon incompatability in vegetatively growing fun

97 ns is dependent upon genetic constitution at heterokaryon incompatibility (het) loci.

98 e growth in filamentous fungi is mediated by heterokaryon incompatibility (het) loci.

99 nserved programmed cell death pathway called heterokaryon incompatibility (HI).

100 n filamentous ascomycete fungi and is termed heterokaryon incompatibility (HI).

101 s required for het-c nonself recognition and heterokaryon incompatibility (HI).

102 seemed plausible that N. tetrasperma avoids heterokaryon incompatibility by maintaining compatible a

103 prion-driven neurodegenerative diseases and heterokaryon incompatibility in fungi, is discussed.

104 is conferred by genetic differences at het (heterokaryon incompatibility) loci.

105 ses the question of how this organism avoids heterokaryon incompatibility.

106 spora anserina, and is involved in mediating heterokaryon incompatibility.

107 in a self/nonself recognition process called heterokaryon incompatibility.

108 the evolved biological function of HET-s in heterokaryon incompatibility.

109 self/non-self recognition phenomenon called heterokaryon incompatibility.

110 gene products of Podospora anserina trigger heterokaryon incompatibility.

111 egulation, inducibility of other prions, and heterokaryon incompatibility.

112 However, the viability of such heterokaryons is dependent upon genetic constitution at

113 reprogramming towards pluripotency in single heterokaryons is initiated without cell division or DNA

114 We conclude that nuclear reprogramming in heterokaryons is rapid, extensive, bidirectional, and di

115 ted with Crm1 and showed nuclear export in a heterokaryon nucleocytoplasmic shuttling assay.

116 Since heterokaryons obtained by somatic fusion of an inf1-sile

117 d antigen is reversible by immunization with heterokaryons of dendritic cells and MUC1-positive carci

118 Findings from studies involving forced heterokaryons of opposite mating-type strains show that

119 s well as the subsequent formation of stable heterokaryons, offers a tantalizing potential solution t

120 ort of proteins and RNAs has been studied in heterokaryons or by microinjecting test substrates into

121 Heterokaryons or partial diploids that contain het-c all

122 e of proliferation (embryonic stem [ES] cell heterokaryons) or DNA replication (nuclear transfer).

123 In this work, transport experiments based on heterokaryons, photobleaching, and micronucleation demon

124 development in zebrafish and mice as well as heterokaryons point to a role beyond immunology.

125 ed for hyphal elongation and survival of the heterokaryon produced by cell fusion.

126 I(f)-mediated pacemaker activity arises from heterokaryons rather than electrotonic coupling.

127 In the heterokaryon rescue technique, gene deletions are carrie

128 are essential and can only be propagated by heterokaryon rescue.

129 Heterokaryon shuttling assays with NIH3T3 (mouse) cells

130 otein from the nucleus is greatly reduced in heterokaryon shuttling assays.

131 Analysis of reciprocal heterokaryons suggested the absence of an inhibitor of v

132 e function of SRE was further confirmed by a heterokaryon test and by gene complementation.

133 ele is maintained in spontaneously generated heterokaryons that consist of two genetically distinct t

134 o autologous DC resulted in the formation of heterokaryons that express the CA-125 Ag and DC-derived

135 attern of gene expression in the ESCs of the heterokaryons that recapitulated ontogeny, with early me

136 Heterokaryons that silently harbor homozygous recessive

137 genic homokaryotic progeny from the silenced heterokaryons, thereby demonstrating that the presence o

138 at one or more of these loci (termed het for heterokaryon), they cannot form stable heterokaryons aft

139 at Tox1B; (2) the ability of Tox1A- + Tox1B- heterokaryons to complement for T-toxin production; and

140 We show that, in addition to shuttling in heterokaryons, TRalpha shuttles rapidly in an unfused mo

141 n het specificity undergo hyphal fusion, the heterokaryon undergoes a programmed cell death reaction

142 nts showed that the membrane surface area of heterokaryons was similar to that of NHBEs.

143 By forming HeLa-L929 cell heterokaryons, we demonstrate that HuR shuttles between

144 By using human-simian cell heterokaryons, we show that the inhibition of assembly i

145 No mononucleate polyploid Purkinje cell heterokaryons were found.

146 When these heterokaryons were mated, the exconjugant progeny cells

147 that the vif-deleted virions released by the heterokaryons were noninfectious whereas the wild-type v

148 ase defect in HeLa versus T cells, transient heterokaryons were produced between HeLa cells and the J

149 of the block to HIV-1 assembly, mouse-human heterokaryons were tested for ability to assemble and re

150 These knockout heterokaryons were used to demonstrate that gene transfe

151 is mobility of Nup2p was also detected using heterokaryons where, unlike nucleoporins, Nup2p was obse

152 ls of different VCGs fail to form productive heterokaryons, while those of the same VCG form viable h

153 mating of gamma-tubulin gene, GTU1, knockout heterokaryons with a GTU1 gene inserted into the MTT1 lo

154 n of human cultured cells to produce mitotic heterokaryons with two spindles fused in a V conformatio

155 protein gp120-gp41, and we asked whether the heterokaryons would release infectious HIV gpt virions.

156 nfined to the nucleus, we created binucleate heterokaryon yeast cells in which one nucleus suffered a